Leuconostoc mesenteroides and Liquorilactobacillus mali strains, isolated from Algerian food products, are producers of the postbiotic compounds dextran, oligosaccharides and mannitol
AbstractSix lactic acid bacteria (LAB) isolated from Algerian sheep ’s milk, traditional butter, date palm sap and barley, which produce dextran, mannitol, oligosaccharides and vitamin B2 have been characterized. They were identified asLeuconostoc mesenteroides (A4X, Z36P, B12 and O9) andLiquorilactobacillus mali (BR201 and FR123). Their exopolysaccharides synthesized from sucrose by dextransucrase (Dsr) were characterized as dextrans with (1,6)-d-glucopyranose units in the main backbone and branched at positionsO-4,O-2 and/orO-3, withd-glucopyranose units in the side chain. A4X was the best dextran producer (4.5 g/L),...
Source: World Journal of Microbiology and Biotechnology - February 29, 2024 Category: Microbiology Source Type: research
Mexidol, Cytoflavin, and succinic acid derivatives as antihypoxic, anti ‐ischemic metabolic modulators, and ergogenic aids in athletes and consideration of their potential as performance enhancing drugs
The lines between performance enhancement and therapeutic drugs have narrowed in modern times, and it is more difficult than ever to determine when substance crosses the line and is doping agents. Succinate-based drugs as Mexidol and Cytoflavin are antihypoxic, anti-ischemic aids – have similar biological effects as prohibited by WADA metabolic modulators, meldonium and trimetazidine. The role of Mexidol, Cytoflavin as antihypoxant agents is associated with impact on the Krebs cycle, oxidative phosphorylation and ATP production, expression of hypoxia-inducible factor (HIF) . AbstractEmoxypine (ethylmethylhydroxypyridine)...
Source: Drug Testing and Analysis - February 26, 2024 Category: Drugs & Pharmacology Authors: Karol J ędrejko,
Oliver Catlin,
Timothy Stewart,
Bożena Muszyńska Tags: REVIEW ARTICLE Source Type: research
UV-stimulated riboflavin exerts immunosuppressive effects in BALB/c mice and human PBMCs
This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed. UV-stimulated RF was then administered intravenously to mice via the tail vein for a consecutive period of 5 days. The levels of immunoglobulin (IgG, IgM, IgA), complement (C3, C4) and cytokines (IFN-γ, IL-4, IL17, TGF-β) were detected by ELISA. Flow cytometry was employed to analyze the populations of CD3+T, CD4+T, CD8+T and C...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 24, 2024 Category: Drugs & Pharmacology Authors: Xinghui Chen Shuang Ge Pan Xiao Yulin Liu Yang Yu Yi Liu Liping Sun Lu Yang Deqing Wang Source Type: research
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice
CONCLUSION: The identification of Jordan's anomaly in a pediatric patient with late-onset MADD sheds light on its broader implications within the realm of lipid storage myopathies. The significance of this finding extends beyond its conventional association with NLSD, challenging the notion of its exclusivity. This novel observation serves as a compelling reminder of the diagnostic significance this morphological abnormality holds, potentially revolutionizing diagnostic practices within the field.PMID:38401771 | DOI:10.1016/j.clinbiochem.2024.110735 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 24, 2024 Category: Biochemistry Authors: Ji Liu Wenpeng Ni Kunyi Deng Yanhui Chen Guanghong Gu Source Type: research
UV-stimulated riboflavin exerts immunosuppressive effects in BALB/c mice and human PBMCs
This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed. UV-stimulated RF was then administered intravenously to mice via the tail vein for a consecutive period of 5 days. The levels of immunoglobulin (IgG, IgM, IgA), complement (C3, C4) and cytokines (IFN-γ, IL-4, IL17, TGF-β) were detected by ELISA. Flow cytometry was employed to analyze the populations of CD3+T, CD4+T, CD8+T and C...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 24, 2024 Category: Drugs & Pharmacology Authors: Xinghui Chen Shuang Ge Pan Xiao Yulin Liu Yang Yu Yi Liu Liping Sun Lu Yang Deqing Wang Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
