Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies.
Conclusions: Long-term consumption of pain relievers may affect the rate of orthodontic tooth movement. The orthodontist should be capable of identifying patients taking pain relievers independently of orthodontic treatment and consider the possible implications.
Trial registration: PROSPERO (CRD42017078208).
PMID: 30590549 [PubMed - as supplied by publisher] (Source: European Journal of Orthodontics)
Source: European Journal of Orthodontics - December 27, 2018 Category: Dentistry Authors: Makrygiannakis MA, Kaklamanos EG, Athanasiou AE Tags: Eur J Orthod Source Type: research
Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial.
CONCLUSIONS: The current study showed that both ketorolac and the combination of ketorolac plus tramadol/acetaminophen showed good control of pain after the extraction of the lower third molars. Although the combination group showed lower pain at 9 h, the difference is small and not clinically relevant.
PMID: 30573715 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 24, 2018 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
Herbal medicines in Iran advertised as opioid withdrawal drugs - analysis by gas chromatography-mass spectrometry
ConclusionsNearly all of the handmade and illegally distributed herbal medicines for the treatment of drug withdrawal contained at least one opioid or illegal drug, indicating that there was evidence of adulteration and highlighting the dangers to users. It is important to raise awareness of people, particularly warning them against the use of such products sold by herbal shops for the treatment of addiction. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - December 3, 2018 Category: Complementary Medicine Source Type: research
Opioid Prescribing Habits in Sickle Cell Disease: An International Survey of Providers
This study aimed to describe the opioid prescribing habits among international providers treating individuals with SCD, to better assess the different medications used for outpatient management of SCD-related pain both in the United States (US) and internationally.Methods: A thirty-question REDcap survey was disseminated electronically. Participants were recruited using a combination purposive and snowball sampling strategy. Providers were initially identified by email using databases from SCD conferences. After the initial responses were received, responding participants were asked to refer other providers who treat SCD.R...
Source: Blood - November 21, 2018 Category: Hematology Authors: El-Amin, N., Nietert, P., Kanter, J. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster II Source Type: research
Acetaminophen reduces acute and persistent incisional pain after hysterectomy.
CONCLUSIONS: Our results suggest that acetaminophen reduces the risk and intensity of persistent incisional pain. However, there are other mechanisms by which acetaminophen might reduce persistent pain.
KEY WORDS: Anesthesia, acetaminophen, Persistent surgical pain, Postoperative acute pain.
PMID: 30337510 [PubMed - in process] (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - October 21, 2018 Category: Surgery Tags: Ann Ital Chir Source Type: research
Effect on morphine requirement of early administration of oral acetaminophen versus acetaminophen/tramadol combination in acute pain
Pain Practice,Volume 0, Issue ja, -Not available-. (Source: Pain Practice)
Source: Pain Practice - October 10, 2018 Category: Anesthesiology Authors: Wahid Bouida,
Kaouthar Beltaief,
Mohamed Amine Msolli,
Maryem Ben Marzouk,
Hamdi Boubaker,
Mohamed Habib Grissa,
Asma Zorgati,
Mehdi Methamem,
Riadh Boukef,
Asma Belguith,
Semir Nouira Source Type: research
Impact of rescheduling hydrocodone-combination products in an urban Texas county healthcare system.
CONCLUSION: The scheduling change of HCPs is associated with an immediate decrease in hydrocodone-acetaminophen use at our institution while a simultaneous rise in acetaminophen-codeine products was observed.
PMID: 30234922 [PubMed - in process] (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - September 22, 2018 Category: Addiction Tags: J Opioid Manag Source Type: research
Acetaminophen, ibuprofen, and tramadol analgesic interactions after adenotonsillectomy
Pediatric Anesthesia, EarlyView. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - August 17, 2018 Category: Anesthesiology Authors: Jacqueline A. Hannam
,
Brian J. Anderson
,
Amanda Potts
,
Suellen Walker Source Type: research
Acetaminophen, ibuprofen, and tramadol analgesic interactions after adenotonsillectomy.
CONCLUSION: Ibuprofen has an EC50 for analgesia in children similar to that of adults (3.95 mg/L; 95%CI 2.57-7.53, vs 5-10 mg/L adults). The maximum effect from combination therapy (ie, 65% reduction in pain score) achieves satisfactory analgesia with commonly used doses but increased dose adds little additional benefit. The addition of tramadol to this analgesic mixture prolongs analgesia duration.
