Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Anthropization and tick-borne diseases: the example of Lyme borreliosis
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.115. Online ahead of print.ABSTRACTTicks and tick-borne diseases are on the rise throughout the world. The reasons are multifactorial but all associated with human practices, including climate change and socio-economic and eco systemic changes. In the northern hemisphere, Lyme borreliosis and its vector, the tick belonging to the Ixodes ricinus complex, are particularly studied. Changes in forestry and the expansion of certain wild ungulates since the Second World War could explain the increasing presence of this tick in our environment. As it is likely to transmit other microorga...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Nathalie Boulanger Source Type: research
Which contribution of wastewater treatment plants in the fight against antimicrobial resistance?
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.113. Online ahead of print.ABSTRACTDue to the massive use of antibiotics, antimicrobial resistance (AMR) continues to spread, endangering global disease control and environmental quality. The sources of bacteria or antimicrobial resistance genes are linked to human activities: urban, hospital and industrial discharges, livestock farms). The role of sanitation systems-sewerage, wastewater treatment and sludge treatment (WWTP)-in the problem of AMR has not yet been clearly established by the scientific community. The data available to date show that they eliminate part of the bacter...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Charlotte Arnal Faten Belhadj-Kaabi Val érie Ingrand Source Type: research
Foreword : One health : sharing microbes and antibiotic resistance
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.122. Online ahead of print.NO ABSTRACTPMID:37655922 | DOI:10.5802/crbiol.122 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Andr é Jestin Agn ès Artiges Christine Hache Source Type: research
Development of antibiotic resistance in animals not receiving antibiotic therapy
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.116. Online ahead of print.ABSTRACTThe fight against antibiotic resistance in the animal sector over the last ten years in France (Ecoantibio plans) has largely focused on reducing the veterinary use of antibiotics. However, antibiotic resistance in an animal is not necessarily due to antibiotic therapy, but can also result from the transmission of resistant bacteria or resistance plasmids. Several examples illustrate the importance of this transmission of antibiotic resistance in the animal world, which are detailed in this communication. Like in human medicine, this nosocomial t...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Jean-Yves Madec Source Type: research
Tracking transfers of resistance-carrying bacteria between animals, humans and the environment
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.114. Online ahead of print.ABSTRACTThe fight against antibiotic resistance must incorporate the "One Health" concept to be effective. This means having a holistic approach embracing the different ecosystems, human, animal, and environment. Transfers of resistance genes may exist between these three domains and different stresses related to the exposome may influence these transfers. Various targeted or pan-genomic molecular biology techniques can be used to better characterise the dissemination of bacterial clones and to identify exchanges of genes and mobile genetic elements betw...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Sylvain Meyer Lucie Laval M élanie Pimenta Yolanda Gonz ález-Flores Margaux Gaschet Elodie Couv é-Deacon Olivier Barraud Christophe Dagot Marie-C écile Ploy Source Type: research
A multi-resistant bacterium before the era of antibiotics : the agent of melioidosis
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.109. Online ahead of print.ABSTRACTMelioidosis is an infectious, tropical and emerging disease, due to a bacterium of the hydrotelluric environment, Burkholderia pseudomallei, which is considered as a potential biological weapon because of its exceptional resistance and virulence capacities. Its worldwide spread, outside the original endemic foci of Southeast Asia and Australia, is favoured by global warming and the diabetes mellitus pandemic, which is the main predisposing factor.In humans, melioidosis is an opportunistic infection, following professional (rice farmers, soldiers)...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Yves Buisson Source Type: research
Anthropization and tick-borne diseases: the example of Lyme borreliosis
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.115. Online ahead of print.ABSTRACTTicks and tick-borne diseases are on the rise throughout the world. The reasons are multifactorial but all associated with human practices, including climate change and socio-economic and eco systemic changes. In the northern hemisphere, Lyme borreliosis and its vector, the tick belonging to the Ixodes ricinus complex, are particularly studied. Changes in forestry and the expansion of certain wild ungulates since the Second World War could explain the increasing presence of this tick in our environment. As it is likely to transmit other microorga...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Nathalie Boulanger Source Type: research
Which contribution of wastewater treatment plants in the fight against antimicrobial resistance?
C R Biol. 2023 Aug 31. doi: 10.5802/crbiol.113. Online ahead of print.ABSTRACTDue to the massive use of antibiotics, antimicrobial resistance (AMR) continues to spread, endangering global disease control and environmental quality. The sources of bacteria or antimicrobial resistance genes are linked to human activities: urban, hospital and industrial discharges, livestock farms). The role of sanitation systems-sewerage, wastewater treatment and sludge treatment (WWTP)-in the problem of AMR has not yet been clearly established by the scientific community. The data available to date show that they eliminate part of the bacter...
Source: Comptes Rendus Biologies - September 1, 2023 Category: Biology Authors: Charlotte Arnal Faten Belhadj-Kaabi Val érie Ingrand Source Type: research
