Untargeted UPLC-MS metabolomics reveals multiple changes of urine composition in healthy adult volunteers after consumption of Curcuma longa L. extract
Publication date: Available online 8 October 2019Source: Food Research InternationalAuthor(s): Gregorio Peron, Stefania Sut, Simone Dal Ben, Dario Voinovich, Stefano Dall'AcquaAbstractCurcuma longa L. is used as food supplement to prevent diseases, although limited studies have been performed on healthy subjects up to now. In the present work, an untargeted UPLC-MS metabolomics approach was applied to study the changes of 24-hours urinary composition on healthy volunteers due to a 28-days daily consumption of a dried C. longa extract containing a standardized amount of curcuminoids. Changes in the excretion of different me...
Source: Food Research International - October 19, 2019 Category: Food Science Source Type: research

Metabolites downstream of predicted loss-of-function variants inform relationship to disease
Publication date: Available online 17 October 2019Source: Molecular Genetics and MetabolismAuthor(s): Mengbo Li, Andy Wang, Lake-Ee Quek, Stephen Vernon, Gemma A. Figtree, Jean Yang, John F. O'SullivanAbstractA small minority (400,000 subjects in UK Biobank – with metabolites. We conducted these analyses in three community-based cohorts: the Framingham Heart Study (FHS) Offspring Cohort, FHS Generation 3, and the KORA F4 cohort. We identified 19 new low-frequency or rare (minor allele frequency (MAF)  5%) pLOF variant-metabolite associations. Rare pLOF variants in the genes BTN3A2, ENPEP, and GEM that have been ass...
Source: Molecular Genetics and Metabolism - October 19, 2019 Category: Genetics & Stem Cells Source Type: research

Rice: Importance for Global Nutrition.
Authors: Fukagawa NK, Ziska LH Abstract Rice, a staple food for more than half of the world's population, is grown in>100 countries with 90% of the total global production from Asia. Although there are more than 110,000 cultivated varieties of rice that vary in quality and nutritional content, after post-harvest processing, rice can be categorized as either white or brown. Regional and cultural preferences as well as need for stability during storage and transport are the final determinants of market availability and final consumption. In addition to calories, rice is a good source of magnesium, phosphorus, mang...
Source: Journal of Nutritional Science and Vitaminology - October 18, 2019 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Quantitative structure-activity relationships study of a series of niacinamide analogues as androgen receptor antagonists
In this study, 3D Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were employed to construct quantitative structure-activity relationship (QSAR) models of a series of niacinamide analogues as antiandrogens. The obtained models have good reliability and predictivity. In addition, the contour maps from the models can intuitively aid to understand the vital structural characteristics of niacinamides related with the AR antagonistic activities. Our study provides important guidance for the rational design and screening of highly potential active antiandrogens. (Source...
Source: Journal of Molecular Structure - October 17, 2019 Category: Molecular Biology Source Type: research

Activation of HCAR2 by niacin: benefits beyond lipid lowering
Pharmacogenomics, Ahead of Print. (Source: Future Medicine: Pharmacogenomics)
Source: Future Medicine: Pharmacogenomics - October 16, 2019 Category: Genetics & Stem Cells Authors: Sony Tuteja Source Type: research

Niacin for Treatment of Nonalcoholic Fatty Liver Disease (NAFLD): Novel use for an old drug?
Niacin has been widely used clinically for over half a century for dyslipidemia. Recent new evidence indicates that niacin may be useful in the treatment of nonalcoholic fatty liver disease (NAFLD) and its sequential complications including nonalcoholic steatohepatitis (NASH), and fibrosis. There is an urgent unmet need for a cost-effective solution for this public health problem affecting nearly one in three adults. Niacin inhibits and reverses hepatic steatosis and inflammation in animals and liver cell cultures. (Source: Journal of Clinical Lipidology)
Source: Journal of Clinical Lipidology - October 14, 2019 Category: Lipidology Authors: Moti L. Kashyap, Shobha Ganji, Naresh K. Nakra, Vaijinath S. Kamanna Tags: Review Article Source Type: research

