Are anti-inflammatory foods associated with a protective effect for cutaneous melanoma?
In conclusion, the only anti-inflammatory food item that was consistently associated with a protective effect for cutaneous was coffee in particular caffeinated coffee. (Source: European Journal of Cancer Prevention)
Source: European Journal of Cancer Prevention - August 4, 2020 Category: Cancer & Oncology Tags: Short Paper: Skin cancer Source Type: research

When to lower triglycerides?
Purpose of review Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has remained unclear. Recent findings Several lines of evidence indicate that TRL are associated with atherogenesis, partly because of associated factors, such as cholesterol-enriched remnant particles, high LDL particle number, high apo-B, high apo-CIII, and others. High triglyceride is increasingly prevalent because of worsening of lifestyle factors, obesity, and diabetes. Tr...
Source: Current Opinion in Lipidology - July 30, 2020 Category: Lipidology Tags: HYPERLIPIDEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

Long-Term Vegan Meditation Improved Human Gut Microbiota.
Conclusions: These results indicate that long-term vegan meditation plays a positive role in improving the body's immunity and adjusting endocrine and metabolic levels, enabling the body to be in a state of good health. PMID: 32714427 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - July 29, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Molecules, Vol. 25, Pages 3323: Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects
In conclusion, research suggests that in the future, a healthy diet may be considered a reliable tool for maintaining and optimizing our key internal parameters. (Source: Molecules)
Source: Molecules - July 22, 2020 Category: Chemistry Authors: Bogdan Doroftei Ovidiu-Dumitru Ilie Roxana-Oana Cojocariu Alin Ciobica Radu Maftei Delia Grab Emil Anton Jack McKenna Nitasha Dhunna Gabriela Simionescu Tags: Review Source Type: research

Dysfunctional T Cell Mitochondria Lead to Premature Aging.
Abstract Desdín-Micó et al. have shown that Tfam specific knockout in mouse T cells disrupts mitochondrial genome integrity and induces a burst of inflammatory cytokines and tumor necrosis factor (TNF)-α production, resulting in increased senescence, neuromuscular and vascular dysfunction, and molecular features that recapitulate premature aging. Interestingly, treatment with nicotinamide riboside (NR) alleviates this phenotype by reducing senescence and systemic inflammation. PMID: 32709506 [PubMed - as supplied by publisher] (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - July 22, 2020 Category: Molecular Biology Authors: Lenaers G, Bonneau D, Delneste Y, Papon N Tags: Trends Mol Med Source Type: research

Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide  +/ Sirtuin-1 pathway in mice.
In this study, the effects of SG and the underlying mechanisms were evaluated in a mouse model of high-fat diet (HFD)-induced NAFLD. METHODS: C57BL/6 mice were randomly divided into three groups: normal diet with sham operation (NC-Sham group), HFD with sham operation (HFD-Sham group), and HFD with sleeve gastrectomy (HFD-SG group). Glucose metabolism and fat accumulation in the body and liver were analyzed before and after SG. Lipid metabolism and inflammation in the liver were evaluated. Nicotinamide adenine dinucleotide (NAD+) levels as well as nicotinamide riboside kinase (NRK1) and Sirtuin-1 (SIRT1) expression le...
Source: Asian Journal of Surgery - July 22, 2020 Category: Surgery Authors: Hua R, Wang GZ, Shen QW, Yang YP, Wang M, Wu M, Shao YK, He M, Zang Y, Yao QY, Zhang ZY Tags: Asian J Surg Source Type: research

