Lymphomatoid granulomatosis in one patient with newly diagnosed HIV infection and Kaposi ’s sarcoma: a case report and literature review
AbstractLymphomatoid granulomatosis is a very rare B cell lymphoproliferative disease associated with Epstein –Barr virus infection. It is related to states of immunosuppression and affects the lung in more than 90% of cases, forcing the clinician to establish a differential diagnosis with other diseases such as infections, Wegener’s granulomatosis, lymphoma, or lung metastases. There is no standard tre atment for this disease. In this paper, we describe a rare case of a patient with grade 3 lymphomatoid granulomatosis with newly diagnosed HIV infection who started antiretroviral treatment with a gradual improvement of...
Source: Journal of Hematopathology - March 20, 2021 Category: Pathology Source Type: research
Peripheral Ulcerative Keratitis
Peripheral ulcerative keratitis (PUK) is a destructive inflammatory disease of the juxtalimbal cornea associated with crescent-shaped corneal stromal thinning, an epithelial defect, and inflammatory cells in the corneal stroma.109,166 The predilection of the peripheral cornea for PUK is explained by its anatomical and physiological characteristics. PUK could be a presenting manifestation of an underlying ocular or systemic disease, which may be potentially lethal. Vasculitides and collagen vascular diseases of auto-immune etiology, such as rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA, formerly known as ...
Source: Survey of Ophthalmology - February 28, 2021 Category: Opthalmology Authors: Dr. Yogita Gupta, Dr. Alisha Kishore, Dr. Pooja Kumari, Dr. Neelima Balakrishnan, Dr. Neiwete Lomi, Dr. Noopur Gupta, Dr. M. Vanathi, Dr. Radhika Tandon Source Type: research
Missed Otological Presentation of Wegener ’s Granulomatosis: A Case
We present here a case report of a female who presented with breathing difficulty along with Otological symptoms but re mained undiagnosed for a long time leading to permanent morbidity because of facial nerve damage and hearing loss. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 7, 2021 Category: ENT & OMF Source Type: research
Extracorporeal membrane oxygenation in the management of granulomatosis with polyangiitis
We report two GPA patients with DAH that were successfully managed using ECMO support. Examining 13 cases identified in the literature and two of our own, we observed that most patients experienced rapid deterioration in respiratory function in conjunction with a precedent respiratory infection. All 15 patients received veno ‐venous ECMO support. The median duration of ECMO support was 11 days (interquartile range: 7.5–20.75 days). Bleeding was the most common complication, seen in four (26.7%) cases. All patients were successfully weaned off ECMO after a median length of hospital stay of 42 days (interquartile rang e:...
Source: Journal of Cardiac Surgery - December 22, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kanhua Yin,
Robert J. March,
Charles W. Hoopes,
Robert A. Balk,
Jaishankar Raman,
Omar B. Lateef,
Ankur Tiwari,
Erica Bak,
Karl J. Karlson,
Niloo M. Edwards,
Nikola Dobrilovic Tags: CASE REPORT Source Type: research
Therapeutic plasma exchange: A life-saving modality in Wegener & #39;s granulomatosis
We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hen...
Source: Asian Journal of Transfusion Science - December 19, 2020 Category: Hematology Authors: Archana Solanki Ashutosh Singh Abhishek Chauhan Tulika Chandra D Himanshu Source Type: research
Pulmonary Manifestations of Systemic Vasculitis in Children
Vasculitides are defined according to the vessel size involved, and they tend to affect certain organ systems. Pulmonary involvement is rare in the common childhood vasculitides, such as Kawasaki disease, IgA vasculitis (Henoch Schonlein purpura). On the other hand, lung involvement is common in a rare pediatric vasculitis, granulomatosis with polyangiitis (GPA) (Wegener granulomatosis), where respiratory system findings are common. A criterion in the Ankara 2008 classification criteria for GPA is the presence of nodules, cavities, or fixed infiltrates. The adult data suggest that rituximab may be an alternative to cycloph...
Source: Pediatric Clinics of North America - November 21, 2020 Category: Pediatrics Authors: Muserref Kasap Cuceoglu, Seza Ozen Source Type: research
Trussed Structure using ‘LOCK’ Technique Septal Reconstruction in Contracted Nose with Severe Septal Deficiency. A Retrospective Review on 57 Cases.
