Complete genome sequences of two strains of < i > Treponema pallidum < /i > subsp. < i > pertenue < /i > from Ghana, Africa: Identical genome sequences in samples isolated more than 7 years apart
Conclusions/SignificanceThe estimated upper limit for the mutation rate of TPE was slightly lower than the mutation rate ofE.coli, which was determined during a long-term experiment. Given the known diversity between TPA and TPE genomes and the assumption that both TPA and TPE have a similar mutation rate, the most recent common ancestor of syphilis and yaws treponemes appears to be more than ten thousand years old and likely even older. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 8, 2017 Category: Tropical Medicine Authors: Michal Strouhal Source Type: research
Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana
DiscussionThis is the first study that has explored community knowledge, attitudes and practices in relation to yaws in any endemic population. The belief that ‘germs’ are in some way related to disease through a variety of transmission routes including both contact and dirty water are similar to those reported for other skin diseases in Ghana. The prominent role of private healthcare providers is an important finding of this study and suggests engagem ent with this sector will be important in yaws eradication efforts. Strategies to address the substantial minority of individuals who reported they would not take treatm...
Source: PLoS Neglected Tropical Diseases - July 31, 2017 Category: Tropical Medicine Authors: Michael Marks Source Type: research
Bone lesions in yaws – another potential marker of indigenous Australian remains
(Source: Forensic Science, Medicine, and Pathology)
Source: Forensic Science, Medicine, and Pathology - July 11, 2017 Category: Forensic Medicine Source Type: research
Treponema pallidum infection with cutaneous monoclonal B cell response
Syphilis, often referred to as the great imposter, is a venereal disease caused by the spirochete Treponema pallidum. Syphilis has a myriad of presentations, both clinically and histologically, and often mimics other infectious or autoimmune conditions. Subspecies of T pallidum are responsible for the nonvenereal infections pinta, bejel, and yaws. These are referred to as endemic treponemal diseases and occur in limited geographical and ecological niches. To date, there are no serological tests to differentiate these subspecies from each other or venereal syphilis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 31, 2017 Category: Dermatology Source Type: research
< i > Haemophilus ducreyi < /i > DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea
Conclusions/SignificanceThis is the first time thatH.ducreyi DNA and colonization has been demonstrated on the skin of asymptomatic children and thatH.ducreyi DNA andT.p.pertenue DNA has been identified in flies and on fomites. The ubiquity ofH.ducreyi in the environment is a contributing factor to the spread of the organism. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - May 10, 2017 Category: Tropical Medicine Authors: Wendy Houinei Source Type: research
Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities
ConclusionThe five interventions for detecting yaws had a synergistic effect and proved to be valuable components of a yaws eradication program. Well planned, culturally sensitive mass outreach educational programs accompanied by school-based programs proved to be particularly effective in Bankim. Including yaws detection in a Buruli Ulcer outreach program constituted a win-win situation, as the demonstration effect of yaws treatment (rapid cure) increased confidence in early Buruli ulcer treatment. Mass outreach programs functioned as magnets for both diseases as well as other kinds of chronic wounds that future outreach ...
Source: PLoS Neglected Tropical Diseases - May 8, 2017 Category: Tropical Medicine Authors: Alphonse Um Boock Source Type: research
Human < i > Treponema pallidum < /i > 11q/j isolate belongs to subsp. < i > endemicum < /i > but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. < i > pertenue < /i > and subsp. < i > pallidum < /i > , respectively
Conclusions/SignificanceA detailed analysis of two recombinant loci found in the 11q/j clinical isolate revealed that the recombination event occurred just once, in the TP0488, with the donor sequence originating from a TPA strain. Since TEN Bosnia A and Iraq B were found to contain TPA-like sequences at the TP0548 locus, the recombination at TP0548 took place in a treponeme that was an ancestor to both TEN Bosnia A and Iraq B. The sequence of 11q/j isolate in TP0548 represents an ancestral TEN sequence that is similar to yaws-causing treponemes. In addition to the importance of the 11q/j isolate for reconstruction of the ...
Source: PLoS Neglected Tropical Diseases - March 5, 2017 Category: Tropical Medicine Authors: Lenka Mikalov á Source Type: research
Yaws Osteoperiostitis Treated with Single-Dose Azithromycin.
