Depiction of unusual coronary involvement in Wegener's Granulomatosis on CT.
Authors: Chandrashekhara SH, Ojha V, Raju SN, Kumar S PMID: 32186466 [PubMed - as supplied by publisher] (Source: Acta Cardiologica)
Source: Acta Cardiologica - March 19, 2020 Category: Cardiology Tags: Acta Cardiol Source Type: research

Oral manifestation of wegener granulomatosis: case report
An 86-year-old man was evaluated complaining a painful lesion situated in the tongue with 45-day duration. Medical history revealed anemia, heart disease, vasculitis, and glomerulitis associated with the previous diagnosis of Wegener granulomatosis. Positive reaction for antineutrophil cytoplasmic autoantibodies (ANCA) was reported. Intraoral examination revealed an asymptomatic ulceration on the dorsum of the tongue surrounded by a whitish area that measures its 2.0  × 1.0 cm in its largest diameters. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: GISELE CORR ÊA DE OLIVEIRA, FERNANDA BROCHIER CARDOSO, LUAN NATHIEL SANTANA KOVALSKI, VINICIUS COELHO CARRARD, MICHELLE ROXO GONÇALVES, JULIANA ROMANINI, MARCO ANTONIO TREVIZANI MARTINS Source Type: research

Differential diagnosis and management of a patient with paracoccidioidomycosis
Paracoccidioidomycosis (PCM) is a systemic mycosis whose etiologic agent is the thermodimorphic fungus of the genus Paracoccidioides. Differential diagnosis may include oral squamous cell carcinoma (SCC), tuberculosis, histoplasmosis, and Wegener granulomatosis. A 45-year-old male patient was attended in an oral medicine service with complaint of "infection of the tongue." Intraoral examination found deep ulcer of granulomatous bed with raised edges and hard palpation in the lateral tongue and mouth floor with 2 months of evolution. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: J ÉSSICA HELENA DOTTA, LARISSA NATIELE MIOTTO, ANALÚ BARROS DE OLIVEIRA, CLEVERTON ROBERTO DE ANDRADE, ELAINE MARIA SGAVIOLI MASSUCATO, TÚLIO MORANDIN FERRISSE Source Type: research

A 60-year-old with heart failure symptoms due to 1st degree AV-Block caused by granulomatosis with polyangiitis (Wegener’s granulomatosis)
Publication date: Available online 4 December 2019Source: Journal of Cardiology CasesAuthor(s): Davit Saghabalyan, Dirk Schiller, Sven LerchAbstractGranulomatosis with polyangiitis is a rare systemic inflammatory disorder mainly affecting the small vessels. Cardiac involvement is rare, conduction delay being the most rare one. This case reports on a middle-aged male patient with heart failure symptoms due to a 1st degree atrioventricular block with a marked PR prolongation of 480 ms on electrocardiography (ECG). Because of heart failure symptoms as well as elevated N-terminal pro-B-type natriuretic peptide and no othe...
Source: Journal of Cardiology Cases - December 4, 2019 Category: Cardiology Source Type: research

Effects of Wegener's granulomatosis and rheumatoid arthritis on leg health and wound healing.
PMID: 31804881 [PubMed - in process] (Source: British Journal of Community Nursing)
Source: British Journal of Community Nursing - December 1, 2019 Category: Nursing Authors: Spencer-Vaele D, Timmins J, Hampton S Tags: Br J Community Nurs Source Type: research

Strawberry gingivitis: Challenges in the diagnosis of granulomatosis with polyangiitis on gingival specimens
This article highlights the challenges to early-stage diagnosis of initial multiple gingival enlargements because histologic biopsies are often nonspecific and histology alone may not be sufficient to make a correct diagnosis of GPA from gingival specimens. Because strawberry gingivitis may be the first manifestation of GPA, awareness of it should be increased so that it can be diagnosed by its unique clinical appearance and additional related diagnostic parameters even if the histologic gingival findings are nonspecific. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - November 29, 2019 Category: ENT & OMF Source Type: research

Indicaions to surgery for lung tuberculomas today
Conclusions: Examination of surgical material ensures verification of the diagnosis, determination of MDR/XDR MBT and lung cells, creates conditions for adequate chemotherapy. All of these proves the necessity of surgical treatment for lung tuberulomas. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Krasnikova, E., Lepeha, L., Tarasov, R., Erokhina, M., Aliev, V., Sadovnikova, S., Bagirov, M. Tags: Tuberculosis Source Type: research

