A phase 1 study of regorafenib and sildenafil in adults with advanced solid tumors
This study was a phase 1, open-label single-arm dose-escalation trial using a 3 + 3 design. Additional patients were enrolled at the maximum tolerated dose (MTD) until a total of 12 patients were treated at the MTD. A total of 29 patients were treated in this study. The median duration of treatment was 8 weeks. The recommended phase 2 doses determined in this study are regorafenib 160 mg daily with sildenafil 100 mg daily. The most common toxicities included palmar-plantar erythrodysesthesia syndrome (20 patients, 69%) and hypophosphatemia (18 patients, 62%). Two patients (7%) experienced grade 4 lipase increase. Objective...
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: Andrew S Poklepovic Sarah W Gordon Sejal Kothadia William P McGuire Leroy R Thacker Xiaoyan Deng Mary Beth Tombes Ellen Shrader Daniel Hudson Dipankar Bandyopadhyay Alison A Ryan Maciej Kmieciak Steven Smith Paul Dent Source Type: research
Medical Advancements in Benign Prostatic Hyperplasia Treatments
AbstractPurpose of ReviewThis review aims to identify and summarize the current literature on the most recent therapeutic agents and combination strategies for the medical management of lower urinary tract symptoms resulting from benign prostatic hyperplasia.Recent FindingsThe latest advancements in BPH therapy have been in combination strategies. Alpha blockers continue to be the mainstay of treatment, but research is exploring the synergistic benefits of combining them with 5-alpha reductase inhibitors (5-ARIs), phosphodiesterase-5 (PDE5) inhibitors, and beta-3 agonists.SummaryThe alpha-blocker + 5-ARI combination r...
Source: Current Urology Reports - March 7, 2024 Category: Urology & Nephrology Source Type: research
Evaluating the management trends for priapism and assessing the risk of priapism after in-office intracavernosal injections: a cross-sectional analysis
We describe the management trends of patients suffering from any priapism and evaluate the risks of developing priapism after intracavernosal injections (ICI) performed in office. We queried TriNetX for two separate male adult cohorts - those presenting with any priapism based on International Classification of Disease code, N48.3 (priapism) and those who underwent ICI in office based on Current Procedural Terminology code, 54235 (injection of corpora cavernosa with pharmacologic agent[s]). We evaluated treatment options for these patients after any priapism and described demographic risks for developing priapism after ICI...
Source: Cell Research - March 6, 2024 Category: Cytology Authors: Joon Yau Leong Zachary J Prebay David Ebbott Michael Li Paul H Chung Source Type: research
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue
Biomed Pharmacother. 2024 Mar 4;173:116291. doi: 10.1016/j.biopha.2024.116291. Online ahead of print.ABSTRACTThe elderly exhibit a reduced healing capacity after fracture, which is often associated with delayed or failed bone healing. This is due to a plethora of factors, such as an impaired bone vascular system and delayed angiogenesis. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil exerts pro-angiogenic and pro-osteogenic effects. Hence, we herein investigated in aged mice whether sildenafil can improve fracture healing. For this purpose, 40 aged CD-1 mice (16-18 months) were daily treated with 5 mg/kg body weight ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 5, 2024 Category: Drugs & Pharmacology Authors: Maximilian M Menger Maximilian Emmerich Claudia Scheuer Sandra Hans Benedikt J Braun Steven C Herath Mika F Rollmann Michael D Menger Matthias W Laschke Tina Histing Source Type: research
Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue
Biomed Pharmacother. 2024 Mar 4;173:116291. doi: 10.1016/j.biopha.2024.116291. Online ahead of print.ABSTRACTThe elderly exhibit a reduced healing capacity after fracture, which is often associated with delayed or failed bone healing. This is due to a plethora of factors, such as an impaired bone vascular system and delayed angiogenesis. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil exerts pro-angiogenic and pro-osteogenic effects. Hence, we herein investigated in aged mice whether sildenafil can improve fracture healing. For this purpose, 40 aged CD-1 mice (16-18 months) were daily treated with 5 mg/kg body weight ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 5, 2024 Category: Drugs & Pharmacology Authors: Maximilian M Menger Maximilian Emmerich Claudia Scheuer Sandra Hans Benedikt J Braun Steven C Herath Mika F Rollmann Michael D Menger Matthias W Laschke Tina Histing Source Type: research
Cryotherapy-Induced Iatrogenic Frostbite on Distal Digit: Case Report and Review of Management Strategies
Mil Med. 2024 Mar 1:usae051. doi: 10.1093/milmed/usae051. Online ahead of print.ABSTRACTCryotherapy is a widely utilized topical treatment for various dermatological conditions. While generally safe and effective, it carries potential risks, such as frostbite injury. Frostbite, a vascular condition causing skin and tissue freezing, is usually associated with prolonged exposure to freezing environments. Certain populations, like military personnel navigating frigid terrains, face an increased risk of frostbite and other cold-weather injuries. In this case, we present an unusual instance of iatrogenic frostbite in a 23-year-...
Source: Military Medicine - March 2, 2024 Category: International Medicine & Public Health Authors: Gehan Pendlebury Catherine Brahe Rudy Schmiedecke Source Type: research
Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors ̶ Towards Wound Healing
This study explores hybrid compounds, combining NO-releasing diazeniumdiolates with a sildenafil-derived PDE5 inhibitor. One compound demonstrated a favorable NO-release profile, triggered by an esterase (prodrug), and displayed in vitro nanomolar inhibition potency against PDE5 and thrombin-induced platelet aggregation. Both factors are known to promote blood flow and oxygenation. Thus, our findings unveil promising prospects for effective wound healing treatments.PMID:38430555 | DOI:10.1002/cbic.202300801 (Source: Chembiochem)
Source: Chembiochem - March 2, 2024 Category: Biochemistry Authors: Josep Mas-Rosell ó Hermann Tenor Timea Szabo Reto Naef Simon Sieber Karl Gademann Source Type: research
Cryotherapy-Induced Iatrogenic Frostbite on Distal Digit: Case Report and Review of Management Strategies
Mil Med. 2024 Mar 1:usae051. doi: 10.1093/milmed/usae051. Online ahead of print.ABSTRACTCryotherapy is a widely utilized topical treatment for various dermatological conditions. While generally safe and effective, it carries potential risks, such as frostbite injury. Frostbite, a vascular condition causing skin and tissue freezing, is usually associated with prolonged exposure to freezing environments. Certain populations, like military personnel navigating frigid terrains, face an increased risk of frostbite and other cold-weather injuries. In this case, we present an unusual instance of iatrogenic frostbite in a 23-year-...
Source: Military Medicine - March 2, 2024 Category: International Medicine & Public Health Authors: Gehan Pendlebury Catherine Brahe Rudy Schmiedecke Source Type: research
Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors ̶ Towards Wound Healing
This study explores hybrid compounds, combining NO-releasing diazeniumdiolates with a sildenafil-derived PDE5 inhibitor. One compound demonstrated a favorable NO-release profile, triggered by an esterase (prodrug), and displayed in vitro nanomolar inhibition potency against PDE5 and thrombin-induced platelet aggregation. Both factors are known to promote blood flow and oxygenation. Thus, our findings unveil promising prospects for effective wound healing treatments.PMID:38430555 | DOI:10.1002/cbic.202300801 (Source: Chembiochem)
Source: Chembiochem - March 2, 2024 Category: Biochemistry Authors: Josep Mas-Rosell ó Hermann Tenor Timea Szabo Reto Naef Simon Sieber Karl Gademann Source Type: research
Cryotherapy-Induced Iatrogenic Frostbite on Distal Digit: Case Report and Review of Management Strategies
Mil Med. 2024 Mar 1:usae051. doi: 10.1093/milmed/usae051. Online ahead of print.ABSTRACTCryotherapy is a widely utilized topical treatment for various dermatological conditions. While generally safe and effective, it carries potential risks, such as frostbite injury. Frostbite, a vascular condition causing skin and tissue freezing, is usually associated with prolonged exposure to freezing environments. Certain populations, like military personnel navigating frigid terrains, face an increased risk of frostbite and other cold-weather injuries. In this case, we present an unusual instance of iatrogenic frostbite in a 23-year-...
Source: Military Medicine - March 2, 2024 Category: International Medicine & Public Health Authors: Gehan Pendlebury Catherine Brahe Rudy Schmiedecke Source Type: research
Can you name that tablet? A cross-sectional study on recognition of common urology medications
ConclusionPatients often do not reliably know their own medications other than to describe them or show an unpackaged tablet. Prescribing safety is paramount to ensuring patient safety and reducing the risk of adverse drug reactions. This study shows that even experienced clinicians do not recognise the medications they regularly prescribe, and decisions should not be made without accurate medication reconciliation. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 2, 2024 Category: General Medicine Source Type: research
Exploring the Synergistic Effect of Sildenafil and Green Tea Polyphenols on Breast Cancer Stem Cell-like Cells and their Parental Cells: A Potential Novel Therapeutic Approach
(Source: Anti-Cancer Agents in Medicinal Chemistry)
Source: Anti-Cancer Agents in Medicinal Chemistry - February 28, 2024 Category: Cancer & Oncology Authors: Salari Sharif, Marzie Mohseni, Habibeh Sadat Khanavi, Mahnaz Ghadami, Shima Jafarzadeh, Emad Tavajohi, Shohreh Aliebrahimi, Shima Ostad, Seyed Nasser Tags: Research article Source Type: research
Treatment of pulmonary arterial hypertension in patients with connective tissue diseases: a systematic review and meta-analysis
AbstractThe evidence for the treatment of connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) mostly depends on subgroup or post hoc analysis of randomized controlled trials (RCTs). Thus, we performed a meta-analysis of RCTs that reported outcomes for CTD-PAH. PubMed and EMBASE were searched for CTD-PAH treatment. The selected outcomes were functional class (FC) change, survival rates, 6-min walk distance (6-MWD), clinical worsening (CW), N-terminal prohormone BNP (NT-proBNP), pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (mPAP), right atrial pressure (RAP), and cardiac in...
Source: Internal and Emergency Medicine - February 20, 2024 Category: Emergency Medicine Source Type: research
Design, synthesis, and biological evaluation of some new 2-phenyl-3,6-pyridazinedione derivatives as PDE-5 inhibitors
Bioorg Chem. 2024 Feb 16;145:107213. doi: 10.1016/j.bioorg.2024.107213. Online ahead of print.ABSTRACTVarious 2-phenyl-3,6-pyridazinedione derivatives 4a-j, 5a-c, 6a,b, 7a-c, 8, 9, 10a-d, and 11a-d, were effectivelysynthesized, and tested for their potential inhibition of phosphodiesterase enzyme at 10 µM. Then fourteen compounds exhibiting the highest inhibition 4b, 4d, 4e, 4g, 4h, 4i, 5a, 6a,b, 7c, 10a,b, 11a, and 11d were selected for screening their PDE-5 inhibition, where compounds 4b,g,h, and 11a revealed promising PDE-5 inhibition having IC50 values = 25, 53, 22, and 42 nM, respectively in comparison with Sildenafi...
Source: Bioorganic Chemistry - February 18, 2024 Category: Chemistry Authors: Zeinab S Abd-Rabo Riham F George Dalia K Zaafar Aya Y Gawish Aya M Serry Source Type: research
