Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study
ConclusionsThe number of children hospitalized with pneumonia and incidence of common pathogen infections were both reduced, and that allergy and micronutrient status in children were also changed after the outbreak of the COVID-19 pandemic. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - April 23, 2024 Category: Pediatrics Source Type: research
Expression profiles and characterization of microRNAs responding to chitin in Arthrobotrys oligospora
Arch Microbiol. 2024 Apr 17;206(5):220. doi: 10.1007/s00203-024-03949-x.ABSTRACTExtracellular proteases, such as chitinases secreted by Arthrobotrys oligospora (A. oligospora), play a crucial role in the process of nematode infection. However, post-transcriptional regulation of gene expression involving microRNAs (miRNAs) in A. oligospora remains scarcely described. Hereto, transcriptome sequencing was carried out to analyze the expression profiles of chitin-responsive miRNAs in A. oligospora. Based on the RNA-seq data, the differential expression of miRNAs (DEmiRNAs) in response to chitin was screened, identified and char...
Source: Archives of Microbiology - April 17, 2024 Category: Microbiology Authors: Ningxing Li Yansen Sun Yucheng Liu Lixiang Wei Jiahua Zhang Nengxiu Li Dianming Sun Jian Jiao Yufei Zuo Ruobing Li Xuepeng Cai Jun Qiao Qingling Meng Source Type: research
Expression profiles and characterization of microRNAs responding to chitin in Arthrobotrys oligospora
Arch Microbiol. 2024 Apr 17;206(5):220. doi: 10.1007/s00203-024-03949-x.ABSTRACTExtracellular proteases, such as chitinases secreted by Arthrobotrys oligospora (A. oligospora), play a crucial role in the process of nematode infection. However, post-transcriptional regulation of gene expression involving microRNAs (miRNAs) in A. oligospora remains scarcely described. Hereto, transcriptome sequencing was carried out to analyze the expression profiles of chitin-responsive miRNAs in A. oligospora. Based on the RNA-seq data, the differential expression of miRNAs (DEmiRNAs) in response to chitin was screened, identified and char...
Source: Archives of Microbiology - April 17, 2024 Category: Microbiology Authors: Ningxing Li Yansen Sun Yucheng Liu Lixiang Wei Jiahua Zhang Nengxiu Li Dianming Sun Jian Jiao Yufei Zuo Ruobing Li Xuepeng Cai Jun Qiao Qingling Meng Source Type: research
Systematic analysis of the effect of genomic knock-out of non-essential promiscuous HAD-like phosphatases YcsE, YitU and YwtE on flavin and adenylate content in Bacillus subtilis
Chembiochem. 2024 Apr 14:e202400165. doi: 10.1002/cbic.202400165. Online ahead of print.ABSTRACTStudying the metabolic role of non-essential promiscuous enzymes is a challenging task, as genetic manipulations usually do not reveal at which point(s) of the metabolic network the enzymatic activity of such protein is beneficial for the organism. Each of the HAD-like phosphatases YcsE, YitU and YwtE of Bacillus subtilis catalyzes the dephosphorylation of 5-amino-6-ribitylamino-uracil 5'-phosphate, which is essential in the biosynthesis of riboflavin. Using CRISPR technology, we have found that the deletion of these genes, indi...
Source: Chembiochem - April 14, 2024 Category: Biochemistry Authors: Alexandra Scharf Farshad La-Rostami Boris A Illarionov Vivien Nemes Anna M Feldmann Lars S H öft Henri L ösel Adelbert Bacher Markus Fischer Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | DOI:10.1111/jcmm.18288 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | PMC:PMC11005454 | DOI:10.1111/jcmm.18288 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | PMC:PMC11005454 | DOI:10.1111/jcmm.18288 (Source: Molecular Medicine)
Source: Molecular Medicine - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells
In conclusion, radiated riboflavin clearly demonstrates superior antiproliferative and apoptotic effects on C6 cells at lower doses compared to nonradiated riboflavin.PMID:38597418 | PMC:PMC11005454 | DOI:10.1111/jcmm.18288 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 10, 2024 Category: Molecular Biology Authors: Sedat Kacar Ceyhan Hacioglu Fatih Kar Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
