Successful cataract surgery in a patient with refractory Wegener ’s granulomatosis effectively treated with rituximab: A case report
Conclusion: In this patient, rituximab was a well-tolerated and effective remission induction agent for severe refractory Wegener’s granulomatosis and led to successful cataract surgery. (Source: Saudi Journal of Ophthalmology)
Source: Saudi Journal of Ophthalmology - July 20, 2016 Category: Opthalmology Source Type: research
Myeloperoxidase‐ANCA‐Positive and ANCA‐Negative Patients With Granulomatosis With Polyangiitis: Distinct Patient Subsets
Conclusion
We were unable to demonstrate important clinical differences between MPO‐ANCA+ and PR3‐ANCA+ patients with GPA. The risk of relapse was associated more closely with disease type than with ANCA type in this patient cohort. These findings deserve consideration in the assessment of relapse risk in patients with AAV. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - July 17, 2016 Category: Rheumatology Authors: E.M. Miloslavsky, N. Lu, S. Unizony, H.K. Choi, P.A. Merkel, P. Seo, R. Spiera, C.A. Langford, G.S Hoffman, C.G.M. Kallenberg, E.W. St. Clair, N.K. Tchao, F. Fervenza, P.A. Monach, U. Specks, J.H. Stone Tags: Full Length Source Type: research
Myeloperoxidase ‐ANCA‐Positive and ANCA‐Negative Patients With Granulomatosis With Polyangiitis: Distinct Patient Subsets
Conclusion
We were unable to demonstrate important clinical differences between MPO‐ANCA+ and PR3‐ANCA+ patients with GPA. The risk of relapse was associated more closely with disease type than with ANCA type in this patient cohort. These findings deserve consideration in the assessment of relapse risk in patients with AAV. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - July 17, 2016 Category: Rheumatology Authors: E.M. Miloslavsky, N. Lu, S. Unizony, H.K. Choi, P.A. Merkel, P. Seo, R. Spiera, C.A. Langford, G.S Hoffman, C.G.M. Kallenberg, E.W. St. Clair, N.K. Tchao, F. Fervenza, P.A. Monach, U. Specks, J.H. Stone Tags: Full Length Source Type: research
Nationwide Trends in Hospitalizations and In‐Hospital Mortality of Granulomatosis with Polyangiitis
Conclusion: The findings from these nationally representative, contemporary, inpatient data indicate that in‐hospital mortality of GPA has declined substantially over the past two decades while the overall hospitalization rate for GPA increased slightly. Infection remains a common principal hospitalization diagnosis among GPA patients, including hospitalizations resulting in mortality. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - July 6, 2016 Category: Rheumatology Authors: Zachary S. Wallace, Na Lu, Eli Miloslavsky, Sebastian Unizony, John H. Stone, Hyon K. Choi Tags: Brief Report Source Type: research
Nationwide Trends in Hospitalizations and In ‐Hospital Mortality of Granulomatosis with Polyangiitis
Conclusion: The findings from these nationally representative, contemporary, inpatient data indicate that in‐hospital mortality of GPA has declined substantially over the past two decades while the overall hospitalization rate for GPA increased slightly. Infection remains a common principal hospitalization diagnosis among GPA patients, including hospitalizations resulting in mortality. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - July 6, 2016 Category: Rheumatology Authors: Zachary S. Wallace, Na Lu, Eli Miloslavsky, Sebastian Unizony, John H. Stone, Hyon K. Choi Tags: Brief Report Source Type: research
Clinical spectrum and outcome of pulmonary nocardiosis: 5-year experience
Conclusion: The diagnosis of pulmonary nocardiosis is often missed and delayed resulting in delay in appropriate treatment and thus high mortality. A lower threshold for diagnosing pulmonary nocardiosis needs to be exercised, in chest symptomatic patients with underlying chronic lung diseases or systemic immunosuppression, for the early diagnosis, and treatment of this uncommon but potentially lethal disease. Despite treatment mortality remains high, especially in those with brain abscess, HIV positivity, need for mechanical ventilation, solid-organ transplantation, and elderly. (Source: Lung India)
Source: Lung India - June 28, 2016 Category: Respiratory Medicine Authors: Akashdeep SinghDeepinder ChhinaRK SoniChandan KakkarUS Sidhu Source Type: research
Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.
