Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Working with Fran çois Gros at the Institut Pasteur : allostery, the nicotinic receptor and the biology of the future
C R Biol. 2023 Dec 22. doi: 10.5802/crbiol.143. Online ahead of print.ABSTRACTWorking with François Gros was a privileged moment in my scientific life, enabling me to appreciate a scientific personality whose generosity knew no bounds and whose vision of science was far ahead of its time.PMID:38131160 | DOI:10.5802/crbiol.143 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 22, 2023 Category: Biology Authors: Jean-Pierre Changeux Source Type: research
Messenger RNA in differentiating muscle cells-my experience in Fran çois Gros' lab in the 1970s and 80s
C R Biol. 2023 Dec 21. doi: 10.5802/crbiol.132. Online ahead of print.ABSTRACTI joined François Gros' laboratory as a postdoc at the end of 1971 and continued working with him as a research scientist until 1987, when I became an independent group leader at the Institut Pasteur. In the early 1970s, it was the beginning of research in his lab on muscle cell differentiation, as a model eukaryotic system for studying mRNAs and gene regulation. In this article, I recount our work on myogenesis and mention the other research themes in his lab and the people concerned. I remained in close contact with François and pay tribute t...
Source: Comptes Rendus Biologies - December 21, 2023 Category: Biology Authors: Margaret Buckingham Source Type: research
Sixty years of life with Fran çois Gros
C R Biol. 2023 Dec 21. doi: 10.5802/crbiol.137. Online ahead of print.ABSTRACTThis is meant to be a personal account of my relationship with François Gros who, as the director of the laboratory where I had my first team became a close and fatherly friend. Over 60 years we had permanent interactions, whether close or far away. And I wish to revive here some of our relation at the grassroots, as well as the folklore in and around his laboratory. He was not only an excellent scientist but also a Statesman of Science and beyond. Myself a minor figure in his big endeavors, this aspect of his life I just observed from below but...
Source: Comptes Rendus Biologies - December 21, 2023 Category: Biology Authors: Klaus Scherrer Source Type: research
On learning molecular biology in Fran çois Gros' lab in the late 1970s and early 1980s
C R Biol. 2023 Dec 21. doi: 10.5802/crbiol.134. Online ahead of print.ABSTRACTAlthough reflection is obviously crucial in molecular biology, experimentation is nonetheless the basis of most major advances. I was lucky to begin my research career at a particularly interesting time, and privileged to have spent a number of years in Francois Gros' laboratory at the Institut Pasteur. His influence, and that of his lab, were crucial in shaping my early career.PMID:38127064 | DOI:10.5802/crbiol.134 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 21, 2023 Category: Biology Authors: Adrian Minty Source Type: research
Fran çois Gros' laboratory at the Collège de France
C R Biol. 2023 Dec 21. doi: 10.5802/crbiol.135. Online ahead of print.ABSTRACTI was recruited by François Gros as a PhD student in his laboratory at the Institut de Biologie Physico-Chimique in 1965, and continued to work with him after I graduated. In 1973, when he was appointed Professor of Cellular Biochemistry at the Collège de France, François decided to set up a team working on neuronal differentiation. He asked me to take part in this new scientific adventure. Here I'd like to talk about the members of his laboratory and some of their scientific work, in particular that on the cytoskeleton of neurons.PMID:3812709...
Source: Comptes Rendus Biologies - December 21, 2023 Category: Biology Authors: Monique Lazar Source Type: research
Stable coding of aversive associations in medial prefrontal populations
C R Biol. 2023 Dec 20;346:127-138. doi: 10.5802/crbiol.126.ABSTRACTThe medial prefrontal cortex (mPFC) is at the core of numerous psychiatric conditions, including fear and anxiety-related disorders. Whereas an abundance of evidence suggests a crucial role of the mPFC in regulating fear behaviour, the precise role of the mPFC in this process is not yet entirely clear. While studies at the single-cell level have demonstrated the involvement of this area in various aspects of fear processing, such as the encoding of threat-related cues and fear expression, an increasingly prevalent idea in the systems neuroscience field is t...
