Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: The American Journal of Tropical Medicine and Hygiene - May 30, 2023 Category: Tropical Medicine Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: Am J Trop Med Hyg - May 30, 2023 Category: Infectious Diseases Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: The American Journal of Tropical Medicine and Hygiene - May 30, 2023 Category: Tropical Medicine Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: Am J Trop Med Hyg - May 30, 2023 Category: Infectious Diseases Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: The American Journal of Tropical Medicine and Hygiene - May 30, 2023 Category: Tropical Medicine Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Dynamic Incidence of Typhoid Fever over a 10-Year Period (2010-2019) in Kibera, an Urban Informal Settlement in Nairobi, Kenya
Am J Trop Med Hyg. 2023 May 30:tpmd220736. doi: 10.4269/ajtmh.22-0736. Online ahead of print.ABSTRACTTyphoid fever burden can vary over time. Long-term data can inform prevention strategies; however, such data are lacking in many African settings. We reexamined typhoid fever incidence and antimicrobial resistance (AMR) over a 10-year period in Kibera, a densely populated urban informal settlement where a high burden has been previously described. We used data from the Population Based Infectious Diseases Surveillance platform to estimate crude and adjusted incidence rates and prevalence of AMR in nearly 26,000 individuals ...
Source: Am J Trop Med Hyg - May 30, 2023 Category: Infectious Diseases Authors: Eric Ng'eno Margaret Lind Allan Audi Alice Ouma Clifford Oduor Patrick K Munywoki George O Agogo George Odongo Samuel Kiplangat Newton Wamola Mike Powel Osita Robert Mugoh Caroline Ochieng Victor Omballa Ondari D Mogeni Matthew Mikoleit Barry S Fields Joe Source Type: research
Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers
Introduction
This is the first efficacy study of an oral live attenuated vaccine against Salmonella Paratyphi A using a human challenge model of paratyphoid infection. S. Paratyphi A is responsible for 3.3 million cases of enteric fever every year, with over 19 000 deaths. Although improvements to sanitation and access to clean water are vital to reduce the burden of this condition, vaccination offers a cost-effective, medium-term solution. Efficacy trials of potential S. Paratyphi vaccine candidates in the field are unlikely to be feasible given the large number of participants required. Human challenge models therefore o...
Source: BMJ Open - May 24, 2023 Category: General Medicine Authors: McCann, N., Emary, K., Singh, N., Mclean, F., Camara, S., Jones, E., Kim, Y. C., Liu, X., Greenland, M., Conlin, K., Hill, J., Verheul, M., Robinson, H., Angus, B., Ramasamy, M. N., Levine, M. M., Pollard, A. J. Tags: Open access, Infectious diseases Source Type: research
A randomized, observer-blind, controlled phase III clinical trial assessing safety and immunological non-inferiority of Vi-diphtheria toxoid versus Vi-tetanus toxoid typhoid conjugate vaccine in healthy volunteers in eastern Nepal
Volume 19, Issue 1, December 2023 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - April 27, 2023 Category: Allergy & Immunology Authors: Shipra Chaudhary Gauri Shankar Shah Nisha Keshary Bhatta Prakash Poudel Basant Rai Surendra Uranw Prashant Mani Tripathi Basudha Khanal Anup Ghimire Nikita Rai Birendra Prasad Gupta Sridhar Vemula T. Anh Wartel Sushant Sahastrabuddhe Tarun Saluja Source Type: research
Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh
Vaccine. 2023 Apr 13:S0264-410X(23)00397-3. doi: 10.1016/j.vaccine.2023.04.014. Online ahead of print.ABSTRACTA cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of prote...
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Farhana Khanam Golap Babu Nazia Rahman Xinxue Liu Nazmul Hasan Rajib Shams Uddin Ahmed Md Ismail Hossen Prasanta Kumar Biswas Sarah Kelly Katherine Thesis-Nyland Yama Mujadidi Nigel A J McMillan Andrew J Pollard John D Clemens Firdausi Qadri Source Type: research
Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh
Vaccine. 2023 Apr 13:S0264-410X(23)00397-3. doi: 10.1016/j.vaccine.2023.04.014. Online ahead of print.ABSTRACTA cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of prote...
