Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial
Conclusion: This study suggests that, considering both analgesic efficacy and safety, the combination of codeine and acetaminophen is more effective to control moderate to severe pain from acute periradicular abscesses. (Source: Journal of Applied Oral Science)
Source: Journal of Applied Oral Science - October 23, 2017 Category: Dentistry Source Type: research
Pain Management Strategies in Shoulder Arthroplasty
Pain control in total shoulder arthroplasty demands a multidisciplinary approach with collaboration between patients, surgeon, and anesthetist. A multimodal approach with preemptive medication, regional blockade, local anesthetics, and a combination of acetaminophen, nonsteroidal antiinflammatory drugs, tramadol, and gabapentinoids postoperatively leads to pain control and patient satisfaction. Assessment of patients ’ expectations constitutes a vital aspect of the preoperative patient evaluation. Educating and psychologically preparing patients reduces postoperative pain. Patients with anxiety and depression, preoperati...
Source: Orthopedic Clinics of North America - October 6, 2017 Category: Orthopaedics Authors: Jason L. Codding, Charles L. Getz Source Type: research
Successful treatment of mixed (mainly cancer) pain by tramadol preparations.
Authors: Kawahito S, Soga T, Mita N, Satomi S, Kinoshita H, Arase T, Kondo A, Miki H, Takaishi K, Kitahata H
Abstract
The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in ...
Source: Journal of Medical Investigation - September 30, 2017 Category: General Medicine Tags: J Med Invest Source Type: research
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
Abstract
It has been established that both adult and larval zebrafish are capable of showing nociceptive responses to noxious stimuli; however, the use of larvae to test novel analgesics has not been fully explored. Zebrafish larvae represent a low-cost, high-throughput alternative to traditional mammalian models for the assessment of product efficacy during the initial stages of drug development. In the current study, a novel model of nociception using zebrafish larvae is described. During the recovery from an acute exposure to low levels of acetic acid, larvae display innate changes in behaviour that may...
Source: Behavioural Brain Research - September 18, 2017 Category: Neurology Authors: Ellis LD, Berrue F, Morash M, Achenbach JC, Hill J, McDougall JJ Tags: Behav Brain Res Source Type: research
Associations between drugs and small ‐bowel mucosal bleeding: Multicenter capsule‐endoscopy study
ConclusionAlthough the use of NSAIDs was significantly associated with an increased risk of small‐bowel mucosal injury, no significant associations were observed between the use of such drugs and small‐bowel overt bleeding. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - September 4, 2017 Category: Gastroenterology Authors: Ryota Niikura, Atsuo Yamada, Koutarou Maki, Masanao Nakamura, Hirotsugu Watabe, Mitsuhiro Fujishiro, Shiro Oka, Motohiro Esaki, Shunji Fujimori, Atsushi Nakajima, Naoki Ohmiya, Takayuki Matsumoto, Shinji Tanaka, Kazuhiko Koike, Choitsu Sakamoto Tags: Original Article Source Type: research