Pellagra, an Almost-Forgotten Differential Diagnosis of Chronic Diarrhea: More Prevalent Than We Think.
We report that a recently treated patient with the full spectrum of 3D clinical features of pellagra presents as chronic diarrhea of unknown etiology for 1 year. It reminds us that keeping a high index of suspicion and maintaining a broad differential diagnosis are critical for recognition and management of this potentially fatal but treatable condition. PMID: 31599018 [PubMed - as supplied by publisher] (Source: Nutrition in Clinical Practice)
Source: Nutrition in Clinical Practice - October 9, 2019 Category: Nutrition Authors: Cao S, Wang X, Cestodio K Tags: Nutr Clin Pract Source Type: research

A Reduced Form of Nicotinamide Riboside Defines a New Path for NAD+ Biosynthesis and Acts as an Orally Bioavailable NAD+ Precursor
ConclusionsOur data demonstrate a new pathway for NAD+ synthesis and classify NRH as a promising new therapeutic strategy to enhance NAD+ levels. (Source: Molecular Metabolism)
Source: Molecular Metabolism - October 5, 2019 Category: Endocrinology Source Type: research

Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide
AbstractBackgroundNicotinamide (NAM) is a form of vitamin B3 that, when administered at near-gram doses, has been shown or suggested to be therapeutically effective against many diseases and conditions. The target conditions are incredibly diverse ranging from skin disorders such as bullous pemphigoid to schizophrenia and depression and even AIDS. Similar diversity is expected for the underlying mechanisms. In a large portion of the conditions, NAM conversion to nicotinamide adenine dinucleotide (NAD+) may be a major factor in its efficacy. The augmentation of cellular NAD+ level not only modulates mitochondrial production...
Source: Metabolomics - October 5, 2019 Category: Biology Source Type: research

Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials.
Abstract Background: Randomized trials of therapies that primarily lowered triglycerides have not consistently shown reductions in cardiovascular events. Methods: We performed a systematic review and trial-level meta-regression analysis of 3 classes of lipid-lowering therapies that reduce triglycerides to a greater extent than they do LDL-C: fibrates, niacin, and marine-derived omega-3 fatty acids. Key inclusion criteria were a randomized controlled trial that reported on major vascular events. We also incorporated data from a previous meta-regression of 25 statin trials. The main outcome measure was the risk rati...
Source: Circulation - September 18, 2019 Category: Cardiology Authors: Marston NA, Giugliano RP, Im K, Silverman MG, O'Donoghue ML, Wiviott SD, Ference BA, Sabatine MS Tags: Circulation Source Type: research

Does the usual dietary intake of schizophrenia patients require supplementation with vitamins and minerals?
CONCLUSIONS: No supplementation of schizophrenia patients' diet is recommended; it is only justified in individual cases of patients in whom vitamin and mineral deficiencies were found on the basis of analysis of their food habits. However, it is necessary to provide each schizophrenia patient with appropriate food education that will allow them to choose products that contain all nutrients needed for proper functioning of the body, including the central nervous system. PMID: 31522200 [PubMed - in process] (Source: Psychiatria Polska)
Source: Psychiatria Polska - September 17, 2019 Category: Psychiatry Tags: Psychiatr Pol Source Type: research

GSE129811 The effect of an NAD+ precursor vitamin B3, niacin, on muscle transcriptomic profiles of mitochondrial myopathy patients and healthy controls
Conclusions: These results showed that niacin modulated the expression of disease associated pathways and suppressed mTOR signalling in patients but niacin did not affect disease-related ISRmt signalling. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 17, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genetic evidence for Magnaporthe oryzae vitamin B3 acquisition from rice cells.
Abstract Following penetration, the devastating rice blast fungus Magnaporthe oryzae, like some other important eukaryotic phytopathogens, grows in intimate contact with living plant cells before causing disease. Cell-to-cell growth during this biotrophic growth stage must involve nutrient acquisition, but experimental evidence for the internalization and metabolism of host-derived compounds is exceedingly sparse. This striking gap in our knowledge of the infection process undermines accurate conceptualization of the plant-fungal interaction. Here, through our general interest in Magnaporthe metabolism and with a ...
Source: Microbiology - September 13, 2019 Category: Microbiology Authors: Wilson RA, Fernandez J, Rocha RO, Marroquin-Guzman M, Wright JD Tags: Microbiology Source Type: research

Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity [Cell Biology]
Supplementation with NAD precursors such as nicotinamide riboside (NR) has been shown to enhance mitochondrial function in the liver and to prevent hepatic lipid accumulation in high-fat diet (HFD)-fed rodents. Hepatocyte-specific knockout of the NAD+-synthesizing enzyme nicotinamide phosphoribosyltransferase (NAMPT) reduces liver NAD+ levels, but the metabolic phenotype of Nampt-deficient hepatocytes in mice is unknown. Here, we assessed Nampt's role in maintaining mitochondrial and metabolic functions in the mouse liver. Using the Cre-LoxP system, we generated hepatocyte-specific Nampt knockout (HNKO) mice, having a 50% ...
Source: Journal of Biological Chemistry - September 6, 2019 Category: Chemistry Authors: Morten Dall, Samuel A. J. Trammell, Magnus Asping, Anna S. Hassing, Marianne Agerholm, Sara G. Vienberg, Matthew P. Gillum, Steen Larsen, Jonas T. Treebak Tags: Metabolism Source Type: research

Dermal arteritis of the nasal philtrum: a retrospective study of 23 dogs.
CONCLUSIONS AND CLINICAL IMPORTANCE: The distinctive presentation of DANP substantiates the clinical diagnosis. Medical treatment seems to be effective in controlling DANP and tacrolimus used as sole or adjunctive therapy appears to manage the disease satisfactorily. PMID: 31486556 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - September 5, 2019 Category: Veterinary Research Authors: Souza CP, Torres SMF, Koch SN, Bernardi de Souza L Tags: Vet Dermatol Source Type: research

GSE136821 Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis
This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment with L-carnitine and nicotinamide riboside, i.e., components that can enhance fatty acid transfer across the inner mitochondrial membrane and increase nicotinamide adenine nucleotide (NAD+) levels, which are necessary for β-oxidation and the TCA cycle, respectively. Ldlr −/−.Leiden mice were treated with high-fat diet (HFD) supplemented with L-carnitine (LC; 0.4% w/w), nicotinamide riboside (NR; 0.3% w/w) or both (COMBI) for 21 weeks. L-carnitine plasma levels were reduced by HFD and normalized by LC. NR suppl...
Source: GEO: Gene Expression Omnibus - September 4, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Fast-Acting Insulin Aspart: The Rationale for a New Mealtime Insulin
AbstractAttenuating postprandial hyperglycaemia is a critical factor in the achievement of optimal glucose control. Prandial insulin analogues have been developed to replicate the physiology of normal endogenous insulin secretion and action, with the aim of limiting postprandial glucose excursions. There is still, however, a significant unmet need, with many people failing to achieve desired glycaemic control targets despite the current armamentarium of prandial insulin analogues. Such insulins have a delayed onset and a longer duration of action than endogenous insulin production. There has been considerable focus on atte...
Source: Diabetes Therapy - September 4, 2019 Category: Endocrinology Source Type: research

N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis
Abstractβ-amyloid protein (Aβ) is thought to be the primary cause of the pathogenesis of Alzheimer’s disease (AD). Niacin has been reported to have beneficial effects on AD. Previously, we synthesized a novel compound lipoicacid–niacin dimer (N2L) and revealed that it had potent blood-lipid regulation and antioxidative properties without aflushing effect. Given that lipid metabolism is also associated with AD, the present study aimed to investigate the neuroprotective effects of N2L on Aβ1 –42-induced cytotoxicity in HT22 cells. We found that N2L significantly attenuated cell apoptosis, MDA...
Source: Metabolic Brain Disease - September 2, 2019 Category: Neurology Source Type: research

