Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway
Biomed Pharmacother. 2024 May 3;175:116689. doi: 10.1016/j.biopha.2024.116689. Online ahead of print.ABSTRACTIschemic heart disease invariably leads to devastating damage to human health. Nicotinamide ribose (NR), as one of the precursors of NAD+ synthesis, has been discovered to exert a protective role in various neurological and cardiovascular disorders. Our findings demonstrated that pretreatment with 200 mg/kg NR for 3 h significantly reduced myocardial infarct area, decreased levels of CK-MB and LDH in serum, and improved cardiac function in the rats during myocardial ischemia-reperfusion (I/R) injury. Meanwhile, 0.5 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Kai Zhao Jie Tang Hong Xie Lin Liu Qin Qin Bo Sun Zheng-Hong Qin Rui Sheng Jiang Zhu Source Type: research
Nicotinamide riboside attenuates myocardial ischemia-reperfusion injury via regulating SIRT3/SOD2 signaling pathway
Biomed Pharmacother. 2024 May 3;175:116689. doi: 10.1016/j.biopha.2024.116689. Online ahead of print.ABSTRACTIschemic heart disease invariably leads to devastating damage to human health. Nicotinamide ribose (NR), as one of the precursors of NAD+ synthesis, has been discovered to exert a protective role in various neurological and cardiovascular disorders. Our findings demonstrated that pretreatment with 200 mg/kg NR for 3 h significantly reduced myocardial infarct area, decreased levels of CK-MB and LDH in serum, and improved cardiac function in the rats during myocardial ischemia-reperfusion (I/R) injury. Meanwhile, 0.5 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2024 Category: Drugs & Pharmacology Authors: Kai Zhao Jie Tang Hong Xie Lin Liu Qin Qin Bo Sun Zheng-Hong Qin Rui Sheng Jiang Zhu Source Type: research
The role of vitamins and nutrients in rosacea
AbstractRosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Inc...
Source: Archives of Dermatological Research - May 2, 2024 Category: Dermatology Source Type: research
Nicotinamide Mononucleotide and Nicotinamide Riboside Reverse Ovarian Aging in Rats Via Rebalancing Mitochondrial Fission and Fusion Mechanisms
ConclusionThis study reveals that NMN alone or NR alone can rebalance mitochondrial dynamics by decreasing excessive fission in middle-aged rat ovaries, thus alleviating mitochondrial stress and correcting aging-induced folliculogenesis abnormalities. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 29, 2024 Category: Drugs & Pharmacology Source Type: research
Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In Silico Analyses
CONCLUSION: The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.PMID:38676525 | DOI:10.2174/0113816128283420240409050754 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Myltykbay S Rysmakhanov Afshin Zare Aibolat S Smagulov Nurgul A Abenova Nadiar M Mussin Yerlan B Sultangereyev Bazylbek S Zhakiyev Gani K Kuttymuratov Mehmet Haberal Nazanin Jafari Hanieh Baneshi Shabnam Bakhshalizadeh Mahdi Mahdipour Farhad Rahmanifar Am Source Type: research
Comprehensive Overview of Innovative Strategies in Preventing Renal Ischemia-reperfusion Injury: Insights from Bibliometric and In Silico Analyses
CONCLUSION: The insights provided in this analysis will assist clinicians and researchers in selecting effective preventive approaches for renal IRI in surgical settings, potentially improving patient outcomes.PMID:38676525 | DOI:10.2174/0113816128283420240409050754 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Myltykbay S Rysmakhanov Afshin Zare Aibolat S Smagulov Nurgul A Abenova Nadiar M Mussin Yerlan B Sultangereyev Bazylbek S Zhakiyev Gani K Kuttymuratov Mehmet Haberal Nazanin Jafari Hanieh Baneshi Shabnam Bakhshalizadeh Mahdi Mahdipour Farhad Rahmanifar Am Source Type: research
Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies
J Cardiovasc Dev Dis. 2024 Apr 21;11(4):126. doi: 10.3390/jcdd11040126.ABSTRACTPatients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment. This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining future cardiovascular events. Beyond low-density lipoprotein cholesterol (LDL-c), other lipoprotein particles have not demonstrated similar contribution to the progression of atherosclerosis. Statins, ezetimibe, and more recently, proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors and bempedoic ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Muntaser Omari Mohammad Alkhalil Source Type: research
Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies
J Cardiovasc Dev Dis. 2024 Apr 21;11(4):126. doi: 10.3390/jcdd11040126.ABSTRACTPatients with atherosclerotic disease remain at increased risk of future events despite receiving optimal medical treatment. This residual risk is widely heterogeneous, but lipoprotein particles and their content play a major role in determining future cardiovascular events. Beyond low-density lipoprotein cholesterol (LDL-c), other lipoprotein particles have not demonstrated similar contribution to the progression of atherosclerosis. Statins, ezetimibe, and more recently, proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors and bempedoic ...