Idiopathic granulomatous hypophysitis presenting with galactorrhea, headache, and nausea in a woman: a case report and review of the literature
ConclusionsIdiopathic granulomatous hypophysitis, a rare inflammatory disease of the pituitary gland, is a diagnosis of exclusion for which both medical and surgical management are reported in the literature. We present a case of idiopathic granulomatous hypophysitis who was symptom free with no complications of hypopituitarism following its transsphenoidal resection after 9  months of follow-up. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 16, 2019 Category: General Medicine Source Type: research

Granulomatosis with Polyangiitis (GPA) in a 15-year-old girl with facial Acne-like ulcers: A Case Report.
We described a 15-year-old female with a history of six months of acne-like facial and peri-auricular lesions. She had received the conventional treatment for acne (antibiotics + topical corticosteroid) with no response. She also had a history of chronic coughs which always diagnosed and treated as sinusitis. In addition, she had a history of frequent dysuria which always diagnosed and treated as urinary tract infection. Given the history, with suspicion of a multi-systemic disease such as vasculitis; we performed some diagnostic laboratory and radiologic tests in order to rule out the possible etiologies. The results show...
Source: Infectious Disorders Drug Targets - November 14, 2019 Category: Infectious Diseases Authors: Jamali Moghadam SR, Salehi MR, Mojtahedi SY, Fadaei N, Dadras O, Seyed Alinaghi SA, Mohammadifirouzeh M Tags: Infect Disord Drug Targets Source Type: research

Capillaroscopic findings in Turkish Takayasu arteritis patients
Conclusion: Capillaroscopic abnormalities are frequently seen in TA patients. We consider that abnormal capillaroscopic findings in TA patients reflect the impaired blood flow due to narrowed or occluded arteries rather than the primary capillary involvement of the disease process. PMID: 31648432 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - October 29, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Strawberry Gingivitis – Challenges in the diagnosis of granulomatosis with polyangiitis on gingival specimens
Publication date: Available online 2 August 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Bilal Msallem, Stefano Bassetti, Matthias S. Matter, Florian M. ThieringerAbstractStrawberry gingivitis is a rare oral manifestation of granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). It manifests as a red-purple hyperplastic gingivitis that frequently goes unrecognized as a disease-specific symptom, especially if it is the primary and only manifestation of the disease. GPA is a systemic necrotizing granulomatous vasculitis that takes a fatal course without tre...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - August 2, 2019 Category: ENT & OMF Source Type: research

Strawberry Gingivitis – Challenges in the diagnosis of granulomatosis with polyangiitis on gingival specimens
Strawberry gingivitis is a rare oral manifestation of granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). It manifests as a red-purple hyperplastic gingivitis that frequently goes unrecognized as a disease-specific symptom, especially if it is the primary and only manifestation of the disease. GPA is a systemic necrotizing granulomatous vasculitis that takes a fatal course without treatment. Oral health care providers, who are among the first to examine the oral cavity, should be familiar with its typical appearance, clinical course, diagnostic parameters and management. (Source: Oral Surger...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 2, 2019 Category: ENT & OMF Authors: Bilal Msallem, Stefano Bassetti, Matthias S. Matter, Florian M. Thieringer Tags: Case Report Source Type: research

Strawberry gingivitis: Challenges in the diagnosis of granulomatosis with polyangiitis on gingival specimens
Strawberry gingivitis is a rare oral manifestation of granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). It manifests as a red-purple hyperplastic gingivitis that frequently goes unrecognized as a disease-specific symptom, especially if it is the primary and only manifestation of the disease. GPA is a systemic necrotizing granulomatous vasculitis that takes a fatal course without treatment. Oral health care providers, who are among the first to examine the oral cavity, should be familiar with its typical appearance, clinical course, diagnostic parameters, and management. (Source: Oral Surge...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 2, 2019 Category: ENT & OMF Authors: Bilal Msallem, Stefano Bassetti, Matthias S. Matter, Florian M. Thieringer Tags: Case Report Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - April 26, 2019 Category: Neurology Source Type: research