The presence of white cell Jordan's anomaly in multiple Acyl-CoA dehydrogenase deficiency: A case report and implications for clinical practice
CONCLUSION: The identification of Jordan's anomaly in a pediatric patient with late-onset MADD sheds light on its broader implications within the realm of lipid storage myopathies. The significance of this finding extends beyond its conventional association with NLSD, challenging the notion of its exclusivity. This novel observation serves as a compelling reminder of the diagnostic significance this morphological abnormality holds, potentially revolutionizing diagnostic practices within the field.PMID:38401771 | DOI:10.1016/j.clinbiochem.2024.110735 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 24, 2024 Category: Biochemistry Authors: Ji Liu Wenpeng Ni Kunyi Deng Yanhui Chen Guanghong Gu Source Type: research
UV-stimulated riboflavin exerts immunosuppressive effects in BALB/c mice and human PBMCs
This study pioneered a novel application method of RF. Firstly, UV-stimulated RF was co-cultured with human peripheral blood mononuclear cells in vitro, and the apoptosis rate of lymphocyte subsets, cell proliferation inhibition rate and concentrations of IL-1β, IL-6, IL-10, TNF-α were assessed. UV-stimulated RF was then administered intravenously to mice via the tail vein for a consecutive period of 5 days. The levels of immunoglobulin (IgG, IgM, IgA), complement (C3, C4) and cytokines (IFN-γ, IL-4, IL17, TGF-β) were detected by ELISA. Flow cytometry was employed to analyze the populations of CD3+T, CD4+T, CD8+T and C...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 24, 2024 Category: Drugs & Pharmacology Authors: Xinghui Chen Shuang Ge Pan Xiao Yulin Liu Yang Yu Yi Liu Liping Sun Lu Yang Deqing Wang Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
Glucose-lightened upconversion nanoprobes for accurate cellular-discrimination based on Warburg effect
Anal Chim Acta. 2024 Apr 1;1296:342334. doi: 10.1016/j.aca.2024.342334. Epub 2024 Feb 7.ABSTRACTAccurate cellular-recognition based disease therapy is of significance for precision medicine. However, except of specific antibody-coupling strategy, very few probes have been reported to efficiently discriminate normal cells and lesion cells through cellular microenvironment. Herein, we proposed a glucose selectively-lightened upconversion nanoprobe to recognize cancer cells from a pile of normal cells based on Warburg effect, that indicated a heightened demand for glucose intake for cancer cells. The nanoprobes were construct...
Source: Analytica Chimica Acta - February 24, 2024 Category: Chemistry Authors: Zihe Wang Cheng Liao Qi Lu Yaru Sun Ying Wang Yi Zhang Jinming Liu Xiaohu Su Qingsong Mei Source Type: research
Riboflavin-loaded soy protein isolate cold gel treated with combination of high intensity ultrasound and high hydrostatic pressure: Gel structure, physicochemical properties and gastrointestinal digestion fate
Ultrason Sonochem. 2024 Feb 20;104:106819. doi: 10.1016/j.ultsonch.2024.106819. Online ahead of print.ABSTRACTTransglutaminase (TGase) was added to soy protein isolate (SPI) dispersion after the combination treatment of high intensity ultrasound (HIU) and high hydrostatic pressure (HHP) to catalyze the formation of cold gel, which was used to encapsulate riboflavin. The structure, physicochemical properties and in vitro digestion characteristics of riboflavin-loaded SPI cold gel were investigated. HIU-HHP combined treatment enhanced the strength, water retention, elastic property, thermal stability and protein denaturation...
Source: Ultrasonics Sonochemistry - February 22, 2024 Category: Chemistry Authors: Yuxuan Mao Xinqi Li Qi Qi Fang Wang Hao Zhang Yuzhu Wu Jingsheng Liu Chengbin Zhao Xiuying Xu Source Type: research
