Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

Vaccine. 2023 Apr 13:S0264-410X(23)00397-3. doi: 10.1016/j.vaccine.2023.04.014. Online ahead of print.ABSTRACTA cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection.PMID:37061369 | DOI:10.1016/j.vaccine.2023.04.014

Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Farhana Khanam Golap Babu Nazia Rahman Xinxue Liu Nazmul Hasan Rajib Shams Uddin Ahmed Md Ismail Hossen Prasanta Kumar Biswas Sarah Kelly Katherine Thesis-Nyland Yama Mujadidi Nigel A J McMillan Andrew J Pollard John D Clemens Firdausi Qadri Source Type: research