Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
Restricted access and advanced disease in post-pandemic testicular cancer
CONCLUSIONS: There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.PMID:38587978 | DOI:10.5489/cuaj.8648 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Mitchell Fagan W C Ian Janes Matthew Andrews David R Harvey Geoff M Warden Michael K Organ Paul Johnston Source Type: research
The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals
Congenital cryptorchidism, also known as undescended testis, is the condition where one or both testes are not in place in the scrotum at birth and is one of the most common birth defects in boys. Temporal trends and geographic variation in the prevalence of cryptorchidism from 1% to 9% have been reported in prospective cohort studies. The testes develop in the abdominal cavity and descend to the scrotum in two phases, which should be completed by gestational week 35. Thus, the risk of cryptorchidism is higher in preterm boys. In many cases a spontaneous descent occurs during the first months of life during the surge of go...
Source: Frontiers in Endocrinology - April 3, 2024 Category: Endocrinology Source Type: research
Role of urinary pregnancy testing in the diagnosis of men with testicular cancer
Ann R Coll Surg Engl. 2024 Apr 2. doi: 10.1308/rcsann.2023.0029. Online ahead of print.NO ABSTRACTPMID:38563075 | DOI:10.1308/rcsann.2023.0029 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: L Paramore A S Chetwood Source Type: research
Role of urinary pregnancy testing in the diagnosis of men with testicular cancer
Ann R Coll Surg Engl. 2024 Apr 2. doi: 10.1308/rcsann.2023.0029. Online ahead of print.NO ABSTRACTPMID:38563075 | DOI:10.1308/rcsann.2023.0029 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: L Paramore A S Chetwood Source Type: research
Role of urinary pregnancy testing in the diagnosis of men with testicular cancer
Ann R Coll Surg Engl. 2024 Apr 2. doi: 10.1308/rcsann.2023.0029. Online ahead of print.NO ABSTRACTPMID:38563075 | DOI:10.1308/rcsann.2023.0029 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: L Paramore A S Chetwood Source Type: research
Self-perceptions of masculinities and testicular cancer: Qualitative explorations
CONCLUSION: Leveraging traditionally masculine norms such as physical strength and control and developing flexible adaptations of masculinities should be encouraged with men with TC to retain self-perception and potentially enable better coping. Masculine self-perception of gay/bisexual men may centre around sexual functioning, though further research is required.PMID:38520671 | DOI:10.1002/pon.6333 (Source: Cancer Control)
Source: Cancer Control - March 23, 2024 Category: Cancer & Oncology Authors: Victoria Dax Maria Ftanou Ben Tran Jeremy Lewin Darshini Ayton Zac Seidler Tania Wallace Joshua F Wiley Source Type: research
GSE228501 Single-cell Multi-omics Analysis of Human Testicular Germ Cell Tumor Reveals its Molecular Features and Microenvironment
Contributors : Xiaojian Lu ; Xichen Nie ; Hao Bo ; Jingtao GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSeminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its molecular features and tumor microenvironment (TME) is largely unexplored. Here, we performed a series of studies via genomics profiling (single cell multi-omics and spatial transcriptomics) and functional examination using seminoma samples and a seminoma cell line. We identified key gene expression programs shared between seminoma and primordial germ cells, and further characterized t...
Source: GEO: Gene Expression Omnibus - March 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE229823 Single-cell Multi-omics Analysis of Human Testicular Germ Cell Tumor Reveals its Molecular Features and Microenvironment II
Contributors : Xiaojian Lu ; Xichen Nie ; Hao Bo ; Jingtao GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSeminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its molecular features and tumor microenvironment (TME) is largely unexplored. Here, we performed a series of studies via genomics profiling (single cell multi-omics and spatial transcriptomics) and functional examination using seminoma samples and a seminoma cell line. We identified key gene expression programs shared between seminoma and primordial germ cells, and further characterized t...
Source: GEO: Gene Expression Omnibus - March 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE261811 T cells in testicular germ cell tumors: new evidence of fundamental contributions by rare subsets
In this study, we found that T cells including Treg and Tfh were most abundant in seminoma compared to mixed tumors and embryonal carcinoma. Taken together, despite significant heterogeneity between patients, this study demonstrated that T cell subtypes form a key component of the TGCT microenvironment. The novel finding of rare Treg and Tfh cells in the human testis suggests their involvement in TGCT pathobiology, with implications for understanding tumor progression, assessing patient prognosis, and as putative targets for personalized immunotherapy. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Synchronous Anal Squamous Cell Carcinoma and Diffuse Large B Cell Lymphoma of Stomach: the First Report of an Odd Couple
AbstractThe unique case study presented here explores an exceptionally rare occurrence in an HIV-positive female —synchronous diagnoses of anal squamous cell carcinoma and diffuse large B cell lymphoma (DLBCL) of the stomach. With limited existing literature on such clinical scenarios, this case serves as an unprecedented insight into the complexities of managing such synchronous malignancies in HIV-positive patients. The article also examines the heightened risk of specific cancer types in individuals living with HIV compared to those without the virus, focusing on AIDS-defining cancers such as Kaposi sarcoma, various l...
Source: Indian Journal of Surgical Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Breast Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Lung Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Prognostic factors for relapse in patients with clinical stage I testicular non-seminoma: a nationwide, population-based cohort study
Approximately 30% of patients with clinical stage I non-seminoma (CSI-NS) relapse. Current risk stratification is based on lymphovascular invasion (LVI) alone. The extent to which additional tumor characteristics can improve risk prediction remains unclear. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Thomas Wagner, Birgitte Gr ønkær Toft, Jakob Lauritsen, Mikkel Bandak, Ib Jarle Christensen, Birte Engvad, Michael Kreiberg, Mads Agerbæk, Lars Dysager, Andreas Carus, Josephine Julie Rosenvilde, Daniel Berney, Gedske Daugaard Tags: Original Research Source Type: research
