The Pasteurian contribution to the history of vaccines
C R Biol. 2022 Sep 13;345(3):93-107. doi: 10.5802/crbiol.83.ABSTRACTVaccination, the transmission of "vaccine", a benign disease of cows, to immunize human beings against smallpox, was invented by Jenner at the end of the eighteenth century. Pasteur, convinced that the vaccine microbe was an attenuated form of the smallpox microbe, showed that, similarly, attenuated forms of other microbes immunized against animal diseases. When applying this principle to rabies, he realized that, in this case, the vaccine was in fact composed of dead microbes. One of his students immediately exploited this result to devise a vaccine again...
Source: Comptes Rendus Biologies - February 28, 2023 Category: Biology Authors: Maxime Schwartz Source Type: research
The Pasteurian contribution to the history of vaccines
C R Biol. 2022 Sep 13;345(3):93-107. doi: 10.5802/crbiol.83.ABSTRACTVaccination, the transmission of "vaccine", a benign disease of cows, to immunize human beings against smallpox, was invented by Jenner at the end of the eighteenth century. Pasteur, convinced that the vaccine microbe was an attenuated form of the smallpox microbe, showed that, similarly, attenuated forms of other microbes immunized against animal diseases. When applying this principle to rabies, he realized that, in this case, the vaccine was in fact composed of dead microbes. One of his students immediately exploited this result to devise a vaccine again...
Source: Comptes Rendus Biologies - February 28, 2023 Category: Biology Authors: Maxime Schwartz Source Type: research
The Pasteurian contribution to the history of vaccines
C R Biol. 2022 Sep 13;345(3):93-107. doi: 10.5802/crbiol.83.ABSTRACTVaccination, the transmission of "vaccine", a benign disease of cows, to immunize human beings against smallpox, was invented by Jenner at the end of the eighteenth century. Pasteur, convinced that the vaccine microbe was an attenuated form of the smallpox microbe, showed that, similarly, attenuated forms of other microbes immunized against animal diseases. When applying this principle to rabies, he realized that, in this case, the vaccine was in fact composed of dead microbes. One of his students immediately exploited this result to devise a vaccine again...
Source: Comptes Rendus Biologies - February 28, 2023 Category: Biology Authors: Maxime Schwartz Source Type: research
New typhoid vaccine using sponge-like reduced protocol: development and evaluation
CONCLUSION: The SLRP provided a simple, economical, and feasible method for BGs preparation.PMID:36844684 | PMC:PMC9950223 | DOI:10.7774/cevr.2023.12.1.70 (Source: Cell Research)
Source: Cell Research - February 27, 2023 Category: Cytology Authors: Rehab Bahy Asmaa Gaber Hamdallah Zedan Mona Mabrook Source Type: research
Immune response of S. Typhi-derived Vi polysaccharide and outer membrane protein A conjugate in mice
Typhoid fever is a serious concern precisely in developing nations. Still investigators are exploring a better conjugate partner for Vi-polysaccharide to develop a more effective vaccine for typhoid fever. Here, we cloned and expressed S. Typhi outer membrane protein A (OmpA). The conjugation of Vi-polysaccharide with OmpA was carried out by the carbodiimide (EDAC) method employing ADH as a linker. Total Ig and IgG generated against OmpA, and Vi polysaccharide was quantified by ELISA. Vi polysaccharide alone induced very low levels of Vi polysaccharide antibody. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - February 17, 2023 Category: Perinatology & Neonatology Authors: Shabirul Haque, Sanjukta Sengupta, Azhar Khan, Asok Kumar Mukhopadhyay, Maharaj Kishan Bhan, Ramesh Kumar, Bansilal Jailkhani Tags: Original Article Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
Typhoid Fever Surveillance, Incidence Estimates, and Progress Toward Typhoid Conjugate Vaccine Introduction - Worldwide, 2018-2022
This report describes typhoid fever surveillance, incidence estimates, and the status of typhoid conjugate vaccine introduction during 2018-2022. Because routine surveillance for typhoid fever has low sensitivity, population-based studies have guided estimates of case counts and incidence in 10 countries since 2016 (3-6). In 2019, an updated modeling study estimated that 9.2 million (95% CI = 5.9-14.1) typhoid fever cases and 110,000 (95% CI = 53,000-191,000) deaths occurred worldwide, with the highest estimated incidence in the WHO South-East Asian (306 cases per 100,000 persons), Eastern Mediterranean (187), and African ...
