A retrospective study of intravenous pentamidine for Pneumocystis jirovecii pneumonia prophylaxis in adult patients with hematologic malignancies —its utility during respiratory virus pandemics
In hematology, prophylaxis for Pneumocystis jirovecii pneumonia (PCP) is recommended for patients undergoing hematopoietic stem cell transplantation (HSCT) and in selected categories of intensive chemotherapy for hematologic malignancies (HMs) [1]. Trimethoprim-sulfamethoxazole (TMP-SMX) is the recommended first-line agent; however, its use is not straightforward because it can be associated with myelosuppression and elevation of potassium and creatinine [2]. Furthermore, many patients have a sulfa allergy and some are glucose-6-phosphate dehydrogenase –deficient [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 12, 2024 Category: Infectious Diseases Authors: Yi Xin Liew, Aloysius Yew Leng Ho, Gee Chuan Wong, Shimin Jasmine Chung, Thuan Tong Tan, Ban Hock Tan Tags: Short Communication Source Type: research
Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research
Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research
A Multidrug-Resistant Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacter hormaechei Strain from Mixed Sprouts
Curr Microbiol. 2024 Apr 9;81(5):131. doi: 10.1007/s00284-024-03663-3.ABSTRACTFresh vegetables can harbor antibiotic-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Enterobacterales. Enterobacter hormaechei is a bacterium belonging to the Enterobacterales order and the most commonly identified nosocomial pathogen of Enterobacter cloacae complex. The purpose of this study was to characterize a multi-drug resistant ESBL-producing E. hormaechei strain isolated from a sample of mixed sprouts. Vegetable samples were pre-enriched in buffered peptone water, followed by enrichment in Enterobacteria En...
Source: Current Microbiology - April 9, 2024 Category: Microbiology Authors: Elizabeth A Leighton Chelsea N Gale En Huang Xu Yang Erin L DiCaprio Xinhui Li Source Type: research
Serotype diversity and antimicrobial susceptibility profiles of Actinobacillus pleuropneumoniae isolated in Italian pig farms from 2015 to 2022
AbstractActinobacillus pleuropneumoniae (APP) is a bacterium frequently associated with porcine pleuropneumonia. The acute form of the disease is highly contagious and often fatal, resulting in significant economic losses for pig farmers. Serotype diversity and antimicrobial resistance (AMR) of APP strains circulating in north Italian farms from 2015 to 2022 were evaluated retrospectively to investigate APP epidemiology in the area. A total of 572 strains isolated from outbreaks occurring in 337 different swine farms were analysed. The majority of isolates belonged to serotypes 9/11 (39.2%) and 2 (28.1%) and serotype diver...
Source: Veterinary Research - April 9, 2024 Category: Veterinary Research Source Type: research
Variations in Antimicrobial Resistance Genes Present in the Rectal Faeces of Seals in Scottish and Liverpool Bay Coastal Waters
Environ Pollut. 2024 Apr 6:123936. doi: 10.1016/j.envpol.2024.123936. Online ahead of print.ABSTRACTAntibiotic resistance genes originating from human activity are considered important environmental pollutants. Wildlife species can act as sentinels for coastal environmental contamination and in this study we used qPCR array technology to investigate the variety and abundance of antimicrobial resistance genes (ARGs), mobile genetic elements (MGEs) and integrons circulating within seal populations both near to and far from large human populations located around the Scottish and northwest English coast. Rectal swabs were take...
