Impacts of high-dose riboflavin on cytotoxicity, antioxidant, growth, reproductive gene expressions, and genotoxicity in the rainbow trout gonadal cells
This report aimed to examine the actions of riboflavin on cell viability, the transcriptional expressions of antioxidant enzyme (gsr and gpx1a), growth (gh1, igf1, and igf2), the reproductive (bol) genes and DNA damage in the rainbow trout gonad cells (RTG-2) for 48 h. All concentrations of riboflavin (3.125, 6.25, 12.5, 25, 50, and 100 μM) significantly reduced the RTG-2 cell viability. Riboflavin (LD50: 12.5 μM) significantly downregulated the transcriptional expressions of gpx1a, igf1, and bol genes, while it non-significantly upregulated or downregulated the transcriptional expression of gsr, igf2, and gh1 genes in t...
Source: Toxicology in Vitro - November 9, 2023 Category: Toxicology Authors: Sevda I şik Semra Çiçek Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Crocin Ameliorates Diabetic Nephropathy through Regulating Metabolism, CYP4A11/PPAR γ, and TGF-β/Smad Pathways in Mice
CONCLUSION: In conclusion, our study validated the considerable therapeutic, anti-inflammatory, and antioxidative impacts of crocin on DN mice. The mechanism of crocin treatment may be related to the regulation of biotin riboflavin and arachidonic acid metabolism, the activation of CYP4A11/PPARγ pathway, and the inhibition of TGF-β/Smad pathway in the kidney.PMID:37936469 | DOI:10.2174/0113892002257928231031113337 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - November 8, 2023 Category: Drugs & Pharmacology Authors: Wei Chen Jinhao Su Yubin Liu Tianmei Gao Xiaohui Ji Hanzhou Li Huajun Li Yuansong Wang Hui Zhang Shuquan Lv Source Type: research
Photosensitization can be an effective risk-reduction strategy against the post-baking mold spoilage of bread
Food Microbiol. 2024 Feb;117:104390. doi: 10.1016/j.fm.2023.104390. Epub 2023 Sep 21.ABSTRACTPhotosensitization was developed as a risk-reduction strategy against the contamination by environmental mold spores during the bread cooling phase. Two food-grade photosensitizers -chlorophyllin (CHL) and riboflavin (RBF), were used to evaluate the effect of visible (blue) LED illumination against three common bread spoilage molds. Aided by CHL, 405 nm LEDs inactivated Rhizopus stolonifer and Penicillium expansum by 77.4 ± 3.3% and 52.1 ± 7.3% respectively in 30 min on dichloran rose bengal chloramphenicol agar. These reductions...
Source: Food Microbiology - November 2, 2023 Category: Food Science Authors: Leonard Chong Vinayak Ghate Cassandra Seah Weibiao Zhou Source Type: research
