Fran çois Gros, my boss
This article shares the author's memories of his collaborations with François Gros when the latter was Professor at the University of Paris 7, then Director of the Institut Pasteur, then President of the Pasteur-Weizmann Council. He underlines the major contributions of "his boss" in the exercise of these functions.PMID:38113094 | DOI:10.5802/crbiol.128 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Michel Elie Goldberg Source Type: research
Our journey with Fran çois Gros
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.140. Online ahead of print.ABSTRACTGillian Butler-Browne began working on muscle at the Institut Pasteur in the laboratory of François Gros in 1978. She characterized the expression profile of different myosin isoforms during both human and rodent development. Vincent Mouly joined this laboratory for his PhD in 1982, and defined the different populations of myoblasts appearing during development in birds and then in humans. Together, they demonstrated the impact of the limit in proliferation of the precursor cells on the regenerative capacity of human skeletal muscle, and their g...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Gillian Butler-Browne Vincent Mouly Source Type: research
Memories of Professor Fran çois Gros
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.141. Online ahead of print.ABSTRACTI joined the laboratory of Professor Francois Gros in 1987 and worked there as a postdoc with Robert Whalen until 1992. I recount the research we carried out and mention that of the other scientists also working on skeletal muscle on the 6th floor of the Molecular Biology Department of the Institut Pasteur at that time. I then present my subsequent research when I returned to Japan. I pay tribute to the influence of Professor Gros and to his support in establishing Japanese/French meetings on muscle biology and muscular dystrophy. I also invoke p...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Shin'ichi Takeda Source Type: research
Organizing collective cell migration through guidance by followers
This article summarizes how migratory reactions to cell-cell contacts, also called "contact regulation of locomotion" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called "guidance by followers", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of mov...
Source: Comptes Rendus Biologies - December 14, 2023 Category: Biology Authors: Arthur Boutillon Source Type: research
Organizing collective cell migration through guidance by followers
This article summarizes how migratory reactions to cell-cell contacts, also called "contact regulation of locomotion" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called "guidance by followers", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of mov...
Source: Comptes Rendus Biologies - December 14, 2023 Category: Biology Authors: Arthur Boutillon Source Type: research
Organizing collective cell migration through guidance by followers
This article summarizes how migratory reactions to cell-cell contacts, also called "contact regulation of locomotion" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called "guidance by followers", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of mov...
Source: Comptes Rendus Biologies - December 14, 2023 Category: Biology Authors: Arthur Boutillon Source Type: research
Organizing collective cell migration through guidance by followers
This article summarizes how migratory reactions to cell-cell contacts, also called "contact regulation of locomotion" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called "guidance by followers", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of mov...
Source: Comptes Rendus Biologies - December 14, 2023 Category: Biology Authors: Arthur Boutillon Source Type: research
Organizing collective cell migration through guidance by followers
This article summarizes how migratory reactions to cell-cell contacts, also called "contact regulation of locomotion" behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called "guidance by followers", through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of mov...
Source: Comptes Rendus Biologies - December 14, 2023 Category: Biology Authors: Arthur Boutillon Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
