Fight Aging! Newsletter, May 13th 2019
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - May 12, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Boosting Levels of NAD+ May Make Senescent Cells More Aggressively Inflammatory
Enhancing levels of NAD+ in mitochondria via delivery of various precursor compounds as supplements is growing in popularity as an approach to boost faltering mitochondrial function and thus modestly slow the progression of aging. A human trial demonstrated improved vascular function as a result of nicotinamide riboside supplementation, for example. Researchers here show that increased NAD+ will likely make worse the inflammatory signaling of senescent cells, however. Senescent cells accumulate with age, and are an important cause of the chronic inflammation of aging that drives the progression of many age-related diseases...
Source: Fight Aging! - May 6, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 8th 2019
This study did not confirm the hypothesis that ELL individuals have lower polygenic risk scores for cardiovascular-related phenotypes. Only the HDL cholesterol and triglyceride PRS were nominally significantly associated with ELL participants. In contrast and as expected, ELL individuals had higher polygenic risk scores for exceptional longevity (EL). In regards to the associations of the various cardiovascular PRS with EL, no findings survived correction for multiple testing. This is despite validating the utility of the lipid PRS by confirming positive associations with measured lipid levels in our sample. Interestingly,...
Source: Fight Aging! - April 7, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Nicotinamide Riboside Reverses Age-Related Decline in Intestinal Stem Cell Populations
Nicotinamide riboside supplementation is one of the ways to increase levels of NAD+ in mitochondria, thus improving mitochondrial function. This probably does little for young people, particularly young and physically fit people, but in old age NAD+ levels decline along with mitochondrial function. Mitochondria are the power plants of the cell, and with aging they suffer a general malaise that is detrimental to tissue function, especially in energy-hungry tissues such as muscles and the brain. The causes are still poorly understood, though a faltering of the quality control mechanism of mitophagy due to loss of mitochondri...
Source: Fight Aging! - April 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 7th 2019
This study suggests that advantages and disadvantages vary by environment and diet, however, which might explain why evolution has selected for multiple haplogroups rather than one dominant haplogroup. This is all interesting, but none of it stops the research community from engineering a globally better-than-natural human mitochondrial genome, and then copying it into the cell nucleus as a backup to prevent the well-known contribution of mitochondrial DNA damage to aging. Further, nothing stops us from keeping the haplogroups we have and rendering the effects of variants small and irrelevant through the development...
Source: Fight Aging! - January 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at the Rejuvenation Research and Advocacy of 2018
Discussion of Mitochondrial Hormesis as an Approach to Slow Aging Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System An Interview with a Programmed Aging Theorist An Interview with Reason at the Life Extension Advocacy Foundation An Interview on Mitochondrial Damage and Dysfunction in Aging An Interview with Vadim Gladyshev on Research into the Causes of Aging An Interview with Jim Mellon, and Update on Juvenescence A Lengthy Interview with Aubrey de Grey of the SENS Research Foundation An Interview with Peter de Keize...
Source: Fight Aging! - December 31, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Fight Aging! Newsletter, November 5th 2018
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss. Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/ In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atheroscl...
Source: Fight Aging! - November 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Grander Lessons from a Failure of Robotic Surgery
This week on my podcast, I deviated briefly from cardiology to discuss a shocking and sad study highlighting the vital nature of doing randomized controlled trials in the practice of medicine. The reason I mentioned a trial comparing 2 types of hysterectomy (removal of the uterus) in women with early stage cervical cancer was not to opine on matters of cancer, but because the tragic story shows the harm doctors can do if we incorporate therapies without proper testing. The New England Journal of Medicine published a trial in which women with early cervical cancer were randomized to two types of hysterectomy: One...
Source: Dr John M - November 4, 2018 Category: Cardiology Authors: Dr John Source Type: blogs

Final Stretch Goal for the Lifespan.io NAD+ Mouse Study Crowdfunding Event
The latest Lifespan.io crowdfunding project launched last month and is already closing in on the final stretch goal of $75,000; congratulations to everyone involved. The funds will be used to run a mouse study of nicotinamide mononucleotide (NMN) supplementation, one of a number of similar approaches that can increase NAD+ levels in older animals. This in turn improves mitochondrial function, though without addressing any of the underlying causes of mitochondrial decline with aging - it is a way to narrowly compensate for some of the metabolic consequences of aging, or to selectively override some of the reactions to the b...
Source: Fight Aging! - November 1, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Niacin hasn ’t lived up to its original promise in cardiovascular prevention
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - September 21, 2018 Category: Internal Medicine Tags: cardiovascular pharmacology Source Type: blogs

