Coexistence of IgG4-related disease and ANCA-associated vasculitis: case report and review of the literature
AbstractIgG4-related disease (IgG4-RD) is a fibroinflammatory condition that is characterized by storiform fibrosis, infiltration of IgG4-positive lymphocytes, obliterative phlebitis, and high IgG4 levels. Since IgG4-RD affects a wide variety of organs, a differential diagnosis must include multiple conditions. IgG4-RD is also believed to coexist with certain diseases. In recent years, case reports and case series describing the co-occurrence of IgG4-RD and ANCA-associated vasculitis (AAV) have been published. We intended to evaluate patients with IgG4-RD and AAV overlap in the literature using a case similar to one that w...
Source: Rheumatology International - February 18, 2024 Category: Rheumatology Source Type: research
Clinical Manifestations of Wegener Granulomatosis in Iranian Ethnicities Using the K-Means Algorithm: A Descriptive Study
Conclusion Our findings indicated that the sinus, nose, lungs, and ears were the sites most involved, and gastrointestinal and cardiac involvement were less common. In the present study, involvement of the upper and lower respiratory tract was higher than that reported in Western and Asian case series. Moreover, we report for the first time that, in all patients with ear involvement, the left ear was the first to be affected. The clinical manifestations among Iranian ethnicities were not different, and the Gilaki ethnicity had the highest BVAS, mostly because the weather was humid; therefore, in Iran, in areas with humid...
Source: International Archives of Otorhinolaryngology - February 5, 2024 Category: ENT & OMF Authors: Khedmatkon, Fahimeh Alesaeidi, Samira Hajialiasgari, Fatemeh Shoshtarian Malak, Jaleh Tags: Original Research Source Type: research
An unusual case of granulomatosis with polyangiitis with unilateral parotid gland enlargement
Acute leukocytoclastic vasculitis of skin biopsy. Key Clinical MessageHere, we report a case of granulomatosis with polyangiitis presenting with unilateral parotid gland enlargement and later developed skin lesions on the lower extremities and abdomen. Although rare, salivary gland enlargement may be the presenting sign of Wegener's granulomatosis or other ANCA associated vasculitides. (Source: Clinical Case Reports)
Source: Clinical Case Reports - November 1, 2023 Category: General Medicine Authors: Toktam Safari Giv,
Ghazal Mardani,
Azadeh Rakhshan,
Mohammad Kouhestany,
Hamideh Moravvej Tags: CASE REPORT Source Type: research
Granulomatosis with polyangiitis mimicking COVID ‐19 pneumonia: A case report
We present a case of a 26-year-old Asian woman who was transferred to our center from a nearby hospital, where she presented with shortness of breath, tested positive for COVID-19, and was being managed for COVID-19 pneumonia. She also had hemoptysis, skin lesions, and left foot numbness. Serological markers and VATS-guided lung biopsy confirmed the diagnosis. Treatment with methylprednisolone and rituximab led to stabilization, despite complications of subcutaneous emphysema and lower extremity neuropathic symptoms. Early recognition and appropriate management of GPA are crucial for optimal outcomes. (Source: Clinical Case Reports)
Source: Clinical Case Reports - October 7, 2023 Category: General Medicine Authors: Arjun Basnet,
Sajog Kansakar,
Nava Raj Sharma,
Sudarshan Gautam,
Saral Lamichhane,
Kripa Tiwari,
Madalasa Pokhrel,
Sehajpreet Singh Tags: CASE REPORT Source Type: research
The Challenges of Diagnosis and Management of Wegener's Granulomatosis with Negative ANCA
Acta Med Indones. 2023 Apr;55(2):194-200.ABSTRACTABSTRAK Penyakit Granulomatosis Wegener merupakan suatu penyakit autoimun yang mengenai dinding pembuluh darah terutama pembuluh darah kecil dan sedang akibat adanya reaksi komplek imun. Sampai saat ini etiologi penyakit Granulomatosis Wegener belum diketahui secara pasti. Diagnosis Granulosis Wegener salah satunya adalah terdeteksinya antibodi cytoplasmic antineutrophilic cytoplasmic antibody (c-ANCA), akan tetapi pemeriksaan ANCA negatif atau tidak ditemukan pada kasWegener's granulomatosis is an autoimmune disease that affects the walls of small and medium-sized blood ves...
Source: Acta medica Indonesiana - July 31, 2023 Category: Internal Medicine Authors: Lia Sasmithae Source Type: research
