No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh
This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.PMID:33939630 | DOI:10.4269/ajtmh.21-0124 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 3, 2021 Category: Infectious Diseases Authors: Gretchen M Cooley Leora R Feldstein Sarah D Bennett Concepcion F Estivariz Lauren Weil Rajendra Bohara Maya Vandenent Asm Mainul Hasan Mohammad Saifuddin Akhtar M Salim Uzzaman Mallick Masum Billah Laura Conklin Daniel C Ehlman Kingsley Asiedu Anthony W S Source Type: research
No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh
This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.PMID:33939630 | DOI:10.4269/ajtmh.21-0124 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - May 3, 2021 Category: Tropical Medicine Authors: Gretchen M Cooley Leora R Feldstein Sarah D Bennett Concepcion F Estivariz Lauren Weil Rajendra Bohara Maya Vandenent Asm Mainul Hasan Mohammad Saifuddin Akhtar M Salim Uzzaman Mallick Masum Billah Laura Conklin Daniel C Ehlman Kingsley Asiedu Anthony W S Source Type: research
No Serological Evidence of Trachoma or Yaws Among Residents of Registered Camps and Makeshift Settlements in Cox's Bazar, Bangladesh
This study illustrates how integrated serologic testing can provide needed data to help NTD programs prioritize limited resources.PMID:33939630 | DOI:10.4269/ajtmh.21-0124 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - May 3, 2021 Category: Infectious Diseases Authors: Gretchen M Cooley Leora R Feldstein Sarah D Bennett Concepcion F Estivariz Lauren Weil Rajendra Bohara Maya Vandenent Asm Mainul Hasan Mohammad Saifuddin Akhtar M Salim Uzzaman Mallick Masum Billah Laura Conklin Daniel C Ehlman Kingsley Asiedu Anthony W S Source Type: research
Antibody Responses to Two Recombinant Treponemal Antigens (rp17 and TmpA) before and after Azithromycin Treatment for Yaws in Ghana and Papua New Guinea [Epidemiology]
WHO and its partners aim to interrupt yaws transmission in countries of endemicity and to certify others as being yaws-free. Transmission can be assessed using rapid plasma reagin (RPR) tests, reflecting current or recent infection, but RPR is operationally impractical. We evaluated changes in antibody levels against two recombinant treponemal antigens, rp17 (also known as Tp17) and TmpA, after antibiotic treatment given as part of a randomized controlled trial for yaws in Ghana and Papua New Guinea. Paired serum samples from children aged 6 to 15 years with confirmed yaws, collected before and after treatment, were tested...
Source: Journal of Clinical Microbiology - April 20, 2021 Category: Microbiology Authors: Parameswaran, N., Mitja, O., Bottomley, C., Kwakye, C., Houinei, W., Pillay, A., Danavall, D., Chi, K.-H., Ballard, R. C., Solomon, A. W., Chen, C. Y., Bieb, S. V., Adu-Sarkodie, Y., Mabey, D. C. W., Asiedu, K., Marks, M., Martin, D. L. Tags: Epidemiology Source Type: research
Epidemiologic and Genomic Reidentification of Yaws, Liberia
Emerg Infect Dis. 2021 Apr;27(4):1123-1132. doi: 10.3201/eid2704.204442.ABSTRACTWe confirmed endemicity and autochthonous transmission of yaws in Liberia after a population-based, community-led burden estimation (56,825 participants). Serologically confirmed yaws was rare and focal at population level (24 cases; 2.6 [95% CI 1.4-3.9] cases/10,000 population) with similar clinical epidemiology to other endemic countries in West Africa. Unsupervised classification of spatially referenced case finding data indicated that yaws was more likely to occur in hard-to-reach communities; healthcare-seeking was low among communities, a...
Source: Emerging Infectious Diseases - March 23, 2021 Category: Infectious Diseases Authors: Joseph W S Timothy Mathew A Beale Emerson Rogers Zeela Zaizay Katherine E Halliday Tarnue Mulbah Romeo K Giddings Stephen L Walker Nicholas R Thomson Karsor K Kollie Rachel L Pullan Michael Marks Source Type: research
Epidemiologic and Genomic Reidentification of Yaws, Liberia
J. Timothy et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - March 11, 2021 Category: Infectious Diseases Source Type: research
Ulcerative skin lesions among children in Cameroon: It is not always Yaws
by Jean-Philippe Ndzomo Ngono, Serges Tchatchouang, Mireille Victorine Noah Tsanga, Earnest Njih Tabah, Albert Tchualeu, Kingsley Asiedu, Lorenzo Giacani, Sara Eyangoh, Tania Crucitti
Outbreaks of yaws-like ulcerative skin lesions in children are frequently reported in tropical and sub-tropical countries. The origin of these lesions might be primarily traumatic or infectious; in the latter case,Treponema pallidum subspeciespertenue, the yaws agent, andHaemophilus ducreyi, the agent of chancroid, are two of the pathogens commonly associated with the aetiology of skin ulcers. In this work, we investigated the presence ofT.p...
