Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level

Conclusions: It was predicted that the increased expression of the MKi67 gene by TAA leads to the increase in TP53, which negatively regulates the cell cycle via increased CDKN3 expression in kidneys and the restoration of TP53 levels in the liver. These findings contribute to our understanding of the effects of olmutinib and WGO on TAA-induced gene expression changes and highlight their contrasting effects based on cell cycle alterations.PMID:38674285 | DOI:10.3390/medicina60040639

Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Seema Zargar Tanveer A Wani Salman Alamery Fatimah Yaseen Source Type: research