Source: Environmental Pollution - April 8, 2024 Category: Environmental Health Authors: Eleanor Watson Scott Hamilton Nuno Silva Simon Moss Craig Watkins Johanna Baily Thorsten Forster Ailsa J Hall Mark P Dagleish Source Type: research
Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis
ConclusionThe network meta-analysis demonstrated that Fosfomycin is the most effective antibiotic in treating uncomplicated UTIs with respect to clinical cure, microbiological cure, and adverse events profile. (Source: World Journal of Urology)
Source: World Journal of Urology - April 8, 2024 Category: Urology & Nephrology Source Type: research
Antibiotic resistance profiling and phylotyping of human-diarrheagenic Escherichia coli pathotypes detected from diarrheic and non-diarrheic calves in Iran
CONCLUSIONS: The prevalence of VG-positive E. coli isolates was higher in healthy calves compared to diarrheic cases. AR was widespread among VG-positive isolates. These findings suggest that calves may serve as potential reservoirs of antimicrobial-resistant hybrid pathotypes of E. coli.PMID:38581525 | DOI:10.1007/s11033-024-09494-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 6, 2024 Category: Molecular Biology Authors: Zahede Naderi Reza Ghanbarpour Maziar Jajarmi Sanaz Dehdashti Mahboube Bagheri Neda Eskandarzade Parvin Mohseni Hesam Alizade Source Type: research
Antibiotic resistance profiling and phylotyping of human-diarrheagenic Escherichia coli pathotypes detected from diarrheic and non-diarrheic calves in Iran
CONCLUSIONS: The prevalence of VG-positive E. coli isolates was higher in healthy calves compared to diarrheic cases. AR was widespread among VG-positive isolates. These findings suggest that calves may serve as potential reservoirs of antimicrobial-resistant hybrid pathotypes of E. coli.PMID:38581525 | DOI:10.1007/s11033-024-09494-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 6, 2024 Category: Molecular Biology Authors: Zahede Naderi Reza Ghanbarpour Maziar Jajarmi Sanaz Dehdashti Mahboube Bagheri Neda Eskandarzade Parvin Mohseni Hesam Alizade Source Type: research
Prolonged suppressive antibiotic therapy for inferior vena cava filter infection following emphysematous pyelonephritis and cystitis: a case report
CONCLUSION: Infections of implanted devices, such as IVC filters, secondary to severe infections can cause persistent bacteremia. PSAT may be an alternative option to treat IVC filter infection, when the IVC filter is considered difficult to remove.PMID:38576969 | PMC:PMC10990323 | DOI:10.1097/MS9.0000000000001886 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Yasuhiro Suzuki Akira Kuriyama Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
Prolonged suppressive antibiotic therapy for inferior vena cava filter infection following emphysematous pyelonephritis and cystitis: a case report
CONCLUSION: Infections of implanted devices, such as IVC filters, secondary to severe infections can cause persistent bacteremia. PSAT may be an alternative option to treat IVC filter infection, when the IVC filter is considered difficult to remove.PMID:38576969 | PMC:PMC10990323 | DOI:10.1097/MS9.0000000000001886 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Yasuhiro Suzuki Akira Kuriyama Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
Prolonged suppressive antibiotic therapy for inferior vena cava filter infection following emphysematous pyelonephritis and cystitis: a case report
CONCLUSION: Infections of implanted devices, such as IVC filters, secondary to severe infections can cause persistent bacteremia. PSAT may be an alternative option to treat IVC filter infection, when the IVC filter is considered difficult to remove.PMID:38576969 | PMC:PMC10990323 | DOI:10.1097/MS9.0000000000001886 (Source: Annals of Medicine)
Source: Annals of Medicine - April 5, 2024 Category: Internal Medicine Authors: Yasuhiro Suzuki Akira Kuriyama Source Type: research
Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea
CONCLUSION: Most gram-negative bacteria displayed higher resistance of >45% to ampicillin, trimethoprim-sulfamethoxazole, and tetracycline. Among gram-positive bacteria, a higher resistance rate with ampicillin, trimethoprim-sulfamethoxazole, tetracycline, oxacillin, vancomycin, and penicillin G was recorded. S. aureus showed no resistance to rifampicin and clindamycin, and Strep. spp. indicated 100% resistance to rifampicin and vancomycin. This study highlights critical gaps and areas for further exploration. Expanding the spectrum of antibiotics tested and investigating underlying multidrug resistance mechanisms would...
Source: Biomed Res - April 5, 2024 Category: Research Authors: Khalid Hussein Berhe Tesfai Okbu Frezgi Hagos Hayelom Yosan Gebremeskel Azania Werede Hailemichael Gebremariam Fitsum Kibreab Mohammed Elfatih Hamida Source Type: research
