Trial By Error: My Letter to Lead REGAIN Trial Investigator Seeking Correction of Bogus Claims of Clinical Effectiveness
By David Tuller, DrPH Two weeks ago, I sent a letter to The BMJ on behalf of myself and 12 colleagues seeking a correction in a study published last month. The study, called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial,” claimed that the intervention … Trial By Error: My Letter to Lead REGAIN Trial Investigator Seeking Correction of Bogus Claims of Clinical Effectiveness Read More » (Source: virology blog)
Source: virology blog - March 28, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ Long Covid REGAIN rehabilitation Source Type: blogs
Microsoft Teams and Boostlingo Integration Improves Healthcare Interpretation Efficiency
Talking with a CIO this week, he described how telehealth is now just part of the infrastructure for how they see patients. Certainly telehealth balooned during COVID and has come back to more reasonable levels now, but in many cases telehealth appointments have still settled at 100 times what they were before COVID. Patients and clinicians are now more comfortable with telehealth as an option that provides great convenience for the patients.
One of the most common telehealth platforms being used right now is Microsoft Teams. My guess is that it was widely adopted because it was included in the Microsoft package that...
Source: EMR and HIPAA - March 28, 2024 Category: Information Technology Authors: John Lynn Tags: Ambulatory Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops LTPAC Telemedicine and Remote Monitoring Boostlingo Healthcare Interpreters Healthcare Sc Source Type: blogs
Further Considering the Altered Transcription of Longer Genes with Age
The machinery of gene expression changes with age. In recent years, it has been noted that the length of gene sequences correlates with the degree to which transcription of gene sequences into RNA molecules changes over the course of aging. Later work has started to examine the proximate causes of these changes, various fine detail mechanisms buried in the depths of transcription. The research community is not yet at the point of being able to conclusively demonstrate that altered transcription of longer genes produces meaningful downstream consequences in degenerative aging, as interventions specifically targeting just th...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inhibiting P16 in Microglia Reduces Amyloid Plaques in Mice
Researchers here show that targeting microglia in a mouse model of Alzheimer's disease to suppress p16 expression can reduce amyloid-β plaques. This appears to be a way to interfere in a maladaptive reaction to amyloid-β on the part of microglia, innate immune cells responsible for clearing molecular debris from brain tissue. P16 is a marker of cellular senescence, though may also be characteristic of non-senescent but still problematic, pro-inflammatory microglia. There is a good amount of evidence to suggest that both senescent and overly active microglia are important to the progression of neurodegenerative conditions...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Loss of Anti-Microbial Peptides as a Mechanism for Age-Related Changes in Gut Microbiome Composition
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression promotes increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes. (Source: Fight Aging!)
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Investigating the Primary Cilium: Q & A With Xuecai Ge
Credit: Courtesy of Dr. Xuecai Ge.
The brain is a large and complex organ, but some very small structures guide its development. Xuecai Ge, Ph.D., an associate professor of molecular and cell biology at the University of California, Merced (UC Merced), has devoted her career to understanding one of these structures called the primary cilium. In an interview, Dr. Ge shared how her childhood experience inspired her to study science and what makes the primary cilium fascinating.
Q: How did you first become interested in science?
A: When I was a little kid, my mom was a primary care doctor, and I saw her treat patients...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 27, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Cellular Processes Profiles Source Type: blogs
When Insurance and Patients Start Demanding 24/7 Availability
It would be really nice if injuries, illnesses, and dental issues only happened during 9-5 working hours. However, we know that’s not the case. The need for medical and dental care can spring up at any time. In fact, it seems like most healthcare situations happen after hours at really inconvenient times. Of course, on the other hand, healthcare providers can’t be available 24/7. It’s a truly challenging situation that has to be navigated carefully by practices that want to provide the needed care and maintain their reputation, but also not burn out their staff.
Increasing Demand for 24/7 Availa...