PMID: 30117229 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - August 16, 2018 Category: Anesthesiology Authors: Hannam JA, Anderson BJ, Potts A Tags: Paediatr Anaesth Source Type: research
Alternating Current Iontophoresis for Control of Postoperative Pain.
Authors: Kubota K, Miyamoto T, Inoue T, Fukayama H
Abstract
Control of early postoperative pain entails the use of various medications including acetaminophen, nonsteroidal anti-inflammatory drugs, selective cyclooxygenase-2 inhibitors, tramadol, and opioids. However, these medications should be carefully administered in patients with aspirin-exacerbated respiratory disease because some medications may trigger adverse reactions after maxillofacial surgeries. The goal of postoperative pain control in patients with aspirin-exacerbated respiratory disease is to eliminate pain without complications. Local anes...
Source: Anesthesia Progress - June 30, 2018 Category: Anesthesiology Tags: Anesth Prog Source Type: research
Comparing the Efficacy of Peritonsillar Injection of Tramadol With Honey in Controlling Post-Tonsillectomy Pain in Adults
Conclusion:
The current investigation confirmed the positive impact of tramadol on post-tonsillectomy pain relief in adults. The authors also found that honey can be used as a complementary treatment along with acetaminophen and other analgesics for reducing post-tonsillectomy pain. Considering honey impact on wound healing and its anti-inflammatory effect, it is suggested for relieving complications after surgery. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2018 Category: Surgery Tags: Brief Clinical Studies Source Type: research
Acetaminophen Reduces acute and persistent incisional pain after hysterectomy.
CONCLUSIONS: Our results suggest that acetaminophen reduces the risk and intensity of persistent incisional pain. However, there are other mechanisms by which acetaminophen might reduce persistent pain.
KEY WORDS: Anesthesia, acetaminophen, Persistent surgical pain, Postoperative acute pain.
PMID: 29779020 [PubMed - as supplied by publisher] (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - May 21, 2018 Category: Surgery Tags: Ann Ital Chir Source Type: research
Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.
The objective of this study was to investigate the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the sulfating activity of SULT1A3 allozymes toward these analgesic compounds. Twelve non-synonymous coding SNPs (cSNPs) of SULT1A3/SULT1A4 were investigated, and the corresponding cDNAs were generated by site-directed mutagenesis. SULT1A3 allozymes, bacterially expressed and purified, exhibited differential sulfating activity toward each of the four analgesic compounds tested as substrates. Kinetic analyses of SULT1A3 allozymes further revealed significant differences in binding affinit...
Source: Archives of Biochemistry and Biophysics - April 26, 2018 Category: Biochemistry Authors: Bairam AF, Rasool MI, Alherz FA, Abunnaja MS, El Daibani AA, Kurogi K, Liu MC Tags: Arch Biochem Biophys Source Type: research
Novel Pharmacological Nonopioid Therapies in Chronic Pain
AbstractPurpose of ReviewOpioid use and abuse has led to a worldwide opioid epidemic. And while opioids are clinically useful when appropriately indicated, they are associated with a wide range of dangerous side effects and whether they are effective at treating or eliminating chronic pain is controversial. There has long been a need for the development of nonopioid alternative treatments for patients that live in pain, and until recently, only a few effective treatments were available. Today, there are a wide range of nonopioid treatments available including NSAIDs, acetaminophen, corticosteroids, nerve blocks, SSRIs, neu...
Source: Current Pain and Headache Reports - April 3, 2018 Category: Neurology Source Type: research
Comparison of tramadol/acetaminophen fixed-dose combination, tramadol, and acetaminophen in patients undergoing ambulatory arthroscopic meniscectomy.
CONCLUSION: The fixed-dose combination of tramadol/acetaminophen or tramadol alone is better than acetaminophen alone as a preemptive analgesic in patients undergoing ambulatory arthroscopic meniscectomy.
LEVEL OF EVIDENCE: Level III, therapeutic study.
PMID: 29598842 [PubMed - as supplied by publisher] (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - March 26, 2018 Category: Orthopaedics Authors: Solmaz FA, Kovalak E Tags: Acta Orthop Traumatol Turc Source Type: research
