Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain.
Conclusions. Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP. PMID: 27445626 [PubMed - in process] (Source: Pain Research and Management)
Source: Pain Research and Management - July 26, 2016 Category: Anesthesiology Authors: Tetsunaga T, Tetsunaga T, Tanaka M, Nishida K, Takei Y, Ozaki T Tags: Pain Res Manag Source Type: research

Change in prescription habits after federal rescheduling of hydrocodone combination products.
Abstract Nationally, health care providers wrote 259 million prescriptions for narcotic analgesics in 2012, or roughly one bottle of narcotics per US adult (1). In an effort to combat this ever-growing problem, the Drug Enforcement Administration changed the schedule of hydrocodone combination products from schedule III to schedule II on October 6, 2014. Fourteen Baylor Scott & White pharmacies encompassing a 200-mile radius in Central Texas were queried for prescription information on hydrocodone/acetaminophen, morphine, codeine/acetaminophen, and tramadol before and after the rescheduling to evaluate trends ...
Source: Baylor University Medical Center Proceedings - June 30, 2016 Category: Universities & Medical Training Authors: Seago S, Hayek A, Pruszynski J, Newman MG Tags: Proc (Bayl Univ Med Cent) Source Type: research

How to Apply the AHS Evidence Assessment of the Acute Treatment of Migraine in Adults to your Patient with Migraine.
Abstract The "Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies" provides levels of evidence for medication efficacy for acute treatment of migraine. The goal of this companion paper is to provide guidance on how to choose between evidence-based treatment options, and, based on the clinical characteristics of the patient and their migraine attacks, to provide guidance on designing an individualized strategy for managing migraine attacks. The acute pharmacological treatments described in the American Headache Society evidence assessment ...
Source: Headache - June 19, 2016 Category: Neurology Authors: Pringsheim T, Davenport WJ, Marmura MJ, Schwedt TJ, Silberstein S Tags: Headache Source Type: research

What are the therapeutic alternatives to Dextropropoxyphene in France? A prescribers ’ survey
Publication date: Available online 16 June 2016 Source:Anaesthesia Critical Care & Pain Medicine Author(s): Frédéric Aubrun, Emilie Chrétien, Laurent Letrilliart, Marine Ginoux, Manon Belhassen, Michel Lanteri-Minet, Eric Van Ganse, Hélène Beloeil About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic ha...
Source: Anaesthesia, Critical Care and Pain Medicine - June 17, 2016 Category: Anesthesiology Source Type: research

What are the therapeutic alternatives to Dextropropoxyphene in France? A prescribers’ survey
Publication date: Available online 16 June 2016 Source:Anaesthesia Critical Care & Pain Medicine Author(s): Frédéric Aubrun, Emilie Chrétien, Laurent Letrilliart, Marine Ginoux, Manon Belhassen, Michel Lanteri-Minet, Eric Van Ganse, Hélène Beloeil About a year after dextropropoxyphene (DXP) withdrawal from the French market, we conducted a survey among members of the French Society of Anesthesia & Intensive Care Medicine (Sfar) and of the French Society of the Study and Treatment of Pain (SFETD) to identify the indications for which this WHO level II analgesic ha...
Source: Anaesthesia, Critical Care and Pain Medicine - June 16, 2016 Category: Anesthesiology Source Type: research

How to Apply the AHS Evidence Assessment of the Acute Treatment of Migraine in Adults to your Patient with Migraine
The “Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies” provides levels of evidence for medication efficacy for acute treatment of migraine. The goal of this companion paper is to provide guidance on how to choose between evidence‐based treatment options, and, based on the clinical characteristics of the patient and their migraine attacks, to provide guidance on designing an individualized strategy for managing migraine attacks. The acute pharmacological treatments described in the American Headache Society evidence assessment can be divided...
Source: Headache: The Journal of Head and Face Pain - May 31, 2016 Category: Neurology Authors: Tamara Pringsheim, William Jeptha Davenport, Michael J. Marmura, Todd J. Schwedt, Stephen Silberstein Tags: Views and Perspectives Source Type: research

