Benchmarking the Cost per Person of Mass Treatment for Selected Neglected Tropical Diseases: An Approach Based on Literature Review and Meta-regression with Web-Based Software Application
DiscussionThe available evidence confirms that mass treatment offers a low cost public health intervention on the path towards universal health coverage. However, more costing studies focussed on elimination are needed. Unit cost benchmarks can help in monitoring value for money in programme plans, budgets and accounts, or in setting a reasonable pay-out for results-based financing mechanisms. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 4, 2016 Category: Tropical Medicine Authors: Christopher Fitzpatrick Source Type: research
Mathematical Modeling of Programmatic Requirements for Yaws Eradication
M. Marks et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - November 30, 2016 Category: Infectious Diseases Source Type: research
WHO Declares India Free of Yaws and Maternal and Neonatal Tetanus
India was recognized by the World Health Organization in July with official certificates of elimination for 2 neglected tropical diseases —yaws and maternal and neonatal tetanushttp://bit.ly/29VXMeD. These achievements, which were carried out through the existing health system and health workforce in India, illustrate the nation ’s commitment to their elimination and serve as an example to other countries. (Source: JAMA)
Source: JAMA - September 20, 2016 Category: Journals (General) Source Type: research
Mass Treatment with Single-Dose Azithromycin for Yaws
New England Journal of Medicine,Volume 375, Issue 11, Page 1093-1094, September 2016. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - September 13, 2016 Category: Internal Medicine Source Type: research
Opportunities for Integrated Control of Neglected Tropical Diseases That Affect the Skin.
Abstract
Many neglected tropical diseases (NTDs) affect the skin, causing considerable disability, stigma, and exacerbation of poverty. However, there has been relatively little investment into laboratory research, epidemiology, diagnostic tools or management strategies to control tropical skin disease. Integration may advance the control of skin disease across a range of domains, including mapping, diagnosis, clinical management, and community control measures such as mass drug administration. Examples of successful integration strategies include programs targeting scabies, impetigo, yaws, and diseases ca...
Source: Trends in Parasitology - September 12, 2016 Category: Parasitology Authors: Engelman D, Fuller LC, Solomon AW, McCarthy JS, Hay RJ, Lammie PJ, Steer AC Tags: Trends Parasitol Source Type: research
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma
We examined children aged 1 –14 years and took blood and lesion samples for yaws diagnosis using theTreponema pallidum particle agglutination assay (TPPA) and the non-treponemal Rapid Plasma Reagin (RPR) test. ResultsA total of 1,284 children were enrolled in the study. Amongst children aged 5 –14 years, 223 had a positive TPPA (27.5%, 95% CI 13.6–47.7%). The TPPA seroprevalence amongst this age group did not differ significantly from either our pre-mass treatment survey or our initial follow-up survey. Thirty-five children had positive TPPA and positive RPR (4.3%, 95% CI 2.1–8.7%), and this did not differ signific...
Source: PLoS Neglected Tropical Diseases - August 22, 2016 Category: Tropical Medicine Authors: Michael Marks Source Type: research
Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana
To describe the recalled medical history, clinical manifestations and treatment of yaws and syphilis by syphilis sero-reactive blood donors in Kumasi, Ghana (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - August 11, 2016 Category: Infectious Diseases Authors: Francis Sarkodie, Ellis Owusu-Dabo, Oliver Hassall, Imelda Bates, Ib C. Bygbjerg, Henrik Ullum Tags: Short Communication Source Type: research
Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws
Conclusions. The RDT has good sensitivity and specificity of the treponemal and nontreponemal components both in cases of suspected syphilis and yaws, although the sensitivity is decreased at lower antibody titers. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - August 11, 2016 Category: Infectious Diseases Authors: Marks, M., Yin, Y.-P., Chen, X.-S., Castro, A., Causer, L., Guy, R., Wangnapi, R., Mitja, O., Aziz, A., Castro, R., da Luz Martins Pereira, F., Taleo, F., Guinard, J., Belec, L., Tun, Y., Bottomley, C., Ballard, R. C., Mabey, D. C. W. Tags: ARTICLES AND COMMENTARIES Source Type: research
Yaws: towards the WHO eradication target
In 2012 WHO declared a target to eradicate yaws by 2020. The cornerstone of this strategy is community mass treatment with azithromycin. Initial studies suggest this is a very effective tool that may be capable of interrupting transmission. Alongside this there has been progress in the development and validation of diagnostic tests for yaws. Several new challenges have also emerged, in particular, evidence that Haemophilus ducreyi can cause phenotypically similar ulcers in yaws endemic communities, and evidence for a possible non-human primate reservoir. The 2020 eradication target remains ambitious and more challenges sho...
