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4-Terpineol attenuates pulmonary vascular remodeling via suppressing PI3K/Akt signaling pathway in hypoxia-induced pulmonary hypertension rats
Toxicol Appl Pharmacol. 2023 Jun 14;473:116596. doi: 10.1016/j.taap.2023.116596. Online ahead of print.ABSTRACTThe hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs) plays a pivotal role in pulmonary arterial remodeling (PAR) of hypoxia-induced pulmonary hypertension (HPH). 4-Terpineol is a constituent of Myristic fragrant volatile oil in Santan Sumtang. Our previous study found that Myristic fragrant volatile oil alleviated PAR in HPH rats. However, the effect and pharmacological mechanism of 4-terpineol in HPH rats remain unexplored. Male Sprague-Dawley rats were exposed to hypobaric hypoxia chamber (s...
Source: Toxicology and Applied Pharmacology - June 16, 2023 Category: Toxicology Authors: Cunlin Gu Zhanting Yang Shanshan Su Ke Ma Xingmei Nan Zhanqiang Li Dianxiang Lu Source Type: research

Rare blue dye faces risky path from rainforest to product
Polines, Colombia— The road ends in Luz del Mundo. A few kilometers’ walk from here, just across the Chigorodó River, lies Polines, a scattering of open-sided houses on the edge of the forest. It’s a settlement of Indigenous Emberá people, about 80,000 of whom live in communities across Colombia and Panama. On a recent hot day, an Emberá man named Alirio Niaza scaled a large tree. Standing on one of the lower branches, he wielded a long pole with shears at the end. He carefully positioned the tip against a tiny branch, then pulled a cord that closed the blades. With a thud, a green, fist-size fruit landed in ...
Source: Science of Aging Knowledge Environment - June 15, 2023 Category: Geriatrics Source Type: research

Haemodynamic Effects of Sildenafil on Subpulmonic Morphological Left Ventricle in Congenitally Corrected Transposition of Arteries After Left Ventricular Assist Device Implantation
Postoperative right ventricular failure is a major cause of postoperative mortality and morbidity after implantation of a left ventricular assist device (LVAD).1 The morphological right ventricle (RV) is more sensitive to afterload than the morphological left ventricle (LV). In patients with conco... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - June 9, 2023 Category: Cardiology Authors: dbarot525787 Source Type: research

Pulmonary hypertension, nephrotic syndrome, and polymyositis due to hepatitis C virus infection: A case report
CONCLUSION: Increasing evidence supports a relationship between hepatitis C infection and diverse extrahepatic manifestations, but it is very rare to have PH, nephrotic syndrome, and polymyositis in a single patient. We conducted a literature review on the management of several specific extrahepatic manifestations of hepatitis C.PMID:37274804 | PMC:PMC10237099 | DOI:10.3748/wjg.v29.i19.3040 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - June 5, 2023 Category: Gastroenterology Authors: Ya-Nan Zhao Guo-Hui Liu Chang Wang Yi-Xuan Zhang Ping Yang Ming Yu Source Type: research

Pulmonary hypertension, nephrotic syndrome, and polymyositis due to hepatitis C virus infection: A case report
CONCLUSION: Increasing evidence supports a relationship between hepatitis C infection and diverse extrahepatic manifestations, but it is very rare to have PH, nephrotic syndrome, and polymyositis in a single patient. We conducted a literature review on the management of several specific extrahepatic manifestations of hepatitis C.PMID:37274804 | PMC:PMC10237099 | DOI:10.3748/wjg.v29.i19.3040 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - June 5, 2023 Category: Gastroenterology Authors: Ya-Nan Zhao Guo-Hui Liu Chang Wang Yi-Xuan Zhang Ping Yang Ming Yu Source Type: research