Abstract
The etiologic agent of yaws, Treponema pallidum subsp. pertenue, causes a multistage infection transmitted by nonsexual contact with the exudates from active lesions. Bone lesions in the form of osteoperiostitis are common and occur in numerous bones simultaneously in early stages. Although a multinational eradication campaign with mass administration of intramuscular benzylpenicillin in the 1950s greatly reduced its global incidence, a resurgence of yaws has occurred since around 2000 in western and central Africa and the Pacific Islands. The finding that a single oral dose of azithromycin (30 mg...
Source: The American Journal of Tropical Medicine and Hygiene - February 12, 2017 Category: Tropical Medicine Authors: González-Beiras C, Vall-Mayans M, González-Escalante Á, McClymont K, Ma L, Mitjà O Tags: Am J Trop Med Hyg Source Type: research
Functional clues from the crystal structure of an orphan periplasmic ligand ‐binding protein from Treponema pallidum
This article is protected by copyright. All rights reserved. (Source: Protein Science)
Source: Protein Science - February 6, 2017 Category: Biochemistry Authors: Chad. A. Brautigam, Ranjit K. Deka, Wei Z. Liu, Diana R. Tomchick, Michael V. Norgard Tags: Full ‐Length Papers Source Type: research
Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu
We examined the skin of 821 children aged 5–14 y ears. Two children had yaws, giving an estimated prevalence of active yaws in those aged 5–14 years of 0.2% (95% CI = 0.03–0.9%). Mass treatment with azithromycin is recommended in these provinces. Given the apparent low burden of yaws, integration of yaws and trachoma control programmes is like ly to be useful and cost-effective to national programmes. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 23, 2017 Category: Tropical Medicine Authors: Fasihah Taleo Source Type: research
New Diagnostics for Yaws.
PMID: 28077737 [PubMed - in process] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - January 10, 2017 Category: Tropical Medicine Authors: Kositz C, Butcher R, Marks M Tags: Am J Trop Med Hyg Source Type: research
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana
ConclusionsA single oral dose of azithromycin, at a dosage of 30mg/kg, was non-inferior to a single dose of intramuscular benzathine penicillin for the treatment of early yaws among Ghanaian patients, and provides additional support for the WHO policy for use of oral azithromycin for the eradication of yaws in resource-poor settings. Trial RegistrationPan African Clinical Trials Registry PACTR2013030005181 http://www.pactr.org/ (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - January 9, 2017 Category: Tropical Medicine Authors: Cynthia Kwakye-Maclean Source Type: research
< i > Haemophilus ducreyi < /i > Cutaneous Ulcer Strains Diverged from Both Class I and Class II Genital Ulcer Strains: Implications for Epidemiological Studies
Conclusions/SignificanceCU strains diverged from multiple lineages within both class I and class II GU strains. Multilocus sequence typing ofdsrA-hgbA-ncaA could be reliably used for epidemiological investigation of CU and GU strains. As class II strains grow relatively poorly and are relatively more susceptible to vancomycin than class I strains, these findings have implications for methods to recover CU strains. Comparison of contemporary CU and GU isolates would help clarify the relationship between these entities. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 26, 2016 Category: Tropical Medicine Authors: Dharanesh Gangaiah Source Type: research
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji
In this study there was neither clinical nor serological evidence that transmission of yaws was ongoing. The Pgp3 seroprevalence pattern was consistent with either low level transmission of ocular Chlamydia trachomatis or exposure to C. trachomatis in the birth canal which is consistent with a survey conducted in the same region in 2013. These data suggest neither yaws nor ocular chlamydia infection are a significant public health problem in the Western Division of Fiji. (Source: Transactions of the Royal Society of Tropical Medicine and Hygiene)
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - December 8, 2016 Category: Tropical Medicine Authors: Cocks, N., Rainima-Qaniuci, M., Yalen, C., Macleod, C., Nakolinivalu, A., Migchelsen, S., Roberts, C. h., Butcher, R., Kama, M., Mabey, D., Marks, M. Tags: Original Articles Source Type: research
Benchmarking the Cost per Person of Mass Treatment for Selected Neglected Tropical Diseases: An Approach Based on Literature Review and Meta-regression with Web-Based Software Application
DiscussionThe available evidence confirms that mass treatment offers a low cost public health intervention on the path towards universal health coverage. However, more costing studies focussed on elimination are needed. Unit cost benchmarks can help in monitoring value for money in programme plans, budgets and accounts, or in setting a reasonable pay-out for results-based financing mechanisms. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - December 4, 2016 Category: Tropical Medicine Authors: Christopher Fitzpatrick Source Type: research
