Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma

We examined children aged 1 –14 years and took blood and lesion samples for yaws diagnosis using theTreponema pallidum particle agglutination assay (TPPA) and the non-treponemal Rapid Plasma Reagin (RPR) test. ResultsA total of 1,284 children were enrolled in the study. Amongst children aged 5 –14 years, 223 had a positive TPPA (27.5%, 95% CI 13.6–47.7%). The TPPA seroprevalence amongst this age group did not differ significantly from either our pre-mass treatment survey or our initial follow-up survey. Thirty-five children had positive TPPA and positive RPR (4.3%, 95% CI 2.1–8.7%), and this did not differ significantly from our initial post-mass drug administration (MDA) follow-up survey (4.3% versus 3.5%,p = 0.43) but remained significantly lower than our initial pre-MDA survey (4.3% vs 21.7%,p
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research