A Phase II/III, Multicenter, Observer-blinded, Randomized, Non-inferiority and Safety, study of typhoid conjugate vaccine (EuTCV) compared to Typbar-TCV ® in healthy 6 Months-45 years aged participants
Vaccine. 2023 Feb 9:S0264-410X(22)01524-9. doi: 10.1016/j.vaccine.2022.12.007. Online ahead of print.ABSTRACTThe typhoid conjugate vaccine (TCV) ensures a long-lasting protective immune response, requires fewer doses and is fit for children under 2 years of age. From Phase I study, EuTCV displayed considerable immunogenicity and reliable safety, thus endorsing further examination in Phase II/III trials. Therefore, a clinical Phase II/III study (NCT04830371) was conducted to evaluate its efficacy in healthy Filipino participants aged 6 months to 45 years through administration of the test vaccine (Arm A, B, and C) or compar...
Source: Vaccine - February 11, 2023 Category: Allergy & Immunology Authors: Yeong Ok Baik Youngjin Lee Chankyu Lee Soo Kyung Kim Jooyoung Park Meixiang Sun DaYe Jung Jin Young Jang Tae Jun Yong Jeong Woo Park Sungho Jeong Suwon Lim Seung Hyun Han Seuk Keun Choi Source Type: research
Comparative frequency of specified adverse events following Vero cell culture-derived Japanese encephalitis and Vi capsular polysaccharide typhoid vaccines in U.S. military personnel, July 2011-August 2019
Vaccine. 2023 Jan 30:S0264-410X(23)00093-2. doi: 10.1016/j.vaccine.2023.01.061. Online ahead of print.ABSTRACTVero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC; Ixiaro) was approved in the United States in 2009. The previous JE vaccine, an inactivated mouse brain-derived vaccine, had been associated with rare, but serious, allergic and neurologic adverse events (AE). Studies and AE surveillance have supported JE-VC's safety, but one evaluation among military personnel found elevated hypersensitivity and neurologic AE rates. However, co-administration of multiple vaccines to some personnel might have affec...
Source: Vaccine - February 1, 2023 Category: Allergy & Immunology Authors: Srihari Seshadri Stacey W Martin Susan L Hills Limone C Collins Source Type: research
Comparative frequency of specified adverse events following Vero cell culture-derived Japanese encephalitis and Vi capsular polysaccharide typhoid vaccines in U.S. military personnel, July 2011-August 2019
Vaccine. 2023 Jan 30:S0264-410X(23)00093-2. doi: 10.1016/j.vaccine.2023.01.061. Online ahead of print.ABSTRACTVero cell culture-derived Japanese encephalitis (JE) vaccine (JE-VC; Ixiaro) was approved in the United States in 2009. The previous JE vaccine, an inactivated mouse brain-derived vaccine, had been associated with rare, but serious, allergic and neurologic adverse events (AE). Studies and AE surveillance have supported JE-VC's safety, but one evaluation among military personnel found elevated hypersensitivity and neurologic AE rates. However, co-administration of multiple vaccines to some personnel might have affec...
Source: Vaccine - February 1, 2023 Category: Allergy & Immunology Authors: Srihari Seshadri Stacey W Martin Susan L Hills Limone C Collins Source Type: research
Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection
Sci Rep. 2023 Jan 9;13(1):393. doi: 10.1038/s41598-023-27400-1.ABSTRACTSalmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice. The Collaborative Cross (CC) is a large panel of recombinant inbred strains which has a wider range of genetic diversity than laboratory inbred mouse strains. We found that the CC003/Unc and CC053/Unc strains are permissive to intraperitoneal but not oral route of S. Typhi infection and show histopatholog...
Source: Cancer Control - January 9, 2023 Category: Cancer & Oncology Authors: Kishore R Alugupalli Sudeep Kothari Matthew P Cravens Justin A Walker Darren T Dougharty Gregory S Dickinson Louis A Gatto Andreas J B äumler Tamding Wangdi Darla R Miller Fernando Pardo-Manuel de Villena Linda D Siracusa Source Type: research
Comparison of model predictions of typhoid conjugate vaccine public health impact and cost-effectiveness
Vaccine. 2022 Dec 29:S0264-410X(22)01557-2. doi: 10.1016/j.vaccine.2022.12.032. Online ahead of print.ABSTRACTModels are useful to inform policy decisions on typhoid conjugate vaccine (TCV) deployment in endemic settings. However, methodological choices can influence model-predicted outcomes. To provide robust estimates for the potential public health impact of TCVs that account for structural model differences, we compared four dynamic and one static mathematical model of typhoid transmission and vaccine impact. All models were fitted to a common dataset of age-specific typhoid fever cases in Kolkata, India. We evaluated ...
Source: Vaccine - December 31, 2022 Category: Allergy & Immunology Authors: Holly Burrows Marina Antill ón Jillian S Gauld Jong-Hoon Kim Vittal Mogasale Theresa Ryckman Jason R Andrews Nathan C Lo Virginia E Pitzer Source Type: research
