Molecules, Vol. 28, Pages 6314: Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats
ifayat Ullah Khan
The traditional use of Mirabilis jalapa L. roots to enhance male sexual performance prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its hydroethanolic extract using normal male rats. Spectroscopic characterization indicated the presence of ß-D-glucopyranoside, methyl-1,9-benzyl-2,6-dichloro-9H-purine, and Bis-(2-ethylhexyl)-phthalate; these compounds have a significant inhibitory effect on the phosphodiesterase-5 (PDE-5) enzyme in silico evaluation and minerals (including zinc, cadmium, and magnesium). Other phytochemical analyses revealed the presenc...
Source: Molecules - August 29, 2023 Category: Chemistry Authors: Asad Ur Rahman Fiaz Alam Muhammad Khan Muhammad Sarfraz Abdul Basit Tawseef Ahmad Muhammad Ali Khokhar Sayyad Ali Kifayat Ullah Khan Tags: Article Source Type: research
Sildenafil to Treat Congenital Chylothorax: The First Case Report in Taiwan
(Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - August 24, 2023 Category: Perinatology & Neonatology Authors: Chun-Wei Li, Ming-Chou Chiang, Reyin Lien, Tzu-Cheng Tsai, Kai-Hsiang Hsu Tags: Letter to the Editor Source Type: research
Case report: Progressive pulmonary artery hypertension in a case of megalencephaly-capillary malformation syndrome
Megalencephaly-capillary malformation syndrome (MCAP, OMIM # 602501) is caused by hyperactivity of the thephosphoinositide-3-kinase (PI3K)–Vakt murine thymoma viral oncogene homolog (AKT)–mammalian target of rapamycin (mTOR) pathway, which results in megalencephaly, capillary malformations, asymmetrical overgrowth, and connective tissue dysplasia. Herein, we report the case of a 7-month-old girl with MCAP due to a PIK3CA somatic mosaic variant who presented with atrial tachycardia, finally diagnosed as pulmonary arterial hypertension (PAH). Oxygen therapy and sildenafil decreased pulmonary blood pressure and improved a...
Source: Frontiers in Genetics - August 8, 2023 Category: Genetics & Stem Cells Source Type: research
