Autopsy case of fatal hypoglycemia following ingestion of a therapeutic dose of tramadol
AbstractAn 86-year-old female was found unconscious the day after taking a prescribed tablet containing a combination of tramadol and acetaminophen. At admission to the hospital, marked hypoglycemia (blood glucose: 4 mg/dL) was confirmed, but serum insulin and C-peptide were within the normal range, which suggested that neither endogenous hyperinsulinemia nor exogenous insulin administration was responsible for the hypoglycemia. Despite resuscitation efforts, the woman subsequently died. At autopsy, there was renal disorder, but any pathological abnormalities that could have caused hypoglycemia were not observed. Blood t...
Source: Forensic Science, Medicine, and Pathology - June 9, 2021 Category: Forensic Medicine Source Type: research
Pain management in people with hemophilia in childhood and young adulthood
Expert Rev Hematol. 2021 May 27. doi: 10.1080/17474086.2021.1935852. Online ahead of print.ABSTRACTINTRODUCTION: People with hemophilia (PWH) commonly experience acute and chronic musculoskeletal pain during childhood and young adulthood, but their treatment is often inadequate.AREAS COVERED: From September 1, 2020 to April 15, 2021, authors performed a literature search in PubMed and the Cochrane Library using "hemophilia AND pain" as keywords. Authors found 1082 articles, 51 of which were chosen because we considered them to be intimately connected with the topic of this report. Multimodal pain treatment, including multi...
Source: Expert Review of Hematology - May 27, 2021 Category: Hematology Authors: E Carlos Rodriguez-Merchan Hortensia De la Corte-Rodriguez Source Type: research
Tramadol Oral Solution (Qdolo) for Pain
Date: May 31, 2021
Issue #:
1625Summary:
The opioid agonist tramadol is now available in an oral
solution (Qdolo– Athena Bioscience) for management
of pain severe enough to require an opioid and for
which alternative treatment options are inadequate.
Tramadol has been available for years in immediate-release
tablets and capsules, extended-release
capsules (Ultram, and others), and in a fixed-dose
combination tablet with acetaminophen (Ultracet,
and generics). (Source: The Medical Letter)
Source: The Medical Letter - May 4, 2021 Category: Drugs & Pharmacology Authors: admin Source Type: research
Manubriosternal arthritis/osteitis: chest wall pain aggravated by Carnett's sign posture
A 56-year-old woman presented to the University hospital with a 4-year history of relapsing chest and upper back pain. The pain was not localized but a generalized chest pain, and was exacerbated while sneezing and turning over or getting up. She was prescribed loxoprofen and tramadol hydrochloride/acetaminophen for the pain. Her past medical history included hypertension, for which she was prescribed amlodipine 5 mg a day. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 30, 2021 Category: General Medicine Authors: Takanori Uehara, Kazutaka Noda, Tomoko Tsukamoto, Hajime Fujimoto, Takuro Horikoshi, Masatomi Ikusaka Tags: Clinical Communication to the Editor Source Type: research
Total Knee Arthroplasty in Freestanding Ambulatory Surgery Centers: 5-Year Retrospective Chart Review of 90-Day Postsurgical Outcomes and Health Care Resource Utilization.
DISCUSSION: With careful patient selection, standardized perioperative pathways, and multimodal analgesia protocols, TKA procedures can be performed in the ASC setting with low complication rates, minimal postdischarge HCRU, and high rates of patient satisfaction.
LEVEL OF EVIDENCE: III.
PMID: 33443387 [PubMed - as supplied by publisher] (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - January 16, 2021 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
An effective case of shichimotsukokato treatment for postherpetic neuralgia in a patient with chronic kidney disease
ConclusionAnalgesics can be inappropriately used in patients with chronic kidney disease. For chronic kidney disease patients with postherpetic neuralgia,shichimotsukokato may have an effect on both pain and renal function and seems to be beneficial. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - December 9, 2020 Category: Complementary Medicine Authors: Tomoaki Fujii,
Yuji Morimoto Tags: CASE REPORT Source Type: research
Effect of preoperative intravenous vs oral acetaminophen on postoperative opioid consumption in an enhanced recovery after surgery (ERAS) program in patients undergoing open gynecologic oncology surgery.
CONCLUSIONS: There was no difference in postoperative opioid consumption between patients receiving preoperative IV or oral acetaminophen within an ERAS program for patients undergoing open gynecologic oncology surgery.