[ANCA-associated vasculitides : State of the art].
Abstract Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis) and microscopic polyangiitis (MPA) are associated with the detection of antibodies against neutrophilic cytoplasmic antigens (ANCA) and are referred to as ANCA-associated vasculitides (AAV). In the event of the clinical suspicion of AAV the ANCA should first be determined by means of an antigen-specific immunoassay for proteinase 3‑ANCA and myeloperoxidase-ANCA, according to current consensus recommendations. The diagnosis of AAV should also be confirmed by biopsy if possible. The classification criteria for AAV are currently bein...
Source: Zeitschrift fur Rheumatologie - April 26, 2019 Category: Rheumatology Authors: Hellmich B Tags: Z Rheumatol Source Type: research

Wegener's Granolomatosis Presenting as Wallenberg Syndrome: A Case Report
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, a vasculitis affecting small and medium sized vessels usually affects the upper and lower respiratory tract, the kidneys, and the eyes. Neurologic manifestation in central nervous system (CNS) is less frequent than the peripheral and usually is in form of stroke. Few cases of lateral medullary ischemic stroke (Wallenberg syndrome) due to GPA have been reported. A 41 year-old female, presented with acute vertigo, nausea/vomiting, hiccups, dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Maziar Emamikhah, Farzad Sina, Mahisa Mokhtari, Fatemeh Shirani, Mohammadreza Asadipanah Tags: Case Report Source Type: research

Wegener's Granulomatosis Presenting as Wallenberg Syndrome: A Case Report
Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, a vasculitis affecting small and medium sized vessels usually affects the upper and lower respiratory tract, the kidneys, and the eyes. Neurologic manifestation in central nervous system (CNS) is less frequent than the peripheral and usually is in form of stroke. Few cases of lateral medullary ischemic stroke (Wallenberg syndrome) due to GPA have been reported. A 41 year-old female, presented with acute vertigo, nausea/vomiting, hiccups, dysphagia. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2019 Category: Neurology Authors: Maziar Emamikhah, Farzad Sina, Mahisa Mokhtari, Fatemeh Shirani, Mohammadreza Asadipanah Tags: Case Report Source Type: research

A boy in his teens with large ulcerations of the head and neck.
We present a case of a teenage boy with pyoderma gangrenosum-like ulcerations of the neck and face. Anti-neutrophil cytoplasmic antibody with antigen specificity for proteinase 3 (PR3-ANCA) was detected. In the absence of other symptoms and organ manifestations, the ulcerations were still considered to be pyoderma gangrenosum. The ulcers started to heal during treatment with corticosteroids and infliximab. One month later the patient developed sinusitis, and eventually lost vision in his left eye. The diagnosis was changed to GPA and he started treatment with methylprednisolone, rituximab and cyclophosphamide with good res...
Source: Tidsskrift for den Norske Laegeforening - April 9, 2019 Category: General Medicine Authors: Moen BH, Nystad TW, Barrett TM, Sandvik LF Tags: Tidsskr Nor Laegeforen Source Type: research

Impact and safety of open lung biopsy in patients with acute respiratory distress syndrome (ARDS)
ConclusionThe information provided by OLB performed at the bedside in ARDS patients of unknown etiology could be relevant, as it may optimize treatment. The risk associated with OLB seems to be acceptable.ResumenIntroducciónEl síndrome de dificultad respiratoria aguda (ARDS, acute respiratory distress syndrome) es una enfermedad pulmonar inflamatoria y su característica distintiva patológica es el daño alveolar difuso (DAD, diffuse alveolar damage). Dado que la biopsia pulmonar abierta (OLB, open lung biopsy) a veces puede dar lugar a efectos secundarios graves, rara vez se realiza en pac...
Source: Medicina Intensiva - March 30, 2019 Category: Intensive Care Source Type: research

P.02.35 intestinal involvement in wegener's granulomatosis mimicking an inflammatory bowel disease: a case report
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: F. Pelizzaro, M. Ghisa, B. Bareberio, I. Barbuscio, M. Della Coletta, E. Cocconcelli, F. Schiavon, E.V. Savarino, F. Farinati, F. Galeazzi Tags: Posters Source Type: research

