Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants
CONCLUSIONS: Our study extends current insights into the effects of inflammation on the neural mechanisms of decision making and shows that exogenous inflammation alters neural activity indexing efficiency of evidence integration, as a function of choice discriminability. Moreover, we replicate previous findings that inflammation blunts striatal reward prediction error signals.PMID:38555987 | DOI:10.1016/j.bbi.2024.03.044 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Filippo Queirazza Jonathan Cavanagh Marios G Philiastides Rajeev Krishnadas Source Type: research
Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants
CONCLUSIONS: Our study extends current insights into the effects of inflammation on the neural mechanisms of decision making and shows that exogenous inflammation alters neural activity indexing efficiency of evidence integration, as a function of choice discriminability. Moreover, we replicate previous findings that inflammation blunts striatal reward prediction error signals.PMID:38555987 | DOI:10.1016/j.bbi.2024.03.044 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - March 31, 2024 Category: Neurology Authors: Filippo Queirazza Jonathan Cavanagh Marios G Philiastides Rajeev Krishnadas Source Type: research
Cost-effectiveness and public health impact of typhoid conjugate vaccine introduction strategies in Bangladesh
CONCLUSIONS: We projected that nationwide TCV introduction with a catch-up campaign would substantially reduce typhoid incidence and very likely be cost saving in Bangladesh.PMID:38531727 | DOI:10.1016/j.vaccine.2024.03.035 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Christopher Weyant Yogesh Hooda Sira Jam Munira Nathan C Lo Theresa Ryckman Arif M Tanmoy Naito Kanon Jessica C Seidman Denise Garrett Samir K Saha Jeremy D Goldhaber-Fiebert Senjuti Saha Jason R Andrews Source Type: research
Cost-effectiveness and public health impact of typhoid conjugate vaccine introduction strategies in Bangladesh
CONCLUSIONS: We projected that nationwide TCV introduction with a catch-up campaign would substantially reduce typhoid incidence and very likely be cost saving in Bangladesh.PMID:38531727 | DOI:10.1016/j.vaccine.2024.03.035 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Christopher Weyant Yogesh Hooda Sira Jam Munira Nathan C Lo Theresa Ryckman Arif M Tanmoy Naito Kanon Jessica C Seidman Denise Garrett Samir K Saha Jeremy D Goldhaber-Fiebert Senjuti Saha Jason R Andrews Source Type: research
A TonB dependent transporter YncD of Salmonella enterica Serovar Typhi possesses vaccine potential
AbstractMultiple TonB dependent transporters (TBDTs) contribute to bacterial virulence due to the importance roles that their substrates play in bacterial growth, and possess vaccine potential. A putative TBDT, YncD, had been identified as one of in vivo induced antigens during human infection of typhoid fever, and is required for the pathogenicity ofSalmonella enterica Serovar Typhi. The present study was aimed to determine the function and immunogenicity of YncD. Homologous recombination method was used to construct anyncD-deletion mutant andcirA-iroN-fepA-deletion mutant from the wild-typeS. Typhi Ty2. The growth of mut...
Source: World Journal of Microbiology and Biotechnology - March 12, 2024 Category: Microbiology Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
