Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors ̶ Towards Wound Healing

This study explores hybrid compounds, combining NO-releasing diazeniumdiolates with a sildenafil-derived PDE5 inhibitor. One compound demonstrated a favorable NO-release profile, triggered by an esterase (prodrug), and displayed in vitro nanomolar inhibition potency against PDE5 and thrombin-induced platelet aggregation. Both factors are known to promote blood flow and oxygenation. Thus, our findings unveil promising prospects for effective wound healing treatments.PMID:38430555 | DOI:10.1002/cbic.202300801

Source: Chembiochem - March 2, 2024 Category: Biochemistry Authors: Josep Mas-Rosell ó Hermann Tenor Timea Szabo Reto Naef Simon Sieber Karl Gademann Source Type: research