PMID: 33298309 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - December 6, 2020 Category: Cancer & Oncology Authors: Cain KE, Iniesta MD, Fellman BM, Suki TS, Siverand A, Corzo C, Lasala JD, Cata JP, Mena GE, Meyer LA, Ramirez PT Tags: Gynecol Oncol Source Type: research
Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
Abstract
Rotigotine-loaded microspheres (RoMS) are sustained-release formulations with prolonged anti-Parkinson's effects. Given that pain is a non-motor symptom of Parkinson's disease, this study investigated the antinociceptive effects of RoMS and their synergistic effects with analgesics on inflammatory pain. A model of inflammatory pain was prepared by intraplantarly injecting male Sprague-Dawley rats with carrageenan. The antinociceptive effects of RoMS, acetaminophen, and tramadol, both alone and in combination, were evaluated using the hind paw withdrawal latency in the hot plate test and Randall-Se...
Source: European Journal of Pharmacology - November 5, 2020 Category: Drugs & Pharmacology Authors: Li T, Wang T, Wang L, Liu R, Zhang L, Zhai R, Fu F Tags: Eur J Pharmacol Source Type: research
A Comprehensive Review of Over the Counter Treatment for Chronic Low Back Pain.
Abstract
PURPOSE OF THE REVIEW: Chronic low back pain (CLBP) is a major contributor to societal disease burden and years lived with disability. Nonspecific low back pain (LBP) is attributed to physical and psychosocial factors, including lifestyle factors, obesity, and depression. Mechanical low back pain occurs related to repeated trauma to or overuse of the spine, intervertebral disks, and surrounding tissues. This causes disc herniation, vertebral compression fractures, lumbar spondylosis, spondylolisthesis, and lumbosacral muscle strain.
RECENT FINDINGS: A systematic review of relevant literatu...
Source: Pain Physician - November 4, 2020 Category: Anesthesiology Authors: Peck J, Urits I, Peoples S, Foster L, Malla A, Berger AA, Cornett EM, Kassem H, Herman J, Kaye AD, Viswanath O Tags: Pain Ther Source Type: research
A Comprehensive Review of Over the Counter Treatment for Chronic Low Back Pain
AbstractPurpose of the ReviewChronic low back pain (CLBP) is a major contributor to societal disease burden and years lived with disability. Nonspecific low back pain (LBP) is attributed to physical and psychosocial factors, including lifestyle factors, obesity, and depression. Mechanical low back pain occurs related to repeated trauma to or overuse of the spine, intervertebral disks, and surrounding tissues. This causes disc herniation, vertebral compression fractures, lumbar spondylosis, spondylolisthesis, and lumbosacral muscle strain.Recent FindingsA systematic review of relevant literature was conducted. CENTRAL, MEDL...
Source: Pain and Therapy - November 4, 2020 Category: Anesthesiology Source Type: research
Feasibility of Implementing Opioid Stewardship Recommendations for Sinonasal Surgery.
CONCLUSION: Opioid stewardship recommendations can be instituted for sinonasal surgery, including multimodal perioperative pain management and substitution of tramadol for breakthrough pain, as a method to decrease the volume of opioids prescribed, without increasing patient phone calls or affecting the likelihood of physician recommendation Press Ganey scores.
PMID: 33138720 [PubMed - as supplied by publisher] (Source: Pain Physician)
Source: Pain Physician - November 3, 2020 Category: Anesthesiology Authors: Jordan JW, Spankovich C, Stringer SP Tags: Otolaryngol Head Neck Surg Source Type: research
Erector spinae plane block with catheter for management of percutaneous nephrolithotomy: A three case report
Conclusion:
These patients were compared to 3 prior patients who had undergone percutaneous nephrolithotomy without ESPC. The 3 patients without ESPC placement reported increased VAS scores, had increased opioid/pain medication consumption intraoperatively and postoperatively, and had increased incidence of perioperative nausea when compared to our ESPC patients. Our report shows that ESPC, in combination with a multimodal pain protocol, can be a good option for management of patients undergoing percutaneous nephrolithotomy. (Source: Medicine)
Source: Medicine - October 2, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
An effective case of shichimotsukokato treatment for postherpetic neuralgia in a patient with chronic kidney disease
ConclusionAnalgesics can be inappropriately used in patients with chronic kidney disease. For chronic kidney disease patients with postherpetic neuralgia,shichimotsukokato may have an effect on both pain and renal function and seems to be beneficial. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - September 2, 2020 Category: Complementary Medicine Authors: Tomoaki Fujii,
Yuji Morimoto Tags: CASE REPORT Source Type: research
