CD38 in Ovarian Aging
The ovaries, like the thymus, are interesting for their comparatively early exhibition of age-related degeneration. Is there anything useful that can be learned about aging more generally by looking at the portions of the body that experience aging more rapidly? That remains to be seen. Here, researchers investigate NAD+ metabolism in the ovaries versus other tissues, noting that CD38, an enzyme that removes NAD+, is more active earlier in life. Approaches to maintain NAD+ levels slow ovarian aging, including knocking out CD38.
Delayed childbearing is prevalent worldwide, and ovarian senescence occurs earlier than...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Power of Spirit – Join the Event
This post is an invitation for you on multiple levels. First, there’s the human-level invitation, which you’ll get by reading the words here. I’m hosting a live event on Zoom this weekend called The Power of Spirit, and I invite you to join us for it. It will be 3 hours each day, 10:00 AM to 1:00 PM Pacific Time on October 7 and 8, 2023.
The second level of this invitation is the spirit level. I’m writing this invitation while feeling very tuned in (thanks in part to a minidose of magic mushrooms this morning). As I’m writing, I can also feel some of the energy of the upcoming event flowing...
Source: Steve Pavlina's Personal Development Blog - October 6, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Abundance Announcements Creating Reality Emotions Lifestyle Relationships Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Urolithin A Supplementation Improves Mitochondrial Function and Hematopoiesis in Mice
A number of supplement-based approaches have been demonstrated to modestly improve mitochondrial function with age. This includes the various ways to increase NAD levels using vitamin B3 derivatives, mitochondrially targeted antioxidants such as SkQ1, MitoQ, and SS-31, and other compounds such as urolithin A for which the mechanism causing improved mitochondrial function is not as well determined. There is an argument to be made that all of these compounds work because they in some way improve the operation of mitophagy, a mitochondrial quality control mechanism that senses worn and damaged mitochondria, before directing t...
Source: Fight Aging! - September 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Vitamins and Wound Healing
Wound healing is a complex biological process that involves inflammation, tissue formation, and tissue remodeling. Vitamin supplements can play a role in wound healing by supporting various aspects of the body’s natural healing processes. Here are some key vitamins and minerals that are important for wound healing:
Vitamin C: Vitamin C, also known as ascorbic acid, is essential for collagen synthesis, a protein that helps in the formation of skin, blood vessels, and connective tissue. Collagen is a crucial component of wound healing. Adequate vitamin C intake can promote tissue repair and reduce the risk of infectio...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 9, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Geriatric Medicine Pressure Injuries & Wound Care aging skin bedsore bedsores decubiti decubitus ulcer geriatrics gerontology Healthcare Quality Improving Medical Care Jeff Levine MD Jeffrey M Levine MD Nursing Homes pressure s Source Type: blogs
Reviewing Nicotinamide Riboside as a Strategy to Increase NAD Levels
The vitamin B3 derivative nicotinamide riboside is one of the more studied ways to increase nicotinamide adenine dinucleotide (NAD) levels in aged tissues. NAD is important in mitochondrial function, but for incompletely understood reasons becomes less available with advancing age. Delivering precursors to NAD synthesis such as nicotinamide riboside can help to boost NAD levels, but researchers have failed to show that the increase in NAD levels and resulting health benefits of this sort of approach are any better than those produced by regular exercise. Clinical trials of various means of increasing NAD levels have produc...
Source: Fight Aging! - September 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Heart Has High Energy Needs, Making it Vulnerable to Age-Related Mitochondrial Dysfunction
Not all tissues are equal in their energy needs. The brain and more consistently active muscles, such as the heart, are at the top of the list. Energy for cell and tissue processes is provided by the chemical energy store molecule adenosine triphosphate (ATP), which is produced by mitochondria. Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now evolved to become fully integrated cell components. Mitochondria still replicate much like bacteria, each containing a small remnant circular genome. When damaged or dysfunctional, mitochondria are cleared by the complex process of mitoph...
Source: Fight Aging! - September 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Exploring Psychedelic Microdosing
Recently I’ve taken an interest in microdosing, specifically with magic mushrooms. I began learning about it a few months ago and then learned even more at the Psychedelic Science conference in June. I’ve also had some recent conversations with people I know who’ve been microdosing, all of them reporting positive long-term effects. Most use mushrooms for microdosing, although one prefers microdosing with LSD.
The point of microdosing is to take a very small amount of a psychedelic substance in order to access some neurological gains without any obvious psychedelic effects or impairments. Those gains can be both sh...
Source: Steve Pavlina's Personal Development Blog - August 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Productivity Source Type: blogs
Ultrasound Patch Delivers Drugs Through the Skin
Engineers at MIT have developed a patch that uses ultrasound to deliver drugs through the skin. Ultrasound can create temporary openings in skin, allowing drugs to pass through. The skin is typically a difficult area for drug delivery, as it forms a tough barrier. However, the patch, which contains piezoelectric transducers, can push drugs through the skin highly efficiently. The current iteration of the device can deliver drug molecules to the upper few millimeters of skin, suggesting applications in treating relatively superficial conditions, but the MIT researchers believe they can adapt the device to allow drugs to pen...
Source: Medgadget - May 2, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Source Type: blogs
Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context.
Glycine Supplementation as a Methionine Restriction Mimetic
https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/
Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restricti...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nicotinamide Riboside Affects the Gut Microbiome Differently in Mice and Humans
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context. (Source: Fight Aging!)
Source: Fight Aging! - April 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in thi...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Loss of Odor Discrimination is the Earliest Age-Related Loss of Olfaction
Aspects of the sense of smell are some of the earlier casualties of central nervous system aging. Assessments of age-related olfactory dysfunction can provide some insight into the road to neurodegenerative conditions, as the same underlying mechanisms are at work. Researchers here assessed different aspects of olfaction in aging mice, finding that odor discrimination is first loss. Given the data provided to show that upregulation of NAD+ can slow this loss, we might think that mitochondrial dysfunction is an important contributing mechanism in this form of neurodegeneration.
Olfactory dysfunction is a prevalent...
Source: Fight Aging! - March 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/20...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