Fight Aging! Newsletter, September 17th 2018
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - September 16, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How to Organize and Run a Comparatively Simple Self-Experiment to Assess the Impact of MitoQ and Niagen on Cardiovascular Aging
The objective here is a set of tests that (a) match up to the expected outcome based on human trials of MitoQ and Niagen, and (b) that anyone can run without the need to involve a physician, as that always adds significant time and expense. These tests are focused on the cardiovascular system, particularly measures influenced by vascular stiffness, and some consideration given to parameters relevant to oxidative stress and the development of atherosclerosis. A standard blood test, with inflammatory markers. An oxidized LDL cholesterol assessment. Resting heart rate and blood pressure. Pulse wave velocity. Biolog...
Source: Fight Aging! - September 10, 2018 Category: Research Authors: Reason Tags: Self-Experimentation Source Type: blogs

Fight Aging! Newsletter, August 20th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 19, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Napa Therapeutics Formed to Develop Drugs to Influence NAD Metabolism
The involvement of In Silico Medicine in the formation of Napa Therapeutics to run drug discovery based on advances in understanding of mitochondrial metabolism in aging is an example of the premium placed on any approach that might plausibly reduce the cost and time involved in finding drug candidates. We will no doubt see a lot more of this sort of thing as computational methodologies become a plausible replacement for greater portions of the existing costly, hands-on, mechanical screening processes. Draw a triangle in the present field of aging research with the three points set at calorie restriction mimetics, e...
Source: Fight Aging! - August 17, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 16th 2018
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - July 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

More than You Wanted to Know About NAD+ in Metabolism and Aging
Manipulating levels of nicotinamide adenine dinucleotide (NAD+) so as to improve mitochondrial function in older individuals is a popular topic these days, particularly now that numerous groups are selling supplements alleged to raise NAD+ levels usefully. These might be thought of as a form of exercise mimetic drug, in the cases where they actually perform. Even given an intriguing early human trial, this is most likely a road to only minor benefits in the matter of aging. At 90, even the best of former athletes looks like a 90-year old, with a significant degree of dysfunction, and a high chance of failing to live to see...
Source: Fight Aging! - July 11, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Improving the Understanding of Chronic Inflammation in Atherosclerosis
Atherosclerosis is an inflammatory condition. Oxidized lipids//en.wikipedia.org/wiki/Lipid_peroxidation">Oxidized lipids lead to the formation of fatty plaques that narrow and weaken blood vessels, the growth of those plaques driven by the activities of macrophages that try and fail to repair the damage. They become overwhelmed and die: plaques are a mix of fat and the cellular debris from dead macrophages. Prior to their destruction, macrophages generate inflammatory signaling as atherosclerosis worsens, but how is it that other sources of age-related chronic inflammation can accelerate the progression of atherosc...
Source: Fight Aging! - June 25, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Skin serum: What it can and can ’t do
Many things improve with age; unfortunately, your skin is not one of them. Wrinkles, brown spots, and general dullness often start to creep in as the years tick by. To reverse these problems many women are turning to a skin serum. Serums are light, easily absorbed oil- or water-based liquids that you spread on your skin. They typically come in small bottles with a dropper, and you only need a few drops to treat your whole face. A skin serum is not a moisturizer, like a lotion or cream, says Dr. Abigail Waldman, instructor of dermatology at Harvard Medical School. Rather, they are highly concentrated formulations that are d...
Source: Harvard Health Blog - June 12, 2018 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Health Healthy Aging Skin and Hair Care Source Type: blogs

Fight Aging! Newsletter, June 11th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 10, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Arguing for Nicotinamide Riboside to Improve Hematopoietic Stem Cell Function
Researchers here argue for enhanced levels of NAD+ to boost stem cell function through improved mitochondrial function. This is an area of metabolism that has gained increasing attention of late, a second pass at the whole topic of sirtuins, mitochondrial function, and metabolism in aging. I'd say the jury is still out on whether it is worth pursing aggressively in human medicine. One or two early trials seem promising, in the sense of obtaining benefits that look similar to those derived from exercise, but the magnitude and reliability of those benefits is the important question. The bone marrow stem cell populatio...
Source: Fight Aging! - June 5, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

