Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Atherosclerosis - April 7, 2024 Category: Cardiology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Myricanol improves metabolic profiles in dexamethasone induced lipid and protein metabolism disorders in mice
This study for the first time applied widely targeted metabolomics to investigate the beneficial effects of MY on glucose, lipids, and protein metabolism in DEX-induced metabolic abnormality in mice. The results showed that MY significantly reversed DEX-induced soleus and gastrocnemius muscle weight loss, muscle fiber damage, and muscle strength loss. MY alleviated DEX-induced metabolic disorders by increasing SIRT1 and glucose transporter type 4 (GLUT4) expressions. Additionally, myricanol prevented muscle cell apoptosis and atrophy by inhibiting caspase 3 cleavages and muscle ring-finger protein-1 (MuRF1) expression. Met...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 7, 2024 Category: Drugs & Pharmacology Authors: Tiandan Li Xiaochao Hu Lingyang Fan Yong Yang Kai He Source Type: research
Evaluating the polymerization effectiveness and biocompatibility of bio-sourced, visible light-based photoinitiator systems
In this study, we evaluated the effectiveness of bio-sourced synergist candidates, with a focus on amino acids, due to their amine functional groups, in combination with two bio-sourced photoinitiator molecules: riboflavin and curcumin. We tested the effectiveness of these photoinitiator systems under both violet (405 nm) and blue (460-475 nm) light using photo-rheology. We found that several synergist candidates, namely lysine, arginine, and histidine, increased the polymerization effectiveness of riboflavin when used with both violet and blue light. With curcumin, we found that almost all tested synergist candidates slig...
Source: Biomed Res - April 4, 2024 Category: Research Authors: Rion J Wendland Matthew T Conway Kristan S Worthington Source Type: research
Effects of exogenous riboflavin or cytochrome addition on the cathodic reduction of Cr(VI) in microbial fuel cell with Shewanella putrefaciens
Environ Sci Pollut Res Int. 2024 Apr 3. doi: 10.1007/s11356-024-33118-y. Online ahead of print.ABSTRACTBioreduction of Cr(VI) is recognized as a cost-effective and environmentally friendly method, attracting widespread interest. However, the slow rate of Cr(VI) bioreduction remains a practical challenge. Additionally, the direct removal efficiency of microbes for high concentrations of Cr(VI) is not ideal due to the toxicity. Therefore, this study investigated the effects of exogenous riboflavin or cytochrome on the cathodic reduction of Cr(VI) in microbial fuel cells. The results demonstrated that the exogenous riboflavin...
Source: Cell Research - April 3, 2024 Category: Cytology Authors: Jing Ding Yonglei Guo Mingfang Tang Sijia Zhou Source Type: research
Multiplexed in-situ mutagenesis driven by a dCas12a-based dual-function base editor
Nucleic Acids Res. 2024 Apr 3:gkae228. doi: 10.1093/nar/gkae228. Online ahead of print.ABSTRACTMutagenesis driving genetic diversity is vital for understanding and engineering biological systems. However, the lack of effective methods to generate in-situ mutagenesis in multiple genomic loci combinatorially limits the study of complex biological functions. Here, we design and construct MultiduBE, a dCas12a-based multiplexed dual-function base editor, in an all-in-one plasmid for performing combinatorial in-situ mutagenesis. Two synthetic effectors, duBE-1a and duBE-2b, are created by amalgamating the functionalities of cyto...
Source: Cell Research - April 3, 2024 Category: Cytology Authors: Yaokang Wu Yang Li Yanfeng Liu Xiang Xiu Jiaheng Liu Linpei Zhang Jianghua Li Guocheng Du Xueqin Lv Jian Chen Rodrigo Ledesma-Amaro Long Liu Source Type: research
Effects of exogenous riboflavin or cytochrome addition on the cathodic reduction of Cr(VI) in microbial fuel cell with Shewanella putrefaciens
Environ Sci Pollut Res Int. 2024 Apr 3. doi: 10.1007/s11356-024-33118-y. Online ahead of print.ABSTRACTBioreduction of Cr(VI) is recognized as a cost-effective and environmentally friendly method, attracting widespread interest. However, the slow rate of Cr(VI) bioreduction remains a practical challenge. Additionally, the direct removal efficiency of microbes for high concentrations of Cr(VI) is not ideal due to the toxicity. Therefore, this study investigated the effects of exogenous riboflavin or cytochrome on the cathodic reduction of Cr(VI) in microbial fuel cells. The results demonstrated that the exogenous riboflavin...
Source: Environmental Science and Pollution Research International - April 3, 2024 Category: Environmental Health Authors: Jing Ding Yonglei Guo Mingfang Tang Sijia Zhou Source Type: research
Photocrosslinkable triple helical protein with enhanced higher-order formation for biomaterial applications
J Biomed Mater Res A. 2024 Mar 30. doi: 10.1002/jbm.a.37716. Online ahead of print.ABSTRACTBacterial collagen, produced via recombinant DNA methods, offers advantages including consistent purity, customizable properties, and reduced allergy potential compared to animal-derived collagen. Its controlled production environment enables tailored features, making it more sustainable, non-pathogenic, and compatible with diverse applications in medicine, cosmetics, and other industries. Research has focused on the engineering of collagen-like proteins to improve their structure and function. The study explores the impact of introd...
Source: Biomed Res - March 30, 2024 Category: Research Authors: Gopalan Akilandeswari Vijayakumar Varshashankari Shalini Muthusamy Mayilvahanan Aarthy Karthigeyan Thamizhvani Jebakumar Mercyjayapriya Sundarapandian Ashokraj Pachaiyappan Mohandass Suresh Prem Niraikulam Ayyadurai Source Type: research
Photocrosslinkable triple helical protein with enhanced higher-order formation for biomaterial applications
J Biomed Mater Res A. 2024 Mar 30. doi: 10.1002/jbm.a.37716. Online ahead of print.ABSTRACTBacterial collagen, produced via recombinant DNA methods, offers advantages including consistent purity, customizable properties, and reduced allergy potential compared to animal-derived collagen. Its controlled production environment enables tailored features, making it more sustainable, non-pathogenic, and compatible with diverse applications in medicine, cosmetics, and other industries. Research has focused on the engineering of collagen-like proteins to improve their structure and function. The study explores the impact of introd...
Source: Biomed Res - March 30, 2024 Category: Research Authors: Gopalan Akilandeswari Vijayakumar Varshashankari Shalini Muthusamy Mayilvahanan Aarthy Karthigeyan Thamizhvani Jebakumar Mercyjayapriya Sundarapandian Ashokraj Pachaiyappan Mohandass Suresh Prem Niraikulam Ayyadurai Source Type: research
Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway
Riboflavin is the precursor of several cofactors essential for normal physical and cognitive development, but only plants and some microorganisms can produce it. Humans thus rely on their dietary intake, which... (Source: BMC Plant Biology)
Source: BMC Plant Biology - March 26, 2024 Category: Biology Authors: Maria Faustino, Tiago Louren ço, Simon Strobbe, Da Cao, André Fonseca, Isabel Rocha, Dominique Van Der Straeten and M. Margarida Oliveira Tags: Research Source Type: research
Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research
Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research
Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research
Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research