A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium.
Authors: Liu T, Zhou N, Xu R, Cao Y, Zhang Y, Liu Z, Zheng X, Feng W Abstract Chrysanthemum morifolium (Chr) is a traditional Chinese medicine (TCM) that has been used in the treatment of inflammation-linked diseases for hundreds of years. Naringenin (Nar) and apigenin (Api) are the major active components in aqueous extracts of C. morifolium. The aim of our study was to clarify the roles of Chr, Nar and Api in ameliorating depression-like behaviour induced by corticosterone. First, the behavioural and biochemical indicators closely related to depression were examined to evaluate the therapeutic effects of Chr/Nar/...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 15, 2020 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Micronutrient supplementation of lactating Guatemalan women acutely increases infants' intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial.
Abstract BACKGROUND: Maternal supplementation during lactation could increase milk B-vitamin concentrations, but little is known about the kinetics of milk vitamin responses. OBJECTIVES: We compared acute effects of maternal lipid-based nutrient supplement (LNS) consumption (n = 22 nutrients, 175%-212% of the RDA intake for the nutrients examined), as a single dose or at spaced intervals during 8 h, on milk concentrations and infant intake from milk of B-vitamins. METHODS: This randomized crossover trial in Quetzaltenango, Guatemala included 26 mother-infant dyads 4-6 mo postpartum who were ran...
Source: The American Journal of Clinical Nutrition - July 10, 2020 Category: Nutrition Authors: Donohue JA, Solomons NW, Hampel D, Shahab-Ferdows S, Orozco MN, Allen LH Tags: Am J Clin Nutr Source Type: research

Impaired nicotinamide adenine dinucleotide (NAD+) metabolism in diabetes and diabetic tissues: Implications for nicotinamide ‐related compound treatment
Diabetes causes nicotinamide adenine dinucleotide metabolism dysregulation characterized by increasing consumption of nicotinamide adenine dinucleotide to produce nicotinamide and decreasing conversion of nicotinamide to nicotinamide adenine dinucleotide (salvage cascade) by biochemical abnormalities, which have been postulated for the etiology of diabetic complications. This results in increasing production of nicotinamide catabolites, which might cause oxidative stress. For diabetes patients, nicotinamide ‐related compounds, such as nicotinamide riboside and nicotinamide mononucleotide might be useful after correcting ...
Source: Journal of Diabetes Investigation - July 7, 2020 Category: Endocrinology Authors: Lan Fan, Jose M. Cacicedo, Yasuo Ido Tags: Review Article Source Type: research

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy.
ainen A PMID: 32640244 [PubMed - in process] (Source: Cell Metabolism)
Source: Cell Metabolism - July 7, 2020 Category: Cytology Authors: Pirinen E, Auranen M, Khan NA, Brilhante V, Urho N, Pessia A, Hakkarainen A, Ulla Heinonen JK, Schmidt MS, Haimilahti K, Piirilä P, Lundbom N, Taskinen MR, Brenner C, Velagapudi V, Pietiläinen KH, Suomalainen A Tags: Cell Metab Source Type: research

Metabolic signature of eyelid basal cell carcinoma.
In conclusion, eyelid BCC has a signature change of cell metabolome. Metabolites in NAD metabolic pathways could potentially be biomarkers or therapeutic targets for eyelid BCC. PMID: 32649951 [PubMed - as supplied by publisher] (Source: Experimental Eye Research)
Source: Experimental Eye Research - July 7, 2020 Category: Opthalmology Authors: Huang J, Schaefer J, Wang Y, Gioia L, Pei Y, Shi X, Waris S, Zhao C, Nguyen J, Du J Tags: Exp Eye Res Source Type: research

Equity implications of rice fortification: a modelling study from Nepal.
CONCLUSIONS: Consumption of purchased fortified rice improves adequacy and gender equity of nutrient intake, especially in non-rice-growing areas. PMID: 32627728 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Source: Public Health Nutrition - July 6, 2020 Category: International Medicine & Public Health Authors: Saville NM, Maharjan M, Manandhar DS, Harris-Fry HA Tags: Public Health Nutr Source Type: research

Nutritional and Medicinal Importance of Dioscorea glabra R. Baron, a Potent Wild Edible Plant Consumed by the Lodha Tribal Community of West Bengal, India
Conclusion: The abundance of protein, fat, carbohydrate, minerals, water soluble vitamins and natural antioxidant components in this plant makes them as a considerable source of nutrition and could be consumed as a regular diet to the human being. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - June 30, 2020 Category: Nutrition Source Type: research

Relative validity of a computer-based semi-quantitative FFQ for use in the Pelotas (Brazil) Birth Cohort Studies.
CONCLUSIONS: The FFQ provides a reasonable dietary intake assessment for habitual food consumption. However, the relative validity was weak for specific nutrients and food groups. PMID: 32597741 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Source: Public Health Nutrition - June 29, 2020 Category: International Medicine & Public Health Authors: Vaz JS, Buffarini R, Schneider BC, Bielemann RM, Gonçalves H, Assunção MCF Tags: Public Health Nutr Source Type: research

Kahweol Found in Coffee Inhibits IL-2 Production Via Suppressing the Phosphorylations of ERK and c-Fos in Lymphocytic Jurkat Cells.
Authors: Park JB Abstract Interleukin-2 (IL-2) is a cytokine involved in the development and maturation of the subsets of T cells, critically associated with the progression of several immune-related diseases (e.g. liver disease, bowel disease). Interestingly, a recent study suggests that coffee may contain several compounds to inhibit IL-2 expression in activated T-lymphocytic cells. However, there is little information about the potential effects of several coffee compounds (e.g. kahweol, cafestol, trigonelline, niacin and chlorogenic acids) on IL-2 expression in activated T-lymphocytic cells. Therefore, in this ...
Source: Journal of Dietary Supplements - June 27, 2020 Category: Nutrition Tags: J Diet Suppl Source Type: research

The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?
Abstract Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric disorders such as major depression, bipolar disorder and schizophrenia. The first part of this paper details mitochondrial antioxidant mechanisms and their importance in reactive oxygen species (ROS) detoxification, including details of NO networks, the roles of H2O2 and the thioredoxin/peroxiredoxin system, and the relationship between mitochondrial respiration and NADPH production. The second part highlights and identifies the causes of the multiple pathological sequelae arising from self-amplifying increases in ...
Source: Molecular Biology Reports - June 20, 2020 Category: Molecular Biology Authors: Morris G, Walder KR, Berk M, Marx W, Walker AJ, Maes M, Puri BK Tags: Mol Biol Rep Source Type: research

Genome-Scale Metabolic Model Driven Design of a Defined Medium for Campylobacter jejuni M1cam
Campylobacter jejuni, the most frequent cause of food-borne bacterial gastroenteritis, is a fastidious organism when grown in the laboratory. Oxygen is required for growth, despite the presence of the metabolic mechanism for anaerobic respiration. Amino acid auxotrophies are variably reported and energy metabolism can occur through several electron donor/acceptor combinations. Overall, the picture is one of a flexible, but vulnerable metabolism. To understand Campylobacter metabolism, we have constructed a fully curated, metabolic model for the reference organism M1 (our variant is M1cam) and validated it through laborator...
Source: Frontiers in Microbiology - June 19, 2020 Category: Microbiology Source Type: research

250 Combination of niacinamide, a tripeptide, and yeast extract show synergistic induction of autophagy and stress response biothemes in human epidermal keratinocytes
Niacinamide (N, aka nicotinamide, Vitamin B3) has been used in skin care formulations for decades and clinically proven to improve skin ’s surface barrier integrity, appearance of skin color, and topographical attributes. To improve N’s effectiveness, we screened for chemistries that would significantly increase protection against stress-induced processes when combined with N in in vitro models. Human hTERT keratinocytes were us ed to screen for inhibitors of UVB-induced PGE2 synthesis (15 mJ/cm2) and for inducers of autophagy. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: J. Oblong, T.L. Laughlin, J.D. Sherrill, L.A. Mullins, J.C. Bierman Tags: Epidermal Structure and Barrier Function Source Type: research

249 Optimized low pH niacinamide formulations show a significant induction of autophagy gene expression over neutral niacinamide control formula
Niacinamide (N, aka nicotinamide, Vitamin B3) has been used in skin care formulations for decades and clinically proven to improve barrier integrity, appearance of skin color, and topographical attributes. Mechanistically it is believed that N can impact autophagy in skin by increasing cellular NAD+ and NADPH pools, which are known to decrease in skin with age. N based formulations have historically been practiced within a neutral pH range in order to maintain stability and thereby prevent formation of niacin, a known vasodilator. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: J. Oblong, T.L. Laughlin, J.D. Sherrill, S. Zhao, B.B. Jarrold, Y.M. DeAngelis, J.C. Bierman, B. Fang, T. Hakozaki Tags: Epidermal Structure and Barrier Function Source Type: research

Environmentally benign corrosion inhibitors based on cellulose niacin nano-composite for corrosion of copper in sodium chloride solutions.
Abstract There is a high demand for high performance, effective and eco-friendly corrosion inhibitors for industrial applications. Therefore, novel benign high performance corrosion inhibitors based on biopolymer were synthesized in-situ using different cellulosic materials and niacin. Characterization of the cellulose nano-composite was carried out by Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). The anticorrosive performance of cellulose composites for copper in 3.5% NaCl solutions were ...
Source: International Journal of Biological Macromolecules - June 8, 2020 Category: Biochemistry Authors: Hasanin MS, Al Kiey SA Tags: Int J Biol Macromol Source Type: research

Ignition mechanism of flammable dust and dust mixtures: An insight through thermogravimetric/differential scanning calorimetry analysis
AbstractUnderstanding flame propagation mechanism and thermal behavior of flammable dusts is of crucial importance, since they strongly affect the flammability and explosion parameters. In a previous work, we found that the volatile point of anthraquinone/nicotinic acid mixtures can be lower than the one of the pure dusts, suggesting a synergistic effect. In this work, thermogravimetric and differential scanning calorimetry analyses of anthraquinone/niacin mixtures were carried out both in open and closed cup, to explain the observed synergistic behavior. FTIR analysis on solid residue and evolved gaseous species showed th...
Source: AIChE Journal - June 5, 2020 Category: Science Authors: Maria Portarapillo, Giuseppina Luciani, Roberto Sanchirico, Almerinda Di Benedetto Tags: PARTICLE TECHNOLOGY AND FLUIDIZATION Source Type: research

Of Mice and Men: NAD+ Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients.
Abstract In this issue of Cell Metabolism, Pirinen et al. (2020) show that disruption in NAD+ homeostasis is a key component of the pathogenesis of mitochondrial myopathy in humans that can be targeted by the administration of the NAD+ precursor niacin, identifying NAD+ boosting as a potential treatment for this devastating disease. PMID: 32492387 [PubMed - as supplied by publisher] (Source: Cell Metabolism)
Source: Cell Metabolism - June 2, 2020 Category: Cytology Authors: Chini EN Tags: Cell Metab Source Type: research

Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging.
Abstract Loss of follicles together with decreased oocyte quality and quantity contribute to age-associated ovarian senescence and infertility. Although underlying mechanisms for ovarian senescence are still unknown, mitochondrial dysfunctions have been reported. Here, we showed age-dependent decreases in ovarian Nicotinamide Adenine Dinucleotide (NAD+) levels in mice whereas supplementing aging mice with nicotinamide riboside (NR), an NAD+ precursor, increased ovarian NAD+ content. We found that increases in ovarian NAD+ levels in aging mice led to increased number of ovarian follicles and ovulatory potential as ...
Source: Free Radical Biology and Medicine - May 31, 2020 Category: Biology Authors: Yang Q, Cong L, Wang Y, Luo X, Li H, Wang H, Zhu J, Dai S, Jin H, Yao G, Shi S, Hsueh AJ, Sun Y Tags: Free Radic Biol Med Source Type: research

Impact of nicotinamide riboside supplementation on skeletal muscle mitochondria and whole-body glucose homeostasis: challenging the current hypothesis.
PMID: 32463114 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 28, 2020 Category: Physiology Authors: Moore MP, Mucinski JM Tags: J Physiol Source Type: research

Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?
Abstract Maintaining physical mobility is important for preventing age-related comorbidities in older adults. Endurance and resistance training prevent mobility loss in aging, but exercise alone does not always achieve the expected improvements in physical and cardiopulmonary function. Recent preclinical evidence suggests that a reason for the variability in exercise training responses may be the age-related dysregulation of the nicotinamide adenine dinucleotide (NAD+) metabolome. NAD+ is an essential enzymatic cofactor in energetic and signaling pathways. Endogenous NAD+ pool is lower in several chronic and degen...
Source: Experimental Gerontology - May 22, 2020 Category: Geriatrics Authors: Custodero C, Saini SK, Shin MJ, Jeon YK, Christou DD, McDermott MM, Leeuwenburgh C, Anton SD, Mankowski RT Tags: Exp Gerontol Source Type: research

Synthesis of Stable NAD+  Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC.
Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. Chembiochem. 2020 May 18;: Authors: van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC, Filippov DV Abstract Stable NAD +  analogues carrying single atom substitutions in either the furanose ring or the nicotinamide part have proven their value as inhibitors for NAD +  consuming enzymes. To investigate the potential of such compounds to inhibit the adenosine diphosphate ribosyl (ADPr) transferase activity of the Legione...
Source: Chembiochem - May 18, 2020 Category: Biochemistry Authors: van der Heden van Noort G, Madern JM, Kim RQ, Misra M, Dikic I, Zhang Y, Ovaa H, Codee JDC, Filippov DV Tags: Chembiochem Source Type: research

GC-FID-based quantification of the sum of the three forms of vitamin B3 from animal liver.
t O Abstract Vitamin B3 (nicotinic acid, nicotinamide) is an essential water-soluble vitamin and cellular energy metabolism depends on the vitamin B3-derived cofactors. Inaccessible covalently-linked nicotinic acid in food such as maize can cause vitamin B3 deficiency in animals since maize is also deficient in tryptophan, the precursor of nicotinic acid. A sensitive and reproducible GC-FID-based method for the quantification of the sum of the three forms of vitamin B3 from animal liver was developed. Free nicotinic acid, free nicotinamide and nicotinamide moiety of NAD+/NADP+(and their riboside precursors) were s...
Source: Analytical Biochemistry - May 18, 2020 Category: Biochemistry Authors: Hämmerle M, Le MH, Hekmat O Tags: Anal Biochem Source Type: research

Ignition mechanism of flammable dust and dust mixtures: an insight through TG/DSC analysis
This article is protected by copyright. All rights reserved. (Source: AIChE Journal)
Source: AIChE Journal - May 15, 2020 Category: Science Authors: Maria Portarapillo, Giuseppina Luciani, Roberto Sanchirico, Almerinda Di Benedetto Tags: PARTICLE TECHNOLOGY AND FLUIDIZATION Source Type: research

Fat mobilization without weight loss is a potentially rapid response to nicotinamide riboside in obese people: it's time to test with exercise.
PMID: 32412605 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - May 15, 2020 Category: Nutrition Authors: Fluharty NT, Brenner C Tags: Am J Clin Nutr Source Type: research

Ignition mechanism of flammable dust and dust mixtures: an insight through TG/DSC analysis
This article is protected by copyright. All rights reserved. (Source: AIChE Journal)
Source: AIChE Journal - May 15, 2020 Category: Science Authors: Maria Portarapillo, Giuseppina Luciani, Roberto Sanchirico, Almerinda Di Benedetto Tags: PARTICLE TECHNOLOGY AND FLUIDIZATION Source Type: research

Niacin increases diet-induced hepatic steatosis in B6129 mice
Publication date: Available online 11 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Han Fang, Zhuoyue Li, Emily C. Graff, Kayleen J. McCafferty, Robert L. Judd (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - May 13, 2020 Category: Lipidology Source Type: research

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy
Nicotinamide adenine dinucleotide (NAD) is a cofactor of many enzymatic reactions as well as being a substrate for a number of NAD-consuming enzymes (e.g., PARPS, sirtuins, etc). NAD can be synthesized de novo starting from tryptophan, nicotinamide, nicotinic acid, or nicotinamide riboside from the diet. On the other hand, the nicotinamide that is liberated by NAD-consuming enzymes can be salvaged to re-form NAD. In this former instance, nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme. In the many cells in which the salvage pathway is predominant, NAMPT, therefore, represents an important controller...
Source: Frontiers in Pharmacology - May 12, 2020 Category: Drugs & Pharmacology Source Type: research

Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside.
CONCLUSION: NMN and NR modulate intracellular NAD content in endothelium, inhibit endothelial inflammation and improve NO-dependent function by CD73-dependent and independent pathways, respectively. Extracellular conversion of NMN to NR by CD73 localized in the luminal surface of endothelial cells represent important vasoprotective mechanisms to maintain intracellular NAD. PMID: 32389638 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - May 7, 2020 Category: Drugs & Pharmacology Authors: Mateuszuk Ł, Campagna R, Kutryb-Zając B, Kuś K, Słominska EM, Smolenski RT, Chlopicki S Tags: Biochem Pharmacol Source Type: research

Niacin contents of cereal-milling products in food-composition databases need to be updated
Publication date: Available online 5 May 2020Source: Journal of Food Composition and AnalysisAuthor(s): Bhawani Chamlagain, Saija Rautio, Minnamari Edelmann, Velimatti Ollilainen, Vieno Piironen (Source: Journal of Food Composition and Analysis)
Source: Journal of Food Composition and Analysis - May 5, 2020 Category: Food Science Source Type: research

Nutritional and Medicinal Importance of Dioscorea glabra R. Baron, a Potent Wild Edible Plant Consumed by the Lodha Tribal Community of West Bengal, India
Conclusion: The abundance of protein, fat, carbohydrate, minerals, water soluble vitamins and natural antioxidant components in this plant makes them as a considerable source of nutrition and could be consumed as a regular diet to the human being. (Source: Current Nutrition and Food Science)
Source: Current Nutrition and Food Science - April 27, 2020 Category: Nutrition Source Type: research

Dietary patterns related to cardiovascular disease based on reduced rank regression analysis of healthy middle-aged Koreans: data from the community-based Korean Genome and Epidemiology Study (KoGES) cohort.
CONCLUSIONS: In this study, we identified DPs related to CVD, and a DP characterized by high intakes of eggs, fish, milk, and dairy products protected against incident CVD in women. PMID: 32338724 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 27, 2020 Category: Nutrition Authors: Lee HAH, An H, Lee E Tags: Am J Clin Nutr Source Type: research

Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.
Abstract Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War (GW), who suffer from symptoms that reflect ongoing mitochondria dysfunction. Brain mitochondria bioenergetics dysfunction in GWI animal models corresponds with astroglia activation and neuroinflammation. In a pilot study of GW veterans (n = 43), we observed that blood nicotinamide adenine dinucleotide (NAD) and sirtuin 1 (Sirt1) protein levels were decreased in the blood of veterans with GWI compared to healthy GW veterans. Since nicotinamide riboside (NR)-mediated targeting of Sirt1 is shown to improve mitochondria funct...
Source: Neurotoxicology - April 25, 2020 Category: Neurology Authors: Joshi U, Evans JE, Pearson A, Saltiel N, Cseresznye A, Darcey T, Ojo J, Keegan AP, Oberlin S, Mouzon B, Paris D, Klimas N, Sullivan K, Mullan M, Crawford F, Abdullah L Tags: Neurotoxicology Source Type: research

Lipoprotein(a) and Cardiovascular Diseases  - Revisited.
Lipoprotein(a) and Cardiovascular Diseases - Revisited. Circ J. 2020 Apr 24;: Authors: Jang AY, Han SH, Sohn IS, Oh PC, Koh KK Abstract Two decades ago, it was recognized that lipoprotein(a) (Lp(a)) concentrations were elevated in patients with cardiovascular disease (CVD). However, the importance of Lp(a) was not strongly established due to a lack of both Lp(a)-lowering therapy and evidence that reducing Lp(a) levels improves CVD risk. Recent advances in clinical and genetic research have revealed the crucial role of Lp(a) in the pathogenesis of CVD. Mendelian randomization studies have shown that ...
Source: Circulation Journal - April 24, 2020 Category: Cardiology Authors: Jang AY, Han SH, Sohn IS, Oh PC, Koh KK Tags: Circ J Source Type: research

Molecules, Vol. 25, Pages 1940: Structural and Functional Characterization of NadR from Lactococcus lactis
Slotboom NadR is a bifunctional enzyme that converts nicotinamide riboside (NR) into nicotinamide mononucleotide (NMN), which is then converted into nicotinamide adenine dinucleotide (NAD). Although a crystal structure of the enzyme from the Gram-negative bacterium Haemophilus influenzae is known, structural understanding of its catalytic mechanism remains unclear. Here, we purified the NadR enzyme from Lactococcus lactis and established an assay to determine the combined activity of this bifunctional enzyme. The conversion of NR into NAD showed hyperbolic dependence on the NR concentration, but sigmoidal dependence o...
Source: Molecules - April 22, 2020 Category: Chemistry Authors: Artem Stetsenko Rajkumar Singh Michael Jaehme Albert Guskov Dirk Jan Slotboom Tags: Article Source Type: research

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.
CONCLUSIONS: NR supplementation of 1000 mg/d for 6 wk in healthy overweight or obese men and women increased skeletal muscle NAD+ metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced minor changes in body composition and sleeping metabolic rate. However, no other metabolic health effects were observed.This trial was registered at clinicaltrials.gov as NCT02835664. PMID: 32320006 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 22, 2020 Category: Nutrition Authors: Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schr Tags: Am J Clin Nutr Source Type: research

Impurity Profiling HPTLC Method involving Assay of Essential Human Micronutrient Niacin with Eco Scale Assessment.
Abstract Recently, the special attention of analytical society is being paid to reducing reliance on hazardous chemicals in various analytical methods. By embracing this concept, an eco-friendly HPTLC method is developed as an alternative for the conventional HPLC method for determination of an essential human micronutrient, Niacin (NIA) which was introduced in the market to improve the lipid profile of patients. Furthermore, the proposed HPTLC method is capable of determination of the structurally related impurities of NIA such as pyridine-2,5-dicarboxylic acid (PDC), isonicotinic acid (ISO), pyridine (PYR), and ...
Source: Biomedical Chromatography : BMC - April 19, 2020 Category: Biomedical Science Authors: Naguib IA, Draz ME, Abdallah FF Tags: Biomed Chromatogr Source Type: research

Lipid-Modifying Drugs: Pharmacology and Perspectives.
Authors: Xu RX, Wu YJ Abstract Coronary artery disease (CAD) is one of the leading causes of death worldwide. It is well known that dyslipidemia is a major pathogenic risk factor for atherosclerosis and CAD, which results in cardiac ischemic injury and myocardial infarction. Lipid-modifying drugs can effectively improve lipid abnormalities including reducing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) or increasing high-density lipoprotein cholesterol (HDL-C), and eventually decrease the incidence of cardiovascular events. This chapter will review basic principles of lipid metabolism and focu...
Source: Advances in Experimental Medicine and Biology - April 5, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Nicotinamide riboside –amino acid conjugates that are stable to purine nucleoside phosphorylase
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00134A, PaperFaisal Hayat, Marie E. Migaud O5 ′ amino acid ester conjugates of nicotinamide riboside, generatedvia a reduced intermediate, are stable to purine nucleoside phosphorylase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 1, 2020 Category: Molecular Biology Authors: Faisal Hayat Source Type: research

[Research Articles] Control of brain tumor growth by reactivating myeloid cells with niacin
Glioblastomas are generally incurable partly because monocytes, macrophages, and microglia in afflicted patients do not function in an antitumor capacity. Medications that reactivate these macrophages/microglia, as well as circulating monocytes that become macrophages, could thus be useful to treat glioblastoma. We have discovered that niacin (vitamin B3) is a potential stimulator of these inefficient myeloid cells. Niacin-exposed monocytes attenuated the growth of brain tumor–initiating cells (BTICs) derived from glioblastoma patients by producing anti-proliferative interferon-α14. Niacin treatment of mice bea...
Source: Science Translational Medicine - April 1, 2020 Category: Biomedical Science Authors: Sarkar, S., Yang, R., Mirzaei, R., Rawji, K., Poon, C., Mishra, M. K., Zemp, F. J., Bose, P., Kelly, J., Dunn, J. F., Yong, V. W. Tags: Research Articles Source Type: research

Nicotinamide riboside protects noise-induced hearing loss by recovering the hair cell ribbon synapses
Publication date: 23 April 2020Source: Neuroscience Letters, Volume 725Author(s): Shuguang Han, Zhengde Du, Ke Liu, Shusheng Gong (Source: Neuroscience Letters)
Source: Neuroscience Letters - March 26, 2020 Category: Neuroscience Source Type: research

Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
The article Niacin ‑mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system, written by Khalil S. Rawji, Adam M.H. Young, Tanay Ghosh, Nathan J. Michaels, Reza Mirzaei, Janson Kappen, Kathleen L. Kolehmainen, Nima Alaeiilkhchi, Brian Lozinski, Manoj K. Mishra, Annie P u, Weiwen Tang, Salma Zein, Deepak K. Kaushik, Michael B. Keough, Jason R. Plemel, Fiona Calvert, Andrew J. Knights, Daniel J. Gaffney, Wolfram Tetzlaff, Robin J. M. Franklin and V. Wee Yong, was originally published electronically on the publisher’s internet. (Source: Acta Neuropathologica)
Source: Acta Neuropathologica - March 24, 2020 Category: Neurology Source Type: research

Rate of inappropriate energy and micronutrient intake among the Korean working population.
CONCLUSIONS: We found different rates of inappropriate energy and micronutrient intakes according to working conditions. Younger workers with long hours and shift work schedules were vulnerable to inappropriate energy and nutrient intakes. PMID: 32183914 [PubMed - as supplied by publisher] (Source: Public Health Nutrition)
Source: Public Health Nutrition - March 18, 2020 Category: International Medicine & Public Health Authors: Lee W, Jung J, Ahn J, Kim HR Tags: Public Health Nutr Source Type: research

A Treatment Combination of Peels, Oral Antioxidants, and Topical Therapy for Refractory Melasma: A Report of 4 Cases.
Conclusion: This protocol of trichloroacetic acid, phytic acid and ascorbic acid peel combined with an oral supplement and topical daily treatment is a viable treatment option for refractory melasma. PMID: 32161485 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 13, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

[Membrane lipids in schizophrenia and early phases of psychosis: Potential biomarkers and therapeutic targets?]
Authors: Frajerman A, Kebir O, Chaumette B, Tessier C, Lamazière A, Nuss P, Krebs MO Abstract The various roles of membrane lipids in human health has urged researchers to study their impact in neuropsychiatric diseases, especially in schizophrenia spectrum disorders and more recently in early stages of psychosis. The progress in mass spectrometry technologies now allows a more comprehensive analysis of phospholipids (PL) and their fatty acid (FA) molecular species. FA are defined by a carbon chain of variable length and are said to be unsaturated when their chain has one or more carbon-carbon double bonds. ...
Source: L Encephale - March 12, 2020 Category: Psychiatry Tags: Encephale Source Type: research