No Cardiovascular Health Benefits Result from Most Common Dietary Supplements
It is well known within the research community that dietary supplements as a class achieve next to nothing for basically healthy people, those lacking any specific deficiency or medical condition that might cause that deficiency. In fact the evidence strongly suggests that some supplements, antioxidants for example, may even be modestly harmful over the long term. This scientific consensus has to compete with the marketing budget of the supplement industry, which seems to be doing fairly well for a community focused on selling a mix of largely useless and mildly harmful products. So studies such as this one continue to rol...
Source: Fight Aging! - May 30, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 30th 2018
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated. Recent Research on the Benefits of Exercise in Later Life https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/ A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case ...
Source: Fight Aging! - April 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

4 ways to protect against skin cancer (other than sunscreen)
It’s almost May and here in the northeast, front-of-the-pharmacy aisles are filled with myriad brands and types of sunscreen. While sunscreen is essential to lowering your risk for skin cancer, there are other simple, over-the-counter options you can incorporate into your summer skin protection routine. Nicotinamide may help prevent certain skin cancers Nicotinamide is a form of vitamin B3 that has been shown to reduce the number of skin cancers. In a randomized controlled trial performed in Australia (published in the New England Journal of Medicine), the risks of basal cell carcinoma and squamous cell carcinoma wer...
Source: Harvard Health Blog - April 27, 2018 Category: Consumer Health News Authors: Emily S. Ruiz, MD, MPH Tags: Cancer Health Prevention Skin and Hair Care Source Type: blogs

A Set of Marginal and Alleged Senolytics Show No Meaningful Benefits in a Cell Study
Senolytic compounds are those that selectively destroy senescent cells. As the accumulation of senescent cells is one of the root causes of aging, and senescent cells contribute directly to many specific age-related diseases, there is some interest in the development of effective senolytics. As is the case for any field of medical development, however, there are as many marginal and possible senolytic drugs as there are useful and proven senolytic drugs. The size of effect, the nature of the side-effects, and the quality of the evidence all matter greatly - indeed, this is the whole of the point when looking at whether a p...
Source: Fight Aging! - April 23, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 2nd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - April 1, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Isagenix. – Diet Review
Conclusion – Does Isagenix Work? Isagenix Isalean’s shake is marketed well, but it’s loaded with sugar and calories. There’s also a lot of protein added, but once you research what kinds of ingredients are included, you realize it’s not a quality meal replacement. The protein added is cheap and can be found for a reduced price elsewhere. Many customers have also complained about the taste, lack of weight loss, and the hard to drink consistency. There are better options which have only 1 gram of sugar, no added fructose, only high quality whey protein, and great reviews to back up their weight ...
Source: Nursing Comments - March 30, 2018 Category: Nursing Authors: M1gu3l Tags: Weight Loss Source Type: blogs

Isagenix. – Diet Review
Conclusion – Does Isagenix Work? Isagenix Isalean’s shake is marketed well, but it’s loaded with sugar and calories. There’s also a lot of protein added, but once you research what kinds of ingredients are included, you realize it’s not a quality meal replacement. The protein added is cheap and can be found for a reduced price elsewhere. Many customers have also complained about the taste, lack of weight loss, and the hard to drink consistency. There are better options which have only 1 gram of sugar, no added fructose, only high quality whey protein, and great reviews to back up their weight ...
Source: Nursing Comments - March 30, 2018 Category: Nursing Authors: M1gu3l Tags: Weight Loss Source Type: blogs