Niacin nutrition and rumen-protected niacin supplementation in dairy cows: an updated review.
Abstract As the precursor to nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, niacin is important for catabolic and anabolic redox reactions. In addition, niacin is known for its antilipolytic action via a hydroxycarboxylic acid 2 (HCA2) receptor dependent mechanism. The antilipolytic effects of traditional free niacin supplementation during transition periods had been studied extensively, but the reported effects are ambiguous. In the past decade, a series of studies were conducted to evaluate the effects of rumen-protected niacin (RPN) on production performance and metabolic sta...
Source: The British Journal of Nutrition - September 2, 2019 Category: Nutrition Authors: Chen J, Yang Z, Dong G Tags: Br J Nutr Source Type: research

GSE133261 Nicotinamide riboside augments the human skeletal muscle NAD+ 1 metabolome and induces transcriptomic and anti-inflammatory signatures in aged subjects: a placebo-controlled, randomized trial
Contributors : Yasir Elhassan ; Ildem Akerman ; Gareth LaverySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNAD+is modulated by conditions of metabolic stress and has been reported to decline with aging, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction in rodents. We aimed to establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome, and questioned if tissue NAD+levels are depressed with aging. We supplemented 12 aged men with NR 1g per day for 21-days in a placebo-controlled,...
Source: GEO: Gene Expression Omnibus - August 29, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Identifying labelling and marketing advantages of nutrients in minced beef meat: A case study
Publication date: Available online 22 August 2019Source: Meat ScienceAuthor(s): Bjørg Egelandsdal, Marije Oostindjer, Ellen-Margrethe Hovland, Bolette Okholm, Kristin Saarem, Frøydis Bjerke, Lene Ruud, Vladana Grabež, Anna HaugAbstractIn 2006, the European Commission approved nutrition and health claim regulations of foods to stimulate healthier choices. To document how commercial, minced beef meat complied with regulations, meat samples from 72 carcasses were analysed. These samples were a source of niacin (B3), pyridoxine (B6), phosphorus and iron (cow meat only), and a rich source of protein, monounsatura...
Source: Meat Science - August 24, 2019 Category: Food Science Source Type: research

Niacin regulates apolipoprotein M expression via liver X receptor ‑α.
In conclusion, niacin upregulates ApoM expression by increasing LXRα expression in vivo and in vitro. PMID: 31432166 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 23, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Serious Adverse Effects of Extended-Release Niacin/Laropiprant: Results From the Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) Trial.
Abstract PURPOSE: The Heart Protection Study 2-Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial of patients at high risk of vascular disease found that adding extended-release niacin-laropiprant to intensive statin-based LDL-lowering therapy had no benefit on cardiovascular outcomes. However, the trial also identified previously unrecognized serious adverse effects (including new-onset diabetes, bleeding, and infection). Our objective was to explore the safety profile of niacin-laropiprant and examine whether any patients were at lower (or higher) risk of its adverse effects. ME...
Source: Clinical Therapeutics - August 22, 2019 Category: Drugs & Pharmacology Authors: Haynes R, Valdes-Marquez E, Hopewell JC, Chen F, Li J, Parish S, Landray MJ, Armitage J, HPS2-THRIVE Collaborative Group, HPS2-THRIVE Writing Committee members, HPS2-THRIVE Steering Committee members Tags: Clin Ther Source Type: research

Niacinamide reduces inflammatory response due to skin barrier disruption
Introduction: Impaired skin barrier function has been suggested to underlie sensitive skin. Sensitive skin triggers such as surfactant irritation or mechanical abrasion result in barrier damage and skin inflammation. In subjects with darker skin types, inflammation will also often result in the formation of postinflammatory hyperpigmentation (PIH). In vivo efficacy of niacinamide against inflammation caused by barrier damage has not yet been demonstrated. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Dietary Intake and Its Related Factors in Peritoneal Dialysis Patients in Tehran, Iran.
Authors: As'habi A, Najafi I, Tabibi H, Hedayati M Abstract INTRODUCTION: Poor nutritional status is prevalent in peritonealdialysis (PD) patients and is related to morbidity and mortality.Therefore, the aim of the present study was to assess the dietaryintake and its related factors in PD patients in Tehran, Iran. METHODS: All eligible PD patients in Tehran peritoneal dialysiscenters were included in this cross-sectional study. Dietary intakeof PD patients was determined using a 3-day dietary recall. Also,a 4 mL blood sample was obtained from each patient to measureserum biochemical parameters. RESULTS: In...
Source: Iranian Journal of Kidney Diseases - August 21, 2019 Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research

