New insights into the nutritional genomics of adult-onset riboflavin-responsive diseases
Riboflavin, or vitamin B2, is an essential nutrient that serves as a precursor to flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). The binding of the FAD and/or FMN cofactors to flavoproteins... (Source: Nutrition and Metabolism)
Source: Nutrition and Metabolism - October 16, 2023 Category: Nutrition Authors: Chiara Murgia, Ankush Dehlia and Mark A. Guthridge Tags: Review Source Type: research
MAIT cells altered phenotype and cytotoxicity in lupus patients are linked to renal disease severity and outcome
We report here that blood MAIT cells display proinflammatory and cytotoxic function in severe lupus nephritis which may play a pathogenesis role, but without association with systemic lupus activity. Finally, low cytotoxic profile of MAIT cells may represent a promising prognostic factor of lupus nephritis remission one year after induction therapy. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 10, 2023 Category: Allergy & Immunology Source Type: research
Fabrication of multifunctional bio-macromolecule organic-inorganic hybrid system for protein silk: Photochromic, UV protection, fire-proof and super durability
This study focused on the fabrication of silk with photochromism, flame retardancy, UV resistance and durability using riboflavin sodium phosphate (RSP) and various metal ions (Fe2+, Fe3+, Al3+, and Ti4+). Attractively, the photochromic performance was one of the most distinctive features of the modified silk, and the yellow silk fabric turned into fluorescent green under UV lamp. After a detailed comparison, it was determined that RSP/Fe3+ hybrid system was most effective in improving anti-UV performance of the silk with a high UPF of 25.8, achieving a "Good" level of UV protection. Specifically, it achieved a B1 fire pro...
Source: International Journal of Biological Macromolecules - October 9, 2023 Category: Biochemistry Authors: Wen-Jie Jin Yu Xin Jin-Ping Guan Xian-Wei Cheng Meng-Kai Zhu Dong Wang Source Type: research
Fabrication of multifunctional bio-macromolecule organic-inorganic hybrid system for protein silk: Photochromic, UV protection, fire-proof and super durability
This study focused on the fabrication of silk with photochromism, flame retardancy, UV resistance and durability using riboflavin sodium phosphate (RSP) and various metal ions (Fe2+, Fe3+, Al3+, and Ti4+). Attractively, the photochromic performance was one of the most distinctive features of the modified silk, and the yellow silk fabric turned into fluorescent green under UV lamp. After a detailed comparison, it was determined that RSP/Fe3+ hybrid system was most effective in improving anti-UV performance of the silk with a high UPF of 25.8, achieving a "Good" level of UV protection. Specifically, it achieved a B1 fire pro...
Source: International Journal of Biological Macromolecules - October 9, 2023 Category: Biochemistry Authors: Wen-Jie Jin Yu Xin Jin-Ping Guan Xian-Wei Cheng Meng-Kai Zhu Dong Wang Source Type: research
Exploring the potential mechanism of < em > Rubus corchorifolius < /em > L. fruit polyphenol-rich extract in mitigating non-alcoholic fatty liver disease by integration of metabolomics and transcriptomics profiling
Food Funct. 2023 Oct 2. doi: 10.1039/d3fo02653a. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD), as the commonest chronic liver disease, is accompanied by liver oxidative stress and inflammatory responses. Herein, the extract obtained from Rubus corchorifolius fruits was purified and characterized for its polyphenol composition. The liver protective effect of the purified R. corchorifolius fruit extract (RCE) on mice with high-fat-diet (HFD)-induced NAFLD were investigated, and the potential mechanisms were explored through the integration of transcriptomics and metabolomics. Results showed that the...
Source: Atherosclerosis - October 2, 2023 Category: Cardiology Authors: Yin Qin Ruyan Fan Yingxin Liu Shuyi Qiu Lu Wang Source Type: research
Characterization of Indian gut microbiome for B-vitamins production and its comparison with Chinese cohort
Br J Nutr. 2023 Oct 2:1-28. doi: 10.1017/S0007114523002179. Online ahead of print.ABSTRACTThe human gut microbiota can biosynthesize essential micronutrients such as B-vitamins, and is also known for its metabolic cooperative behaviour. The current study characterizes such B-vitamin biosynthesizers, their biosynthetic pathways, explores their prevalence and abundance, and examines how lifestyle or diet affects them in multiple Indian cohorts, and compares it with the Chinese cohort. To achieve this, publicly available fecal metagenome data of healthy individuals from multiple Indian (two urban and three tribal populations)...
Source: The British Journal of Nutrition - October 2, 2023 Category: Nutrition Authors: Nisha Chandel Pramod Rajaram Somvanshi Vivek Thakur Source Type: research
Exploring the potential mechanism of < em > Rubus corchorifolius < /em > L. fruit polyphenol-rich extract in mitigating non-alcoholic fatty liver disease by integration of metabolomics and transcriptomics profiling
Food Funct. 2023 Oct 2. doi: 10.1039/d3fo02653a. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD), as the commonest chronic liver disease, is accompanied by liver oxidative stress and inflammatory responses. Herein, the extract obtained from Rubus corchorifolius fruits was purified and characterized for its polyphenol composition. The liver protective effect of the purified R. corchorifolius fruit extract (RCE) on mice with high-fat-diet (HFD)-induced NAFLD were investigated, and the potential mechanisms were explored through the integration of transcriptomics and metabolomics. Results showed that the...
Source: Atherosclerosis - October 2, 2023 Category: Cardiology Authors: Yin Qin Ruyan Fan Yingxin Liu Shuyi Qiu Lu Wang Source Type: research
Characterization of Indian gut microbiome for B-vitamins production and its comparison with Chinese cohort
Br J Nutr. 2023 Oct 2:1-28. doi: 10.1017/S0007114523002179. Online ahead of print.ABSTRACTThe human gut microbiota can biosynthesize essential micronutrients such as B-vitamins, and is also known for its metabolic cooperative behaviour. The current study characterizes such B-vitamin biosynthesizers, their biosynthetic pathways, explores their prevalence and abundance, and examines how lifestyle or diet affects them in multiple Indian cohorts, and compares it with the Chinese cohort. To achieve this, publicly available fecal metagenome data of healthy individuals from multiple Indian (two urban and three tribal populations)...
Source: The British Journal of Nutrition - October 2, 2023 Category: Nutrition Authors: Nisha Chandel Pramod Rajaram Somvanshi Vivek Thakur Source Type: research