Spray-dried high-amylose sodium carboxymethyl starch: impact of α-amylase on drug-release profile.
In this study, the influence of α-amylase and the residence time in acidic conditions on the drug-release profile was evaluated for a once-daily acetaminophen formulation (Acetaminophen SR) and a once-daily tramadol hydrochloride formulation (Tramadol SR). Both formulations were based on SD HASCA. α-Amylase concentrations ranging from 0 IU/L to 20000 IU/L did not significantly affect the drug-release profiles of acetaminophen and tramadol hydrochloride from SD HASCA tablets (f2> 50) for all but only one of the studied conditions (f2 = 47). Moreover, the drug-release properties from both SD HASC...
Source: Drug Development and Industrial Pharmacy - April 27, 2016 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Conservative treatment of acute knee osteoarthritis: A review of the Cochrane Library
Conclusions Five main strategies for the conservative treatment of knee osteoarthritis exist that must be used before indicating surgical treatment: medical treatment, physical medicine and rehabilitation, intra-articular injections, acupuncture, and self-management education programs. (Source: Journal of Acute Disease)
Source: Journal of Acute Disease - April 1, 2016 Category: Emergency Medicine Source Type: research

Controversy: hirudotherapy (leech therapy) as an alternative treatment for osteoarthritis.
Authors: Gunawan F, Wibowo YR, Bunawan NC, Turner JH Abstract Osteoarthritis (OA) is the most common degenerative joint disease found in the elderly. Drug options that are recommended by the American Academy of Orthopaedic Surgeon (AAOS) are acetaminophen, NSAIDs, tramadol, capscaicin and intraarticular corticosteroids. However, there is concern for the possible side effects resulting from long term use of those medications. Researchers are searching for a safer treatment modality for OA. Leech therapy (hirudotheraphy) is one of the therapies under investigation, given its purported analgesic and antiinflammatory p...
Source: Acta medica Indonesiana - December 11, 2015 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Novel management of postoperative pain using only oral analgesics after LADG
Conclusion Postoperative pain management using oral analgesics after LADG is feasible and safe, and is an ideal pain treatment associated with few adverse events while providing pain relief not inferior to epidural anesthesia. (Source: Surgery Today)
Source: Surgery Today - December 9, 2015 Category: Surgery Source Type: research

Effect Size Comparison of Ketorolac Nasal Spray and Commonly Prescribed Oral Combination Opioids for Pain Relief After Third Molar Extraction Surgery.
CONCLUSIONS: The treatment effect sizes of ketorolac nasal spray were similar to or higher than the opioid comparators after third molar surgery, a well-accepted pain model. These results support ketorolac nasal spray as an effective treatment for moderate to moderately severe short-term pain. PMID: 26616001 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - December 1, 2015 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Preoperative Local Administration of Morphine as an Add-on Therapy in Patients Undergoing Surgical Removal of an Odontogenic Maxillary Cyst. A Randomized, Double-Blind Pilot Study.
CONCLUSION: Within the limitations of this study, local administration of 1 mg of morphine prior to the surgical removal of an odontogenic maxillary cyst was safe, but it did not prove to be very effective as an add-on therapy for postoperative pain control. PMID: 26485385 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - October 23, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Clinical efficacy of hydrocodone-acetaminophen and tramadol for control of postoperative pain in dogs following tibial plateau leveling osteotomy.
CONCLUSIONS AND CLINICAL RELEVANCE Overall, differences in pain scores between dogs that received hydrocodone-acetaminophen or tramadol were minor. The percentage of dogs with treatment failure in both groups was considered unacceptable. PMID: 26309103 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - August 29, 2015 Category: Veterinary Research Authors: Benitez ME, Roush JK, McMurphy R, KuKanich B, Legallet C Tags: Am J Vet Res Source Type: research

Pharmacokinetics of hydrocodone and tramadol administered for control of postoperative pain in dogs following tibial plateau leveling osteotomy.
CONCLUSIONS AND CLINICAL RELEVANCE The pharmacokinetics of tramadol and metabolites were similar to those in previous studies. Serum tramadol concentrations varied widely, and concentrations of the active M1 metabolite were low. Metabolism of hydrocodone to hydromorphone in dogs was poor. Further study is warranted to assess variables that affect metabolism and efficacy of these drugs in dogs. PMID: 26309104 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - August 29, 2015 Category: Veterinary Research Authors: Benitez ME, Roush JK, KuKanich B, McMurphy R Tags: Am J Vet Res Source Type: research

