Yaws Disease Caused by Treponema pallidum subspecies pertenue in Wild Chimpanzee, Guinea, 2019
B. Mubemba et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - May 6, 2020 Category: Infectious Diseases Source Type: research
Transatlantic slavery introduced infectious diseases to the Americas
The remains of three slaves found in Mexico contain the earliest signs of the hepatitis B virus and yaws bacteria in the Americas, suggesting transatlantic slavery introduced these diseases (Source: New Scientist - Health)
Source: New Scientist - Health - April 30, 2020 Category: Consumer Health News Source Type: research
Ocular syphilis in Pacific peoples-are we making misdiagnoses secondary to yaws?
CONCLUSION: Syphilitic uveitis is common in New Zealand, occurring in 1 in 55 patients seen in consultant uveitis clinics. Clinicians should consider a history of yaws in Pacific peoples presenting with ocular inflammation and positive treponemal serology. In these cases alternative causes of ocular pathology should be included as differentials. In cases of diagnostic uncertainty, the risk of treatment versus the potentially severe sequelae of untreated syphilis need to be considered.
PMID: 32325468 [PubMed - in process] (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - April 25, 2020 Category: General Medicine Tags: N Z Med J Source Type: research
A Loop-Mediated Isothermal Amplification Assay for the Detection of Treponema pallidum subsp. pertenue.
Abstract
The eradication of yaws caused by Treponema pallidum subsp. pertenue is constrained by the lack of rapid, accurate diagnosis. We sought to develop a molecular point-of-care test for the diagnosis of yaws. A loop-mediated isothermal amplification (LAMP) assay with primers targeting the conserved gene, tp0967, with visual detection by lateral flow test strip was developed and optimized. The limit of detection was evaluated while 63 samples from clinical cases of yaws and five samples with polymerase chain reaction (PCR)-confirmed syphilis were used to determine the sensitivity and specificity of the...
Source: The American Journal of Tropical Medicine and Hygiene - April 19, 2020 Category: Tropical Medicine Authors: Basing LAW, Simpson SV, Adu-Sarkodie Y, Linnes JC Tags: Am J Trop Med Hyg Source Type: research
Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana
ConclusionsPoor personal hygiene, overcrowding and lack of access to improved sanitary facilities are the factors that facilitate the transmission of yaws in the Awutu Senya West and Upper West Akyem districts. Yaws was also more common among males and school-aged children. Improving living conditions, access to good sanitary facilities and encouraging good personal hygiene practices should be core features of eradication programs in endemic communities. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 11, 2020 Category: Infectious Diseases Source Type: research
Yaws in the Philippines: first reported cases since the 1970s
ConclusionsThe clinical, serological, and histopathological confirmation of four yaws cases among children has made the Philippines the 14th country endemic for yaws. This report can help health personnel recognize hidden cases of yaws based on skin signs and serological tests. Yaws remained unrecognized and unreported in the Philippines and in countries previously endemic for yaws probably due to the unsustained integration of the yaws program in the general health services and complacency after the 1950s eradication campaign. Our findings have provided the necessary evidence and stimulus to develop a yaws control and era...
Source: Infectious Diseases of Poverty - January 29, 2020 Category: Infectious Diseases Source Type: research
The "Scourge of the Renaissance". A short review about Treponema pallidum infection.
CONCLUSIONS: The first of the three hypotheses about its origins is the Columbian hypothesis, which states that Columbus's crew acquired syphilis from Native Americans and carried it back to Europe in 1493 A. D. On the contrary, the second hypothesis (pre-Columbian) asserts that syphilis was present in Europe long before Columbus's voyage and was transferred to the New World by Columbus's men. The Unitarian theory argues that syphilis, bejel, yaws, and pinta are not separate diseases but they represent syndromes caused by slightly different strains of one organism. Nowadays, Syphilis' origin is still uncertain and remains ...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 20, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Comments on “Experimental measurements, equilibrium study and model correlation of methyl paraben in ethanol and methanol aqueous solutions from = (293.15–323.15) K”
Publication date: 15 December 2019Source: Journal of Molecular Liquids, Volume 296Author(s): William E. AcreeAbstractA polemic is given regarding the curve-fitting parameters for the Van’t Hoff and Yaws equations that were reported in the published paper by Noubigh and Akemi. For several of the binary solvent mixtures studied the reported curve-fitting parameters yielded Van’t Hoff equation mathematical representations that were far superior to the mathematical representations based on the Yaws equation. Based on the similarities between the mathematical forms of the Van’t Hoff and Yaws equations one would expect the...