Effect of nutrient intakes on anthropometric profiles among university students from a selected private University in Klang Valley, Malaysia
Conclusion: Micronutrients, especially B vitamins, are important in weight management among the young adults.Keywords: Anthropometric measurements, fiber, macronutrients, micronutrients, malaysian university students. (Source: African Health Sciences)
Source: African Health Sciences - August 21, 2019 Category: African Health Source Type: research

Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes.
In this study, we explored how NAD+ affects TLR4 and NOD-like receptor with a PYD-domain 3 (NLRP3) inflammasome activation, two key innate immune responses. Human primary monocytes were isolated from buffy coats obtained from healthy individuals. Intracellular NAD+ was manipulated by nicotinamide riboside and the NAMPT inhibitor FK866. Cells were primed with LPS with or without subsequent NLRP3 activation with ATP or cholesterol crystals to analyze the effects of NAD+ levels on TLR4-mediated NF-κB activation and NLRP3 activity, respectively. Cytokine release was quantified, and the downstream signal pathway of TLR4 w...
Source: Journal of Immunology - August 19, 2019 Category: Allergy & Immunology Authors: Yang K, Lauritzen KH, Olsen MB, Dahl TB, Ranheim T, Ahmed MS, Attramadal H, Aukrust P, Halvorsen B, Nyman TA, Sandanger Ø, Yndestad A Tags: J Immunol Source Type: research

12th IFDC Special Issue – Prioritizing commonly consumed traditional dishes of southeast Nigeria for comprehensive analyses and inclusion in food composition database
Publication date: Available online 16 August 2019Source: Journal of Food Composition and AnalysisAuthor(s): Gloria Ifeoma Davidson, Henrietta Nkechi Ene-ObongAbstractDocumentation of commonly consumed dishes and their contribution to the energy and nutrient intake of adults in southeast Nigeria were the aims of the study. Twenty communities were selected from the study area using a stratified sampling technique. Twenty-four-hour dietary recall, focus group discussion (FGD) and a 3-day weighed food intake conducted in each of the selected communities were used to collect the data, which were analyzed using percentages, mean...
Source: Journal of Food Composition and Analysis - August 17, 2019 Category: Food Science Source Type: research

MON-PO452: Association Between Pyridoxine an Niacin with Natriuretic Peptide in Patients with Heart Failure
(Source: Clinical Nutrition)
Source: Clinical Nutrition - August 15, 2019 Category: Nutrition Authors: R. Herrera Saucedo, J.B. Ivey Miranda, D. Gonz ález Islas, E. Almeida Gutiérrez, G. Saturno Chiu, L. Verdeja Vendrell, A. Chávez Mendoza, G.H. Mendoza Zavala, J.A. Magaña Serrano, A.D.J. Treviño Mejía, R.B. Rivera Leaños Tags: Nutrition and chronic disease II Source Type: research

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Publication date: 13 August 2019Source: Cell Reports, Volume 28, Issue 7Author(s): Yasir S. Elhassan, Katarina Kluckova, Rachel S. Fletcher, Mark S. Schmidt, Antje Garten, Craig L. Doig, David M. Cartwright, Lucy Oakey, Claire V. Burley, Ned Jenkinson, Martin Wilson, Samuel J.E. Lucas, Ildem Akerman, Alex Seabright, Yu-Chiang Lai, Daniel A. Tennant, Peter Nightingale, Gareth A. Wallis, Konstantinos N. Manolopoulos, Charles BrennerSummaryNicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotin...
Source: Cell Reports - August 14, 2019 Category: Cytology Source Type: research

