Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Genes, Vol. 15, Pages 573: Insights into Salinity Tolerance in Wheat
ngcheng Yin
Salt stress has a detrimental impact on food crop production, with its severity escalating due to both natural and man-made factors. As one of the most important food crops, wheat is susceptible to salt stress, resulting in abnormal plant growth and reduced yields; therefore, damage from salt stress should be of great concern. Additionally, the utilization of land in coastal areas warrants increased attention, given diminishing supplies of fresh water and arable land, and the escalating demand for wheat. A comprehensive understanding of the physiological and molecular changes in wheat under salt stress can ...
Source: Genes - April 29, 2024 Category: Genetics & Stem Cells Authors: Zechao Zhang Zelin Xia Chunjiang Zhou Geng Wang Xiao Meng Pengcheng Yin Tags: Review Source Type: research
Mapping and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species
In this study, we used SNP analysis, sequence comparisons, and cytogenetic assays to determine that the chromosomal segment carrying Lr53 and Yr35 was originated from Ae.longissima or Ae. sharonensis or their derived species. In seedling tests, Lr53 conferred strong resistance against all five Chinese Pt races tested, and Yr35 showed effectiveness against Pst race CYR34 but susceptibility to race CYR32. Using a large population (3892 recombinant gametes) derived from plants homozygous for the ph1b mutation obtained from the cross 98M71 × CSph1b, both Lr53 and Yr35 were successfully mapped to a 6.03-Mb telomeric region of ...
Source: TAG. Theoretical and Applied Genetics - April 28, 2024 Category: Genetics & Stem Cells Authors: Binyang Xu Tao Shen Hong Chen Hongna Li Shams Ur Rehman Shikai Lyu Lei Hua Guiping Wang Chaozhong Zhang Kairong Li Hao Li Caixia Lan Guo-Yue Chen Ming Hao Shisheng Chen Source Type: research
Mapping and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species
In this study, we used SNP analysis, sequence comparisons, and cytogenetic assays to determine that the chromosomal segment carrying Lr53 and Yr35 was originated from Ae.longissima or Ae. sharonensis or their derived species. In seedling tests, Lr53 conferred strong resistance against all five Chinese Pt races tested, and Yr35 showed effectiveness against Pst race CYR34 but susceptibility to race CYR32. Using a large population (3892 recombinant gametes) derived from plants homozygous for the ph1b mutation obtained from the cross 98M71 × CSph1b, both Lr53 and Yr35 were successfully mapped to a 6.03-Mb telomeric region of ...
Source: TAG. Theoretical and Applied Genetics - April 28, 2024 Category: Genetics & Stem Cells Authors: Binyang Xu Tao Shen Hong Chen Hongna Li Shams Ur Rehman Shikai Lyu Lei Hua Guiping Wang Chaozhong Zhang Kairong Li Hao Li Caixia Lan Guo-Yue Chen Ming Hao Shisheng Chen Source Type: research
Mapping and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species
In this study, we used SNP analysis, sequence comparisons, and cytogenetic assays to determine that the chromosomal segment carrying Lr53 and Yr35 was originated from Ae.longissima or Ae. sharonensis or their derived species. In seedling tests, Lr53 conferred strong resistance against all five Chinese Pt races tested, and Yr35 showed effectiveness against Pst race CYR34 but susceptibility to race CYR32. Using a large population (3892 recombinant gametes) derived from plants homozygous for the ph1b mutation obtained from the cross 98M71 × CSph1b, both Lr53 and Yr35 were successfully mapped to a 6.03-Mb telomeric region of ...
Source: TAG. Theoretical and Applied Genetics - April 28, 2024 Category: Genetics & Stem Cells Authors: Binyang Xu Tao Shen Hong Chen Hongna Li Shams Ur Rehman Shikai Lyu Lei Hua Guiping Wang Chaozhong Zhang Kairong Li Hao Li Caixia Lan Guo-Yue Chen Ming Hao Shisheng Chen Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Possible interaction between pectin and gluten alters the starch digestibility and texture of wheat bread
This study incorporated citrus pectin in wheat bread, aiming to develop breads with both desirable texture and slow starch digestibility. Results showed that starch digestibility in wheat bread decreased over the addition of pectin, and the maximum starch digested amount decreased by 6.6 % after the addition of 12 % pectin (wheat flour weight basis). The addition of pectin transferred part of the rapidly digestible starch into slowly digestible starch, and reduced the binding rate constant between slowly digestible starch and digestive enzymes, resulting in overall reduced starch digestibility. Furthermore, the addition of...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Kaixin Qi Senbin Cao Cheng Li Source Type: research
Innovative plasticization technique for talc-powder reinforced wheat-starch biomass composite plastics with enhanced mechanical strength
Int J Biol Macromol. 2024 Apr 25:131894. doi: 10.1016/j.ijbiomac.2024.131894. Online ahead of print.ABSTRACTN-methyl-morpholine-N-oxide (NMMO) was initially created as a plasticizer for starch to produce thermoplastic wheat starch. Subsequently, talc powder was used as a reinforcing filler to enhance the mechanical strength of thermoplastic biomass-based composite plastics. The chemical structure, crystal structure, and microscopic morphology were analyzed using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. Additionally, the thermal properties were explored through thermograv...
Source: International Journal of Biological Macromolecules - April 27, 2024 Category: Biochemistry Authors: Le Jing Yuxuan Wang Juan Li Xuemei Lin Lei Liu Ying Chen Huangyan Liu Zongrong Ying Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | PMC:PMC11052166 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | PMC:PMC11052166 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level
Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | PMC:PMC11052166 | DOI:10.3390/medicina60040639 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research
Epidemiology of Celiac Disease in Western Iran during 2019-2021
This study demonstrated a higher prevalence of celiac disease in Kermanshah compared to global statistics. Given the association of celiac disease with other conditions such as diabetes, irritable bowel syndrome, growth retardation, and iron-deficiency anemia, healthcare providers should consider screening patients for celiac disease. Furthermore, community-based education is crucial in raising awareness about the significance of adhering to a proper diet and reducing wheat consumption.PMID:38665986 | PMC:PMC11045285 | DOI:10.1155/2024/1112812 (Source: Biomed Res)
Source: Biomed Res - April 26, 2024 Category: Research Authors: Maryam Janatolmakan Mehdi Zobeiri Shahab Rezaeian Shima Rostami Mehnosh Akbari Alireza Khatony Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