Results from a Preliminary Human Trial of Nicotinamide Riboside Supplementation
What sort of evidence would it take to challenge my assessment of the data to date that methods of raising NAD+ levels with age, such as nicotinamide riboside supplementation, are not worth pursuing as a major area of focus in research and development? Given the history of work in this area of metabolism, mostly that relating directly to sirtuins and their manipulation, one has to be a little skeptical. Initially promising (and overhyped) results in mice went essentially nowhere, or turned out to make the condition of obesity a little less harmful, while showing little evidence of utility for healthy individuals. To...
Source: Fight Aging! - March 29, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Results from a Preliminary Human Trial of Nicotinomide Riboside Supplementation
What sort of evidence would it take to challenge my assessment of the data to date that methods of raising NAD+ levels with age, such as nicotinomide riboside supplementation, are not worth pursuing as a major area of focus in research and development? Given the history of work in this area of metabolism, mostly that relating directly to sirtuins and their manipulation, one has to be a little skeptical. Initially promising (and overhyped) results in mice went essentially nowhere, or turned out to make the condition of obesity a little less harmful, while showing little evidence of utility for healthy individuals. To...
Source: Fight Aging! - March 29, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Can Nicotinamide Riboside Help Prevent Alzheimer's?
The supplement nicotinamide riboside (NR) – a form of vitamin B3 – prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease.byAlzheimer's Reading RoomThe results of the study, conducted by researchers at the National Institute on Aging (NIA) part of the National Institutes of Health,suggest a potential new target for treating Alzheimer ’s disease.What is the Difference Between Alzheimer ’s and DementiaCompound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer ’s diseaseSubscribe to the Alzheime...
Source: Alzheimer's Reading Room, The - February 14, 2018 Category: Neurology Tags: alzheimer's research Alzheimers Dementia Alzheimers Prevention alzheimers treatment prevent alzheimers science vitamins Source Type: blogs

A Layperson's Video Guide to a Few of the Therapies that Aim to Reverse Aging
Last month a couple of noted YouTube channels, in collaboration with the Life Extension Advocacy Foundation, published a set of popular videos that covered aging and the rationale for seeking to control aging through new medical technologies, aimed at laypeople unfamiliar with both the current promising state of the science and recent years of advocacy for rejuvenation research. The videos are quality productions and were quite widely viewed - a good job on the part of all those involved. We can hope that some of the many viewers will stop to think about how they can help to make this vision for the future a reality, and u...
Source: Fight Aging! - November 3, 2017 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

New Products from Alastin and NIA24
ALASTIN SKINCARE ™ REGENERATING SKIN NECTARLess downtime post procedure is possible with Alastin's Tri-Hex Technology ™Key BenefitsHelps support the skin's natural ability to produce new healthy elastin and collagen.Enhances healthy skin by helping to clear damage and debris in the extracellular matrix.High antioxidant activity is designed to calm the skin and reduce the appearance of redness.NIA INTENSIVE DOUBLE MOISTURE SERUMThis breakthrough serum features isolated aqueous- and lipidic-phase formulas. At the push of a button, the two phases combine to intensely rehydrate and visibly re-plump skin.Key Benefit...
Source: What's New In Plastic Surgery? - October 2, 2017 Category: Cosmetic Surgery Tags: Cape Cod christine hamori duxbury Skin Spa Specials south shore Source Type: blogs

Specials in the Skin Spa for October
Specials in Christine Hamori'sSkin Spa for October are as follows. 10% offCoolsculpting + receive a free ThermiSmooth treatment (new) in one of the following areas: upper face, neck, or hands (both treatments must be done same day)Laser Hair Removal specials: 10% off 1 area; 20% off 2 areas; 30% off 3 areas (all areas must be done same day)Purchase a full faceUltherapy treatment and get a free Ultherapy neck treatment (both areas must be done same day)15% off anyViPeelPurchase 2IPL treatments get a 3rd IPL free (must be same area)You must be an appropriate candidate for your chosen procedure.All specials expire October 31,...
Source: What's New In Plastic Surgery? - October 2, 2017 Category: Cosmetic Surgery Tags: Cape Cod christine hamori duxbury Skin Spa Specials south shore Source Type: blogs

New Products from Alastin and NIA24
ALASTIN SKINCARE ™ REGENERATING SKIN NECTARLess downtime post procedure is possible with Alastin's Tri-Hex Technology ™Key BenefitsHelps support the skin's natural ability to produce new healthy elastin and collagen.Enhances healthy skin by helping to clear damage and debris in the extracellular matrix.High antioxidant activity is designed to calm the skin and reduce the appearance of redness.NIA INTENSIVE DOUBLE MOISTURE SERUMThis breakthrough serum features isolated aqueous- and lipidic-phase formulas. At the push of a button, the two phases combine to intensely rehydrate and visibly re-plump skin.Key Benefit...
Source: What's New In Plastic Surgery? - October 2, 2017 Category: Cosmetic Surgery Tags: Cape Cod christine hamori duxbury Skin Spa Specials south shore Source Type: blogs