Source: Journal of Molecular Liquids - October 15, 2019 Category: Molecular Biology Source Type: research
Endemicity of Yaws and Seroprevalence of Treponema pallidum Antibodies in Nonhuman Primates, Kenya
D. M. Zimmerman et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 15, 2019 Category: Infectious Diseases Source Type: research
Endemicity of Yaws and Treponema pallidum Antibodies in Nonhuman Primates, Kenya
D. M. Zimmerman et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 3, 2019 Category: Infectious Diseases Source Type: research
The rise or fall of Neglected Tropical Diseases in East Asia Pacific.
Abstract
While the East Asia Pacific (EAP) region has experienced tremendous economic growth and development, the resulting public health gains from reductions in its neglected tropical diseases (NTDs) have been less than expected due to opposing forces of urbanization, political instability, food insecurity, and climate change, together with co-morbidities with non-communicable diseases, including diabetes and hypertension. To be sure there's been progress towards the elimination of lymphatic filariasis and trachoma through mass drug administration, and there are opportunities to extend MDA to yaws and sc...
Source: Acta Tropica - September 20, 2019 Category: Infectious Diseases Authors: Hotez PJ Tags: Acta Trop Source Type: research
Experimental measurements, equilibrium study and model correlation of methyl paraben in ethanol and methanol aqueous solutions from = (293.15 to 323.15) K
Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): Adel Noubigh, Ali AkremiAbstractData on corresponding solid–liquid equilibrium of methyl paraben (MP) in methanol, ethanol and binary aqueous systems are essential for industrial design and further theoretical studies. By the gravimetric method, the solubility of MP in pure water and two binary mixed solvents (methanol + water, ethanol + water) were measured over the temperature range from 293.15 to 323.15 K at atmospheric pressure. According to the experimental results, it could be found that the solubility of MP in three teste...
Source: Journal of Molecular Liquids - August 23, 2019 Category: Molecular Biology Source Type: research
Solubility and mixing thermodynamic properties of levamisole hydrochloride in twelve pure solvents at various temperatures
Publication date: Available online 30 July 2019Source: The Journal of Chemical ThermodynamicsAuthor(s): Pengshuai Zhang, Yameng Wan, Chi Zhang, Rui Zhao, Jiao Sha, Yu Li, Tao Li, Baozeng RenAbstractThe solubility of solid compounds and active pharmaceutical ingredient in different solvents is important for its crystallization and purification industry. In this work, by using a laser dynamic method, the solubility of levamisole hydrochloride in methanol (MT), ethanol (ET), isopropanol (IPA), n-propanol (NPA), n-butanol (NBA), 2-butanol (SBA), isobutanol (IBA), n-pentanol (NPT), 3-methyl-1-butanol (IAA) and n-hexanol (NHA) f...
Source: The Journal of Chemical Thermodynamics - July 31, 2019 Category: Chemistry Source Type: research
Identification of positively selected genes in human pathogenic treponemes: Syphilis-, yaws-, and bejel-causing strains differ in sets of genes showing adaptive evolution
Conclusions/SignificanceThe syphilis-, yaws-, and bejel-causing strains differed relative to sets of positively selected genes. Most of the positively selected chromosomal loci were identified among the TPA treponemes. The local accumulation of genetic variability suggests that the diversification of TPA strains took place predominantly in a limited number of genomic regions compared to the more dispersed genetic diversity differentiating TPE and TEN strains. The identification of positively selected sites intpr genes and genes encoding outer membrane proteins suggests their role during infection of human and animal hosts....
Source: PLoS Neglected Tropical Diseases - June 18, 2019 Category: Tropical Medicine Authors: Denisa Mad ěránková Source Type: research
