Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
Cell migration in dense microenvironments
C R Biol. 2023 Sep 21;346:89-93. doi: 10.5802/crbiol.124.ABSTRACTThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense intersti...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Guilherme Pedreira de Freitas Nader Juan Manuel Garc ía-Arcos Source Type: research
Impact of R-loops on oncogene-induced replication stress in cancer cells
C R Biol. 2023 Sep 22;346:95-105. doi: 10.5802/crbiol.123.ABSTRACTReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils o...
Source: Comptes Rendus Biologies - October 2, 2023 Category: Biology Authors: Jonathan Heuz é Yea-Lih Lin Armelle Lengronne J érôme Poli Philippe Pasero Source Type: research
