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Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial
This study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/4225-1/2021/EKU). The results will be disseminated by publication of peer-reviewed manuscripts. Trial registration number NCT05055544. (Source: BMJ Open)
Source: BMJ Open - June 24, 2022 Category: General Medicine Authors: Toth, B., Javorhazy, A., Nyirady, P., Csupor-Löffler, B., Birinyi, P., Zhanel, G., Naber, K., Länger, R., Vörhendi, N., Gede, N., Vancsa, S., Hegyi, P., Csupor, D. Tags: Open access, Urology Source Type: research

Gurgem-7 toxicity assessment: Regulation of cell survival or death by traditional Mongolian prescription
In conclusion, we provide preliminary molecular evidence of the toxic properties of Gurgem-7 preparation to Caco-2 and CT26. WT cells related to insufficient action of their repair and adaptive mechanisms to stress conditions.PMID:35605329 | DOI:10.1016/j.ecoenv.2022.113660 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - May 23, 2022 Category: Environmental Health Authors: Ariunzaya Batjargal Przemyslaw Solek Wirginia Kukula-Koch Baigalmaa Urjin Wojciech Koch Dorota Koman Ewa Dudzinska Source Type: research

Molecules, Vol. 27, Pages 2247: Variation in Population and Solvents as Factors Determining the Chemical Composition and Antioxidant Potential of Arctostaphylos uva-ursi (L.) Spreng. Leaf Extracts
The objective of this study was to characterize the variability of the phytochemical composition and antioxidant activity of water and ethanol bearberry extracts from raw material collected from different natural populations. In each of the twelve A. uva-ursi sites, three leaf samples were collected and analyzed. The water extracts from bearberry leaves were characterized by similar concentration of arbutin (77.64&ndash;105.56 mg g&minus;1) and a significantly higher concentration of hydroquinone (6.96&ndash;13.08 mg g&minus;1) and corilagin (0.83&ndash;2.12 mg g&minus;1) in ...
Source: Molecules - March 30, 2022 Category: Chemistry Authors: Piotr Sugier Łukasz Sęczyk Danuta Sugier Tags: Article Source Type: research

Investigation of phenolic compounds at the leaves and shoots < em > Arctostaphylos < /em > spp. and their antioxidant and antityrosinase activities
Nat Prod Res. 2022 Jan 12:1-6. doi: 10.1080/14786419.2021.2025370. Online ahead of print.ABSTRACTComparative phytochemical and pharmacological analysis of leaves and shoots of Arctostaphylos uva-ursi (L.) Spreng. and endemic of Transcaucasia and North Caucasia Arctostaphylos caucasica Lipsch. was carried out. Phenolic compounds in methanol extracts were investigated by HPLC-PDA-ESI-MS. Pharmacological investigation was carried out at the models of generation of superoxide, DPPH, hydroxyl and nitrosyl radicals. The antityrosinase properties were evaluated in the reaction of tyrosinase inhibition using L -tyrosine as a subst...
Source: Natural Product Research - January 12, 2022 Category: Biochemistry Authors: Arnold Alexeevich Shamilov Daniil Nikolaevich Olennikov Dmitryi Igorevich Pozdnyakov Valentina Nikolaevna Bubenchikova Ekaterina Robertovna Garsiya Source Type: research

Molecules, Vol. 26, Pages 7692: Chemical Characteristics and Antioxidant Activity of Arctostaphylos uva-ursi L. Spreng. at the Southern Border of the Geographical Range of the Species in Europe
Andrzej Plak The bearberry (Arctostaphylos uva-ursi L. Spreng.) is a source of herbal material&mdash;bearberry leaf (Uvae ursi folium), which is highly valued and sought by pharmaceutical and cosmetic industries. For many years, leaves of this plant have been used in traditional medicine as a diuretic, antimicrobial, and anti-inflammatory agent for various diseases of the urogenital tract. The bearberry has also been proposed as a natural antioxidant additive due to the high contents of phenolic compounds in its leaves. The study was focused on characterization of the basic phytochemical composition and antioxi...
Source: Molecules - December 20, 2021 Category: Chemistry Authors: Piotr Sugier Łukasz Sęczyk Danuta Sugier Rafa ł Krawczyk Ma łgorzata Wójcik Joanna Czarnecka Sylwia Oko ń Andrzej Plak Tags: Article Source Type: research

Potential radioprotective properties of arbutin against ionising radiation on human leukocytes in vitro
Mutat Res Genet Toxicol Environ Mutagen. 2021 Dec;872:503413. doi: 10.1016/j.mrgentox.2021.503413. Epub 2021 Sep 24.ABSTRACTArbutin is a simple phenolic glucoside biosynthesised in many plant families. Some of the everyday foods that contain arbutin are species of the genus Origanum, peaches, cereal products, coffee and tea and Arctostaphyllos uva ursi L. leaves. Arbutin possesses various beneficial effects in the organism, and was confirmed effective in the treatment of urinary tract infections as well as in preventing skin hyperpigmentation. It shows antioxidant and anti-inflammatory properties, and antitumor activity. T...
Source: Cell Research - November 20, 2021 Category: Cytology Authors: Vesna Benkovi ć Nives Mar čina Anica Horvat Kne žević Dunja Šikić Vedran Rajevac Mirta Mili ć Nevenka Kopjar Source Type: research

[ASAP] Discovery and Characterization of Phenolic Compounds in Bearberry ( < italic toggle="yes" > Arctostaphylos uva-ursi < /italic > ) Leaves Using Liquid Chromatography –Ion Mobility–High-Resolution Mass Spectrometry
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.1c02845 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - September 8, 2021 Category: Food Science Authors: Xue-Chao Song, Elena Canellas, Nicola Dreolin, Cristina Nerin, and Jeff Goshawk Source Type: research

Nanostructured Ethosomal Gel Loaded with Arctostaphylos uva-ursi extract; In-vitro/In-vivo Evaluation as a Cosmeceutical Product
CONCLUSION: A stable AUU based ethosomal gel formulation could be a better vehicle for phytoextracts than conventional formulations for cosmeceutical applications such as for skin rejuvenation and depigmentation etc.PMID:34325633 | DOI:10.2174/1567201818666210729111026 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 30, 2021 Category: Drugs & Pharmacology Authors: Nayla Javed Shakeel Ijaz Naveed Akhtar Haji Muhammad Shoaib Khan Source Type: research