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - June 28, 2016 Category: Tropical Medicine Authors: Marks, M. Tags: Commentary Source Type: research
The Prevalence of Scabies and Impetigo in the Solomon Islands: A Population-Based Survey
Conclusions and Significance Scabies and impetigo are very common in the rural Western Province of the Solomon Islands. Scabies infestation is strongly associated with impetigo. Community control strategies for scabies may reduce the burden of both conditions and their downstream complications. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - June 26, 2016 Category: Tropical Medicine Authors: Daniel S. Mason Source Type: research
Evaluation of Multiplex-Based Antibody Testing for Use in Large-Scale Surveillance for Yaws: a Comparative Study [Epidemiology]
WHO has targeted yaws for global eradication by 2020. The program goals are to interrupt the transmission in countries where yaws is endemic and to certify countries as yaws free where yaws was endemic in the past. No new rapid plasmin reagin (RPR) seroreactivity in young children is required for certification of elimination at a country level. We sought to evaluate whether antibody responses to specific treponemal antigens measured in a high-throughput multiplex bead array (MBA) assay differentiate past versus current infection and whether a nontreponemal lipoidal antigen test can be incorporated into the MBA. Serum and d...
Source: Journal of Clinical Microbiology - April 24, 2016 Category: Microbiology Authors: Cooley, G. M., Mitja, O., Goodhew, B., Pillay, A., Lammie, P. J., Castro, A., Moses, P., Chen, C., Ye, T., Ballard, R., Martin, D. L. Tags: Epidemiology Source Type: research
A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans
by Kobina Assan Ampah, Beatrice Nickel, Prince Asare, Amanda Ross, Daniel De-Graft, Sarah Kerber, Ralf Spallek, Mahavir Singh, Gerd Pluschke, Dorothy Yeboah-Manu, Katharina Röltgen
The debilitating skin disease Buruli ulcer (BU) is caused by infection with Mycobacterium ulcerans. While various hypotheses on potential reservoirs and vectors of M. ulcerans exist, the mode of transmission has remained unclear. Epidemiological studies have indicated that children below the age of four are less exposed to the pathogen and at lower risk of developing BU than older children. In the present study we compared the age at which chi...
Source: PLoS Neglected Tropical Diseases - January 25, 2016 Category: Tropical Medicine Authors: Kobina Assan Ampah et al. Source Type: research
Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen
This article provides an overview of the biology, epidemiology, clinical features, diagnostic tests, and treatment of Haemophilus ducreyi infection, with special reference to the decline of chancroid and the recent emergence of H. ducreyi as a pathogen responsible for chronic limb ulceration clinically similar to yaws.
Recent findings: Chancroid has declined in importance as a sexually transmitted infection in most countries where it was previously endemic. Chancroid may be caused by either class I or class II H. ducreyi isolates; these two classes diverged from each other approximately 1.95 million years ago. H. ducreyi h...
Source: Current Opinion in Infectious Diseases - December 23, 2015 Category: Infectious Diseases Tags: SEXUALLY TRANSMITTED DISEASES: Edited by Karen E. Rogstad Source Type: research
Diagnosis and evaluation of causative factors for the presence of endemic treponemal disease in a Japanese sub-tropical island population from the Tokugawa period
We present a description and differential diagnosis of pathological lesions observed on skeletal elements found during surface surveys of the Nagabaka site on Miyako-jima Island, Japan. The Nagabaka site served as a bone depository during the Early Modern period (c. AD 1600–1870). We evaluated remains via macroscopic inspection to classify infectious lesions according to criteria in Weston (2008). We also obtained CT scans of three bone elements for more extensive lesion analysis and carried out a differential diagnosis utilizing paleopathological literature. Subsequent investigation yielded convincing evidence of trepon...
Source: International Journal of Paleopathology - December 12, 2015 Category: Pathology Source Type: research
Trachoma and Yaws: Common Ground?
by Anthony W. Solomon, Michael Marks, Diana L. Martin, Alexei Mikhailov, Rebecca M. Flueckiger, Oriol Mitjà, Kingsley Asiedu, Jean Jannin, Dirk Engels, David C. W. Mabey (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 3, 2015 Category: Tropical Medicine Authors: Anthony W. Solomon et al. Source Type: research