Septal reconstruction is commonly performed in cases of septal deformity or deficiency but can be technically challenging. The contracted nose, a complication of alloplastic nasal implant used in Asian rhinoplasty, is the most commonly seen condition associated with severe septal deficiency in our centre. It represents almost 82% of all the cases requiring septal reconstruction. Other causes include congenital anomaly (Binder's syndrome), autoimmune disorders (Wegener granulomatosis, relapsing polychondritis), previous septal surgery, trauma and infection. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - November 8, 2020 Category: Cosmetic Surgery Authors: Dong-Hak Jung, Sang Min Hyun, Kit Liang Gan Source Type: research
Acne fulminans in a young man with granulomatosis with polyangiitis (Wegener & #39;s granulomatosis): A chance association or marker of serious systemic disease ?
Shyam Verma, Rajiv Joshi, Ripal ShahIndian Journal of Dermatology, Venereology, and Leprology 2020 86(6):669-673
A 19-year-old man with granulomatosis with polyangiitis (Wegener's disease) presented with hemorrhagic facial nodules mimicking severe inflammatory acne (acne fulminans) as one of the first symptoms of the disease. The lesions were earlier treated as nodulocystic acne with isotretinoin without any benefit. Complete resolution was seen with pulsed methylprednisolone and oral prednisolone and mycophenolate mofetil thereafter. He also developed acute onset of severe pustular eruption of the face and a d...
Source: Indian Journal of Dermatology, Venereology and Leprology - November 5, 2020 Category: Dermatology Authors: Shyam Verma Rajiv Joshi Ripal Shah Source Type: research
Spontaneous resolutive pulmonary necrotizing granulomatosis
We report the case of necrotizing granulomatosis in a 23-yr-old Caucasian non-smoker healthy female without significant medical history. She initially developed important respiro-dependent migratory back pain. Laboratory test showed mild inflammation syndrome without evidence of auto-immunity. Chest X-ray revealed areas of parenchymal consolidation and chest-computed tomography demonstrated non-specific nodular and non-cavitary retracted infiltrates. Pulmonary function tests were normal. Bronchoscopy with broncho-alveolar lavage showed lymphocytosis (21,3% of the total white cells count) without infection. Surgical lung bi...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Weicker, B., Rosoux, A., Gielen, I., Coulier, B., Frognier, R. Tags: Clinical problems Source Type: research
Granulomatosis with Poliangeitis (Wegener's Granulomatosis): Orofacial Manifestations. Systematic Review and Case Report
Conclusion: GPA is a multisystem disorder associated with considerable morbidity and mortality if not treated. Early diagnosis improves the prognosis. The first manifestation of the disease can be seen in the oral cavity. It is important that dentists recognise the oral manifestation in order to improve the prognosis.Key words: granulomatosis, polyangiiitis, Wegener's granulomatosis (Source: Oral health and Preventive dentistry)
Source: Oral health and Preventive dentistry - October 27, 2020 Category: Dentistry Source Type: research
Granulomatosis (Wegener's granulomatosis) with polyangiitis presented as pulmonary manifestation: a case report
The diagnosis of vasculitis is often delayed because several other disorders may mimic the same clinical manifestations; therefore, the knowledge of the main radiographic and high ‐resolution computed tomography (HRCT) findings, in association with clinical, laboratory, and serum data, often enables non‐invasive diagnosis of pulmonary vasculitis. AbstractPulmonary vasculitis can be the manifestation of several systemic illnesses such as primary systemic vasculitis, collagen vascular diseases, and systemic diseases associated with autoantibodies. It may be associated with granulomatous, eosinophilic, lymphoplasmacytic a...
Source: Respirology Case Reports - October 13, 2020 Category: Respiratory Medicine Authors: Qusay Jummaa Lazim,
Sinan Shakir Gheni Atrah,
Khalid Jawad Mutlag,
Haider Saadoon Qasim Alhilfi,
Ahmed Muhi Fahad,
Ahmed Salih Alshewered Tags: Case Report Source Type: research