Source: EMR and HIPAA - March 27, 2024 Category: Information Technology Authors: John Lynn Tags: Administration Ambulatory Communication and Patient Experience Health IT Company Healthcare IT Complete Dental Care Healthcare Scene Featured Healthcare Staff Burnout Medical Answering Service Medical Receptionists Physician Burnout Source Type: blogs
Wednesday Bible Study: False prophecy
Psalm 87 is rather opaque. What seems to be going on here is that Zion, i.e Jerusalem, is envisioned as essentially the capital of the world -- that is, the world as it was known to the ancient Judeans. Obviously that never happened. It ' s not clear when this was written or what the intent really is. " Rahab " apparently refers to a legendary monster supposedly slain by Yahweh, as mentioned later in Psalm 89, not the helpful brothel keeper of the Book of Joshua, and it is thought to be a metonym for Egypt, though I ' m not sure why scholars think so. Regarding Psalm 88, nobody knows whatMahalath Leannoth means. Mahal...
Source: Stayin' Alive - March 27, 2024 Category: American Health Source Type: blogs
Case report: regression of MGUS with long-term use of curcumin!
I wonder if these case reports will ever catch the eye of our MM organisations, which, unfortunately, are so heavily sponsored by big Pharma…Doubtful…
Well, Margaret, this is intended to be a celebratory post, and I really don’t have the energy to dive into THAT discussion again. It’s just so bloody frustrating that sometimes I have to let off some steam. But no, not today. Today is a super good day!
Pinga, 14.5 years old
A new case report, led by Terry Golombick (if you don’t know who she is, you can do a search of my blog…she’s one of my favourite people on the planet…!!...
Source: Margaret's Corner - March 27, 2024 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll case report on curcumin MGUS patient and curcumin Terry Golombick Source Type: blogs
More Commentary on the Role of PF4 in Reducing Brain Inflammation
Platelets in the blood are not just involved in clotting. Near every aspect of our biology has evolved many different functions, and the complexity of our biochemistry is still far from fully explored. Increased platelet factor 4 (PF4) shows up as a feature in a number of different interventions known to reduce inflammation in the aging brain. Researchers are now moving in the direction of developing therapies for neurodegenerative conditions based on the upregulation of PF4 or the delivery of recombinant PF4.
Platelets are a component of blood best known for their role in clotting, but research in recent years ha...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Gen Z ’s Mid-Life Crisis
By KIM BELLARD
These are not happy times in America.
Now, I’m not thinking about the increasing cultural wars, the endless political bickering, the troubles in the Med-East or Ukraine, the looming threat of climate crisis, or the omnipresent campaigning for the November 2024 elections, although all those play a part. I’m talking about quantifiable data, from the latest World Happiness Report. It found that America has slipped out of the top 20 countries for the first time, falling to 23rd – behind countries like Slovenia and the U.A.E. and barely ahead of Mexico or Uruguay.
Even worse, the fall in U.S. score...
Source: The Health Care Blog - March 27, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Happiness Kim Bellard Mental Health Social Media Source Type: blogs
Interesting Epidemiological Results for Time Restricted Feeding
In this study, researchers investigated the potential long-term health impact of following an 8-hour time-restricted eating plan. They reviewed information about dietary patterns for participants in the annual 2003-2018 National Health and Nutrition Examination Surveys (NHANES) in comparison to data about people who died in the U.S., from 2003 through December 2019, from the Centers for Disease Control and Prevention's National Death Index database.
The analysis found: (a) people who followed a pattern of eating all of their food across less than 8 hours per day had a 91% higher risk of death due to cardiovascular d...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why Managing Mobile Devices at Scale Matters in Healthcare
Healthcare organizations are increasingly reliant on mobile devices for daily operations, enabling tasks that range from clinical communications to electronic record access. The proliferation of devices brings new challenges including loss, security risks, and a strain on IT resources. Managing those devices effectively not only reduces risk, but also improves workflow efficiency says Daniel Siegal, MD, CEO of Navv Systems, a company that offers a mobile device management platform.
Healthcare IT Today sat down with Dr. Siegal to discuss the challenges of managing mobile devices in healthcare.
Healthcare Has Embraced Mobile...
Source: EMR and HIPAA - March 25, 2024 Category: Information Technology Authors: Colin Hung Tags: Communication and Patient Experience EMR-EHR Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops Security and Privacy device tracking Dr. Daniel Siegal healthcare mobile devices Healthcare Scene Featu Source Type: blogs