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Farhana Khanam Golap Babu Nazia Rahman Xinxue Liu Nazmul Hasan Rajib Shams Uddin Ahmed Md Ismail Hossen Prasanta Kumar Biswas Sarah Kelly Katherine Thesis-Nyland Yama Mujadidi Nigel A J McMillan Andrew J Pollard John D Clemens Firdausi Qadri Source Type: research
Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh
Vaccine. 2023 Apr 13:S0264-410X(23)00397-3. doi: 10.1016/j.vaccine.2023.04.014. Online ahead of print.ABSTRACTA cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of prote...
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Farhana Khanam Golap Babu Nazia Rahman Xinxue Liu Nazmul Hasan Rajib Shams Uddin Ahmed Md Ismail Hossen Prasanta Kumar Biswas Sarah Kelly Katherine Thesis-Nyland Yama Mujadidi Nigel A J McMillan Andrew J Pollard John D Clemens Firdausi Qadri Source Type: research
Screening of lipid-A related genes and development of low-endotoxicity live-attenuated Salmonella gallinarum by arnT deletion that elicits immune responses and protection against fowl typhoid in chickens
Dev Comp Immunol. 2023 Apr 10:104707. doi: 10.1016/j.dci.2023.104707. Online ahead of print.ABSTRACTIn the present study, lipid-A gene mutants of Salmonella gallinarum (SG) were screened, and the arnT mutant exhibited optimal acidic and oxidative-stress and macrophage-survival. Modifying lipid-A by arnT-deletion resulted in significantly reduced endotoxicity, virulence, and mortality. Therefore, the arnT-deleted vaccine-candidate strain JOL2841 was constructed and demonstrated to be safe due to appropriate clearance by the chicken immune system. The reduced-endotoxicity of JOL2841 was evident from the downregulation of TNF...
Source: Developmental and Comparative Immunology - April 12, 2023 Category: Allergy & Immunology Authors: Chandran Sivasankar Chamith Hewawaduge John Hwa Lee Source Type: research
Screening of lipid-A related genes and development of low-endotoxicity live-attenuated Salmonella gallinarum by arnT deletion that elicits immune responses and protection against fowl typhoid in chickens
Dev Comp Immunol. 2023 Apr 10:104707. doi: 10.1016/j.dci.2023.104707. Online ahead of print.ABSTRACTIn the present study, lipid-A gene mutants of Salmonella gallinarum (SG) were screened, and the arnT mutant exhibited optimal acidic and oxidative-stress and macrophage-survival. Modifying lipid-A by arnT-deletion resulted in significantly reduced endotoxicity, virulence, and mortality. Therefore, the arnT-deleted vaccine-candidate strain JOL2841 was constructed and demonstrated to be safe due to appropriate clearance by the chicken immune system. The reduced-endotoxicity of JOL2841 was evident from the downregulation of TNF...
Source: Developmental and Comparative Immunology - April 12, 2023 Category: Allergy & Immunology Authors: Chandran Sivasankar Chamith Hewawaduge John Hwa Lee Source Type: research
Screening of lipid-A related genes and development of low-endotoxicity live-attenuated Salmonella gallinarum by arnT deletion that elicits immune responses and protection against fowl typhoid in chickens
Dev Comp Immunol. 2023 Apr 10:104707. doi: 10.1016/j.dci.2023.104707. Online ahead of print.ABSTRACTIn the present study, lipid-A gene mutants of Salmonella gallinarum (SG) were screened, and the arnT mutant exhibited optimal acidic and oxidative-stress and macrophage-survival. Modifying lipid-A by arnT-deletion resulted in significantly reduced endotoxicity, virulence, and mortality. Therefore, the arnT-deleted vaccine-candidate strain JOL2841 was constructed and demonstrated to be safe due to appropriate clearance by the chicken immune system. The reduced-endotoxicity of JOL2841 was evident from the downregulation of TNF...
Source: Developmental and Comparative Immunology - April 12, 2023 Category: Allergy & Immunology Authors: Chandran Sivasankar Chamith Hewawaduge John Hwa Lee Source Type: research