IJERPH, Vol. 16, Pages 2852: Validation of the CIMI-Ethiopia Program and Seasonal Variation in Maternal Nutrient Intake in Enset (False Banana) Growing Areas of Southern Ethiopia
Conclusions: It has been found that CIMI-Ethiopia is a valid tool for estimating nutrient intakes at an individual level in Southern Ethiopia. The study demonstrated a decline in intakes of iron; zinc; magnesium; pantothenic acid; vitamin B1, B12, and D; protein; and energy in the lean wet season. This result provides some hint for fortification and supplementation programs that aim to combat maternal malnutrition in rural Southern Ethiopia. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - August 9, 2019 Category: Environmental Health Authors: Tafese Bosha Christine Lambert Simon Riedel Ute Gola Aberra Melesse Hans K. Biesalski Tags: Article Source Type: research

Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in obese, non-diabetic men.
CONCLUSION: The present study does not provide evidence to support that dietary supplementation with the NAD+ precursor NR serves to impact glucose tolerance, β-cell secretory capacity, α-cell function, and incretin hormone secretion in obese, non-diabetic males. Moreover, bile acid levels in plasma did not change in response to NR supplementation. PMID: 31390002 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 7, 2019 Category: Endocrinology Authors: Dollerup OL, Trammell SAJ, Hartmann B, Holst JJ, Christensen B, Møller N, Gillum MP, Treebak JT, Jessen N Tags: J Clin Endocrinol Metab Source Type: research

Effects Of Vitamin B3 On Lipoprotein Metabolism In A Mouse Model Of Hypercholesterolemia
Background and Aims: HDL are dysfunctional in hypercholesterolemic patients. We tested the hypothesis that the administration of a vitamin B3 derivative will improve HDL metabolism in a mouse model of hypercholesterolemia (Source: Atherosclerosis)
Source: Atherosclerosis - August 3, 2019 Category: Cardiology Authors: K. M éndez Lara, D. Santos, V. Pallarés, J.C. Escolá Gill, F. Blanco Vaca, J. Julve Gil Tags: E-poster session Source Type: research

[ASAP] De Novo Design of Cu(II) Complex Containing CNC –Pincer–Vitamin B3 and B7 Conjugates for Breast Cancer Application
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00399 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - August 2, 2019 Category: Drugs & Pharmacology Authors: Leila Tabrizi* † and Fatemeh Abyar*‡ Source Type: research

Monounsaturated Fatty Acids in a High ‐Fat Diet and Niacin Protect from White Fat Dysfunction in the Metabolic Syndrome
ConclusionNiacin in combination with dietary MUFAs can favor WAT homeostasis in the development of HFD ‐induced obesity and metabolic syndrome.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - July 25, 2019 Category: Food Science Authors: Sergio Montserrat ‐de la Paz, Maria C. Naranjo, Maria C. Millan‐Linares, Sergio Lopez, Rocio Abia, Erik A.L. Biessen, Francisco J.G. Muriana, Beatriz Bermudez Tags: Research Article Source Type: research

Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery.
Abstract Neuroplasticity is a natural process occurring in the brain for entire life. Stroke is the leading cause of long term disability and huge medical and financial problem throughout the world. Research conducted over the past decade focused mainly on neuroprotection in the acute phase of stroke while very little studies targets chronic stage. Recovery after stroke depends on the ability of our brain to reestablish structural and functional organization of neurovascular networks. Combining adjuvant therapies and drugs may enhance the repair processes and restore impaired brain functions. Currently, there are ...
Source: Current Neuropharmacology - July 25, 2019 Category: Drugs & Pharmacology Authors: Szelenberger R, Kostka J, Saluk-Bijak J, Miller E Tags: Curr Neuropharmacol Source Type: research

Association of Schizophrenia Risk With Disordered Niacin Metabolism
This genome-wide association study evaluates genetic loci for schizophrenia in a unique Indian population. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - July 3, 2019 Category: Psychiatry Source Type: research