Source: Comptes Rendus Biologies - December 20, 2023 Category: Biology Authors: Cyril Herry Daniel Jercog Source Type: research
Stable coding of aversive associations in medial prefrontal populations
C R Biol. 2023 Dec 20;346:127-138. doi: 10.5802/crbiol.126.ABSTRACTThe medial prefrontal cortex (mPFC) is at the core of numerous psychiatric conditions, including fear and anxiety-related disorders. Whereas an abundance of evidence suggests a crucial role of the mPFC in regulating fear behaviour, the precise role of the mPFC in this process is not yet entirely clear. While studies at the single-cell level have demonstrated the involvement of this area in various aspects of fear processing, such as the encoding of threat-related cues and fear expression, an increasingly prevalent idea in the systems neuroscience field is t...
Source: Comptes Rendus Biologies - December 20, 2023 Category: Biology Authors: Cyril Herry Daniel Jercog Source Type: research
Science and development : the action of François Gros at COPED
This article is a tribute to the action of François Gros within the COPED (Committee of Developing Countries) which he created in 1997 and led until 2017. The COPED aims to reflect on the major scientific problems posed to developing countries and to try to provide them with solutions in partnership with them. Its actions have resulted in the organization of mini-forums, workshops, international symposia and reports for governments and authorities. Without being exhaustive, a number of actions carried out by François Gros or on his initiative are described in fields as diverse as health, chemistry, agronomy, energy, appl...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Pierre Auger Michel Delseny Source Type: research
Fran çois Gros : an intelligent, kind-hearted man who couldn't say no
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.133. Online ahead of print.ABSTRACTHere I recall some privileged moments in my interactions with François: when he helped me obtain a grant for an NGO; when I participated in the work of COPED; when I returned to hospital medicine, his support for writing and publishing books that give patients a voice.PMID:38113068 | DOI:10.5802/crbiol.133 (Source: Comptes Rendus Biologies)
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Marie-H élène Buc Source Type: research
Along the road with Fran çois
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.136. Online ahead of print.ABSTRACTIt was at the Pasteur Institute, in François Gros' laboratory, that I had the opportunity to discover the world of research. An opportunity in more ways than one, first because of the nature of the subject, myogenesis, which lent itself particularly well to cellular and genetic approaches to development and differentiation in vertebrates. An opportunity also because the head of the laboratory, François Gros, who was responsible for the choice of this topic, had created an environment in which researchers could develop their projects with great ...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Didier Montarras Source Type: research
Fran çois Gros: from antibiotics to messenger RNA
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.130. Online ahead of print.ABSTRACTFrançois Gros was a prominent French Molecular Biologist who made a major contribution to the discovery of messenger RNA in 1961. He pursued outstanding research on bacterial mRNA and its translation into proteins followed by pioneering work on muscle differentiation. I was lucky to be among his graduate students and owe much of my success in science to him. In this short text I will describe how the initial post-war studies of François guided him to discover the existence of short-lived RNA in bacteria, the messenger RNA containing the informa...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Moshe Yaniv Source Type: research
Epigenetic and gene regulatory functions of small RNAs
C R Biol. 2023 Dec 19. doi: 10.5802/crbiol.131. Online ahead of print.ABSTRACTIn this review article, I summarize the intervention I made during the "Hommage à François Gros" held at the Institut Pasteur in Paris on the 25th of April, 2023. I discuss how the discovery of the existence of an RNA intermediate between genetic information and protein translation has changed our perspective on the role of RNA in gene regulation in these past years. I also discuss new emerging paradigms, highlighting the role of RNA in heritable information similar to the well-known DNA function.PMID:38113091 | DOI:10.5802/crbiol.131 (Source: ...
Source: Comptes Rendus Biologies - December 19, 2023 Category: Biology Authors: Germano Cecere Source Type: research
