Genome analysis of “Candidatus Aschnera chinzeii,” the bacterial endosymbiont of the blood-sucking bat fly Penicillidia jenynsii (Insecta: Diptera: Nycteribiidae)
In this study, we report the first complete genome sequence of Aschnera from the bristled bat fly Penicillidia jenynsii. The Aschnera genome consisted of a 748,020 bp circular chromosome and a 18,747 bp circular plasmid. The chromosome encoded 603 protein coding genes (including 3 pseudogenes), 33 transfer RNAs, and 1 copy of 16S/23S/5S ribosomal RNA operon. The plasmid contained 10 protein coding genes, whose biological function was elusive. The genome size, 0.77 Mbp, was drastically reduced in comparison with 4–6 Mbp genomes of free-living γ-proteobacteria. Accordingly, the Aschnera genome was devoid of many important...
Source: Frontiers in Microbiology - January 22, 2024 Category: Microbiology Source Type: research
A comparative study on riboflavin responsive multiple acyl-CoA dehydrogenation deficiency due to variants in FLAD1 and ETFDH gene
We described here a case with riboflavin responsive LSM and MADD resulting fromFLAD1 gene variants (c.1588 C > T p.Arg530Cys and c.1589 G > C p.Arg530Pro,FLAD1-RRMADD). And we compared our patient together with 9FLAD1-RRMADD cases from literature to 106ETFDH-RRMADD cases in our neuromuscular center on clinical history, laboratory investigations and pathological features. Furthermore, the transcriptomics study onFLAD1-RRMADD andETFDH-RRMADD were carried out. On muscle pathology, bothFLAD1-RRMADD andETFDH-RRMADD were proved with lipid storage myopathy in which atypical ragged red fibers were more frequen...
Source: Journal of Human Genetics - January 17, 2024 Category: Genetics & Stem Cells Source Type: research
Metabolic changes before and after weaning in Dezhou donkey foals in relation to gut microbiota
This study is based on the fecal 16S rRNA and serum metabolomes of Dezhou donkey foals. In total, 10 samples (fecal and serum) were collected during the following three stages: before weaning (F.M.1), during weaning (F.M.3), and postweaning (F.M.6). To study the alterations in intestinal microflora, serum metabolites, and their correlation before and postweaning. We found that with the growth and weaning progress of donkey foals, the intestinal microbiota of donkey foals underwent obvious changes, and the diversity of fecal bacteria increased (Chao1 and Shannon indexes). The main intestinal microbial flora of donkey foals ...
Source: Frontiers in Microbiology - January 12, 2024 Category: Microbiology Source Type: research
Metal- and base-free, aerobic photoredox catalysis with riboflavin to synthesize 2-substituted benzothiazoles
Org. Biomol. Chem., 2024, Advance Article DOI: 10.1039/D3OB01851B, PaperAdri án A. Heredia, Juan E. Argüello, Luciana C. Schmidt A straightforward and environmentally friendly riboflavin-based photocatalytic approach for the synthesis of 2-substituted benzothiazoles has been described. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 11, 2024 Category: Molecular Biology Authors: Adri án A. Heredia Source Type: research
Metal ‑ and Base-Free, Aerobic Photoredox Catalysis with Riboflavin to Synthesize 2-Substituted Benzothiazoles
Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01851B, PaperAdri án Alberto Heredia, Juan Elias Argüello, Luciana Carina Schmidt Sustainable approaches for the synthesis of 2-substituted benzothiazoles are sought after for their use in organic chemistry, bioorganic chemistry, and industrial applications. Here, we described a visible light-driven photoredox catalytic... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - January 8, 2024 Category: Molecular Biology Authors: Adri án Alberto Heredia Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 22;67. doi: 10.29219/fnr.v67.10315. eCollection 2023.ABSTRACTOnly a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activit...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Vegard Lysne Hanna Sara Strandler Source Type: research
Identification of a mutation in TNRC18 in a patient with clinical features of Fazio ‐Londe disease
Key Clinical MessageFazio-Londe disease and Brown-Vialetto-Van Laere syndrome are rare related neurological disorders. AlthoughSLC52A3 andSLC52A2 that encode riboflavin transporters are their only known causative genes, many patients without mutations in these genes have been reported. Clinical and genetic data of a patient with features suggestive of Fazio-Londe disease are presented. Neurological examination revealed significant involvement of cranial nerves and weakness in the lower extremities. Pontobulbar presentations were prominent. EDX study suggested motor neuronopathy. Hearing was normal. She was diagnosed with F...
Source: Clinical Case Reports - January 5, 2024 Category: General Medicine Authors: Marzieh Khani,
Hosein Shamshiri,
Shahriar Nafissi,
Najmeh Salehi,
Hamidreza Moazzeni,
Hanieh Taheri,
Elahe Elahi Tags: CASE REPORT Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
Glycosaminoglycans and collagen fibril distribution at various depths of the corneal stroma of normal and CXL treated rats
Exp Eye Res. 2024 Jan 2:109780. doi: 10.1016/j.exer.2024.109780. Online ahead of print.ABSTRACTCorneal collagen cross-linking (CXL) is widely used to treat keratoconus and ecstatic corneal disorders. The present studies were carried out to investigate the distribution of glycosaminoglycans (GAGs) and collagen fibril (CF) at different depths of the normal and CXL treated corneal stroma of four week old rats 7 days after standard CXL application. Ten Wistar rats' corneas were used for the study. The epithelium of the cornea from the left eye of each rat was removed and treated with standard CXL application using riboflavin a...
Source: Experimental Eye Research - January 4, 2024 Category: Opthalmology Authors: Saeed Akhtar Adrian Smedowski Adnan Ali Khan Hind Debasi Hanan Mofty Ramachandran Samivel Turki Almubrad Source Type: research
