Safety and immunogenicity of conjugate vaccine for typhoid (Vi-DT): Finding from an observer-blind, active-controlled, randomized, non-inferiority, phase III clinical trial among healthy volunteers
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - January 8, 2024 Category: Allergy & Immunology Authors: Dipesh TamrakarPranodan PoudelPragya ThapaSrijana SinghAmit KhadgiSameera ThapaRajendra TamrakarAnmol ShresthaSurendra MadhupGanesh Kumar RaiBirendra Prasad GuptaTarun SalujaSushant SahastrabuddheRajeev Shresthaa Dhulikhel Hospital, Kathmandu University H Source Type: research
Vaccine value profile for Salmonella enterica serovar Paratyphi A
Vaccine. 2023 Nov 3;41 Suppl 2:S114-S133. doi: 10.1016/j.vaccine.2023.01.054. Epub 2023 Oct 6.ABSTRACTIn Asia, there are an estimated 12 million annual cases of enteric fever, a potentially fatal systemic bacterial infection caused by Salmonella enterica serovars Typhi (STy) and Paratyphi A (SPA). The recent availability of typhoid conjugate vaccines (TCV), an increasing incidence of disease caused by SPA and growing antimicrobial resistance (AMR) across the genus Salmonella makes a bivalent STy/SPA vaccine a useful public health proposition. The uptake of a stand-alone paratyphoid vaccine is likely low thus, there is a pi...
Source: Vaccine - November 11, 2023 Category: Allergy & Immunology Authors: Laura B Martin Farhana Khanam Firdausi Qadri Ibrahim Khalil Michael J Sikorski Stephen Baker Source Type: research
Trends in antimicrobial resistance amongst < i > Salmonella < /i > Paratyphi A isolates in Bangladesh: 1999 –2021
ConclusionsSalmonella Paratyphi A has remained susceptible to most antibiotics, unlikeSalmonella Typhi, despite widespread usage of many antibiotics in Bangladesh. The data can guide evidence-based policy decisions for empirical treatment of paratyphoid fever, especially in the post typhoid vaccine era, and with the availability of new paratyphoid diagnostics. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 8, 2023 Category: Tropical Medicine Authors: Mohammad S. I. Sajib Source Type: research
Early transcriptional responses to human enteric fever challenge
Infection and Immunity, Ahead of Print. (Source: Infection and Immunity)
Source: Infection and Immunity - September 19, 2023 Category: Infectious Diseases Authors: Amber Barton
Jennifer Hill
Daniel O'Connor
Claire Jones
Elizabeth Jones
Susana Camara
Sonu Shrestha
Celina Jin
Malick M. Gibani
Hazel C. Dobinson
Claire Waddington
Thomas C. Darton
Christoph J. Blohmke
Andrew J. Pollard
1
Oxford Vaccine Group, Departmen Source Type: research
Salmonella delivers H9N2 influenza virus antigens via a prokaryotic and eukaryotic dual-expression vector and elicits bivalent protection against avian influenza and fowl typhoid
Dev Comp Immunol. 2023 Sep 13:105058. doi: 10.1016/j.dci.2023.105058. Online ahead of print.ABSTRACTThe H9N2 avian influenza virus significantly affects the health of poultry and humans. We identified a prokaryotic and eukaryotic dual-expression vector system, pJHL270, that can provide simultaneous MHC class I and II stimulation of the host immune system, and we designed vaccine antigens by selecting the consensus HA1 sequence and M2e antigens from H9N2 virus circulating in South Korea from 2000 to 2021. The genes were cloned into the pJHL270 vector, and the cloned plasmid was delivered by a live-attenuated Salmonella Gall...
Source: Developmental and Comparative Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Chamith Hewawaduge Jun Kwon Chandran Sivasankar Ji-Young Park Amal Senevirathne John Hwa Lee Source Type: research
Salmonella delivers H9N2 influenza virus antigens via a prokaryotic and eukaryotic dual-expression vector and elicits bivalent protection against avian influenza and fowl typhoid
Dev Comp Immunol. 2023 Sep 13:105058. doi: 10.1016/j.dci.2023.105058. Online ahead of print.ABSTRACTThe H9N2 avian influenza virus significantly affects the health of poultry and humans. We identified a prokaryotic and eukaryotic dual-expression vector system, pJHL270, that can provide simultaneous MHC class I and II stimulation of the host immune system, and we designed vaccine antigens by selecting the consensus HA1 sequence and M2e antigens from H9N2 virus circulating in South Korea from 2000 to 2021. The genes were cloned into the pJHL270 vector, and the cloned plasmid was delivered by a live-attenuated Salmonella Gall...
Source: Developmental and Comparative Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Chamith Hewawaduge Jun Kwon Chandran Sivasankar Ji-Young Park Amal Senevirathne John Hwa Lee Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667608 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: El żbieta Tabor Kamil Tabor Wojciech Pluskiewicz Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667608 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: El żbieta Tabor Kamil Tabor Wojciech Pluskiewicz Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 | DOI:10.31952/amha.21.1.4 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
THE HEALTH SYSTEM OF THE FIRST CZECHOSLOVAK REPUBLIC AND ITS ROLE IN COMBATING CONTAGIOUS DISEASES IMMEDIATELY AFTER THE FIRST WORLD WAR (THE 1920s)
Conclusion: The systematic development of new legislation contributed to the new Republic's proficiency at the task and the gradual reduction in the number of infectious diseases.PMID:37667605 | DOI:10.31952/amha.21.1.4 (Source: Medical History)
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Andrej T óth Inka Kratochv ílová Luk áš Novotný Jakub Dr ábek V ěra Hellerová Martin Červený Val érie Tóthová Source Type: research
Bacterial ghost cell based bivalent candidate vaccine against Salmonella Typhi and Salmonella Paratyphi A: A prophylactic study in BALB/c mice
Vaccine. 2023 Aug 23:S0264-410X(23)00992-1. doi: 10.1016/j.vaccine.2023.08.049. Online ahead of print.ABSTRACTTyphoid and emerging paratyphoid fever are a severe enteric disease worldwide with high morbidity and mortality. Licensed typhoid vaccines are in the market, but no paratyphoid vaccine is currently available. In the present study we developed a bivalent vaccine against Salmonella Typhi and Paratyphi A using a bacterial ghost platform. Bacterial ghost cells (BGs) are bacteria-derived cell membranes without cytoplasmic contents that retain their cellular morphology, including all cell surface features. Furthermore, B...
Source: Vaccine - August 25, 2023 Category: Allergy & Immunology Authors: Prolay Halder Suhrid Maiti Soumalya Banerjee Sanjib Das Moumita Dutta Shanta Dutta Hemanta Koley Source Type: research
Bacterial ghost cell based bivalent candidate vaccine against Salmonella Typhi and Salmonella Paratyphi A: A prophylactic study in BALB/c mice
Vaccine. 2023 Aug 23:S0264-410X(23)00992-1. doi: 10.1016/j.vaccine.2023.08.049. Online ahead of print.ABSTRACTTyphoid and emerging paratyphoid fever are a severe enteric disease worldwide with high morbidity and mortality. Licensed typhoid vaccines are in the market, but no paratyphoid vaccine is currently available. In the present study we developed a bivalent vaccine against Salmonella Typhi and Paratyphi A using a bacterial ghost platform. Bacterial ghost cells (BGs) are bacteria-derived cell membranes without cytoplasmic contents that retain their cellular morphology, including all cell surface features. Furthermore, B...
Source: Vaccine - August 25, 2023 Category: Allergy & Immunology Authors: Prolay Halder Suhrid Maiti Soumalya Banerjee Sanjib Das Moumita Dutta Shanta Dutta Hemanta Koley Source Type: research
Molecular correlates of vaccine-induced protection against typhoid fever
CONCLUSION The study reports a series of contemporary analyses that reveal the transcriptomic signatures after vaccination and infectious challenge, while identifying molecular correlates of protection that may inform future vaccine design and assessment.TRIAL REGISTRATION ClinicalTrials.gov NCT02324751. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - August 15, 2023 Category: Biomedical Science Authors: Henderson Zhu, Irina Chelysheva, Deborah L. Cross, Luke Blackwell, Celina Jin, Malick M. Gibani, Elizabeth Jones, Jennifer Hill, Johannes Trück, Dominic F. Kelly, Christoph J. Blohmke, Andrew J. Pollard, Daniel O’Connor Source Type: research
