Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
BMC Pharmacol Toxicol. 2024 Feb 27;25(1):23. doi: 10.1186/s40360-024-00743-9.ABSTRACTThis bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a 7-day washout period, these subjects received one dose of reference drug or test drug. Blood samples were collected from participants before an...
Source: BMC Pharmacology and Toxicology - February 28, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo Xin Zhao Jinjin Shi Tiandong Zhang Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
BMC Pharmacol Toxicol. 2024 Feb 27;25(1):23. doi: 10.1186/s40360-024-00743-9.ABSTRACTThis bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a 7-day washout period, these subjects received one dose of reference drug or test drug. Blood samples were collected from participants before an...
Source: BMC Pharmacology and Toxicology - February 28, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo Xin Zhao Jinjin Shi Tiandong Zhang Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
BMC Pharmacol Toxicol. 2024 Feb 27;25(1):23. doi: 10.1186/s40360-024-00743-9.ABSTRACTThis bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a 7-day washout period, these subjects received one dose of reference drug or test drug. Blood samples were collected from participants before an...
Source: BMC Pharmacology and Toxicology - February 28, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo Xin Zhao Jinjin Shi Tiandong Zhang Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
BMC Pharmacol Toxicol. 2024 Feb 27;25(1):23. doi: 10.1186/s40360-024-00743-9.ABSTRACTThis bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a 7-day washout period, these subjects received one dose of reference drug or test drug. Blood samples were collected from participants before an...
Source: BMC Pharmacology and Toxicology - February 28, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo Xin Zhao Jinjin Shi Tiandong Zhang Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Pharmacokinetics and bioequivalence evaluation of two oral formulations of cotrimoxazole tablets in healthy Chinese volunteers under fasting conditions
BMC Pharmacol Toxicol. 2024 Feb 27;25(1):23. doi: 10.1186/s40360-024-00743-9.ABSTRACTThis bioequivalence study was conducted to evaluate two oral formulations of cotrimoxazole tablets in healthy Chinese subjects. All 26 subjects recruited to this study were randomly and evenly classified into two groups and received a single dose (sulfamethoxazole: 400 mg and trimethoprim: 80 mg) of test cotrimoxazole tablets (generic drug) or reference cotrimoxazole tablets (branded drug). After a 7-day washout period, these subjects received one dose of reference drug or test drug. Blood samples were collected from participants before an...
Source: BMC Pharmacology and Toxicology - February 28, 2024 Category: Drugs & Pharmacology Authors: Xu Zuo Xin Zhao Jinjin Shi Tiandong Zhang Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
Dissemination of Urinary Escherichia coli Phylogroup B2 in Provincial and Community Hospitals in Uthai Thani, Central Thailand
This study examined the antimicrobial susceptibility and genetic relationship based on Clermont phylotyping and ERIC-PCR of 84 E. coli urinary isolates from provincial and community hospitals in Thailand. All the isolates were completely susceptible to nitrofurantoin, whereas almost all isolates were susceptible to carbapenem, fosfomycin, and amikacin. A high resistance rate was found to fluoroquinolone, ampicillin, and trimethoprim/sulfamethoxazole. Clermont phylogroup B2 was predominant (n=58). Subtyping of the B2 phylogroup revealed diverse subgroups, of which subgroup V (n=11) was predominant, followed by VII (n=9), II...
Source: Japanese Journal of Infectious Diseases - February 28, 2024 Category: Infectious Diseases Authors: Chanihcha Anudit Pornthip Saraisuwan Chantana Kimterng Chanakan Puangmanee Nicharee Bamphensin Anusak Kerdsin Source Type: research