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings
ConclusionImaging studies may provide clues for diagnosis of non-squamous cell laryngeal lesions. Clinical and imaging findings and previous clinical history should be evaluated together in clinical management of laryngeal lesions.ResumoIntroduçãoO carcinoma de células escamosas é a neoplasia laríngea mais comum, representando aproximadamente 95% de todas as neoplasias malignas da laringe. No entanto, vários outros tumores benignos e malignos, e doenças inflamatórias, podem afetar a laringe.ObjetivoO objetivo deste estudo é analisar os achados clínicos e...
Source: Brazilian Journal of Otorhinolaryngology - March 17, 2019 Category: ENT & OMF Source Type: research

Cough and Nasal Pain: Putting Together an Uncommon Diagnosis
The pulmonary vasculitides include a wide spectrum of disorders that have in common inflammation and destruction of pulmonary blood vessels. Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is the most common of the antineutrophil cytoplasmic antibody–associated small-vessel vasculitides, and affects a number of organ systems. GPA affects a wide age range, although it typically presents in middle adulthood. The classic triad of GPA—upper airway involvement (sinusitis, otitis media, mucosal ulcerations, airway inflammation), lower respiratory tract disease, and glomerulonephritis...
Source: Clinical Pulmonary Medicine - March 1, 2019 Category: Respiratory Medicine Tags: Images In Pulmonary Medicine Source Type: research

Rituximab as an effective and probably safe treatment for granulomatosis with polyangiitis (Wegener's Granulomatosis).
PMID: 30785092 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - February 20, 2019 Category: Allergy & Immunology Authors: Tavakolpour S, Alesaeidi S Tags: Int Immunopharmacol Source Type: research

Face Transplantation for Granulomatosis With Polyangiitis (Wegener Granulomatosis): Technical Considerations, Immunological Aspects, and 3-Year Posttransplant Outcome
Conclusions This case represents a new underlying disease (trauma + GPA) leading to face transplantation and a unique clinical scenario where allografting was indicated for potentially life-threatening and sight-preserving reasons and not for mere functional and aesthetic concerns. Despite complexity, 3-year clinical outcome is encouraging, and the patient is no longer at risk for dural exposure, meningitis, and related morbidity. (Source: Annals of Plastic Surgery)
Source: Annals of Plastic Surgery - February 7, 2019 Category: Cosmetic Surgery Tags: Transplantation Surgery and Research Source Type: research

Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities
AbstractErythematous lesions of the oral mucosa are common and can reflect a variety of conditions, ranging from benign reactive or immunologically-mediated disorders to malignant disease. Together with vascular abnormalities, which can vary from reddish to bluish-purple in color, the differential diagnosis for erythematous oral mucosal change is quite diverse. This review focuses on salient clinical features and histopathologic findings of selected conditions which clinically present as red or vascular-like oral mucosal alterations, including oral vascular malformations and neoplasms, pyogenic granuloma, localized juvenil...
Source: Head and Neck Pathology - January 29, 2019 Category: Pathology Source Type: research

Isolated choroid plexus involvement in a case of granulomatosis with polyangiitis negative for antineutrophil cytoplasmic antibodies (ANCA)
granulomatosis with polyangiitis (GPA, formerly Wegener's) is a systemic necrotizing vasculitis that predominantly involves respiratory tract and kidneys [1,2]. GPA usually presents with nervous system involvement in the later course, mainly affecting the peripheral nervous system [3]. Vasculitis has been reported up to 6% of GPA cases with central nervous system (CNS) involvement [2,4]. Detection of either anti-proteinase 3 (PR3)-ANCA or myeloperoxidase (MPO)-ANCA can support the diagnosis, but in some cases ANCA are not detected [3]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - January 26, 2019 Category: Neurology Authors: Margoni M, Barbareschi M, Rozzanigo U, Chioffi F, Paolazzi G, Marangoni S Tags: Letter to the Editor Source Type: research

Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener & rsquo;s granulomatosis: how much radiation dose is needed?
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - January 22, 2019 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

[Modern management of otologic consequences of Wegener's granulomatosis - a case report and review of the literature].
Gerlinger I, Révész P Abstract Wegener's granulomatosis - or, in other words, granulomatosis with polyangiitis - is an anti-neutrophil cytoplasmic antibody associated granuloma forming vasculitis, mainly affecting the respiratory tract and the renal system. Otologic manifestations of Wegener's disease can be otitis media with effusion or chronic silent mastoiditis with conductive hearing loss, but sensorineural hearing loss can also evolve. The diagnosis is based on the clinical appearance as well as the immunoserological and histopathological results. It is of paramount importance to begin a combine...
Source: Orvosi Hetilap - January 1, 2019 Category: General Medicine Authors: Tóth I, Kaszás B, Horváth G, Piski Z, Bakó P, Lujber L, Gerlinger I, Révész P Tags: Orv Hetil Source Type: research

