Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Exploring the Multifaceted Potential of Sildenafil in Medicine
Medicina (Kaunas). 2023 Dec 17;59(12):2190. doi: 10.3390/medicina59122190.ABSTRACTPhosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and vasodilation. By targeting cGMP for degradation, PDE5 inhibits sustained vasodilation. PDE5 operates in diverse anatomical regions, with its upregulation linked to various pathologies, including cancer and neurodegenerative diseases. Sildenafil, a selective PDE5 inhibitor, is prescribed for erectile dysfunction and pulmonary arterial hypertension. However, considering the extensive...
Source: Medicina (Kaunas) - December 23, 2023 Category: Universities & Medical Training Authors: Ciprian Pu șcașu Anca Zanfirescu Simona Negre ș Oana Cristina Șeremet Source Type: research
Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): A randomized, double-blind, placebo-controlled phase Ib clinical trial
To test feasibility and safety of administering sildenafil in neonates with neonatal encephalopathy (NE), developing brain injury despite therapeutic hypothermia (TH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2023 Category: Pediatrics Authors: Pia Wintermark, Anie Lapointe, Robin Steinhorn, Emmanouil Rampakakis, J ürgen Burhenne, Andreas D. Meid, Gzona Bajraktari-Sylejmani, May Khairy, Gabriel Altit, Marie-Therese Adamo, Alishia Poccia, Guillaume Gilbert, Christine Saint-Martin, Daniela Toffol Tags: Original Articles Source Type: research
Etiology, Diagnosis and Management of Persistent Pulmonary Hypertension of the Newborn in Resource-limited Settings
Persistent Pulmonary Hypertension of the Newborn (PPHN) is more common in Low and middle income countries (LMICs) due to high incidence of sepsis, perinatal asphyxia and meconium aspiration syndrome. Presence of hypoxic respiratory faillure and greater than 5% difference in preductal and post ductal saturation increases clinical sucipision for PPHN. The availability of Inhaled nitric oxide and extracorporaeal membrane oxygenation is limited but pulmonary vasodilators such as sildenafil are readily available in most LMICs. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - December 13, 2023 Category: Perinatology & Neonatology Authors: Prathik Bandiya, Rajeshwari Madappa, Ajay Raghav Joshi Source Type: research