Source: Atherosclerosis - April 26, 2024 Category: Cardiology Authors: Muntaser Omari Mohammad Alkhalil Source Type: research
Structural characterization and therapeutic effect of Alhagi honey oligosaccharide on liver fibrosis in mice
In conclusion, the results of our study highlight the promising potential of Mel, derived from Alhagi honey, as a viable candidate drug for treating liver fibrosis. This discovery offers a potentially advantageous option for individuals seeking natural and effective means to promote liver health.PMID:38663563 | DOI:10.1016/j.fitote.2024.105974 (Source: Fitoterapia)
Source: Fitoterapia - April 25, 2024 Category: Biochemistry Authors: Zhiyuan Lv Jianzhong Song Yang Xiang Zhanghao Chen Zinan Lu Quanqian Zhou Kaizhen Wang Hailiqian Taoer Dahong Jiarui Zheng Chunyu Zhang Shuang Gao Chunjun Qin Junmin Chang Source Type: research
Structural characterization and therapeutic effect of Alhagi honey oligosaccharide on liver fibrosis in mice
In conclusion, the results of our study highlight the promising potential of Mel, derived from Alhagi honey, as a viable candidate drug for treating liver fibrosis. This discovery offers a potentially advantageous option for individuals seeking natural and effective means to promote liver health.PMID:38663563 | DOI:10.1016/j.fitote.2024.105974 (Source: Fitoterapia)
Source: Fitoterapia - April 25, 2024 Category: Biochemistry Authors: Zhiyuan Lv Jianzhong Song Yang Xiang Zhanghao Chen Zinan Lu Quanqian Zhou Kaizhen Wang Hailiqian Taoer Dahong Jiarui Zheng Chunyu Zhang Shuang Gao Chunjun Qin Junmin Chang Source Type: research
Structural characterization and therapeutic effect of Alhagi honey oligosaccharide on liver fibrosis in mice
In conclusion, the results of our study highlight the promising potential of Mel, derived from Alhagi honey, as a viable candidate drug for treating liver fibrosis. This discovery offers a potentially advantageous option for individuals seeking natural and effective means to promote liver health.PMID:38663563 | DOI:10.1016/j.fitote.2024.105974 (Source: Fitoterapia)
Source: Fitoterapia - April 25, 2024 Category: Biochemistry Authors: Zhiyuan Lv Jianzhong Song Yang Xiang Zhanghao Chen Zinan Lu Quanqian Zhou Kaizhen Wang Hailiqian Taoer Dahong Jiarui Zheng Chunyu Zhang Shuang Gao Chunjun Qin Junmin Chang Source Type: research
Structural characterization and therapeutic effect of Alhagi honey oligosaccharide on liver fibrosis in mice
In conclusion, the results of our study highlight the promising potential of Mel, derived from Alhagi honey, as a viable candidate drug for treating liver fibrosis. This discovery offers a potentially advantageous option for individuals seeking natural and effective means to promote liver health.PMID:38663563 | DOI:10.1016/j.fitote.2024.105974 (Source: Fitoterapia)
Source: Fitoterapia - April 25, 2024 Category: Biochemistry Authors: Zhiyuan Lv Jianzhong Song Yang Xiang Zhanghao Chen Zinan Lu Quanqian Zhou Kaizhen Wang Hailiqian Taoer Dahong Jiarui Zheng Chunyu Zhang Shuang Gao Chunjun Qin Junmin Chang Source Type: research
A Magnesium Binding Site And The Anomeric Effect Regulate The Abiotic Redox Chemistry Of Nicotinamide Nucleotides
Chemistry. 2024 Apr 19:e202400411. doi: 10.1002/chem.202400411. Online ahead of print.ABSTRACTNicotinamide adenine dinucleotide (NAD+) is a redox active molecule that is universally found in biology. Despite the importance and simplicity of this molecule, few reports exist that investigate which molecular features are important for the activity of this ribodinucleotide. By exploiting the nonenzymatic reduction and oxidation of NAD+ by pyruvate and methylene blue, respectively, we were able to identify key molecular features necessary for the intrinsic activity of NAD+ through kinetic analysis. Such features may explain how...
Source: Chemistry - April 19, 2024 Category: Chemistry Authors: Lorenzo Sebastianelli Harpreet Kaur Ziniu Chen Ramanarayanan Krishnamurthy Sheref S Mansy Source Type: research
Nicotinic acid availability impacts redox cofactor metabolism in Saccharomyces cerevisiae during alcoholic fermentation
This study elucidated the timing of nicotinic acid uptake during grape juice-like fermentation and its impact on NAD(H) levels, the NAD+/NADH ratio, and metabolites produced. Complete uptake of extracellular nicotinic acid occurred pre-mid-exponential phase, thereafter small amounts of vitamin B3 were exported back into the medium. Suboptimal levels of nicotinic acid were correlated with slower fermentation and reduced biomass, disrupting redox balance and impeding NAD+ regeneration, thereby affecting metabolite production. Metabolic outcomes varied with nicotinic acid concentrations, linking NAD+ availability to fermentat...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: James D Duncan Mathabatha E Setati Benoit Divol Source Type: research
Niacin supplementation attenuates the regression of three ‐dimensional capillary architecture in unloaded female rat skeletal muscle
In this study involving adult female Sprague –Dawley rats, the animals were randomly assigned to one of four groups: control (CON), hindlimb unloading (HU), NA, and HU with NA supplementation (HU + NA). For a period of 2 weeks, the rats in the HU and HU + NA groups underwent HU, while those in the NA and HU + NA groups received NA (750 mg/kg) twice daily through oral administration. The results demonstrated that HU lowered capillary number, luminal diameter, and capillary volume, as well as decreased succinate dehydrogenase activity, slow fiber composition, and PGC-1α expression within the soleus muscle....
Source: Physiological Reports - April 17, 2024 Category: Physiology Authors: Hao Lin,
Jihao Xing,
Han Pan,
Takumi Hirabayashi,
Noriaki Maeshige,
Ryosuke Nakanishi,
Hiroyo Kondo,
Hidemi Fujino Tags: ORIGINAL ARTICLE Source Type: research