Specials in the Skin Spa for September
Specials in Christine Hamori'sSkin Spa for September are as follows. 20% offCoolsculpting when you purchase 2 or more areasFree IPL with the purchase of aClear& Brilliant Treatment (a $250 savings) (both treatments must be done on the same day)25% offMicroneedling packages (PRP package of 3 or HGF package of 4)Purchase aMicrodermabrasion and get a free Nia Exfoliating Peel (a $150 savings) (both treatments must be done on the same day)15% off Cutera ExcelV 15 minLaser Treatmentsor20% off Cutera ExcelV 30 min. TreatmentsYou must be an appropriate candidate for your chosen procedure.All specials expire September 29, 2017...
Source: What's New In Plastic Surgery? - September 7, 2017 Category: Cosmetic Surgery Tags: Cape Cod christine hamori duxbury Skin Spa Specials south shore Source Type: blogs

Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires. I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal ch...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing the Commercial Application of Longevity Science
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires. I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal ch...
Source: Fight Aging! - August 3, 2017 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

5 Practical Tips to Improve Poor Circulation
If you have Poor Circulation, like someone who has cold hands and feet, and maybe even experience symptoms like in Reynaud’s disease, such as hands that can’t even hold a cold drink cup, or hands that turn red when the temperature is barely cool outside, then you might want to pay attention to thess practical tips on how to improve circulation. 1. Get Your Vitamin D Level Up to Optimal Levels Almost every organ in the body has receptors for Vitamin D, and so Vitamin D is a nutrient that is vital for a vast array of health issues, including the proper functioning of the circulatory and muscular system. Vitamin D...
Source: Immune Health Blog - March 18, 2017 Category: Nutrition Authors: Kerri Knox, RN Tags: Heart Health and Cholesterol Vitamin D improve poor circulation improve Reynaud's intermittant claudication reynaud's disease Source Type: blogs

5 Practical Tips to Improve Poor Circulation
If you have Poor Circulation, like someone who has cold hands and feet, and maybe even experience symptoms like in Reynaud’s disease, such as hands that can’t even hold a cold drink cup, or hands that turn red when the temperature is barely cool outside, then you might want to pay attention to thess practical tips on how to improve circulation. 1. Get Your Vitamin D Level Up to Optimal Levels Almost every organ in the body has receptors for Vitamin D, and so Vitamin D is a nutrient that is vital for a vast array of health issues, including the proper functioning of the circulatory and muscular system. Vitamin D...
Source: Immune Health Blog - March 18, 2017 Category: Nutrition Authors: Kerri Knox, RN Tags: Heart Health and Cholesterol Vitamin D improve poor circulation improve Reynaud's intermittant claudication reynaud's disease Source Type: blogs

5 Practical Tips to Improve Poor Circulation
If you have Poor Circulation, like someone who has cold hands and feet, and maybe even experience symptoms like in Reynaud’s disease, such as hands that can’t even hold a cold drink cup, or hands that turn red when the temperature is barely cool outside, then you might want to pay attention to thess practical tips on how to improve circulation. 1. Get Your Vitamin D Level Up to Optimal Levels Almost every organ in the body has receptors for Vitamin D, and so Vitamin D is a nutrient that is vital for a vast array of health issues, including the proper functioning of the circulatory and muscular system. Vitamin D...
Source: Immune Health Blog - March 18, 2017 Category: Nutrition Authors: Kerri Knox, RN Tags: Heart Health and Cholesterol Vitamin D improve poor circulation improve Reynaud's intermittant claudication reynaud's disease Source Type: blogs

Some things you might not know about corn
Corn (also known as maize) is among the oldest of cultivated grains, dating back 10,000 years to pre-Mayan times in South America. But corn didn’t make it onto European menus until 1493 when Christopher Columbus brought seeds to Spain. Corn was rapidly embraced, largely replacing barley and millet due to its spectacular yield per acre. Widespread, habitual consumption of cornbread and polenta resulted in deficiencies of niacin (vitamin B3) and the amino acids lysine and tryptophan, causing epidemics of pellagra, evidenced as what physicians of the age called “The Four Ds”: dermatitis, diarrhea, dementia, ...
Source: Wheat Belly Blog - February 14, 2017 Category: Cardiology Authors: Dr. Davis Tags: Corn Cornstarch Dr. Davis High-Fructose Weight loss Wheat Belly Lifestyle Wheat-Free Lifestyle gluten-free grain Wheat Belly Total Health Source Type: blogs