Transfusion of Soluble Target Antigens to Pre-Immunized Recipients: A Previously Overlooked Mechanism in Transfusion-Related Acute Lung Injury
Transfusion related lung injury (TRALI) is a leading cause for transfusion related morbidity and mortality in industrialized countries. The majority of cases is induced by antibodies present in donor plasma, and exclusion of antibody carriers from the donor pool has decreased the number of TRALI cases significantly. However, TRALI is still reported. We have identified a new and previously overlooked mechanism in which soluble antigens present in the blood component become the target of pre-existing antibodies present in the recipient.Some of us have recently reported a case of TRALI in a female patient precipitating after ...
Source: Blood - November 21, 2018 Category: Hematology Authors: Bayat, B., Nielsen, K., Burg-Roderfeld, M., Bein, G., Sachs, U. J. Tags: 401. Basic Science and Clinical Practice in Blood Transfusion: Clinical and Translational Studies Source Type: research

Eyelid oedema as an initial manifestation of Wegener's granulomatosis
RESUMEN Objetivo: Evaluar la eficacia de la azitromicina asociada al RAR en pacientes con periodontitis cr ónica. Material y método: El presente ensayo clínico paralelo aleatorizado, controlado y triple ciego, se desarrolló en la Clínica Estomatológica de la Universidad Católica los Ángeles de Chimbote (Trujillo, Perú), entre marzo del 2015 y febrero del 2017. Participaron 70 pacientes adultos, distribuidos aleatoriamente en 2 grupos, designados con las letras A y B, de 35 integrantes cada uno. Cada paciente fue evaluado periodontalmente antes de realizarle el ...
Source: Revista Espanola de Cirugia Oral y Maxilofacial - November 12, 2018 Category: ENT & OMF Source Type: research

Pattern of Scleritis in an Egyptian Cohort.
CONCLUSION: The visual prognosis of an eye with scleritis varies with the subtype of scleral inflammation. In our cohort, it was found to be poorer in eyes with necrotizing scleritis with inflammation compared to other subtypes. PMID: 30412434 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - November 10, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Diffuse Alveolar Hemorrhage and Pulmonary Vasculitides: Histopathologic Findings
Semin Respir Crit Care Med 2018; 39: 425-433 DOI: 10.1055/s-0038-1669412Vasculitides are a heterogeneous group of disorders in which inflammation of blood vessel walls is present at least some time during the course of the disease. Vasculitides can affect any caliber or type of vessel in many anatomic sites; however, the disease can alter more than just vasculature. Given the diversity of vasculitides, in 2012, a revised classification system was proposed to categorize vasculitides by the type of vessel involved including size, function, and structural attributes. In the lung, vasculitis impacts both the pulmonary vessels ...
Source: Seminars in Respiratory and Critical Care Medicine - November 7, 2018 Category: Respiratory Medicine Authors: Scapa, Jason V. Fishbein, Gregory A. Wallace, W. Dean Fishbein, Michael C. Tags: Review Article Source Type: research

Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment
Semin Respir Crit Care Med 2018; 39: 434-458 DOI: 10.1055/s-0038-1660874Granulomatosis with polyangiitis (GPA), formerly termed Wegener's granulomatosis, is the most common of the pulmonary vasculitides. GPA typically involves the upper respiratory tract, lower respiratory tract (bronchi and lung), and kidney, with varying degrees of disseminated vasculitis. Cardinal histologic features include a necrotizing vasculitis involving small vessels, extensive “geographic” necrosis, and granulomatous inflammation. The spectrum and severity of the disease is heterogeneous, ranging from indolent disease involving only o...
Source: Seminars in Respiratory and Critical Care Medicine - November 7, 2018 Category: Respiratory Medicine Authors: Lynch, Joseph P. Derhovanessian, Ariis Tazelaar, Henry Belperio, John A. Tags: Review Article Source Type: research

Reconstruction of Wegener Granulomatosis Nose Deformity Using Fascia Lata Graft
Wegener granulomatosis (WG) is a necrotizing vasculitis that involves the upper respiratory tract, the lungs, and the kidneys. It also causes deformities of the nose in practically all patients, altering the cartilaginous and bony structure as well as the inner lining of the nose. The surgical repair of these nasal distortions is a challenge mainly due to the impairment of wound healing and graft take that is caused both by the disease itself and by the prolonged immunosuppressant treatment. Many different reconstruction plans have been developed, using costal or calvarial bone grafts, cartilage grafts and local skin and...
Source: Journal of Craniofacial Surgery - November 1, 2018 Category: Surgery Tags: Clinical Studies Source Type: research

Brown Tumor of the Cervical Spine in a patient with secondary hyperparathyroidism: A case Report
ConclusionThe importance of the prompt diagnosis of the brown tumor is to establish a multidisciplinary management to prevent progression, neurologic complications and sequelae despite its benign behavior. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - September 18, 2018 Category: Surgery Source Type: research

Application of 3D Printing for Patient-Specific Silicone Stents: 1-Year Follow-Up on 2 Patients
We report the 1-year outcome of 2 patients with airway disease caused by granulomatosis with polyangiitis (Wegener ’s) affecting the left main bronchus and secondary carina. These patients had not responded to systemic therapy or standard bronchoscopic techniques and had complications with commercially available airway stents. We describe a first-in-human, clinical experience to address these issues. Using com puted tomography (CT) imaging and 3D printing technology, we generated and implanted patient-specific silicone airway stents to address airway disease. 3D patient-specific stent prescription was created using a...
Source: Respiration - September 17, 2018 Category: Respiratory Medicine Source Type: research

Targeted Immunotherapy Strategies in ANCA-Associated Vasculitis
This article reviews the current role for targeted immunotherapy in AAV, its validated indications, and avenues for further development. Rituximab is a validated induction treatment for GPA and severe MPA. Rituximab in these indications is not less effective than cyclophosphamide and is particularly useful in patients with refractory or relapsing disease, women of childbearing potential, and patients previously treated with cyclophosphamide. Rituximab is more effective than cyclophosphamide for treating relapses. For remission maintenance therapy, which is indispensable, rituximab has been proven superior over conventional...
Source: Joint Bone Spine - September 8, 2018 Category: Orthopaedics Source Type: research

Clinical manifestations of granulomatosis with polyangiitis: key considerations and major features.
CONCLUSION: Major advances in the understanding and treatment of GPA over recent decades have contributed to the notable decline in morbidity and mortality of patients. The ultimate goal is an improved prognosis through outcome measures which assesses the disease control with minimal adverse effects of intensive immunosuppressive regimens, an integral part of the clinical approach to improve the quality of life of GPA patients. PMID: 30071173 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - August 4, 2018 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India
AbstractGranulomatosis with polyangiitis (GPA) previously known as Wegener ’s granulomatosis is one of the forms of idiopathic systemic vasculitis. There is very scanty data available on GPA in Asian and Indian population. We studied data of 60 patients from southern India, diagnosed with GPA to describe the physical characteristics, the treatment, and outcome. Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Disease activity and damage were ...
Source: Clinical and Experimental Medicine - August 1, 2018 Category: Research Source Type: research

A case of rheumatoid nodules in the buccal subcutaneous : A novel case report of review and the literature
Publication date: May 2018Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Volume 30, Issue 3Author(s): Kazuhiro Ogi, Akihiro Miyazaki, Shota Shimizu, Masato Abe, Ryoichi Genba, Sho Miyamoto, Koyo Nishiyama, Hiroyoshi HiratsukaAbstractMethotrexate (MTX) has been reported to be effective for the treatment of rheumatoid arthritis (RA) when a weekly low dose is administered to patients. We carried out microscopic examination of a biopsied specimen suspected of being Wegener’s granulomatosis, IgG4-related disease, or malignant lymphoma. Finally we diagnosed a rheumatoid nodule because his medic...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - July 10, 2018 Category: ENT & OMF Source Type: research