Tramadol versus codeine/acetaminophen after pediatric tonsillectomy: A prospective, double-blinded, randomized controlled trial.
CONCLUSIONS: As part of multimodal analgesia, scheduled plus as-needed tramadol may be considered for children in the postoperative setting due to its analgesic properties, low potential for side effects, and good safety profile. PMID: 26312955 [PubMed - as supplied by publisher] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - August 28, 2015 Category: Addiction Tags: J Opioid Manag Source Type: research

Safety and Tolerability of Biphasic Immediate ‐Release/Extended‐Release Oxycodone/Acetaminophen Tablets: Analysis of 11 Clinical Trials
Abstract ObjectivesTo characterize the safety of immediate‐release (IR)/extended‐release (ER) oxycodone (OC)/acetaminophen (APAP). MethodsData were assessed from 9 phase 1 trials in healthy volunteers and recreational users of prescription opioids (N = 405), including 5 single‐dose and 3 multidose open‐label pharmacokinetic studies of IR/ER OC/APAP and active comparators; and 1 randomized, controlled, single‐dose human abuse potential (HAP) study comparing IR/ER OC/APAP, IR OC/APAP, and placebo in recreational users of opioids; and 2 phase 3 trials (N = 701) including a 48‐hour placebo...
Source: Pain Practice - August 21, 2015 Category: Anesthesiology Authors: Thomas Barrett, Kenneth Kostenbader, Srinivas Nalamachu, Michael Giuliani, Jim L. Young Tags: Original Article Source Type: research

[Analgesics in geriatric patients : Adverse side effects and interactions].
Abstract Pain is a widespread symptom in clinical practice. Older adults and chronically ill patients are particularly affected. In multimorbid geriatric patients, pharmacological pain treatment is an extension of a previously existing multimedication. Besides the efficacy of pain treatment, drug side effects and drug-drug interactions have to be taken into account to minimize the health risk for these patients. Apart from the number of prescriptions, the age-related pharmacokinetic and pharmacodynamic changes significantly increase the risk among older adults. The use of non-steroidal anti-inflammatory drugs (NSA...
Source: Zeitschrift fur Gerontologie und Geriatrie - July 8, 2015 Category: Geriatrics Authors: Gosch M Tags: Z Gerontol Geriatr Source Type: research

Safety and Tolerability of Biphasic Immediate‐Release/Extended‐Release Oxycodone/Acetaminophen Tablets: Analysis of 11 Clinical Trials
Abstract ObjectivesTo characterize the safety of immediate‐release (IR)/extended‐release (ER) oxycodone (OC)/acetaminophen (APAP). MethodsData were assessed from 9 phase 1 trials in healthy volunteers and recreational users of prescription opioids (N = 405), including 5 single‐dose and 3 multidose open‐label pharmacokinetic studies of IR/ER OC/APAP and active comparators; and 1 randomized, controlled, single‐dose human abuse potential (HAP) study comparing IR/ER OC/APAP, IR OC/APAP, and placebo in recreational users of opioids; and 2 phase 3 trials (N = 701) including a 48‐hour placebo...
Source: Pain Practice - July 1, 2015 Category: Anesthesiology Authors: Thomas Barrett, Kenneth Kostenbader, Srinivas Nalamachu, Michael Giuliani, Jim L. Young Tags: Original Article Source Type: research

Double-blind randomized placebo-controlled trial to compare the effects of gabapentin, pregabalin and tramadol + acetaminophen combination in improvement of pain in patients with painful diabetic neuropathy
Abstract Double-blind randomized placebo-controlled trial to compare the effects of gabapentin (900–3600 mg/per day)/pregabalin (150–600 mg per day) in improvement of pain in patients with painful diabetic neuropathy. All diabetic patients were subjected to detailed history and thorough clinical examination, and those with painful diabetic neuropathy were taken into account for study after informed consent. Total of 120 cases were examined and investigated (30 patients in each group, for a total of four groups). Each group was allotted one of the four drugs including placebo, methylcobalamin ...
Source: International Journal of Diabetes in Developing Countries - March 27, 2015 Category: Endocrinology Source Type: research

