Nanostructured Ethosomal Gel Loaded with Arctostaphylos uva-ursi extract; In-vitro/In-vivo Evaluation as a Cosmeceutical Product
CONCLUSION: A stable AUU based ethosomal gel formulation could be a better vehicle for phytoextracts than conventional formulations for cosmeceutical applications such as for skin rejuvenation and depigmentation etc.PMID:34325633 | DOI:10.2174/1567201818666210729111026 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 30, 2021 Category: Drugs & Pharmacology Authors: Nayla Javed Shakeel Ijaz Naveed Akhtar Haji Muhammad Shoaib Khan Source Type: research
Molecules, Vol. 24, Pages 2046: Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits
rişan
Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of whi...
Source: Molecules - May 28, 2019 Category: Chemistry Authors: Bianca Eugenia Ștefănescu Katalin Szabo Andrei Mocan Gianina Cri şan Tags: Review Source Type: research
Antioxidant and antimicrobial markers by UPLC ®-ESI-Q-TOF-MSE of a new multilayer active packaging based on Arctostaphylos uva-ursi.
Antioxidant and antimicrobial markers by UPLC®-ESI-Q-TOF-MSE of a new multilayer active packaging based on Arctostaphylos uva-ursi.
Talanta. 2019 May 01;196:498-509
Authors: Wrona M, Blasco S, Becerril R, Nerin C, Sales E, Asensio E
Abstract
49 different non-volatile compounds were determined in Spanish Arctostaphylos uva-ursi leaves using UPLC®-ESI-Q-TOF with MSE technology. Both positive and negative electrospray ionization were applied. MarkerLynx® was proposed as a powerful tool to distinguish samples from eight wild populations of Spain by determining their non-volatile ma...
Source: Talanta - January 28, 2019 Category: Chemistry Authors: Wrona M, Blasco S, Becerril R, Nerin C, Sales E, Asensio E Tags: Talanta Source Type: research
Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions.
Abstract
Uva-ursi leaf is widely used to treat symptoms of lower urinary tract infections. Here, we evaluated the in vitro inhibitory effects of uva-ursi extracts on 10 major human UDP-glucuronosyltransferases (UGT) isoforms. Of the 10 tested UGT isoforms, uva-ursi extracts exerted the strongest inhibitory effect on UGT1A1-mediated β-estradiol 3-glucuronidation with the lowest IC50 value of 8.45 ± 1.56 μg/mL. To identify the components of uva-ursi extracts showing strong inhibitory effects against UGT1A1, the inhibitory effects of nine major constituents of the extracts were assessed. Among the te...
Source: Food and Chemical Toxicology - July 31, 2018 Category: Food Science Authors: Park JB, Kim D, Min JS, Jeong S, Cho DY, Zheng YF, Yoon KD, Bae SK Tags: Food Chem Toxicol Source Type: research
Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) – a double-blind, randomized, controlled comparative effectiveness trial
Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial sho... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - July 3, 2018 Category: Complementary Medicine Authors: Kambiz Afshar, Nina Fleischmann, Guido Schmiemann, Jutta Bleidorn, Eva Hummers-Pradier, Tim Friede, Karl Wegscheider, Michael Moore and Ildik ó Gágyor Tags: Study protocol Source Type: research
Constituents of Arctostaphylos uva-ursi Leaves
A new natural compound p-digallic acid ethyl ester and 1,3,6-trigalloylglucose first time isolated from Arctostaphylos uva-ursi, and also known for this plant compounds tetragalloylglucose, gallic acid, arbutin, and hyperoside were characterized by PMR ,13C NMR, and UV spectroscopy and mass spectrometry. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - April 11, 2018 Category: Chemistry Source Type: research
Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial
Women with acute uncomplicated urine infection are usually treated with antibiotics. One trial has demonstrated that delayed antibiotic treatment offered without symptom relief results in a modest reduction in... (Source: Trials)
Source: Trials - September 8, 2017 Category: General Medicine Authors: Jeanne Trill, Catherine Simpson, Frances Webley, Mike Radford, Louise Stanton, Tom Maishman, Angeliki Galanopoulou, Andrew Flower, Caroline Eyles, Merlin Willcox, Alastair Hay, Gareth Griffiths, Paul Little, George Lewith and Michael Moore Tags: Study protocol Source Type: research
Limited effectiveness of over ‐the‐counter plant preparations used for the treatment of urinary tract infections as inhibitors of the urease activity from Staphylococcus saprophyticus
ConclusionsThese results indicate that only a few of the commercially available over‐the‐counter plant preparations commonly used for the treatment of urinary tract infections can inhibit the urease activity from S. saprophyticus.This article is protected by copyright. All rights reserved. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - February 27, 2017 Category: Microbiology Authors: Charles E. Deutch Tags: Original Article Source Type: research
HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells
Conclusion: The data from this study show that plant- based HDACis are relatively rare, and can elicit a similar pattern to TSA in up-regulating miRNAs involved with tumor suppression of HeLa cervical carcinoma. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 27, 2016 Category: Cancer & Oncology Authors: MAZZIO, E. A., SOLIMAN, K. F. A. Tags: Article Source Type: research
Recycling of filter tea industry by-products: Application of subcritical water extraction for recovery of bioactive compounds from A. uva-ursi herbal dust
In this study, classical extraction (CE) and subcritical water extraction (SWE) of polyphenolic compounds from A. uva-ursi herbal dust (a by-product of a filter tea factory) were performed. The extraction yields obtained through the application of these two extraction techniques were comparable, but higher a concentration of polyphenolic compounds (total phenols (TP) from 7.3088 to 10.6441g GAE/100g, and total flavonoids (TF) from 1.0344 to 1.8638g CE/100g) were recovered using SWE during a significantly shorter extraction time. SWE, as the more appropriate extraction technique, was further optimized by simultaneous maximi...
