Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome
This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.PMID:...
Source: Comptes Rendus Biologies - April 19, 2024 Category: Biology Authors: Nour El Houda Mimouni Paolo Giacobini Source Type: research
Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome
This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.PMID:...
Source: Comptes Rendus Biologies - April 19, 2024 Category: Biology Authors: Nour El Houda Mimouni Paolo Giacobini Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
On the involvement of the second heart field in congenital heart defects
C R Biol. 2024 Mar 15;347:9-18. doi: 10.5802/crbiol.151.ABSTRACTCongenital heart defects (CHD) affect 1 in 100 live births and result from defects in cardiac development. Growth of the early heart tube occurs by the progressive addition of second heart field (SHF) progenitor cells to the cardiac poles. The SHF gives rise to ventricular septal, right ventricular and outflow tract myocardium at the arterial pole, and atrial, including atrial septal myocardium, at the venous pole. SHF deployment creates the template for subsequent cardiac septation and has been implicated in cardiac looping and in orchestrating outflow tract ...
Source: Comptes Rendus Biologies - March 15, 2024 Category: Biology Authors: Clara Guijarro Robert G Kelly Source Type: research
