Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
Genomic determinants of antibody response to a typhoid vaccine in Indian recipients
J Genet. 2024;103:12.ABSTRACTTyphoid is endemic in India and has high global incidence. There were large outbreaks of typhoid in India between 1990 and 2018. Available typhoid vaccines induce variable levels of protective antibodies among recipients; thus, there is variability in response to the vaccine. Interindividual genomic differences is hypothesized to be a determinant of the variability in response. We studied the antibody response of ~1000 recipients of the Vi-polysaccharide typhoid vaccine from Kolkata, India, who showed considerable variability of antibody response, i.e., anti-Vi-polysaccharide antibody level 28 ...
Source: Journal of Genetics - March 5, 2024 Category: Genetics & Stem Cells Authors: Vijay Laxmi Roy Partha Pratim Majumder Source Type: research
O-Antigen decorations in Salmonella enterica play a key role in eliciting functional immune responses against heterologous serovars in animal models
DiscussionSuch results, if confirmed in humans, could have a great impact on the design of a simplified vaccine composition able to maximize functional immune responses against clinically relevant Salmonella enterica serovars. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - February 29, 2024 Category: Microbiology Source Type: research
Immune responses to typhoid conjugate vaccine in a two dose schedule among Nepalese children & lt;2 years of age
Vaccine. 2024 Feb 22:S0264-410X(24)00156-7. doi: 10.1016/j.vaccine.2024.02.010. Online ahead of print.ABSTRACTBACKGROUND: Previously, the Vi-typhoid conjugate vaccine (Vi-TT) was found to be highly efficacious in Nepalese children under 16 years of age. We assessed the immunogenicity of Vi-TT at 9 and 12 months of age and response to a booster dose at 15 months of age.METHODS: Infants were recruited at Patan Hospital, Kathmandu and received an initial dose of Vi-TT at 9 or 12 months of age with a booster dose at 15 months of age. Blood was taken at four timepoints, and antibody titres were measured using a commercial ELISA...
Source: Vaccine - February 23, 2024 Category: Allergy & Immunology Authors: Sanjeev M Bijukchhe Meeru Gurung Bhishma Pokhrel Mila Shakya Dikshya Pant Pratistha Maskey Himang Maskey Babita Dhakal Shristy Rajkarkinar Sabitri Bista Merryn Voysey Yama F Mujadidi Young Chan Kim Rachel Atherton Elizabeth Jones Florence Mclean Sonu Shre Source Type: research
Immune responses to typhoid conjugate vaccine in a two dose schedule among Nepalese children & lt;2 years of age
Vaccine. 2024 Feb 22:S0264-410X(24)00156-7. doi: 10.1016/j.vaccine.2024.02.010. Online ahead of print.ABSTRACTBACKGROUND: Previously, the Vi-typhoid conjugate vaccine (Vi-TT) was found to be highly efficacious in Nepalese children under 16 years of age. We assessed the immunogenicity of Vi-TT at 9 and 12 months of age and response to a booster dose at 15 months of age.METHODS: Infants were recruited at Patan Hospital, Kathmandu and received an initial dose of Vi-TT at 9 or 12 months of age with a booster dose at 15 months of age. Blood was taken at four timepoints, and antibody titres were measured using a commercial ELISA...
Source: Vaccine - February 23, 2024 Category: Allergy & Immunology Authors: Sanjeev M Bijukchhe Meeru Gurung Bhishma Pokhrel Mila Shakya Dikshya Pant Pratistha Maskey Himang Maskey Babita Dhakal Shristy Rajkarkinar Sabitri Bista Merryn Voysey Yama F Mujadidi Young Chan Kim Rachel Atherton Elizabeth Jones Florence Mclean Sonu Shre Source Type: research
Old tools, new applications: Use of environmental bacteriophages for typhoid surveillance and evaluating vaccine impact
by Yogesh Hooda, Shuborno Islam, Rathin Kabiraj, Hafizur Rahman, Himadree Sarkar, Kesia E. da Silva, Rajan Saha Raju, Stephen P. Luby, Jason R. Andrews, Samir K. Saha, Senjuti Saha
Typhoid-conjugate vaccines (TCVs) provide an opportunity to reduce the burden of typhoid fever, caused bySalmonella Typhi, in endemic areas. As policymakers design vaccination strategies, accurate and high-resolution data on disease burden is crucial. However, traditional blood culture-based surveillance is resource-extensive, prohibiting its large-scale and sustainable implementation.Salmonella Typhi is a water-borne pathogen, and here, we tes...
Source: PLoS Neglected Tropical Diseases - February 15, 2024 Category: Tropical Medicine Authors: Yogesh Hooda Source Type: research
A review of potential use cases for measles-rubella, measles-mumps-rubella, and typhoid-conjugate vaccines presented on microarray patches
Vaccine. 2024 Feb 6:S0264-410X(23)01493-7. doi: 10.1016/j.vaccine.2023.12.047. Online ahead of print.ABSTRACTAs an innovative vaccine delivery technology, vaccine microarray patches could have a meaningful impact on routine immunization coverage in low- and middle-income countries, and vaccine deployment during epidemics and pandemics. This review of the potential use cases for a subset of vaccine microarray patches in various stages of clinical development, including measles-rubella, measles-mumps-rubella, and typhoid conjugate, highlights the breadth of their applicability to support immunization service delivery and the...
Source: Vaccine - February 7, 2024 Category: Allergy & Immunology Authors: Adam Soble Melissa Ko Shawn Gilchrist Stefano Malvolti Mateusz Hasso-Agopsowicz Birgitte Giersing Jean-Pierre Amorij Courtney Jarrahian Fayad El Sheikh Marion Menozzi-Arnaud Tiziana Scarna Source Type: research
A candidate glycoconjugate vaccine induces protective antibodies in the serum and intestinal secretions, antibody recall response and memory T cells and protects against both typhoidal and non-typhoidal Salmonella serovars
Human Salmonella infections pose significant public health challenges globally, primarily due to low diagnostic yield of systemic infections, emerging and expanding antibiotic resistance of both the typhoidal and non-typhoidal Salmonella strains and the development of asymptomatic carrier state that functions as a reservoir of infection in the community. The limited long-term efficacy of the currently licensed typhoid vaccines, especially in smaller children and non-availability of vaccines against other Salmonella serovars necessitate active research towards developing a multivalent vaccine with wider coverage of protecti...
Source: Frontiers in Immunology - January 9, 2024 Category: Allergy & Immunology Source Type: research
