Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
CONCLUSION: In Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death.PMID:37314600 | DOI:10.1007/s10147-023-02365-3 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Shingo Sato Hideyuki Tomitori Atsushi Okawa Kyoko Akano Source Type: research
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
CONCLUSION: In Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death.PMID:37314600 | DOI:10.1007/s10147-023-02365-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Shingo Sato Hideyuki Tomitori Atsushi Okawa Kyoko Akano Source Type: research
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
CONCLUSION: In Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death.PMID:37314600 | DOI:10.1007/s10147-023-02365-3 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Shingo Sato Hideyuki Tomitori Atsushi Okawa Kyoko Akano Source Type: research
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
CONCLUSION: In Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death.PMID:37314600 | DOI:10.1007/s10147-023-02365-3 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - June 14, 2023 Category: Cancer & Oncology Authors: Shingo Sato Hideyuki Tomitori Atsushi Okawa Kyoko Akano Source Type: research
Prescription patterns of analgesics in cancer patients with bone metastases in Japan: a retrospective database study
ConclusionIn Japanese cancer patients with bone metastases, acetaminophen, NSAIDs, and weak or strong opioids were commonly used; their use increased after SREs developed. Opioid use increased closer to death. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - June 14, 2023 Category: Cancer & Oncology Source Type: research
Case report: Fatal poisoning caused by additive effects of two barbiturates
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 and 0.22 μg/ml, respectively. We concluded that the death was due to the additive effects of two barbiturates. As both pentobarbital and phenobarbital act on gamma-aminobutyric acid (GABA) receptors, central nervous system activity was suppressed, causing respiratory depression. Additive pharmacological effects should be considered in cases of massive ingestion of multiple ...
Source: Frontiers in Pharmacology - May 24, 2023 Category: Drugs & Pharmacology Source Type: research
A randomized, double-blind pilot study of analgesic and anti-inflammatory effects of naproxen sodium and acetaminophen following dental implant placement surgery
Discussion: Naproxen sodium was more effective than acetaminophen in reducing post-operative pain and systemic inflammation following surgical placement of one or two dental implants. Further studies are needed to determine whether these findings are applicable to more complex implant cases and how they affect clinical outcomes following implant placement.Clinical Trial Registration:ClinicalTrials.gov, identifier NCT04694300 (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - May 17, 2023 Category: Drugs & Pharmacology Source Type: research
Antinociceptive and anti-inflammatory activity of DW-1021, the ionic complex of pelubiprofen and tramadol, in rodents
Biomed Pharmacother. 2023 Apr 28;163:114708. doi: 10.1016/j.biopha.2023.114708. Online ahead of print.ABSTRACTAlthough drugs such as acetaminophen, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs), are commonly used for pain management, the side effects of these drugs such as hepatotoxicity, nephrotoxicity, nausea, and vomiting, can not be neglected. Therefore, combinations of analgesics with different mechanisms raise the possibility of developing novel analgesics. Therefore, the aim of the present study was to evaluate whether DW-1021, the ionic complex of pelubiprofen (NSAID) and tramadol (opioid), has synergi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2023 Category: Drugs & Pharmacology Authors: Young-Seo Yoon Han-Jun Hwang Jae-Min Kim Kyung-Sook Chung Seo-Yun Jang So-Won Heo Su-Yeon Lee Soo-Yeon Kim Hyeon-A Song Seung-Jae Hong Hyo-Jin An Sang-Wook Park Jhong-Jae Im Dong-Ho Oh Ah-Ram Lee Kyung-Tae Lee Source Type: research
IJERPH, Vol. 19, Pages 16736: Burden of Neurological Diseases in the Philippines as Revealed by Web Searches: An Infodemiological Study
This study evaluated the population’s interest in neurological disorders by using search volumes related to neurology, either disease diagnosis or medications. Bid values generated in API were used as a proxy for the interests of the healthcare industry. Spearman’s rank-order correlation was performed between search volumes and bid prices to determine significance. Among the neurologic diseases listed, the most searched were attention deficit hyperactivity disorder, migraine, and Alzheimer’s disease. The most commonly searched drugs were oral antihypertensives (amlodipine, losartan...