Thoracic manifestation of Wegener's granulomatosis: Computed tomography findings and analysis of misdiagnosis.
Authors: Li J, Li C, Li J Abstract The aim of the present study was to investigate the computed tomography (CT) manifestations of Wegener granulomatosis (WG) in the chest and potential reasons for misdiagnosis. Conventional CT scans and clinical data of 45 patients with WG were retrospectively analyzed. Patients typically presented with multiple system involvement, primarily in the upper and lower respiratory tract. The incidence of thoracic involvement was 75.56% (34/45). Radiographic features were varied between cases in the present study, with the most common features being numerous cavitary nodules and masses i...
Source: Experimental and Therapeutic Medicine - June 15, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Severe localised granulomatosis with polyangiitis (Wegener ’s granulomatosis) manifesting with extensive cranial nerve palsies and cranial diabetes insipidus: a case report and literature review
Granulomatosis with polyangiitis (GPA, formerly Wegener ’s granulomatosis) is a multisystem vasculitis of small- to medium-sized blood vessels. Cranial involvement can result in cranial nerve palsies and, rarel... (Source: BMC Neurology)
Source: BMC Neurology - May 1, 2018 Category: Neurology Authors: James E. Peters, Vivek Gupta, Ibtisam T. Saeed, Curtis Offiah and Ali S. M. Jawad Tags: Case report Source Type: research

An ugly nose and a Nazi father: Bad premise for a cardiac rheumatic disorder
The rheumatic disorder reported on by Abe and coworkers1 in this issue of the Journal has long been labeled as Wegner granulomatosis, ever since Friedrich Wegener,2 a Nazi pathologist working in Poland,3 reported 3 cases in 1937, describing the pathologic disorders as vasculitis. Actually, this disease had first been reported by Wegner's friend, a Berlin pathologist named Heinz Klinger,4 who in 1932 described a case of destructive sinusitis, lung abscesses, and uremia, characterized by angiitis and granulomas, in a report entitled, “Borderline Forms of Periarteritis Nodosa.” Today, this rheumatic disorder is kn...
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Massimiliano Foschi, Fabrizio Costantino Tancredi, Michele Di Mauro Tags: Editorial commentary Source Type: research

A case of rheumatoid nodules in the buccal subcutaneous : A novel case report of review and the literature
Publication date: Available online 28 March 2018 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Kazuhiro Ogi, Akihiro Miyazaki, Shota Shimizu, Masato Abe, Ryoichi Genba, Sho Miyamoto, Koyo Nishiyama, Hiroyoshi Hiratsuka Methotrexate (MTX) has been reported to be effective for the treatment of rheumatoid arthritis (RA) when a weekly low dose is administered to patients. We carried out microscopic examination of a biopsied specimen suspected of being Wegener’s granulomatosis, IgG4-related disease, or malignant lymphoma. Finally we diagnosed a rheumatoid nodule because his medical ...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - March 29, 2018 Category: ENT & OMF Source Type: research

Wegener ’s granulomatosis of the heart
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - March 10, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Noriyuki Abe, Hiroaki Takahashi, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita Source Type: research

Wegener granulomatosis of the heart
We report here 2 cases of GPA in which a central fibrous body was involved. The institutional ethics committee provided appropriate approval. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - March 10, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Noriyuki Abe, Hiroaki Takahashi, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita Tags: Adult: Aortic Valve: Case Report Source Type: research

Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India
AbstractGranulomatosis with polyangiitis (GPA) previously known as Wegener ’s granulomatosis is one of the forms of idiopathic systemic vasculitis. There is very scanty data available on GPA in Asian and Indian population. We studied data of 60 patients from southern India, diagnosed with GPA to describe the physical characteristics, the treatment, and outcome. Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Disease activity and damage were ...
Source: Clinical and Experimental Medicine - February 28, 2018 Category: Research Source Type: research

Granulomatosis with polyangiitis presenting as facial nerve palsy in a teenager
Granulomatosis with polyangiitis (GPA, previously known as Wegener's granulomatosis) is an autoimmune systemic small-vessel vasculitis, associated with the presence of anti-neurophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA). It is characterized by necrotizing granulomas, usually affecting the airways and kidneys. GPA should be considered when patients do not improve despite adequate treatment of otologic symptoms, when patients have unspecific symptoms suggesting systemic disease (e.g. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - February 7, 2018 Category: ENT & OMF Authors: James C. Wang, Brittany A. Leader, Ryan A. Crane, Bernadette L. Koch, Matthew M. Smith, Stacey L. Ishman Tags: Case Report Source Type: research