Source: MMWR Morb Mortal Wkl... - February 16, 2023 Category: Epidemiology Authors: Molly Hancuh Jenny Walldorf Anna A Minta Carol Tevi-Benissan Kira A Christian Yoann Nedelec Kristen Heitzinger Matthew Mikoleit Amanda Tiffany Adwoa D Bentsi-Enchill Lucy Breakwell Source Type: research
A tool for evaluating heterogeneity in avidity of polyclonal antibodies
Diversity in specificity of polyclonal antibody (pAb) responses is extensively investigated in vaccine efficacy or immunological evaluations, but the heterogeneity in antibody avidity is rarely probed as convenient tools are lacking. Here we have developed a polyclonal antibodies avidity resolution tool (PAART) for use with label-free techniques, such as surface plasmon resonance and biolayer interferometry, that can monitor pAb-antigen interactions in real time to measure dissociation rate constant (kd) for defining avidity. PAART utilizes a sum of exponentials model to fit the dissociation time-courses of pAb-antigens in...
Source: Frontiers in Immunology - February 16, 2023 Category: Allergy & Immunology Source Type: research
Cost-effectiveness of sub-national geographically targeted vaccination programs: A systematic review
Vaccine. 2023 Feb 11:S0264-410X(23)00132-9. doi: 10.1016/j.vaccine.2023.02.006. Online ahead of print.ABSTRACTImmunization is an essential component of national health plans. However, the growing number of new vaccine introductions, vaccination campaigns and increasing administrative costs create logistic and financial challenges, especially in resource-limited settings. Sub-national geographic targeting of vaccination programs is a potential strategy for governments to reduce the impact of infectious disease outbreaks while optimizing resource allocation and reducing costs, promoting sustainability of critically important...
Source: Vaccine - February 13, 2023 Category: Allergy & Immunology Authors: Marya Getchell Ericka Joinelle Mantaring Kaisin Yee Paul Pronyk Source Type: research
Cost-effectiveness of sub-national geographically targeted vaccination programs: A systematic review
Vaccine. 2023 Feb 11:S0264-410X(23)00132-9. doi: 10.1016/j.vaccine.2023.02.006. Online ahead of print.ABSTRACTImmunization is an essential component of national health plans. However, the growing number of new vaccine introductions, vaccination campaigns and increasing administrative costs create logistic and financial challenges, especially in resource-limited settings. Sub-national geographic targeting of vaccination programs is a potential strategy for governments to reduce the impact of infectious disease outbreaks while optimizing resource allocation and reducing costs, promoting sustainability of critically important...
Source: Vaccine - February 13, 2023 Category: Allergy & Immunology Authors: Marya Getchell Ericka Joinelle Mantaring Kaisin Yee Paul Pronyk Source Type: research
A Phase II/III, Multicenter, Observer-blinded, Randomized, Non-inferiority and Safety, study of typhoid conjugate vaccine (EuTCV) compared to Typbar-TCV ® in healthy 6 Months-45 years aged participants
Vaccine. 2023 Feb 9:S0264-410X(22)01524-9. doi: 10.1016/j.vaccine.2022.12.007. Online ahead of print.ABSTRACTThe typhoid conjugate vaccine (TCV) ensures a long-lasting protective immune response, requires fewer doses and is fit for children under 2 years of age. From Phase I study, EuTCV displayed considerable immunogenicity and reliable safety, thus endorsing further examination in Phase II/III trials. Therefore, a clinical Phase II/III study (NCT04830371) was conducted to evaluate its efficacy in healthy Filipino participants aged 6 months to 45 years through administration of the test vaccine (Arm A, B, and C) or compar...
Source: Vaccine - February 11, 2023 Category: Allergy & Immunology Authors: Yeong Ok Baik Youngjin Lee Chankyu Lee Soo Kyung Kim Jooyoung Park Meixiang Sun DaYe Jung Jin Young Jang Tae Jun Yong Jeong Woo Park Sungho Jeong Suwon Lim Seung Hyun Han Seuk Keun Choi Source Type: research