Abstract
Proteinase 3 (PR3) has received great scientific attention after its identification as the essential antigenic target of antineutrophil cytoplasm antibodies in Wegener's granulomatosis (now called granulomatosis with polyangiitis). Despite many structural and functional similarities between neutrophil elastase (NE) and PR3 during biosynthesis, storage, and extracellular release, unique properties and pathobiological functions have emerged from detailed studies in recent years. The development of highly sensitive substrates and inhibitors of human PR3 and the creation of PR3-selective single knocko...
Source: Pharmacological Reviews - June 23, 2016 Category: Drugs & Pharmacology Authors: Korkmaz B, Lesner A, Guarino C, Wysocka M, Kellenberger C, Watier H, Specks U, Gauthier F, Jenne DE Tags: Pharmacol Rev Source Type: research
An eosinophilic variant granulomatosis with polyangiitis involving the dura, bilateral orbits, and mastoids.
We report a case of a 57-year-old lady presenting with left eye swelling, left ear pain and discharge, but with no pulmonary or renal symptoms. Investigations revealed positive cytoplasmic antineutrophil cytoplasmic antibodies and proteinase 3 antibodies. The CT and MRI showed meningeal thickening and bilateral structural changes of the orbits and mastoids. Lacrimal gland biopsy showed non necrotizing granulation with an eosinophilic infiltration. She was diagnosed with eosinophilic variant of GPA of the eyes and mastoid bones bilaterally extending to dura and sparing the lungs and kidneys. She responded to corticosteroi...
Source: Saudi Medical Journal - June 10, 2016 Category: Middle East Health Tags: Saudi Med J Source Type: research
Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies
Abstract
Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients’ survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF...
Source: Clinical Reviews in Allergy and Immunology - June 7, 2016 Category: Allergy & Immunology Source Type: research
Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Abstract
Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A,...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Bonamichi-Santos R, Castells M Tags: Clin Rev Allergy Immunol Source Type: research
[Case Report Comment] Clinical overlap in proximal artery stenosis: two disorders or one?
ANCA-associated vasculitis comprises three conditions that share overlapping clinical and serological features and are characterised by necrotising inflammation of small vessel walls: granulomatosis with polyangiitis (Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg Strauss syndrome). Although the cause is unknown, ANCA antibodies, cytokine-primed neutrophils, and B lymphocytes are recognised to play an important part in disease pathogenesis. (Source: LANCET)
Source: LANCET - June 2, 2016 Category: Journals (General) Authors: Asad A Zoma Tags: Case Report Comment Source Type: research
Gingival granulomatosis with polyangiitis (wegener's granulomatosis) as a primary manifestation of the disease
This article is protected by copyright. All rights reserved. (Source: Australian Dental Journal)
Source: Australian Dental Journal - May 31, 2016 Category: Dentistry Authors: Felipe Paiva Fonseca, Bernar Monteiro Benites, Ana Luisa Vanalle Ferrari, Zoraida Sachetto, Glécio Vaz Campos, Oslei Paes Almeida, Eduardo Rodrigues Fregnani Tags: Case Report Source Type: research
Wegener's granulomatosis that mimics nasopharyngeal cancer
Publication date: Available online 28 May 2016 Source:Tzu Chi Medical Journal Author(s): Chih-Wei Liu, Yung-Hsiang Hsu (Source: Tzu Chi Medical Journal)
Source: Tzu Chi Medical Journal - May 27, 2016 Category: Universities & Medical Training Source Type: research
[Tumors of the lacrimal drainage system].
CONCLUSION: Differential diagnostic signs in favor of a malignancy include a long medical history, predisposing conditions in the patient's history, a mass above the medial canthal ligament, teleangiectasis above the mass, and serosanguinous secretion.
PMID: 27222017 [PubMed - as supplied by publisher] (Source: HNO)
Source: HNO - May 27, 2016 Category: ENT & OMF Tags: HNO Source Type: research
Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I
Conclusion: Recognition of this rare pathologic association is essential, to prevent delays in diagnosis and treatment that can lead to major craniofacial tissue loss.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. (Source: Plastic and Reconstructive Surgery)
Source: Plastic and Reconstructive Surgery - May 26, 2016 Category: Cosmetic Surgery Tags: Reconstructive: Head and Neck: Original Articles Source Type: research