Efficacy of tramadol–acetaminophen tablets in low back pain patients with depression
This study investigated the outcomes of LBP patients with depression treated with tramadol–acetaminophen tablets. Methods Of 95 patients with chronic LBP, 70 (26 men, 44 women; mean age 64 years) who were judged as having depression by the Self-Rating Depression Scale (SDS) were included in this study. In this trial, patients received one of two randomly assigned 8-week treatment regimes: tramadol–acetaminophen (Tramadol group, n = 35) and non-steroidal anti-inflammatory drugs (NSAIDs) (NSAID group, n = 35). In addition to completing self-report q...
Source: Journal of Orthopaedic Science - February 2, 2015 Category: Orthopaedics Source Type: research

Tramadol-related psychosis in a patient with bipolar I disorder.
CONCLUSIONS: Tramadol HCl is commonly prescribed in clinical practice and psychotic symptoms related to it are uncommon. We should be careful about the rare but important adverse events while prescribing tramadol HCl. PMID: 25603153 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - January 26, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

An Assessment of the Pharmacokinetics of a Sustained-Release Formulation of a Tramadol/Acetaminophen Combination in Healthy Subjects.
This study aimed to evaluate the pharmacokinetic profiles of an SR 75-mg tramadol/650-mg acetaminophen formulation after a single dose compared with an immediate release (IR) 37.5-mg tramadol/325-mg acetaminophen formulation after 2 doses and at steady state and to assess the effect of food on the pharmacokinetic SR formulation profile after a single dose. METHODS: Two clinical trials were conducted: (1) an open-label, randomized, 3-period, 3-treatment, crossover study to assess the pharmacokinetic SR (one 75-mg tramadol/650-mg acetaminophen combination tablet) formulation profiles after a single dose and IR (one 37.5...
Source: Clinical Therapeutics - January 21, 2015 Category: Drugs & Pharmacology Authors: Im YJ, Jeon JY, Kim EY, Kim Y, Oh DJ, Yoo JS, Shin DH, Chae SW, Kim MG Tags: Clin Ther Source Type: research

The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research

The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research

Tramadol and Hypoglycemia One More Thing to Worry About
Pain is one of the leading reasons why patients seek medical attention, and over the past 2 decades, clinicians, health care institutions, medical organizations, and regulators have become increasingly attentive to its management. Yet despite the importance of pain as a clinical entity, the well of approved pharmacologic options is shallow, consisting principally of acetaminophen, nonsteroidal anti-inflammatory drugs, and opioids, along with off-label alternatives including certain anticonvulsants, antidepressants, and a smattering of other drugs for some types of pain. However, the expectation that analgesics can signific...
Source: JAMA Internal Medicine - December 8, 2014 Category: Internal Medicine Source Type: research

Undetected Ultracet™ dependence in an adolescent with nonmalignant back pain.
This report discusses an 18-year-old woman with idiopathic scoliosis and clinical depression secondary to undertreated refractory chronic back pain who underwent surgery to correct pseudoarthrosis after a prior spinal instrumentation operation. This intervention in conjunction with a course of patient-controlled analgesia, hydromorphone, and outpatient tramadol, naproxen, methadone, and gabapentin was successful in addressing her long-standing lumbar pain. The patient, however, continued to complain to her pain management team of postsurgical discomfort and insisted on being prescribed Ultracet™ (acetaminophen-tramad...
Source: Journal of Opioid Management - December 2, 2014 Category: Addiction Tags: J Opioid Manag Source Type: research

Acetaminophen and non-steroidal anti-inflammatory drugs interact with morphine and tramadol analgesia for the treatment of neuropathic pain in rats
Conclusions The combination of opioids with indomethacin or acetaminophen produced a synergistic analgesic effect both in inflammatory and neuropathic pain with some exceptions. The efficacy of these combinations for neuropathic pain was not different from that for inflammatory pain. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 25, 2014 Category: Anesthesiology Source Type: research

A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement
Current Medical Research and Opinion, Ahead of Print. (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 31, 2014 Category: Research Tags: article Source Type: research

Cost/effectiveness evaluation of three fixed combinations of acetaminophen and opioids in the management of acute pain in Colombia
Conclusion The analysis, from the payer and patient perspectives, demonstrates that the AC formulation has a lower cost and is more effective in reducing pain within the first 4–6h after administration, compared with the AH and AT formulations in their specific indications. (Source: Colombian Journal of Anesthesiology)
Source: Colombian Journal of Anesthesiology - October 12, 2014 Category: Anesthesiology Source Type: research

