An Unexpected Cause of Lung Disease Identified After Lung Transplantation
Chest. 2023 Oct;164(4):e111-e115. doi: 10.1016/j.chest.2023.04.041.ABSTRACTA 54-year-old woman with systemic lupus erythematosus with associated interstitial lung disease (ILD) presented to the lung transplant clinic for assessment of candidacy for transplantation. She was initially diagnosed with ILD based on clinical and radiographic features (never underwent lung biopsy). In addition, she had associated mixed group I/III pulmonary arterial hypertension. The patient had no family history of pulmonary disease and had never used tobacco and did not have a history of illicit drug use. She was maintained on systemic immunosu...
Source: Chest - October 7, 2023 Category: Respiratory Medicine Authors: Alyssa Self Kamyar Afshar Aarya Kafi Gordon Yung Eugene Golts Christine M Lin Source Type: research
Myocardial stretch-induced compliance is abrogated under ischemic conditions and restored by cGMP/PKG-related pathways
Discussion: Our results suggest that ischemia impairs the adaptive myocardial response to acute stretching and that this may be partly prevented by pharmacological manipulation of the cGMP/PKG pathway, namely, with PDE5i. Further studies are warranted to further elucidate the potential of this intervention in the clinical setting of acute myocardial ischemia. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - October 2, 2023 Category: Physiology Source Type: research
Sildenafil Intoxication Can Be Complicated by Seizures and an Increase in Creatine Kinase
We read with interest the article by Kim et al. about a 61-year-old man with sildenafil intoxication from taking 1500 mg sildenafil with suicidal intent (1). The intoxication manifested itself clinically with multiple embolic strokes and an increase in creatine kinase (CK), which was interpreted as rhabdomyolysis (1). Symptoms, such as conf usion, drowsiness, palpitations, dysarthria, and dizziness, occurred 1 h after taking sildenafil (1). In the case of multiple embolic strokes, the patient received acetylsalicylic acid plus clopidogrel (1). (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - October 1, 2023 Category: Emergency Medicine Authors: Josef Finsterer, Fulvio A. Scorza, Carla A. Scorza Source Type: research
Authors ’ Reply to Ganijee et al.: “Comment on: Evaluation of the Influence of Sildenafil on Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults”
(Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - September 26, 2023 Category: Drugs & Pharmacology Source Type: research
Comment on: Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults
(Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - September 26, 2023 Category: Drugs & Pharmacology Source Type: research
Authors ’ Reply to Ganijee et al.: “Comment on: Evaluation of the Influence of Sildenafil on Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults”
(Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - September 26, 2023 Category: Drugs & Pharmacology Source Type: research
Comment on: Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults
(Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - September 26, 2023 Category: Drugs & Pharmacology Source Type: research
Physiological Effects of Sildenafil Versus Placebo at High Altitude: A Systematic Review
High Altitude Medicine&Biology, Ahead of Print. (Source: High Altitude Medicine and Biology)
Source: High Altitude Medicine and Biology - September 25, 2023 Category: Sports Medicine Authors: Sangeeta Poudel Sandesh Gautam Purushottam Adhikari Ken Zafren Source Type: research
Real-World Treatment Patterns Among Patients with Connective Tissue Disorder-Related Pulmonary Arterial Hypertension in the United States: A Retrospective Claims-Based Analysis
CONCLUSIONS: Treatment patterns were generally similar between the CTD + PAH and PAH cohorts, although combination therapy was more frequent in the CTD + PAH cohort. Both cohorts may benefit from broader use of all available PAH treatment classes, including combination therapy. Considering the life-threatening nature of PAH, our findings also highlight the need to address the low persistence rates with PAH therapies regardless of etiology.PMID:37728697 | DOI:10.1007/s12325-023-02658-z (Source: Adv Data)
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Therese Sargent Yuen Tsang Sumeet Panjabi Vienica Funtanilla Hayley D Germack Marjolaine Gauthier-Loiselle Ameur M Manceur Martin Cloutier Patrick Lefebvre Source Type: research
Real-World Treatment Patterns Among Patients with Connective Tissue Disorder-Related Pulmonary Arterial Hypertension in the United States: A Retrospective Claims-Based Analysis
CONCLUSIONS: Treatment patterns were generally similar between the CTD + PAH and PAH cohorts, although combination therapy was more frequent in the CTD + PAH cohort. Both cohorts may benefit from broader use of all available PAH treatment classes, including combination therapy. Considering the life-threatening nature of PAH, our findings also highlight the need to address the low persistence rates with PAH therapies regardless of etiology.PMID:37728697 | DOI:10.1007/s12325-023-02658-z (Source: Adv Data)
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Therese Sargent Yuen Tsang Sumeet Panjabi Vienica Funtanilla Hayley D Germack Marjolaine Gauthier-Loiselle Ameur M Manceur Martin Cloutier Patrick Lefebvre Source Type: research
Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature
ConclusionSildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 20, 2023 Category: General Medicine Source Type: research
A real ‐world pharmacovigilance study of FDA adverse event reporting system events for sildenafil
ConclusionsThese findings emphasize the importance of monitoring and understanding the potential risks associated with sildenafil. Further investigation is warranted to validate these associations and address previously unrecognized safety concerns. (Source: Andrology)
Source: Andrology - September 19, 2023 Category: Urology & Nephrology Authors: Yan Wang,
Bin Zhao,
Haiyan Yang,
Zheng Wan Tags: ORIGINAL ARTICLE Source Type: research
Phosphodiesterase-5 (PDE-5) Inhibitors as Therapy for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury
AbstractMultiple phase III randomized controlled trials (RCTs) for pharmacologic interventions in traumatic brain injury (TBI) have failed despite promising results in experimental models. The heterogeneity of TBI, in terms of pathomechanisms and impacted brain structures, likely contributes to these failures. Biomarkers have been recommended to identify patients with relevant pathology (predictive biomarkers) and confirm target engagement and monitor therapy response (pharmacodynamic biomarkers). Our group focuses on traumatic cerebrovascular injury as an understudied endophenotype of TBI and is validating a predictive an...
Source: Neurotherapeutics - September 11, 2023 Category: Neurology Source Type: research