A Randomized, Placebo ‐Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High‐Density Lipoprotein Cholesterol in Subjects With Dyslipidemia
This study evaluated the effects of GSK256073 on lipids in subjects with low high‐density lipoprotein cholesterol (HDLc). Subjects (n = 80) were randomized (1:1:1:1) to receive GSK256073 5, 50, or 150 mg/day or matching placebo for 8 weeks. The prima ry end point was determining the GSK256073 exposure‐response relationship for change from baseline in HDLc. No significant exposure response was observed between GSK256073 and HDLc levels. GSK256073 did not significantly alter HDLc levels versus placebo, but rather revealed a trend at the 150‐mg dose for a nonsignificant decrease in HDLc (‐6.31%;P =...
Source: Clinical Pharmacology in Drug Development - July 3, 2019 Category: Drugs & Pharmacology Authors: Eric J. Olson, Kelly M. Mahar, Thomas F. Haws, Feng Gao, Anne ‐Charlotte Gouville, Dennis L. Sprecher, John J. Lepore Tags: Original Manuscript Source Type: research

Depigmentation and anti-aging treatment by natural molecules.
Abstract Natural molecules are becoming more accepted choices as cosmetic agents, many products in the market today claim to include natural components. Plants include many substances that could be of a value in the whitening skin and working as anti-aging agents. A wide range of articles related to natural skin whitening and anti-aging agents have been reviewed. Many plant-derived and natural molecules have shown to affect melanin synthesis by different mechanisms, examples include Arbutin, Ramulus mori extract, Licorice extract, Glabridin, Liquiritin, Kojic acid, Methyl gentisate, Aloesin, Azelaic acid, Vitamin ...
Source: Current Pharmaceutical Design - July 3, 2019 Category: Drugs & Pharmacology Authors: Zaid A, Al Ramahi R Tags: Curr Pharm Des Source Type: research

A Randomized, Placebo ‐Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High‐Density Lipoprotein Cholesterol in Subjects With Dyslipidemia
This study evaluated the effects of GSK256073 on lipids in subjects with low high‐density lipoprotein cholesterol (HDLc). Subjects (n = 80) were randomized (1:1:1:1) to receive GSK256073 5, 50, or 150 mg/day or matching placebo for 8 weeks. The prima ry end point was determining the GSK256073 exposure‐response relationship for change from baseline in HDLc. No significant exposure response was observed between GSK256073 and HDLc levels. GSK256073 did not significantly alter HDLc levels versus placebo, but rather revealed a trend at the 150‐mg dose for a nonsignificant decrease in HDLc (‐6.31%;P =...
Source: Clinical Pharmacology in Drug Development - July 3, 2019 Category: Drugs & Pharmacology Authors: Eric J. Olson, Kelly M. Mahar, Thomas F. Haws, Feng Gao, Anne ‐Charlotte Gouville, Dennis L. Sprecher, John J. Lepore Tags: Original Manuscript Source Type: research

Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity
This study investigated whether nicotinamide riboside, a precursor of NAD+, prevents doxorubicin cardiotoxicity by improving autophagic flux. We report that administration of nicotinamide riboside elevated NAD+ levels, and reduced cardiac injury and myocardial dysfunction in doxorubicin-injected mice. These protective effects of nicotinamide riboside were recapitulated in cultured cardiomyocytes upon doxorubicin treatment. Mechanistically, nicotinamide riboside prevented the blockage of autophagic flux, accumulation of autolysosomes and oxidative stress in doxorubicin-treated cardiomyocytes, the effects of which were assoc...
Source: Clinical Science - July 2, 2019 Category: Biomedical Science Authors: Zheng, D., Zhang, Y., Zheng, M., Cao, T., Wang, G., Zhang, L., Ni, R., Brockman, J., Zhong, H., Fan, G.-C., Peng, T. Tags: PublishAheadOfPrint Source Type: research

Evolution of Ellipsoid Zone Abnormalities on Optical Coherence Tomography Associated With Niacin Maculopathy
This article presents a case of maculopathy associated with niacin administration and complicated by persistent ellipsoid zone disruptions. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2019 Category: Opthalmology Source Type: research