The addition of tramadol to a standard IV acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy?
PMID: 25279676 [PubMed - in process] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - October 10, 2014 Category: Anesthesiology Authors: Allegaert K, van den Anker JN Tags: Paediatr Anaesth Source Type: research

The addition of tramadol to a standard IV acetaminophen/morphine analgesia protocol in neonates: purposeful or just polypharmacy?
(Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - October 3, 2014 Category: Anesthesiology Authors: Karel Allegaert, John N. Anker Tags: Correspondence Source Type: research

Progressive change in joint degeneration in patients with knee or hip osteoarthritis treated with fentanyl in a randomized trial.
CONCLUSION: Fentanyl may induce progressive changes in knee or hip OA during a relatively short period, compared with oral Non-Steroidal Anti-Inflammatory Drugs or tramadol. PMID: 25048500 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - July 25, 2014 Category: Universities & Medical Training Authors: Fujii T, Takana K, Orita S, Inoue G, Ochiai N, Kuniyoshi K, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Yamauchi K, Toyone T, Nakamura J, Kishida S, Takahashi K, Ohtori S Tags: Yonsei Med J Source Type: research

The addition of tramadol to the standard of IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial.
CONCLUSION: Tramadol's addition to standard analgesia in this small group of postsurgical neonates did not appear to have any positive effect on time to extubation, morphine or midazolam exposure, or pain scores. This questions the benefit of tramadol for postsurgical neonates. Importantly, no seizures occurred in these ill neonates who may potentially be at greater risk of tramadol toxicity compared with adults. PMID: 25040756 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - July 14, 2014 Category: Anesthesiology Authors: Olischar M, Palmer GM, Orsini F, Davidson AJ, Perkins EJ, Lee KJ, Everest NJ, Cranswick NE, Hunt RW Tags: Paediatr Anaesth Source Type: research

The addition of tramadol to the standard of IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo‐controlled trial
ConclusionTramadol's addition to standard analgesia in this small group of postsurgical neonates did not appear to have any positive effect on time to extubation, morphine or midazolam exposure, or pain scores. This questions the benefit of tramadol for postsurgical neonates. Importantly, no seizures occurred in these ill neonates who may potentially be at greater risk of tramadol toxicity compared with adults. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - July 14, 2014 Category: Anesthesiology Authors: Monika Olischar, Greta M. Palmer, Francesca Orsini, Andrew J. Davidson, Elizabeth J. Perkins, Katherine J. Lee, Neil J. Everest, Noel E. Cranswick, Rod W. Hunt Tags: Original Article Source Type: research

[Pain management in chronic pancreatitis and chronic inflammatory bowel diseases].
n JC Abstract Apart from local inflammation and defects in secretion, central mechanisms are important for pain etiology in chronic pancreatitis. Therefore, centrally acting co-analgetic agents can be used in addition to classical pain medications. Endoscopic interventions are preferred in patients with obvious dilation of the pancreatic duct. Surgical interventions are generally more effective although they are usually reserved for patients with prior failure of conservative treatment. Diverse surgical options with different efficacies and morbidities are used in individual patients.One of the main problems in ch...
Source: Schmerz - June 1, 2014 Category: Anesthesiology Authors: Preiß JC, Hoffmann JC Tags: Schmerz Source Type: research

Preparation of NiFe2O4/graphene nanocomposite and its application as a modifier for the fabrication of an electrochemical sensor for the simultaneous determination of tramadol and acetaminophen.
Abstract An effective electrochemical sensor for the rapid and simultaneous determination of tramadol and acetaminophen based on carbon paste electrode (CPE) modified with NiFe2O4/graphene nanoparticles was developed. The structures of the synthesized NiFe2O4/graphene nanocomposite and the electrode composition were confirmed by X-ray diffraction (XRD) spectrometry, Fourier transform infrared (FT-IR) spectrometry and scanning electron microscopy (SEM). The peak currents of square wave voltammetry of tramadol and acetaminophen increased linearly with their concentration in the range of 0.01-9μmolL(-1). The detec...
Source: Analytica Chimica Acta - May 31, 2014 Category: Chemistry Authors: Afkhami A, Khoshsafar H, Bagheri H, Madrakian T Tags: Anal Chim Acta Source Type: research