Source: The Journal of Supercritical Fluids - November 19, 2016 Category: Chemistry Source Type: research
Effects of bearberry, parsley and corn silk extracts on diuresis, electrolytes composition, antioxidant capacity and histopathological features in mice kidneys
Publication date: March 2016 Source:Journal of Functional Foods, Volume 21 Author(s): Marijana Vranješ, Boris M. Popović, Dubravka Štajner, Vesna Ivetić, Anamarija Mandić, Dejan Vranješ The effects of corn silk (Maydis stigma), parsley (Petroselinum crispum) and bearberry leaves (Uva ursi folium) extracts on diuresis, electrolytes composition, antioxidant capacity and histopathological features of pretreated mice kidneys were determined. The first group of ten animals drank corn silk, second parsley and third bearberry leaf extract. Fourth group was the control when animals drank water. Extracts and w...
Source: Journal of Functional Foods - January 12, 2016 Category: Nutrition Source Type: research
New high-performance liquid chromatography-dad method for analytical determination of arbutin and hydroquinone in rat plasma
This study was therefore designed to identify and quantify arbutin and its metabolite hydroquinone, naturally present in Arctostaphylos uva-ursi (L.) Spreng plant in rat plasma, after an acute and subacute administration of aqueous arbutin solution in Wistar rats. For this purpose a reversed-phase high-performance liquid chromatography coupled with photodiode array detection was developed to assess the pharmacokinetic of arbutin and hydroquinone in plasma of female rats treated with aqueous arbutin solutions. The detection (arbutin: 0.0617 µg/ml and hydroquinone 0.0120 µg/ml) and quantification (arb...
Source: Indian Journal of Pharmaceutical Sciences - November 4, 2015 Category: Drugs & Pharmacology Authors: FR GalloG PagliucaG MultariG PanziniE D'amoreI Altieri Source Type: research
An ethnobotanical survey of traditionally used plants on Suva planina mountain (south-eastern Serbia)
Conclusions Our results confirm that medicinal plants are an invaluable resource of the research area and need to be protected as they contribute to an improvement in living standards and the survival of people threatened by unfavourable demographic trends. However, due to over-exploitation, some plants have become exceptionally rare and are under threat, leading to the need for their rational use and protection so as to ensure they are still around for future generations. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - September 15, 2015 Category: Drugs & Pharmacology Source Type: research
UHPLC-PDA-ESI-TOF/MS metabolic profiling of Arctostaphylos pungens and Arctostaphylos uva-ursi. A comparative study of phenolic compounds from leaf methanolic extracts
Publication date: Available online 18 February 2015 Source:Phytochemistry Author(s): Alessia Panusa , Rita Petrucci , Giancarlo Marrosu , Giuseppina Multari , Francesca Romana Gallo The aim of this study was to get a rapid metabolic fingerprinting and to gain insight into the metabolic profiling of Arctostaphylos pungens H. B. K., a plant morphologically similar to Arctostaphylos uva-ursi (L.) Spreng. (bearberry) but with a lower arbutin (Arb) content. According to the European Pharmacopoeia the Arb content in the dried leaf of A . uva-ursi (L.) Spreng. must be at least 7% (wt/wt) but other species, like A. pungen...
Source: Phytochemistry - March 13, 2015 Category: Chemistry Source Type: research
Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth
Conclusions: Nephrologists need to be cognizant of the lack of substantiated proven benefits of these substances and of the potential adverse effects in the animal models that can translate to the patients. Most importantly, the policy needs to change regarding the regulation of these products to prevent patient harm and misinformation.Am J Nephrol 2014;40:393-398 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - November 7, 2014 Category: Neurology Source Type: research