Source: PLoS Neglected Tropical Diseases - February 16, 2021 Category: Tropical Medicine Authors: Jean-Philippe Ndzomo Ngono Source Type: research
Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of < i > Treponema pallidum < /i >
ConclusionThe ability ofT.p.pallidum to stochastically varytprL expression should be considered in any vaccine development effort that includes this antigen. The role of phase variation in contributing toT.p.pallidum antigenic diversity should be further studied. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 26, 2021 Category: Tropical Medicine Authors: Austin M. Haynes Source Type: research
Yaws, Haemophilus ducreyi, and Other Bacterial Causes of Cutaneous Ulcer Disease in the South Pacific Islands
Cutaneous ulcers in the tropics are a painful and debilitating condition that anchors people into poverty. In rural regions of the South Pacific, infectious cutaneous ulcers are caused mainly by bacteria, including Treponema pallidum pertenue (yaws), Haemophilus ducreyi, and polymicrobial ulcers. For this group of infections the term cutaneous ulcer disease (CUD) is proposed. Some infections can cause malformations on the bone that have a permanent impact on lives in endemic communities. Better characterization of CUD may help design diagnostic tools and more effective antimicrobial therapies. This review updates the knowl...
Source: Dermatologic Clinics - October 30, 2020 Category: Dermatology Authors: Camila G-Beiras, Maria Ubals, Marc Corbacho-Monn é, Martí Vall-Mayans, Oriol Mitjà Source Type: research
Novel Diagnostics for Kaposi Sarcoma and Other Skin Diseases in Resource-Limited Settings
In resource-limited settings, point-of-care diagnostic devices have the potential to reduce diagnostic delays and improve epidemiologic surveillance of dermatologic conditions. We outline novel-point-of care diagnostics that have recently been developed for dermatologic conditions that primarily affect patients living in resource-limited settings, namely, Kaposi sarcoma, cutaneous leishmaniasis, leprosy, Buruli ulcer, yaws, onchocerciasis, and lymphatic filariasis. All of the technologies described in this article are prototypes, and some have undergone field testing. These devices still require validation in real-world se...
Source: Dermatologic Clinics - October 30, 2020 Category: Dermatology Authors: Devon E. McMahon, Linda Oyesiku, Aggrey Semeere, Dongkyun Kang, Esther E. Freeman Source Type: research
Modeling Treatment Strategies to Inform Yaws Eradication.
Abstract
Yaws is a neglected tropical disease targeted for eradication by 2030. To achieve eradication, finding and treating asymptomatic infections as well as clinical cases is crucial. The proposed plan, the Morges strategy, involves rounds of total community treatment (i.e., treating the whole population) and total targeted treatment (TTT) (i.e., treating clinical cases and contacts). However, modeling and empirical work suggests asymptomatic infections often are not found in the same households as clinical cases, reducing the utility of household-based contact tracing for a TTT strategy. We use a model...
Source: Emerging Infectious Diseases - October 21, 2020 Category: Infectious Diseases Authors: Holmes A, Tildesley MJ, Solomon AW, Mabey DCW, Sokana O, Marks M, Dyson L Tags: Emerg Infect Dis Source Type: research
Modeling Treatment Strategies to Inform Yaws Eradication
A. Holmes et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 8, 2020 Category: Infectious Diseases Source Type: research
Ancient Bacterial Genomes Reveal a High Diversity of Treponema pallidum Strains in Early Modern Europe.
Abstract
Syphilis is a globally re-emerging disease, which has marked European history with a devastating epidemic at the end of the 15th century. Together with non-venereal treponemal diseases, like bejel and yaws, which are found today in subtropical and tropical regions, it currently poses a substantial health threat worldwide. The origins and spread of treponemal diseases remain unresolved, including syphilis' potential introduction into Europe from the Americas. Here, we present the first genetic data from archaeological human remains reflecting a high diversity of Treponema pallidum in early modern E...
Source: Current Biology - August 6, 2020 Category: Biology Authors: Majander K, Pfrengle S, Kocher A, Neukamm J, du Plessis L, Pla-Díaz M, Arora N, Akgül G, Salo K, Schats R, Inskip S, Oinonen M, Valk H, Malve M, Kriiska A, Onkamo P, González-Candelas F, Kühnert D, Krause J, Schuenemann VJ Tags: Curr Biol Source Type: research
Serosurvey of Treponema pallidum infection among children with skin ulcers in the Tarangire-Manyara ecosystem, northern Tanzania
The first yaws eradication campaign reduced the prevalence of yaws by 95%. In recent years, however, yaws has reemerged and is currently subject to a second, ongoing eradication campaign. Yet, the epidemiologi... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - June 3, 2020 Category: Infectious Diseases Authors: Clara K. C. Lubinza, Simone Lueert, Luisa K. Hallmaier-Wacker, Esther Ngadaya, Idrissa S. Chuma, Rudovick R. Kazwala, Sayoki G. M. Mfinanga, Klaus Failing, Christian Roos and Sascha Knauf Tags: Research article Source Type: research
Yaws Disease Caused by Treponema pallidum subspecies pertenue in Wild Chimpanzee, Guinea, 2019
B. Mubemba et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - May 6, 2020 Category: Infectious Diseases Source Type: research