The efficacy of duloxetine, non-steroidal anti-inflammatory drugs, and opioids in osteoarthritis: a systematic literature review and meta-analysis
Conclusions: This analysis suggests no difference between duloxetine and other post-first line oral treatments for osteoarthritis (OA) in total WOMAC score after approximately 12 weeks of treatment. Significant results for 3 compounds (1 better and 2 worse) were not consistent across performed analyses. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - March 11, 2014 Category: Epidemiology Authors: Julie MyersRonald C WielageBaoguang HanKaren PriceJames GahnMarie-Ange PagetMichael Happich Source Type: research

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of the Extended-Release Tramadol Hydrochloride/Acetaminophen Fixed-Dose Combination Tablet for the Treatment of Chronic Low Back Pain.
Abstract BACKGROUND: Chronic low back pain is a common condition that is often difficult to treat. The combination of tramadol hydrochloride and acetaminophen in an extended-release formulation has been shown to provide rapid and long-lasting analgesic effects resulting from the synergistic activity of these 2 active ingredients. OBJECTIVE: The goal of this study was to evaluate the efficacy and safety of extended-release tramadol hydrochloride 75-mg/acetaminophen 650-mg fixed-dose combination tablets (TA-ER) for the treatment of chronic low back pain. METHODS: This Phase III, double-blind, placebo-contr...
Source: Clinical Therapeutics - October 30, 2013 Category: Drugs & Pharmacology Authors: Hyup Lee J, Lee CS, on behalf of the Ultracet ER Study Group Tags: Clin Ther Source Type: research

Comparative study of intravenous Tramadol versus Ketorolac for preventing postoperative pain after third molar surgery – A prospective randomized study
Abstract: The aim of this comparative, prospective, randomized, controlled study was to evaluate two different regimens of analgesics: a preoperative intravenous dose of either Tramadol or Ketorolac given 10 min prior to surgery to assess their impact on clinical recovery after third molar surgery. Forty patients requiring surgical extraction of unilateral impacted mandibular third molars similar in position were enrolled in the study. Patients were randomly divided into two groups based on permuting the numbers. Patients in Group 1 and Group 2 were administered either Tramadol 50 mg or Ketorolac 30 mg, intr...
Source: Journal of Cranio-Maxillofacial Surgery - October 25, 2013 Category: ENT & OMF Authors: Prathibha Gopalraju, Ramanujapuram Manikarnike Lalitha, Kavitha Prasad, Krishnappa Ranganath Source Type: research

Pre emptive analgesia for reducing pain after cholecystectomy: Oral tramadol vs. acetaminophen codeine.
Abstract BACKGROUND: Considering that protocols of postoperative pain management would be planned regarding the facilities of each center or region and the importance of its proper management to reduce its related complication and improve patient's satisfaction, in this study we compared the effect of orally administrated tramadol and acetaminophen-codeine in this regard. MATERIALS AND METHODS: In this prospective randomized double-blind clinical trial, 136 (68 in tramadol and 68 in acetaminophen codeine groups) ASA I and II patients scheduled for open cholecystectomy under general anaesthesia were enrolled. ...
Source: Pain Physician - August 12, 2013 Category: Anesthesiology Authors: Zavareh SM, Kashefi P, Saghaei M, Emami H Tags: Adv Biomed Res Source Type: research

Spinal and peripheral adenosine A1 receptors contribute to antinociception by tramadol in the formalin test in mice.
In this study, we explored the involvement of spinal and peripheral adenosine A1 receptors in antinociception by tramadol, and determined whether spinal serotonin 5-HT7 receptors were linked to spinal A1 receptor actions. Antinociception was examined using the 2% formalin test in mice. Tramadol was administered systemically (intraperitoneal) or peripherally (intraplantar). Caffeine (non-selective A1/A2A receptor antagonist) and SCH58261 (selective A2A receptor antagonist) were given systemically, while DPCPX (selective A1 receptor antagonist) was given systemically, spinally (lumbar puncture), or peripherally. Systemic tra...
Source: European Journal of Pharmacology - July 16, 2013 Category: Drugs & Pharmacology Authors: Sawynok J, Reid AR, Liu J Tags: Eur J Pharmacol Source Type: research