Current pharmacotherapy for the treatment of dyslipidemia associated with HIV infection.
Authors: Gebhardt A, Fichtenbaum CJ Abstract Introduction: Cardiovascular disease is an important cause of morbidity and mortality in persons with human immunodeficiency virus (PWH). The risk of atherosclerotic cardiovascular disease (ASCVD) is higher in PWH compared to uninfected persons. Dyslipidemia is a critical link in the pathogenesis of ASCVD in PWH. Chronic inflammation associated with HIV infection may drive both dyslipidemia and ASCVD. Areas Covered: The authors review the evidence for using lipid-lowering therapy in PWH and includes an overview of the utility and complexity of using statins in PWH, in pa...
Source: Expert Opinion on Pharmacotherapy - June 26, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Aerobic and resistance exercise training reverses age ‐dependent decline in NAD+ salvage capacity in human skeletal muscle
NAMPT is crucially important for maintaining skeletal muscle NAD+ levels. We show that both endurance ‐ and resistance‐type exercise training reverses the age‐dependent decline in skeletal muscle NAMPT abundance. Our findings highlight the value of exercise training in ameliorating age‐associated deterioration of skeletal muscle function. AbstractAging decreases skeletal muscle mass and strength, but aerobic and resistance exercise training maintains skeletal muscle function. NAD+ is a coenzyme for ATP production and a required substrate for enzymes regulating cellular homeostasis. In skeletal muscle, NAD+ is  ...
Source: Physiological Reports - June 17, 2019 Category: Physiology Authors: Roldan M. de Guia, Marianne Agerholm, Thomas S. Nielsen, Leslie A. Consitt, Ditte S øgaard, Jørn W. Helge, Steen Larsen, Josef Brandauer, Joseph A. Houmard, Jonas T. Treebak Tags: Original Research Source Type: research

Composition requirements of follow-up formula for 6-12-month-old infants: recommendations of a Chinese expert group.
CONCLUSIONS: These nutrient standard modifications based on recent evidence are expected to enhance feeding practices and further guarantee the health of 6-12-month-old infants in China. PMID: 31192564 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - June 14, 2019 Category: Nutrition Authors: Han J, Kang L, Liang D, Li H, Su Y, Zhang Y, Yang Y Tags: Asia Pac J Clin Nutr Source Type: research

Chapter Seven - Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
Publication date: 2019Source: International Review of Neurobiology, Volume 145Author(s): Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho, James W. RussellAbstractSurvival of human peripheral nervous system neurons and associated distal axons is highly dependent on energy. Diabetes invokes a maladaptation in glucose and lipid energy metabolism in adult sensory neurons, axons and Schwann cells. Mitochondrial (Mt) dysfunction has been implicated as an etiological factor in failure of energy homeostasis that results in a low intrinsic aerobic capacity within the neuron...
Source: International Review of Neurobiology - June 14, 2019 Category: Neuroscience Source Type: research

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration
Conclusion: This study revealed that abnormal activation of mTORC1 signaling leads to RPE degeneration, which could provide a promising target for the treatment of RPE dysfunction-related diseases. (Source: Theranostics)
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Jiancheng Huang, Shun Gu, Meng Chen, Shu-jie Zhang, Zhichun Jiang, Xue Chen, Chao Jiang, Guohua Liu, Roxana A Radu, Xiantao Sun, Douglas Vollrath, Jianhai Du, Biao Yan, Chen Zhao Tags: Research Paper Source Type: research

Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis
ConclusionNR attenuated HSC activation, leading to reduced liver fibrosis in a diet-induced mouse model of liver fibrosis. The data suggest that NR may be developed as a potential preventative for human liver fibrosis. (Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease)
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - June 11, 2019 Category: Molecular Biology Source Type: research

Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
Publication date: Available online 8 June 2019Source: International Review of NeurobiologyAuthor(s): Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho, James W. RussellAbstractSurvival of human peripheral nervous system neurons and associated distal axons is highly dependent on energy. Diabetes invokes a maladaptation in glucose and lipid energy metabolism in adult sensory neurons, axons and Schwann cells. Mitochondrial (Mt) dysfunction has been implicated as an etiological factor in failure of energy homeostasis that results in a low intrinsic aerobic capacity withi...
Source: International Review of Neurobiology - June 9, 2019 Category: Neuroscience Source Type: research