MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells
CONCLUSIONS: This is the first study showing the role of miR-320a in upregulating the testicular cancer-specific regulator LRWD1 and the importance of the AGO2/FXR1 complex in miR-320a-mediated upregulation of LRWD1 during testicular cancer progression.PMID:38385979 | DOI:10.18632/aging.205571 (Source: Aging)
Source: Aging - February 22, 2024 Category: Biomedical Science Authors: Yi-Hsiung Lin Chia-Hui Su Hsin-Mei Chen Ming-Syuan Wu Hsien-An Pan Chia-Ning Chang Yu-Sheng Cheng Wen-Tsan Chang Chien-Chih Chiu Yen-Ni Teng Source Type: research
EHMT2/G9a and EZH2: Epimarkers in testicular germ cell tumors
Discussion and conclusionOverall, our data suggest that EZH2 and EHMT2/G9a might be associated with greater aggressiveness and, eventually, involved in the metastatic setting, paving the way for testing targeted therapies. (Source: Andrology)
Source: Andrology - February 22, 2024 Category: Urology & Nephrology Authors: Helena Estev ão‐Pereira,
Catarina Guimarães‐Teixeira,
Bianca C. T. Flores,
Filipa Moreira‐Silva,
Nuno Tiago Tavares,
Rita Guimarães,
Isaac Braga,
Joaquina Maurício,
Rui Henrique,
Carmen Jerónimo,
João Lobo Tags: ORIGINAL ARTICLE Source Type: research
Testicular biopsies in men with testicular microlithiasis and additional risk factors for cancer: A case series
ConclusionThis study found that men with testicular microlithiasis and testicular atrophy are at an increased risk of germ cell neoplasia in situ. Additionally, our results indicate that biopsies should be considered in men with a combination of subfertility and bilateral testicular microlithiasis. Our findings do not support testicular biopsies for men with testicular microlithiasis and other risk factors. (Source: Andrology)
Source: Andrology - February 20, 2024 Category: Urology & Nephrology Authors: Rasmus Hassing Frandsen,
Emil Durukan,
Elena von Rohden,
Christian Fuglesang S. Jensen,
Andreas Key Milan Thamsborg,
Nessn Azawi,
Mikkel Fode Tags: ORIGINAL ARTICLE Source Type: research
Macroscopy of specimens from the genitourinary system
J Clin Pathol. 2024 Feb 19;77(3):177-183. doi: 10.1136/jcp-2023-208831.ABSTRACTMacroscopic specimen examination is often critical for accurate histopathology reporting but has generally received insufficient attention and may be delegated to inexperienced staff with limited guidance and supervision. This review discusses issues around macroscopic examination of some common urological specimens; highlighting findings that are critical for patient management and others that are clinically irrelevant. Macroscopic findings are of limited value in completely submitted radical prostatectomy specimens but may be critical in orchi...
Source: Clinical Prostate Cancer - February 19, 2024 Category: Cancer & Oncology Authors: Murali Varma John Dormer Source Type: research
Macroscopy of specimens from the genitourinary system
Macroscopic specimen examination is often critical for accurate histopathology reporting but has generally received insufficient attention and may be delegated to inexperienced staff with limited guidance and supervision. This review discusses issues around macroscopic examination of some common urological specimens; highlighting findings that are critical for patient management and others that are clinically irrelevant. Macroscopic findings are of limited value in completely submitted radical prostatectomy specimens but may be critical in orchidectomy specimens where identification of focal non-seminomatous components can...
Source: Journal of Clinical Pathology - February 19, 2024 Category: Pathology Authors: Varma, M., Dormer, J. Tags: Review Source Type: research
A population-based validation of the IGCCCG Update Consortium for survival in metastatic non-seminoma testis cancer
CONCLUSIONS: The survival improvement reported by the IGCCCG Update Consortium is also operational in non-seminoma testis cancer patients within the most contemporary SEER database. This observation indicates that the survival improvement is not only applicable to centres of excellence, but also applies to other institutions at large.PMID:38369557 | DOI:10.1093/jjco/hyae011 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - February 18, 2024 Category: Cancer & Oncology Authors: Reha-Baris Incesu Simone Morra Lukas Scheipner Francesco Barletta Andrea Baudo Cristina Cano Garcia Stefano Tappero Mattia Luca Piccinelli Zhe Tian Fred Saad Shahrokh F Shariat Ottavio de Cobelli Carlo Terrone Felix K H Chun Luca Carmignani Alberto Brigan Source Type: research
