Memories of a young student: the early days of splicing regulation with Fran çois Gros
C R Biol. 2024 Jan 18. doi: 10.5802/crbiol.138. Online ahead of print.ABSTRACTI joined the laboratory of François Gros as a young student in the mid-1980s and worked on the characterization of the β-tropomyosin gene in chicken and the regulation of alternative splicing of its transcript, under the supervision of Marc Fiszman. In particular, I was interested in how secondary structures of the RNA influence the recognition of exons specifically used in muscle cells. I will recall a few memories on how interacting with François on this project shaped my perception of the scientific process and of the relationships between ...
Source: Comptes Rendus Biologies - January 18, 2024 Category: Biology Authors: Domenico Libri Source Type: research
mRNA vaccination, a model of transition from basic biology to medicine
C R Biol. 2024 Jan 17. doi: 10.5802/crbiol.129. Online ahead of print.ABSTRACTSixty years elapsed between the discovery of messenger RNA (mRNA) and the use of this molecule in an unprecedented global vaccination campaign that brought the Covid-19 pandemic under control. Sixty years of doubts for some and certainties for others about the possibility of using mRNA-an example of synthetic biology-in therapeutic medicine and vaccinology. Years of "translational" research and development have culminated in the success of anti-Covid-19 mRNA vaccines and the promise of more to come against emerging pathogens. A new paradigm in va...
Source: Comptes Rendus Biologies - January 17, 2024 Category: Biology Authors: Philippe J Sansonetti Source Type: research
Fran çois Gros: a leading figure, a secretive man
C R Biol. 2024 Jan 16. doi: 10.5802/crbiol.142. Online ahead of print.ABSTRACTI joined François Gros' laboratory in 1975, to study mechanisms of gene expression in eukaryotes. Despite the lack of powerful tools, that would be brought later by genetic engineering, I obtained publishable results and was allowed to defend a third cycle thesis. Thereafter, I joined Margaret Buckingham's group, which was empowering within François' laboratory. I maintained regular meetings with François, a leading figure but a secretive man, who did not readily open up. It was my privilege, over the more than 45 years I have been around him,...
Source: Comptes Rendus Biologies - January 16, 2024 Category: Biology Authors: Beno ît Robert Source Type: research
Clonal reproduction by seed of a cultivated hybrid plant: a new perspective for small-scale rice growers
C R Biol. 2024 Jan 11;346:107-116. doi: 10.5802/crbiol.125.ABSTRACTTransferring an asexual mode of reproduction by seeds (apomixis) to cultivated plants would enable clonal reproduction of heterozygous genotypes such as F1 hybrids with hybrid vigor (heterosis), facilitating their access and multiplication by small-scale growers. Although sources of apomixis and the genetic loci controlling its constituent elements have been identified in wild species, their transfer by crossing to cultivated species has so far been unsuccessful. Here, we have introduced synthetic apomixis in hybrid rice to produce a high (95-100%) frequenc...
Source: Comptes Rendus Biologies - January 11, 2024 Category: Biology Authors: Aurore Vernet Donaldo Meynard Emmanuel Guiderdoni Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
