Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Nicotinamide Riboside Regulates Chemotaxis to Decrease Inflammation and Ameliorate Functional Recovery Following Spinal Cord Injury in Mice
The objective of this study was to investigate the impact of NR on these changes in a mouse model of SCI. Four groups were considered: (1) non-SCI without NR (Sham), (2) non-SCI with NR (Sham +NR), (3) SCI without NR (SCI), and (4) SCI with NR (SCI + NR). Female C57BL/6J mice aged 6-8 weeks were intraperitoneally administered with 500 mg/kg/day NR for a duration of one week. The supplementation of NR resulted in a significant elevation of NAD+ levels in the spinal cord tissue of mice after SCI. In comparison to the SCI group, NR supplementation exhibited regulatory effects on the chemotaxis/recruitment of leukocytes, leadi...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Yan Li Chunjia Zhang Zihan Li Fan Bai Yingli Jing Han Ke Shuangyue Zhang Yitong Yan Yan Yu Source Type: research
Patients with first-episode psychosis in northern Taiwan: neurocognitive performance and niacin response profile in comparison with schizophrenia patients of different familial loadings and relationship with clinical features
Examining patients with first-episode psychosis (FEP) provides opportunities to better understand the mechanism underlying these illnesses. By incorporating quantitative measures in FEP patients, we aimed to (... (Source: BMC Psychiatry)
Source: BMC Psychiatry - February 22, 2024 Category: Psychiatry Authors: Shun-Chun Yu, Tzung –Jeng Hwang, Chih-Min Liu, Hung-Yu Chan, Chian-Jue Kuo, Tsung-Tsair Yang, Jen-Pang Wang, Chen-Chung Liu, Ming H. Hsieh, Yi-Ting Lin, Yi-Ling Chien, Po-Hsiu Kuo, Ya-Wen Shih, Sung-Liang Yu, Hsuan-Yu Chen and Wei J. Chen Tags: Research Source Type: research
Study protocol for a randomised open-label clinical trial examining the safety and efficacy of the Android Artificial Pancreas System (AAPS) with advanced bolus-free features in adults with type 1 diabetes: the 'CLOSE IT (Closed Loop Open SourcE In Type 1 diabetes) trial
Introduction
Multiple automated insulin delivery (AID) systems have become commercially available following randomised controlled trials demonstrating benefits in people with type 1 diabetes (T1D). However, their real-world utility may be undermined by user-associated burdens, including the need to carbohydrate count and deliver manual insulin boluses. There is an important need for a ‘fully automated closed loop’ (FCL) AID system, without manual mealtime boluses. The (Closed Loop Open SourcE In Type 1 diabetes) trial is a randomised trial comparing an FCL AID system to the same system used as a hybrid closed l...
Source: BMJ Open - February 20, 2024 Category: General Medicine Authors: Wilkinson, T., Tomic, D., Boyle, E., Burren, D., Elghattis, Y., Jenkins, A., Keesing, C., Middleton, S., Nanayakkara, N., Williman, J., de Bock, M., Cohen, N. D. Tags: Open access, Diabetes and Endocrinology Source Type: research
Niacin supplements linked to greater risk of heart attacks and strokes
People with higher levels of niacin in their blood may be more at risk of a heart attack or stroke, possibly because too much of the vitamin inflames blood vessels (Source: New Scientist - Health)
Source: New Scientist - Health - February 19, 2024 Category: Consumer Health News Source Type: research
Long-term follow-up of an attenuated presentation of NAXE-related disease, a potentially actionable neurometabolic disease: a case report
ConclusionA missense homozygous variant in the NAXE gene is described in this patient with a milder clinical phenotype of the disease. Supplementation with niacin in addition to a mitochondrial cocktail presents a potential supportive therapeutic option to reduce disease progression. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 14, 2024 Category: Neurology Source Type: research
Relationship between dietary niacin intake and erectile dysfunction: a population-based study
This study suggests an inverse association between dietary niacin intake and the risk of ED. However, establishing a cause-and-effect relationship remains elusive, and defining the safe threshold of niacin intake to prevent ED requires further investigation.PMID:38305697 | DOI:10.4103/aja202378 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - February 2, 2024 Category: Urology & Nephrology Authors: Wei-Long Lin Cheng Zheng Hao-Xu Wang Wei Zhang Ming-En Lin Source Type: research
Development of a diet quality score and adherence to the Swiss dietary recommendations for vegans
CONCLUSION: The newly developed DQS-V provides a single score for estimating diet quality among vegan adults. Further validation studies examining the DQS-V in relation to an independent dietary assessment method and to biomarkers of nutritional intake and status are still needed before the general application of the DQS-V.PMID:38291526 | PMC:PMC10829326 | DOI:10.1186/s41043-024-00498-3 (Source: Journal of Health, Population, and Nutrition)
Source: Journal of Health, Population, and Nutrition - January 30, 2024 Category: International Medicine & Public Health Authors: Natalie S Bez Joyce Haddad Giulia S Tedde Karolin Rose Aljoscha V Ivanov Marina Milazzo Jo ëlle Wickart Giulia Casale Michele D'Ascanio Klazine Van der Horst Isabelle Herter-Aeberli Leonie H Bogl Source Type: research
Effect of Egg-white Protein Alone or Combined with Niacin on Nutritional Status, Phosphorus Control, and Circulating FGF-23 in Maintenance Hemodialysis Patients: A Randomized Controlled Trial
Niacin is reported to decrease phosphorus concentration in Maintenance Hemodialysis (MHD) patients. Egg white is one of the main substitutable proteins in MHD patients due to its low phosphorus content. Therefore, we aimed to evaluate the effects of combined egg white and niacin supplementation on dialysis patients' serum phosphorus and nutritional biomarkers. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - January 26, 2024 Category: Urology & Nephrology Authors: Parisa Javadian, Niloofar Nematollahi, Ehsan Ghaedi, Shahram Tahmasebian, Ebrahim Saedi Tags: Original Research Source Type: research