Some things you might not know about corn.
Corn (also known as maize) is among the oldest of cultivated grains, dating back 10,000 years to pre-Mayan times in South America, but corn didn’t make it onto European menus until 1493, when Christopher Columbus brought seeds to Spain. Corn was rapidly embraced, largely replacing barley and millet due to its spectacular yield per acre. Widespread, habitual consumption of cornbread and polenta resulted in deficiencies of niacin (vitamin B3) and the amino acids lysine and tryptophan, causing widespread epidemics of pellagra, evidenced as what physicians of the age called “The Four Ds”: dermatitis, diarrhea...
Source: Wheat Belly Blog - February 14, 2017 Category: Cardiology Authors: Dr. Davis Tags: Corn Cornstarch Dr. Davis High-Fructose Weight loss Wheat Belly Lifestyle Wheat-Free Lifestyle gluten-free grain Wheat Belly Total Health Source Type: blogs

Funtabulously Frivolous Friday Five 167
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 167 Question 1 What is Asturian leprosy? + Reveal the Funtabulous Answer expand(document.getElementById('ddet358938163'));expand(document.getElementById('ddetlink358938163')) Pellagra or vitamin B3 (niacin) deficiency as a result of a corn based diet (Noted in the Asturias community in Spain). In 1915, back when such practices were legal and under the Surgeon General’s sanction in the USA, Dr. Goldbe...
Source: Life in the Fast Lane - November 24, 2016 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five acromegaly Andre the giant as you wish Asturian leprosy bicyclists vulva brown sequard Jake leg OPIDN organophosphate induced delayed neuropathy Pellagra placebo vitamin B3 Source Type: blogs

Nampt Overexpression Reduces Age-Related Loss of Exercise Capacity in Mice
NAD, nicotinamide adenine dinucleotide, plays a central role in energy metabolism, and of late has attracted more attention from researchers who aim to modestly slow aging by adjusting the operation of metabolism. Tinkering with NAD levels though any number of different ways appears to produce some benefits in mice, but these are not sizable outcomes. Essentially this looks only incrementally better for normal animals than the marginal results produced for many forms of dietary supplementation in mouse studies. Researchers examined the role of NAD precursor molecules on mitochondria by specifically disrupting the ...
Source: Fight Aging! - August 10, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, July 25th 2016
This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke. To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
Source: Fight Aging! - July 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aubrey de Grey AMA at /r/Futurology: the SENS Approach to Cancer and More
Today, July 19th, Aubrey de Grey of the SENS Research Foundation and Haroldo Silva, lead SENS cancer researcher, are hosting an AMA - Ask Me Anything - event at /r/futurology. They will be there for a few hours to answer questions on rejuvenation research, fundraising for work on aging and cancer, and other aspects of the work of the SENS Research Foundation. This is a chance to ask about the SENS approach to a universal cancer therapy, one that targets the common mechanism of telomere lengthening that all cancers must employ to grow. The SENS researchers are focused on alternative lengthening of telomeres, ALT, a collecti...
Source: Fight Aging! - July 19, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Fight Aging! Newsletter, July 11th 2016
In conclusion, hTERT expression strictly limits telomerase activation in most of somatic cells, whereas mTERT expression is detectable in most of mouse tissue cells. The interspecies differences between human and mice suggest an improved mouse line, in which both telomerase regulation and telomere length controls are humanized, would considerably benefit the studies of human aging and cancer using mouse models. ON CELLULAR REPROGRAMMING AND CELLULAR REJUVENATION https://www.fightaging.org/archives/2016/07/on-cellular-reprogramming-and-cellular-rejuvenation/ The commentary linked below takes a look at some rece...
Source: Fight Aging! - July 10, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Educational Article on the Business of Selling Nicotinamide Riboside
Readers here probably recall the hype surrounding sirtuins in cellular metabolism, followed by the breathless marketing of compounds supposed to affect their expression such as resveratrol, all of which went to the usual destination for such things, which is to say nowhere. Some knowledge was added to the grand map of mammalian biochemistry, some people were fleeced, some people made a bunch of money on the backs of promises that never materialized, and that was that. This happens over and again. Every time a new link is uncovered in the complex chain of protein machinery relating to cellular repair mechanisms, upregulated...
Source: Fight Aging! - July 7, 2016 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs