Combined Methods (Formal Adjusted Indirect Comparison, Meta-Analysis and Principal Component Analysis) Comparisons of the Safety and Efficacy of Ambrisentan, Bosentan, and Sildenafil in the Patients With Pulmonary Arterial Hypertension
BackgroundThree oral drugs (ambrisentan, bosentan, and sildenafil) have been widely used to treat patients with pulmonary arterial hypertension (PAH). 1) There are no studies that directly compare the safety and efficacy of these three drugs. Existing studies could not meet the physician’s need to select the most beneficial drugs for patients. 2) Principal component analysis is mainly used for scale analysis and has not been reported in clinical field. 3) When the results of the indirect meta-analysis were not satisfactory, no new solutions have been proposed in existing meta-analysis studies.MethodsThe overall proce...
Source: Frontiers in Pharmacology - April 3, 2020 Category: Drugs & Pharmacology Source Type: research

The renal resistive index, a new biomarker for the follow up of vascular modifications in Systemic Sclerosis.
CONCLUSION: RRI and its variation in time are a reliable marker of SSc related vasculopathy, both in renal and extra-renal compartments. PMID: 32238514 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - April 1, 2020 Category: Rheumatology Authors: Gigante A, Bruni C, Lepri G, Tesei G, Maestripieri V, Guiducci S, Moggi-Pignone A, Melchiorre D, Boddi M, Bellando-Randone S, Rosato E, Matucci-Cerinic M Tags: J Rheumatol Source Type: research

Myeloid-Derived Suppressor Cells as Target of Phosphodiesterase-5 Inhibitors in Host-Directed Therapeutics for Tuberculosis
Resistance toward current and new classes of anti-tuberculosis (anti-TB) antibiotics are rapidly emerging; thus, innovative therapies focused on host processes, termed host-directed therapies (HDTs), are promising novel approaches for shortening therapy regimens without inducing drug resistance. Development of new TB drugs is lengthy and expensive, and success is not guaranteed; thus, alternatives are needed. Repurposed drugs have already passed Food and Drug Administration (FDA) as well as European Medicines Agency (EMA) safety requirements and may only need to prove efficacy against Mycobacterium tuberculosis (M.tb). Pho...
Source: Frontiers in Immunology - March 25, 2020 Category: Allergy & Immunology Source Type: research

Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms.
In conclusion, PA relaxed the rat corpus cavernosum attributed to both endothelium-dependent and -independent properties. While the former component was mostly involved in nitric oxide signaling pathway, the endothelium-independent mechanism involved in PA-induced relaxation was probably linked to calcium antagonism. PMID: 32190080 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - March 21, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Sildenafil Citrate on Exercise Capacity in Athletes With Spinal Cord Injury.
Authors: Perret C, Van Biesen D, Strupler M, Pit-Grosheide P, Vanlandewijck Y Abstract PURPOSE: Ingestion of sildenafil citrate has performance-enhancing effects at high altitudes above 3800 m in able-bodied individuals. It is unknown whether it can improve the performance of athletes with spinal cord injury (SCI) at moderate altitudes (
Source: International Journal of Sports Physiology and Performance - March 17, 2020 Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research

Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV ‐INHIBITION study design
ConclusionsThe SV ‐INHIBITION study aims to answer the question whether PDE5 inhibitors should be prescribed in patients with an SV. This trial has been built focusing on the three levels of research defined by the World Health Organization: disability (exercise tolerance), deficit (SV function), and handicap (qual ity of life). (Source: ESC Heart Failure)
Source: ESC Heart Failure - March 9, 2020 Category: Cardiology Authors: Pascal Amedro, Arthur Gavotto, Hamouda Abassi, Marie ‐Christine Picot, Stefan Matecki, Sophie Malekzadeh‐Milani, Marilyne Levy, Magalie Ladouceur, Caroline Ovaert, Philippe Aldebert, Jean‐Benoit Thambo, Alain Fraisse, Marc Humbert, Sara Tags: Study Design Source Type: research

Notice of Retraction: "Sildenafil Citrate Therapy for Oligohydramnios: A Randomized Controlled Trial" (Maher MA, Sayyed TM, and Elkhouly N).
Notice of Retraction: "Sildenafil Citrate Therapy for Oligohydramnios: A Randomized Controlled Trial" (Maher MA, Sayyed TM, and Elkhouly N). Obstet Gynecol. 2020 Mar 09;: Authors: PMID: 32150003 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - March 9, 2020 Category: OBGYN Tags: Obstet Gynecol Source Type: research

New approaches to congenital diaphragmatic hernia
Purpose of review Congenital diaphragmatic hernia (CDH) is a structural birth defect that results in significant neonatal morbidity and mortality. CDH occurs in 2–4 per 10 000 pregnancies, and despite meaningful advances in neonatal intensive care, the mortality rate in infants with isolated CDH is still 25–30%. In this review, we will present data on the molecular underpinnings of pathological lung development in CDH, prenatal diagnosis, and prognostication in CDH cases, existing fetal therapy modalities, and future directions. Recent findings Developments in the prenatal assessment and in-utero therapy o...
Source: Current Opinion in Obstetrics and Gynecology - March 3, 2020 Category: OBGYN Tags: PRENATAL DIAGNOSIS: Edited by Jane Chueh Source Type: research

Isolation and identification of a new sildenafil analogue, hydroxycarbodenafil, found as an adulterant in a health supplement
Publication date: Available online 29 February 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yufan Gu, Qing Hu, Jian Sun, Hong Yu, Huiqin Pan, Xiaotong Zhao, Shen Ji (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - March 2, 2020 Category: Drugs & Pharmacology Source Type: research

Positive Magnetic Resonance Imaging Evidence of Transient Global Amnesia Following the Use of Sildenafil
Transient global amnesia (TGA) has been proposed as a possible adverse effect of sildenafil. There are rare cases in the literature, but none had strong evidence to support. Our case is the first to demonstrate a focal punctate diffusion-weighted imaging lesion at the right hippocampus after the use of sildenafil. This finding, which is suggestive of cytotoxic edema and is typical for TGA, may provide us evidence for the implication of sildenafil in TGA. We speculate that sildenafil may precipitate TGA by altering blood flow, inducing venous congestion or cortical spreading depression at the hippocampus. (Source: Clinical Neuropharmacology)
Source: Clinical Neuropharmacology - March 1, 2020 Category: Neurology Tags: Case Reports Source Type: research

Nifedipine Alone or Combined With Sildenafil Citrate for Management of Threatened Preterm Labour: A Randomized Trial
(BJOG. 2019;126:729–735) (Source: Obstetric Anesthesia Digest)
Source: Obstetric Anesthesia Digest - February 26, 2020 Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research

Combined treatments with metformin and phosphodiesterase inhibitors alleviate non-alcoholic fatty liver disease in high-fat diet-fed rats: A comparative study.
This study was designed to investigate the possible protective effects of metformin alone and in combination with different phosphodiesterase inhibitors (PDEIs). Rats were fed a high-fat diet (HFD) for sixteen weeks to induce NAFLD. Starting from week 12, rats received metformin alone or in combination with pentoxifylline, cilostazol or sildenafil. HFD administration resulted in hepatic steatosis and inflammation in rats. In addition, liver index, body composition index, activities of liver enzymes, and serum lipids deviated from normal. Further, significant elevations were recorded compared to control in terms of serum gl...
Source: Canadian Journal of Physiology and Pharmacology - February 21, 2020 Category: Drugs & Pharmacology Authors: Heeba GH, El-Deen R, Abdel-Latif RG, Khalifa MMA Tags: Can J Physiol Pharmacol Source Type: research

Monitor recipients of phosphodiesterase type 5 inhibitors for glaucoma, pending more clinical evidence of risk
AbstractGlaucoma is a leading cause of bilateral blindness. Phosphodiesterase type 5 inhibitors (PDE5Is; e.g. avanafil, sildenafil, tadalafil and vardenafil) may increase blood flow to the ciliary body, thereby elevating intraocular pressure and increasing the risk of glaucoma. PDE5Is are commonly used to treat erectile dysfunction, as well as benign prostatic hyperplasia (tadalafil) and pulmonary hypertension (sildenafil). Patients receiving PDE5Is require glaucoma education and ongoing screening, especially if they are taking a high dosage of a daily PDE5I or have risk factors for glaucoma (e.g. increased age, African-Am...
Source: Drugs and Therapy Perspectives - February 10, 2020 Category: Drugs & Pharmacology Source Type: research

Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF- α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways.
In this study, we aimed to investigate the regulatory effects of diosmin (DS) on selected phosphodiesterase inhibitors against chronic bile duct ligation (CBDL)-induced HPS. Experimentally, Wistar Albino rats were used and HPS was induced by CBDL for 28 days. DS (100 mg/kg, daily, P.O.), sildenafil (Sild; 10 mg/kg, twice daily, P.O.), and pentoxifylline (PTX; 50 mg/kg, daily, P.O.) were evaluated either alone or in combinations for their anti-angiogenic activity. CBDL significantly altered oxidative stress biomarkers and up-regulated pulmonary mRNA expressions of VEGF, IGF-1, ET-1, iNOS, eNOS, and ANG-2 as well as th...
Source: European Journal of Pharmacology - February 9, 2020 Category: Drugs & Pharmacology Authors: Bakr AG, El-Bahrawy AH, Taha HH, Ali FEM Tags: Eur J Pharmacol Source Type: research

Ocular Side Effects of Sildenafil That Persist Beyond 24 h —A Case Series
In conclusion, because some individuals have heightened sensitivity to sildenafil, perhaps due to metabolic variance, patients should be started on a modest trial dose. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 7, 2020 Category: Neurology Source Type: research

The effect of sildenafil on selenite-induced cataract in rats.
Conclusion: Low doses (0.7 mg/kg) of oral sildenafil might show a protective effect on cataract development by lowering oxidative stress. PMID: 32023416 [PubMed - as supplied by publisher] (Source: Current Eye Research)
Source: Current Eye Research - February 5, 2020 Category: Opthalmology Authors: Atalay HT, Ucgul AY, Turkcu UO, Ozmen MC, Yilmaz S, Bilgihan A Tags: Curr Eye Res Source Type: research

Taking Viagra could prevent emergency caesarean sections
Publication date: 1 February 2020Source: New Scientist, Volume 245, Issue 3267Author(s): Alice Klein (Source: New Scientist)
Source: New Scientist - February 2, 2020 Category: Science Source Type: research

Pharmacology and perspectives in erectile dysfunction in man
Publication date: Available online 25 January 2020Source: Pharmacology & TherapeuticsAuthor(s): Emma Mitidieri, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca, Raffaella SorrentinoAbstractPenile erection is a perfect example of microcirculation modulated by psychological factors and hormonal status. It is the result of a complex neurovascular process that involves the integrative synchronized action of vascular endothelium; smooth muscle; and psychological, neuronal, and hormonal systems. Therefore, the fine coordination of these events is essential to maintain penile flaccidity or allow erection; an altera...
Source: Pharmacology and Therapeutics - January 26, 2020 Category: Drugs & Pharmacology Source Type: research

Taking Viagra in early labour reduces the need for emergency caesarean
A study has found that taking Viagra at the beginning of labour increases blood flow to the baby and halves the chance of needing an emergency c- section (Source: New Scientist - Health)
Source: New Scientist - Health - January 24, 2020 Category: Consumer Health News Source Type: research

Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.
Discussion and conclusion: Our results demonstrated that sildenafil decreased pathological changes in alveoli, bronchioles, interstitial tissue, and arterioles of rats with COPD and PH. PMID: 31967915 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 23, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson's disease.
Authors: Quarracino C, Otero-Losada M, Capani F, Pérez-Lloret S Abstract Introduction: Autonomic dysfunction is one of the most frequent and disabling non-motor symptoms of Parkinson's disease (PD). It includes, among others, orthostatic hypotension (OH), sialorrhea, constipation, erectile dysfunction (ED), urinary dysfunction, and diaphoresis. They are usually under-recognized and suboptimally managed.Areas covered: Recommended treatments for dysautonomias are summarized with a description of the mechanism of action and observed results. The pathophysiology of each disorder is reviewed to pinpoint possible ...
Source: Expert Opinion on Pharmacotherapy - January 22, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Pulmonary veno-occlusive disease: a probably underdiagnosed cause of pulmonary hypertension in systemic sclerosis
We report the case of a 72-year-old woman with limited systemic sclerosis, who was initially diagnosed with systemic sclerosis-related pulmonary arterial hypertension. However, after introduction of sildenafil and bosentan, the patient developed acute pulmonary oedema, and findings from complementary exams were suggestive of PVOD. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - January 22, 2020 Category: Rheumatology Source Type: research

Safety and efficacy of sildenafil citrate to reduce operative birth for intrapartum fetal compromise at term: A Phase 2 Randomized Controlled Trial
Sildenafil citrate is a vasodilator used in erectile dysfunction and pulmonary hypertension. We tested whether it reduces emergency operative births for fetal compromise and improves fetal or utero-placental perfusion in labor in a Phase II double blind randomized controlled trial. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 21, 2020 Category: OBGYN Authors: Jessica TURNER MRCOG, Liam DUNN, William Tarnow-Mordi, Christopher Flatley, Vicki Flenady, Sailesh KUMAR Tags: Report of Major Impact Source Type: research

Development of novel phosphodiesterase 5 inhibitors for the therapy of alzheimer's disease.
Abstract Nitric oxide (NO) is a gaseous molecule that plays a multifactorial role in several cellular processes. In the central nervous system, the NO dual nature in neuroprotection and neurotoxicity has been explored to unveil its involvement in Alzheimer's disease (AD). A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models. In addition t...
Source: Biochemical Pharmacology - January 21, 2020 Category: Drugs & Pharmacology Authors: Zuccarello E, Acquarone E, Calcagno E, Argyrousi EK, Deng SX, Landry DW, Arancio O, Fiorito J Tags: Biochem Pharmacol Source Type: research

Sildenafil Citrate Influences Production of TNF- α in Healthy Men Lymphocytes.
Sildenafil Citrate Influences Production of TNF-α in Healthy Men Lymphocytes. J Immunol Res. 2019;2019:8478750 Authors: Zych M, Roszczyk A, Kniotek M, Kaleta B, Zagozdzon R Abstract The aim of our study was to determine whether sildenafil citrate influences the production of Th1- (TNF-α, INF-γ) or Th2-type (TGF-β, IL-10) cytokines by lymphocytes of healthy men. Sildenafil citrate (SC) is a selective blocker of phosphodiesterase 5, by competing for the binding site with cGMP. It was reported that a higher risk of sexually transmitted diseases (STD) could be correlated with a recre...
Source: Journal of Immunology Research - January 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.
CONCLUSIONS: Sildenafil administration may attenuate inflammation and lung injury by promoting proliferation and suppressing apoptosis in SAP rats. PMID: 31931368 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - January 10, 2020 Category: Allergy & Immunology Authors: Fang D, Lin Q, Wang C, Zheng C, Li Y, Huang T, Ni F, Wu Z, Chen B, Sun L Tags: Int Immunopharmacol Source Type: research

Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis
The two 52-week INPULSIS trials investigated nintedanib versus placebo in patients with IPF, FVC ≥50% predicted and DLco 30–79% predicted. The 24-week INSTAGE trial investigated nintedanib plus sildenafil vers... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - January 8, 2020 Category: Respiratory Medicine Authors: Luca Richeldi, Martin Kolb, St éphane Jouneau, Wim A. Wuyts, Birgit Schinzel, Susanne Stowasser, Manuel Quaresma and Ganesh Raghu Tags: Research article Source Type: research

To evaluate the efficacy and safety of different kinds of PDE5-Is with tamsulosin as a medical therapy for LUTS secondary to benign prostatic hyperplasia: A protocol for systematic review and meta analysis
Conclusions: This NMA and systematic review will generate evidence to help choose the best combination for treatment of LUTS secondary to BPH. PROSPERO registration number: PROSPERO CRD 42019139062 (Source: Medicine)
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Sildenafil Administration in Dogs Heterozygous for a  Functional Null Mutation in Pde6a: Suppressed Rod-Mediated ERG Responses and Apparent Retinal Outer Nuclear Layer Thinning.
This study was designed to assess risk for retinal toxicity associated with administration of high-dose sildenafil citrate to dogs heterozygous for a functionally null mutation in Pde6a over a 4-month period. Three Pde6a +/- dogs were administered 14.3 mg/kg sildenafil per os and two Pde6a +/- dogs placebo once daily for 16 weeks. Three Pde6a +/+ dogs were administered sildenafil for 7 days. Ophthalmic examination, vision testing, and electroretinography (ERG) were regularly performed. At study termination, dogs were euthanized and globes collected. Retinal layer thickness and photoreceptor nuclei counts wer...
Source: Advances in Experimental Medicine and Biology - December 31, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Protection of sildenafil citrate hydrogel against radiation-induced skin wounds
Publication date: Available online 20 December 2019Source: BurnsAuthor(s): Shweta Kulshrestha, Raman Chawla, Sukhvir Singh, Pooja Yadav, Navneet Sharma, Rajeev Goel, Himanshu Ojha, Vinod Kumar, J.S. AdhikariAbstractRadiation induced skin wound/dermatitis is one of the common side effects of radiotherapy or interventional radiobiology. In order to combat impaired healing of radiation wounds, alternative therapy to use sildenafil citrate (SC) topical hydrogel as a therapeutic option was proposed that has known to enhance nitric oxide in wounds. Our aim was to develop a radiation induced skin wound model and to investigate th...
Source: Burns - December 21, 2019 Category: Dermatology Source Type: research

Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model.
Abstract The aim of the study was to evaluate the potential protective role of sildenafil and tadalafil in contrast-induced nephropathy (CIN) by modulating oxidative stress. Thirty Wistar male rats were equally assigned into five groups: sham, CIN, CIN + sildenafil (10 mg/kg bw/day), CIN + tadalafil (5 mg/kg bw/day) and CIN + N-Acetyl Cysteine (NAC) (100 mg/kg bw/day) as a positive control. CIN was induced by 12 h dehydration and administration of indomethacin (10 mg/kg bw), N-ω- nitro-L-arginine methyl ester (10 mg/kg bw), and ioprom...
Source: Food and Chemical Toxicology - December 8, 2019 Category: Food Science Authors: Iordache AM, Docea AO, Buga AM, Zlatian O, Ciurea ME, Rogoveanu OC, Burada F, Sosoi S, Mitrut R, Mamoulakis C, Albulescu D, Vasile RC, Tsatsakis A, Calina D Tags: Food Chem Toxicol Source Type: research

Protein-Losing Enteropathy Following Fontan Palliation
Publication date: December 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 12Author(s): Asim Al Balushi, Andrew S. MackieAbstractProtein-losing enteropathy (PLE) is a chronic condition involving multiple organ systems that may develop any time following Fontan completion. The pathogenesis of PLE is complex and multifactorial. Chronic venous hypertension, low cardiac output, and abnormal lymphatics may all play a role in the pathogenesis of PLE. Common signs and symptoms include chronic diarrhea, abdominal pain, and ascites. Diagnosis is based on the presence of signs and symptoms in addition to hypoalbuminemia...
Source: Canadian Journal of Cardiology - December 6, 2019 Category: Cardiology Source Type: research

Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR.
This study aimed to assess the effect of antenatal SC treatment on metabolic and cardiovascular health in offspring by assessing postnatal weight gain, glucose tolerance, systolic blood pressure and resistance artery function in a mouse model of FGR, the placental-specific insulin-like growth factor 2 (PO) knockout mouse. SC was administered subcutaneously (10 mg.kg-1) daily from embryonic day (E)12.5. Antenatal SC treatment did not alter fetal weight or viability but increased postnatal weight gain in WT female offspring (P
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 6, 2019 Category: Physiology Authors: Renshall LJ, Cottrell EC, Cowley E, Sibley CP, Baker PN, Thorstensen E, Greenwood SL, Wareing M, Dilworth MR Tags: Am J Physiol Heart Circ Physiol Source Type: research

GUA-28 - Nebivolol plus sildenafil in PDE 5 inhibitors non-responder men with arterial hypertension
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): Aleksander Khelaia (Source: European Urology Supplements)
Source: European Urology Supplements - December 4, 2019 Category: Urology & Nephrology Source Type: research

Cadmium-induced adrenal cortical autophagy in rats: possible modulation by sildenafil.
Authors: Imam RA, Motawei AG, Abd Algaleel WA Abstract BACKGROUND: The link between autophagy, inflammatory bowel disease, ischemic injury and cancer had been established. Reasonable evidence is available for Cadmium (Cd) to be related to certain cancers. Sildenafil had been investigated to modulate oxidative stress mechanisms. AIM OF WORK: is to investigate Cadmium-induced adrenal cortical autophagy and to declare possible modulation by sildenafil. MATERIAL AND METHODS: Twenty four Wistar rats weighing 150 -200gm were randomly and equally assigned into: Control group, Sildenafil (20mg/kg/day orally) expose...
Source: Folia Morphologica - November 30, 2019 Category: Anatomy Tags: Folia Morphol (Warsz) Source Type: research

Sildenafil promotes the anti-amnesic activity of estrogen receptor alpha agonist in animals with estrogen insufficiency
Publication date: Available online 25 November 2019Source: Neurochemistry InternationalAuthor(s): Ahsas Goyal, Debapriya GarabaduAbstractThe cognitive function in the females is observed to modulate with the fluctuation in plasma estrogen level. The specific estrogen receptor alpha (ERα) agonist, (4,4′,4″-(4-propyl-[1H] pyrazole-1,3,5-triyl) tris phenol (PPT), exerts similar therapeutic activity to that of estrogen replacement therapy. It can also exert cyclic adenosine monophosphate (cAMP)-dependent carcinogenic activity in the uterus of the ovariectomized animals. However, there is no report of cGMP on ...
Source: Neurochemistry International - November 27, 2019 Category: Neuroscience Source Type: research

Pulmonary Hypertension with Valvular Heart Disease: When to Treat the Valve Disease and When to Treat the Pulmonary Hypertension
This article will review the current guidelines for therapeutic intervention in (pulmonary hypertension) PH related to left heart disease (PH-LHD).Recent FindingsThe 6th World Symposium on Pulmonary Hypertension (WSPH) recommended that the mean pulmonary artery pressure (mPAP) should be lowered to 20  mmHg. In several randomized controlled trials performed in patients with PH-LHD, pulmonary arterial hypertension (PAH)–specific drug therapy demonstrated no evidence of beneficial effects. Furthermore, in the sildenafil for improving outcomes after valvular correction (SIOVAC) trial, the use of sildenafil in the co...
Source: Current Cardiology Reports - November 25, 2019 Category: Cardiology Source Type: research

Rapid Titration of Intravenous Treprostinil to Treat Severe Pulmonary Arterial Hypertension Postpartum: A Retrospective Observational Case Series Study.
CONCLUSIONS: Our experience suggested that rapid uptitration of intravenous treprostinil combined with oral sildenafil in the postpartum period may be a safe and effective approach for these very sick parturients with severe pulmonary hypertension. PMID: 31743181 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - November 21, 2019 Category: Anesthesiology Authors: Wang T, Lu J, Li Q, Chen Y, Ye Q, Gao J, Yang D, Zhao L, Huang J, Zhang J Tags: Anesth Analg Source Type: research

Does brain natriuretic peptide (BNP) at baseline influence the effects of nintedanib plus sildenafil in patients with IPF?
Conclusions: In patients with IPF and severely impaired gas exchange, the benefit of nintedanib plus sildenafil vs nintedanib alone on changes in BNP and FVC seemed more pronounced in patients with baseline BNP above the median. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Behr, J., Kolb, M., Olschewski, H., Song, J. W., Luppi, F., Schinzel, B., Stowasser, S., Quaresma, M., Martinez, F. J. Tags: Idiopathic interstitial pneumonias Source Type: research

Changes in biomarkers in patients with idiopathic pulmonary fibrosis (IPF) treated with nintedanib and sildenafil
Conclusions: In the INSTAGE trial, biomarkers relevant to the pathophysiology of IPF were reduced in subjects treated with nintedanib plus sildenafil vs nintedanib alone for 24 weeks. These results support the potential benefits of this combination suggested by clinical endpoints. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: White, E., Crestani, B., Günther, A., Maher, T. M., Ittrich, C., Diefenbach, C., Rohr, K. B., Quaresma, M., Kolb, M. Tags: Idiopathic interstitial pneumonias Source Type: research

Safety and pharmacokinetics of nintedanib plus sildenafil in the INSTAGE trial
Conclusions: In the INSTAGE trial, gastrointestinal adverse events were generally more frequent in nintedanib-naïve patients than in those who had previously received nintedanib. Plasma concentrations of nintedanib were similar when it was administered alone or with sildenafil. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Costabel, U., Shapera, S., Tomassetti, S., Baba, T., Schinzel, B., Wiebe, S., Quaresma, M., Kolb, M. Tags: Idiopathic interstitial pneumonias Source Type: research

Diffuse lung disease and pulmonary hypertension related to TBX4 mutation in 5 children
We present five cases of TBX4 related DPLD/PH who survived beyond infancy with different disease progression. Registry-based follow-up is mandatory to understand genotype-phenotype correlation and improve treatment strategies and prognosis for this rare disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Carlens, J., Schwerk, N., Länger, F., Hansen, G., Griese, M., Wetzke, M. Tags: Paediatric bronchology Source Type: research

Asymmetric dimethylarginine (ADMA) to monitor treatments of pulmonary hypertension
Conclusions: ADMA paralleled the hemodynamic and clinical benefit of PAH-specific treatments or BPA in patients with PAH and CTEPH. ADMA could be used as a biomarker for the monitoring of the effect of treatments in precapillary PH. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Skoro-Sajer, N., Probst, V., Sadushi-Kolici, R., Gerges, C., Campean, I., Lang, I. Tags: Pulmonary hypertension Source Type: research

Should thrombolysis and sildenafil be given in the acute management of patients with large pulmonary embolism? An assessment of the short and long-term outcomes
Introduction: The role of thrombolysis in the management of patients with haemodynamic compromise in the presence of pulmonary embolism (PE) is recognised although it is unclear whether there is an indication for concomitant use of advanced pulmonary vasodilator therapy.Aims: To assess the potential benefit of sildenafil on outcome when administered acutely with, or without thrombolysis, to patients with large PE.Method: We performed a retrospective review of the outcome of 20 consecutive patients (9 male, 11 female) who presented with acute right heart strain on echocardiographic assessment, computed tomography or biochem...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Hill, N., Bascon, N., Barnes, N., Madden, B. Tags: Pulmonary embolism Source Type: research

Digoxin effect in mortality associated to right ventricular dysfunction in patients with pulmonary hypertension
Conclusions: there is no benefit on survival with the long term use of digoxin, except for rehospitalization and functional class. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Saucedo, H., Zayas-Hernandez, N. G., Lopez-Flores, J. C., Pulido-Zamudio, T. Tags: Pulmonary hypertension Source Type: research

Hemodynamical effects of metformin and sildenafil in the treatment of experimental pulmonary hypertension
Metformin has been reported to have experimental effects that could be beneficial in the treatment of PH (pulmonary hypertension), though the specific mechanism of action is still under speculation. The current management of this condition is sildenafil, even in patients that requiere metformin as part of the treatment for other comorbilities. Both metformin and sildenafil effectively lower the systolic pressure in the right ventricle, however there are no reports comparing the hemodynamical effects of the two treatments. The goal of this study was to do so using a monocrotaline-induced PH rat model. The rats were divided ...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Benavides, V., Silva-Medina Weil, M., Castano, S., Palacios, M. Tags: Pulmonary hypertension Source Type: research

A decade of activity in treating patients with pulmonary arterial hypertension in Timisoara center
Conclusions: Psychological evaluation and social support become mandatory because their prognosis depends on these issues. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Pislaru, L., Bertici, N. S. Tags: Pulmonary hypertension Source Type: research

NTP42, an antagonist of the thromboxane receptor, attenuates experimentally-induced pulmonary arterial hypertension
This study investigated the efficacy of NTP42 in a monocrotaline (MCT)-induced PAH rat model. PAH was induced by subcutaneous injection of 60 mg/kg MCT. Rats were assigned to the groups: 1) No MCT, 2) MCT Only, 3) MCT+NTP42, 4) MCT+Sildenafil and 5) MCT+Selexipag, where 28-day treatment was initiated 24hr post-MCT.From hemodynamic measurements, NTP42 reduced MCT-induced PAH including mean pulmonary arterial pressure (mPAP) and right systolic ventricular pressure (RSVP). Moreover, NTP42 was superior to standard-of-care (SoC) drugs Sildenafil or Selexipag in reducing vessel remodelling, inflammation and fibrosis. A multipara...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Kinsella, B. T., Mulvaney, E., Reid, H. Tags: Pulmonary hypertension Source Type: research

Cyclic nucleotide-dependent relaxation in human umbilical vessels.
Authors: Provitera L, Cavallaro C, Griggio A, Raffaeli G, Amodeo I, Gulden S, Lattuada D, Ercoli G, Lonati C, Tomaselli A, Mosca F, Villamor E Abstract Umbilical vessels have a low sensitivity to dilate, and this property is speculated to have physiological implications. We aimed to investigate the different relaxing responses of human umbilical arteries (HUAs) and veins (HUVs) to agonists acting through the cAMP and cGMP pathways. Vascular rings were suspended in organ baths for isometric force measurement. Following precontraction with the thromboxane prostanoid (TP) receptor agonist U44069, concentration-respons...
Source: Journal of Physiology and Pharmacology - November 20, 2019 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia
ConclusionsThis model for sildenafil in CDH patients shows that concentration-targeted sildenafil dosing of 0.4 mg/kg in 3 h, followed by 1.6 mg/kg/day continuous infusion achieves appropriate sildenafil plasma levels. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 18, 2019 Category: Drugs & Pharmacology Source Type: research