Source: International Journal of Environmental Research and Public Health - December 13, 2022 Category: Environmental Health Authors: Anisah Hayaminnah D. Alonto Almira Doreen Abigail O. Apor Roland Dominic G. Jamora Tags: Article Source Type: research
Compounds of wastewater origin in remote upland lakes in Ireland
The objective of this research was to evaluate whether compounds of wastewater origin were present in four remote upland headwater lakes in Ireland that primarily receive loadings from atmospheric deposition. In Polar Organic Chemical Integrative Samplers (POCIS) deployed in the lakes for between 60 and 68 days, seven compounds were detected at levels that could be quantified but 25 of the target compounds were not detected. The detected compounds included the cannabinoid metabolite, tetrahydrocannabinol carboxylate (THC-COOH), codeine, acetaminophen (paracetamol), ibuprofen, and the artificial sweeteners, sucralose, and s...
Source: Chemosphere - November 4, 2022 Category: Chemistry Authors: Julian Aherne Viviane Yargeau Chris D Metcalfe Source Type: research
Compounds of wastewater origin in remote upland lakes in Ireland
The objective of this research was to evaluate whether compounds of wastewater origin were present in four remote upland headwater lakes in Ireland that primarily receive loadings from atmospheric deposition. In Polar Organic Chemical Integrative Samplers (POCIS) deployed in the lakes for between 60 and 68 days, seven compounds were detected at levels that could be quantified but 25 of the target compounds were not detected. The detected compounds included the cannabinoid metabolite, tetrahydrocannabinol carboxylate (THC-COOH), codeine, acetaminophen (paracetamol), ibuprofen, and the artificial sweeteners, sucralose, and s...
Source: Chemosphere - November 4, 2022 Category: Chemistry Authors: Julian Aherne Viviane Yargeau Chris D Metcalfe Source Type: research
Compounds of wastewater origin in remote upland lakes in Ireland
The objective of this research was to evaluate whether compounds of wastewater origin were present in four remote upland headwater lakes in Ireland that primarily receive loadings from atmospheric deposition. In Polar Organic Chemical Integrative Samplers (POCIS) deployed in the lakes for between 60 and 68 days, seven compounds were detected at levels that could be quantified but 25 of the target compounds were not detected. The detected compounds included the cannabinoid metabolite, tetrahydrocannabinol carboxylate (THC-COOH), codeine, acetaminophen (paracetamol), ibuprofen, and the artificial sweeteners, sucralose, and s...
Source: Chemosphere - November 4, 2022 Category: Chemistry Authors: Julian Aherne Viviane Yargeau Chris D Metcalfe Source Type: research
Compounds of wastewater origin in remote upland lakes in Ireland
The objective of this research was to evaluate whether compounds of wastewater origin were present in four remote upland headwater lakes in Ireland that primarily receive loadings from atmospheric deposition. In Polar Organic Chemical Integrative Samplers (POCIS) deployed in the lakes for between 60 and 68 days, seven compounds were detected at levels that could be quantified but 25 of the target compounds were not detected. The detected compounds included the cannabinoid metabolite, tetrahydrocannabinol carboxylate (THC-COOH), codeine, acetaminophen (paracetamol), ibuprofen, and the artificial sweeteners, sucralose, and s...
Source: Chemosphere - November 4, 2022 Category: Chemistry Authors: Julian Aherne Viviane Yargeau Chris D Metcalfe Source Type: research
A retrospective analysis of the impact of Michigan's opioid prescribing legislation on discharge opioid prescribing at a single institution
CONCLUSIONS AND RELEVANCE: Our results indicate that the legislation implemented in Michigan to regulate opioid prescriptions was associated with a reduction in opioids prescribed to patients discharged from a community-based academic teaching hospital.PMID:36226786 | DOI:10.5055/jom.2022.0740 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 13, 2022 Category: Addiction Authors: Richard Sadowski Emily Hillaker Michael Chavarria Fareea Khaliq Adam Schwark Source Type: research
